EA201890424A1 - Получение клеток пигментного эпителия сетчатки - Google Patents

Получение клеток пигментного эпителия сетчатки

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Publication number
EA201890424A1
EA201890424A1 EA201890424A EA201890424A EA201890424A1 EA 201890424 A1 EA201890424 A1 EA 201890424A1 EA 201890424 A EA201890424 A EA 201890424A EA 201890424 A EA201890424 A EA 201890424A EA 201890424 A1 EA201890424 A1 EA 201890424A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pigment epithelium
epithelium cells
obtaining cell
cell pigment
cells
Prior art date
Application number
EA201890424A
Other languages
English (en)
Inventor
Оснат Бохана-Каштан
Офер Визер
Original Assignee
Селл Кьюр Нейросайансес Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селл Кьюр Нейросайансес Лтд. filed Critical Селл Кьюр Нейросайансес Лтд.
Publication of EA201890424A1 publication Critical patent/EA201890424A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/98—Xeno-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Abstract

Раскрыт способ получения клеток пигментного эпителия сетчатки. Также раскрыты популяции клеток, которые их содержат, и их применения.
EA201890424A 2015-08-05 2016-08-04 Получение клеток пигментного эпителия сетчатки EA201890424A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201156P 2015-08-05 2015-08-05
US201562253738P 2015-11-11 2015-11-11
PCT/IL2016/050857 WO2017021973A1 (en) 2015-08-05 2016-08-04 Preparation of retinal pigment epithelium cells

Publications (1)

Publication Number Publication Date
EA201890424A1 true EA201890424A1 (ru) 2018-06-29

Family

ID=56740278

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890424A EA201890424A1 (ru) 2015-08-05 2016-08-04 Получение клеток пигментного эпителия сетчатки

Country Status (11)

Country Link
US (2) US11066642B2 (ru)
EP (2) EP3331994B1 (ru)
JP (1) JP6864670B2 (ru)
CN (1) CN108138144A (ru)
AU (2) AU2016303632B2 (ru)
CA (1) CA2993912A1 (ru)
DK (1) DK3331994T3 (ru)
EA (1) EA201890424A1 (ru)
ES (1) ES2932823T3 (ru)
PL (1) PL3331994T3 (ru)
WO (1) WO2017021973A1 (ru)

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JP2022532411A (ja) * 2019-05-15 2022-07-14 ノヴォ ノルディスク アー／エス ヒト多能性幹細胞から眼野前駆細胞を得るための方法
EP3754014A1 (en) 2019-06-21 2020-12-23 Centre d'Etude des Cellules Souches (CECS) Automated method for preparing retinal pigment epithelium cells
CN112544612A (zh) * 2020-12-18 2021-03-26 江苏艾尔康生物医药科技有限公司 冻存液及其在rpe细胞冻存中的应用
EP4351334A1 (en) 2021-06-09 2024-04-17 Lineage Cell Therapeutics, Inc. Methods and compositions for treating retinal diseases and conditions
CN113481158A (zh) * 2021-06-24 2021-10-08 暨南大学 一种无支架视网膜色素上皮细胞片的制备方法
KR20240038013A (ko) 2021-07-28 2024-03-22 리니지 셀 테라퓨틱스, 인크. 망막 색소 상피 세포의 확장
WO2023167986A1 (en) 2022-03-02 2023-09-07 Lineage Cell Therapeutics, Inc. Methods and compositions for treating hearing loss
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Also Published As

Publication number Publication date
EP4155391A1 (en) 2023-03-29
CA2993912A1 (en) 2017-02-09
US20210388316A1 (en) 2021-12-16
AU2016303632A1 (en) 2018-02-08
EP3331994B1 (en) 2022-09-14
PL3331994T3 (pl) 2023-01-30
CN108138144A (zh) 2018-06-08
AU2016303632B2 (en) 2022-09-29
AU2022291461A1 (en) 2023-02-02
JP6864670B2 (ja) 2021-04-28
DK3331994T3 (da) 2022-11-21
WO2017021973A1 (en) 2017-02-09
US11066642B2 (en) 2021-07-20
JP2018521678A (ja) 2018-08-09
ES2932823T3 (es) 2023-01-26
US20180230426A1 (en) 2018-08-16
EP3331994A1 (en) 2018-06-13

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