MX2014004214A - Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes. - Google Patents

Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes.

Info

Publication number
MX2014004214A
MX2014004214A MX2014004214A MX2014004214A MX2014004214A MX 2014004214 A MX2014004214 A MX 2014004214A MX 2014004214 A MX2014004214 A MX 2014004214A MX 2014004214 A MX2014004214 A MX 2014004214A MX 2014004214 A MX2014004214 A MX 2014004214A
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MX
Mexico
Prior art keywords
proteins
replicating
rna molecules
complexes
polycistronic rna
Prior art date
Application number
MX2014004214A
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English (en)
Inventor
Anders Lilja
Peter Mason
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2014004214A publication Critical patent/MX2014004214A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A61K39/25—Varicella-zoster virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
    • C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron

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  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta descripción provee moléculas de ácido nucleico policistrónicas recombinantes que contienen por lo menos cuatro secuencias de nucleótidos que codifican una proteína de interés, particularmente proteínas que forman complejos in vivo, cada una operablemente enlazada a un promotor subgenómico separado. En algunas modalidades, estas proteínas y los complejos que éstas forman producen anticuerpos neutralizantes potentes. Por lo tanto, la presentación de proteínas de virus de herpes mediante el uso de las plataformas descritas permite la generación de respuestas inmunitarias amplias y potentes útiles para el desarrollo de vacunas.
MX2014004214A 2011-10-11 2012-10-11 Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes. MX2014004214A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161546002P 2011-10-11 2011-10-11
PCT/US2012/059731 WO2013055905A1 (en) 2011-10-11 2012-10-11 Recombinant self-replicating polycistronic rna molecules

Publications (1)

Publication Number Publication Date
MX2014004214A true MX2014004214A (es) 2014-05-07

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Family Applications (1)

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MX2014004214A MX2014004214A (es) 2011-10-11 2012-10-11 Moleculas de acido ribonucleico policistronicas auto-replicantes recombinantes.

Country Status (11)

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US (2) US20140271829A1 (es)
EP (1) EP2768530A1 (es)
JP (1) JP6305925B2 (es)
CN (1) CN104105504A (es)
AU (1) AU2012322704B2 (es)
BR (1) BR112014008694A2 (es)
CA (1) CA2872033A1 (es)
IL (1) IL231761A0 (es)
MX (1) MX2014004214A (es)
RU (1) RU2014118727A (es)
WO (1) WO2013055905A1 (es)

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AU2012322704B2 (en) 2017-09-07
IL231761A0 (en) 2014-05-28
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US20170342442A1 (en) 2017-11-30
CN104105504A (zh) 2014-10-15
AU2012322704A1 (en) 2014-04-10
EP2768530A1 (en) 2014-08-27
CA2872033A1 (en) 2013-04-18
JP6305925B2 (ja) 2018-04-18
BR112014008694A2 (pt) 2017-06-20
JP2015527871A (ja) 2015-09-24
RU2014118727A (ru) 2015-11-20

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