BR112013000244A2 - lipossomas com lipídeos apresentando pka vantajoso para administração de rna - Google Patents

lipossomas com lipídeos apresentando pka vantajoso para administração de rna

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Publication number
BR112013000244A2
BR112013000244A2 BR112013000244A BR112013000244A BR112013000244A2 BR 112013000244 A2 BR112013000244 A2 BR 112013000244A2 BR 112013000244 A BR112013000244 A BR 112013000244A BR 112013000244 A BR112013000244 A BR 112013000244A BR 112013000244 A2 BR112013000244 A2 BR 112013000244A2
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BR
Brazil
Prior art keywords
pka
advantageous
rna
administration
liposomes
Prior art date
Application number
BR112013000244A
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English (en)
Inventor
Andrew Geall
Original Assignee
Novartis Ag
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44534956&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013000244(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112013000244A2 publication Critical patent/BR112013000244A2/pt

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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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Abstract

lipossomas com lipídios que tenham um valor vantajoso de pka para transcrição de rna. rna codificano um imunogénio é transcrita em um lipossoma, para efeitos de imunização. o lipossoma inclui lipídeos que têm um pka na gama de 5,0 a 7,6 e, de preferência, uma amina terciária. estes lipossomas podem ter carga de superfície essencialmente neutras a um ph fisiológico e que são eficazes para a imunização.
BR112013000244A 2010-07-06 2011-07-06 lipossomas com lipídeos apresentando pka vantajoso para administração de rna BR112013000244A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36183010P 2010-07-06 2010-07-06
US37883710P 2010-08-31 2010-08-31
PCT/US2011/043105 WO2012006378A1 (en) 2010-07-06 2011-07-06 Liposomes with lipids having an advantageous pka- value for rna delivery

Publications (1)

Publication Number Publication Date
BR112013000244A2 true BR112013000244A2 (pt) 2016-05-17

Family

ID=44534956

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013000244A BR112013000244A2 (pt) 2010-07-06 2011-07-06 lipossomas com lipídeos apresentando pka vantajoso para administração de rna

Country Status (19)

Country Link
US (15) US20130171241A1 (pt)
EP (1) EP2590626B1 (pt)
JP (5) JP2013537518A (pt)
CN (1) CN103153284B (pt)
AU (1) AU2011276234B2 (pt)
BR (1) BR112013000244A2 (pt)
CA (1) CA2804396C (pt)
DK (1) DK2590626T3 (pt)
ES (1) ES2557382T3 (pt)
HR (1) HRP20151349T1 (pt)
HU (1) HUE026646T2 (pt)
MX (1) MX2013000164A (pt)
PL (1) PL2590626T3 (pt)
PT (1) PT2590626E (pt)
RS (1) RS54489B1 (pt)
RU (1) RU2589503C2 (pt)
SI (1) SI2590626T1 (pt)
SM (1) SMT201600007B (pt)
WO (1) WO2012006378A1 (pt)

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