BR0116852A - Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4 - Google Patents

Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4

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Publication number
BR0116852A
BR0116852A BR0116852-5A BR0116852A BR0116852A BR 0116852 A BR0116852 A BR 0116852A BR 0116852 A BR0116852 A BR 0116852A BR 0116852 A BR0116852 A BR 0116852A
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BR
Brazil
Prior art keywords
alkyl
derivatives useful
biarylated
nicotinamide derivatives
phenyl
Prior art date
Application number
BR0116852-5A
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English (en)
Inventor
Robert James Chambers
Thomas Victor Magee
Anthony Marfat
Original Assignee
Pfizer Prod Inc
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Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0116852A publication Critical patent/BR0116852A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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Abstract

"DERIVADOS BIARILADOS DE NICOTINAMIDA úTEIS COMO INIBIDORES DE ISOZIMAS PDE4". Compostos úteis como inibidores de PDE4 no tratamento de doenças reguladas pela ativação e desgranulação de eosinófilos, em especial asma, bronquite crónica, e doença obstrutiva pulmonar crónica, com a fórmula em que j é 0 ou 1 desde que, quando j for o, n deverá ser 2; k seja 0 ou 1; m seja 0, 1, ou 2; n seja 1 ou 2; W^ 1^ seja -O-; ou -S(=O)~ t~-, em que t seja 0, 1, ou 2; ou -N(R^ 3~)-; W^ 2^ seja -O-CR^ A^R^ B^ - ou esteja ausente; Y seja =C(R^ 1^~ a~)- ou -[N<sym>(O)~ k~]- em que k seja O ou 1; R^ A^ e R^ B^ sejam -H; -F; -CF~ 3~; -alquila(C~ 1~-C~ 4~); cicloalquila(C~ 3~-C~ 7~); fenila; ou benzila substituída com 0 a 3 substituintes R^ 10^; ou R^ A^ e R^ B^ sejam tomados em conjunto, mas apenas no caso em que m seja 1, para formar uma porção espiro; R^ c^ e R^ D^ tenham o mesmo significado do que R^ A^ e R^ B^ exceto que um deles deva ser -H; R^ 1^ e R^ 2^ sejam -H; -F; -Cl; -CN; -NO~ 2~; (C~ 1~-C~ 4~)-alquila; (C~ 2~-C~ 4~)alquinila; (C~ 1~C~ 3~) alquila fluorada; - OR^ 16^; e -C(=O)NR^ 22^~ a~ R^ 22^ ~ a~ R^ 22^~ b~; R^ 3^ seja - H; -(C~ 1~-C~ 3~)alquila; fenila; benzila; ou -OR^ 16^; R^ 4^, R^ 5^ e R^ 5^, para além de outros significados, possam ser tomados em conjunto para formarem, por exemplo, fórmula (II) Q^ 1^, Q^ 2^ e Z são como definidos no pedido.
BR0116852-5A 2001-01-31 2001-12-06 Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4 BR0116852A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26549201P 2001-01-31 2001-01-31
PCT/IB2001/002341 WO2002060875A1 (en) 2001-01-31 2001-12-06 Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes

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BR0116852A true BR0116852A (pt) 2004-02-25

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BR0116852-5A BR0116852A (pt) 2001-01-31 2001-12-06 Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4

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US (2) US6649633B2 (pt)
EP (1) EP1355884A1 (pt)
JP (1) JP2004520386A (pt)
KR (1) KR20030074761A (pt)
CN (1) CN1518542A (pt)
BG (1) BG108038A (pt)
BR (1) BR0116852A (pt)
CA (1) CA2436535A1 (pt)
CR (1) CR7025A (pt)
CZ (1) CZ20031895A3 (pt)
EA (1) EA200300621A1 (pt)
EC (2) ECSP034709A (pt)
EE (1) EE200300360A (pt)
HU (1) HUP0400637A2 (pt)
IL (1) IL156413A0 (pt)
IS (1) IS6846A (pt)
MA (1) MA26983A1 (pt)
MX (1) MXPA03006887A (pt)
NO (1) NO20033397L (pt)
NZ (1) NZ526453A (pt)
OA (1) OA12540A (pt)
PL (1) PL364135A1 (pt)
SK (1) SK8792003A3 (pt)
WO (1) WO2002060875A1 (pt)
ZA (1) ZA200304894B (pt)

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US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
CN1537018A (zh) * 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
US20040146561A1 (en) * 2001-05-23 2004-07-29 Naoki Sakurai Compositions for promoting healing of bone fracture
US6951869B2 (en) * 2002-02-26 2005-10-04 Schlesinger Stephen L Use of leukotriene receptor antagonist for treatment of scarring
EP1424101A3 (en) * 2002-11-29 2004-08-18 NOZAKI, Masako Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
KR20050115331A (ko) * 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
GB0309781D0 (en) * 2003-04-29 2003-06-04 Glaxo Group Ltd Compounds
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US7132435B2 (en) * 2003-07-25 2006-11-07 Pfizer Inc. Compounds
US20050020587A1 (en) * 2003-07-25 2005-01-27 Pfizer Inc Nicotinamide derivatives useful as PDE4 inhibitors
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317498D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Compounds
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