JO3257B1 - مركبات وتركيبات كمعدلات لفاعلية tlr - Google Patents
مركبات وتركيبات كمعدلات لفاعلية tlrInfo
- Publication number
- JO3257B1 JO3257B1 JOP/2010/0304A JOP20100304A JO3257B1 JO 3257 B1 JO3257 B1 JO 3257B1 JO P20100304 A JOP20100304 A JO P20100304A JO 3257 B1 JO3257 B1 JO 3257B1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- compositions
- activity modulators
- tlr activity
- tlr
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
يعمل الاختراع على إعداد فئة جديد من المركبات، التركيبات المناعية والتركيبات الصيدلية المتضمنة تلك المركبات وطرق استخدام تلك المركبات لمعالجة أو من الامراض أو الاضطرابات المصحوبة بمستقبلات V تشبه Toll. وفي احدى الجوانب، تكون المركبات مفيدة كعوامل إضافة مساعدة لتحسين فاعلية اللقاح.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23921709P | 2009-09-02 | 2009-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3257B1 true JO3257B1 (ar) | 2018-09-16 |
Family
ID=43625759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2010/0304A JO3257B1 (ar) | 2009-09-02 | 2010-08-31 | مركبات وتركيبات كمعدلات لفاعلية tlr |
Country Status (26)
Country | Link |
---|---|
US (2) | US9045470B2 (ar) |
EP (1) | EP2473508B1 (ar) |
JP (1) | JP5525614B2 (ar) |
CN (1) | CN102712636B (ar) |
AR (1) | AR078153A1 (ar) |
AU (1) | AU2010308524B2 (ar) |
BR (1) | BR112012004696B8 (ar) |
CA (1) | CA2772657C (ar) |
CL (1) | CL2012000535A1 (ar) |
CY (1) | CY1119618T1 (ar) |
DK (1) | DK2473508T3 (ar) |
EA (1) | EA020962B1 (ar) |
ES (1) | ES2627669T3 (ar) |
HR (1) | HRP20170707T1 (ar) |
HU (1) | HUE032323T2 (ar) |
IN (1) | IN2012DN02736A (ar) |
JO (1) | JO3257B1 (ar) |
LT (1) | LT2473508T (ar) |
MX (1) | MX2012002654A (ar) |
PE (1) | PE20121156A1 (ar) |
PL (1) | PL2473508T3 (ar) |
PT (1) | PT2473508T (ar) |
SI (1) | SI2473508T1 (ar) |
TW (1) | TWI445708B (ar) |
UY (1) | UY32874A (ar) |
WO (1) | WO2011049677A1 (ar) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8926990B2 (en) | 2009-10-13 | 2015-01-06 | Rutgers, The State University Of New Jersey | Treatment and diagnosis of inflammatory disorders and HIV |
US10149889B2 (en) | 2005-11-25 | 2018-12-11 | Rutgers, The State University Of New Jersey | Compositions for the treatment of cancer, and methods for testing and using the same |
CN102272134B (zh) | 2008-12-09 | 2013-10-16 | 吉里德科学公司 | Toll样受体调节剂 |
JP5988492B2 (ja) | 2009-09-02 | 2016-09-07 | ノバルティス アーゲー | Tlr活性モジュレーターを含む免疫原性組成物 |
BR112012014624A8 (pt) | 2009-12-15 | 2017-12-26 | Novartis Ag | suspensão homogênea de compostos de imunopotenciação e usos dos destes |
EP2402028A1 (en) * | 2010-07-01 | 2012-01-04 | Sanofi Pasteur | Enterovirus vaccines for preventing and treating type 1 diabetes (II) |
CA3169291A1 (en) | 2010-07-06 | 2012-01-12 | Glaxosmithkline Biologicals Sa | Immunisation of large mammals with low doses of rna |
EP2590626B1 (en) | 2010-07-06 | 2015-10-28 | GlaxoSmithKline Biologicals SA | Liposomes with lipids having an advantageous pka-value for rna delivery |
DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
HRP20221533T1 (hr) | 2010-08-31 | 2023-02-17 | Glaxosmithkline Biologicals Sa | Pegilirani liposomi za isporuku rna koja kodira imunogen |
EP2719395A1 (en) | 2010-09-01 | 2014-04-16 | Novartis AG | Adsorption of immunopotentiators to insoluble metal salts |
MX363307B (es) | 2010-10-11 | 2019-03-20 | Novartis Ag Star | Plataformas para suministro de antigenos. |
CA2828844C (en) | 2011-03-02 | 2020-07-14 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
US9352017B2 (en) | 2011-03-16 | 2016-05-31 | Rutgers, The State University Of New Jersey | Combination therapy with leukotoxin |
US8900626B2 (en) * | 2011-06-20 | 2014-12-02 | Senju Usa, Inc. | Transdermal drug delivery system and method of using the same |
EP2729165B1 (en) * | 2011-07-06 | 2017-11-08 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
SG11201400210RA (en) | 2011-09-01 | 2014-03-28 | Novartis Ag | Adjuvanted formulations of staphylococcus aureus antigens |
FI123955B (en) | 2011-11-25 | 2014-01-15 | Oncos Therapeutics Ltd | Oncolytic adenovirus |
EP2822589A1 (en) | 2012-03-07 | 2015-01-14 | Novartis AG | Adjuvanted formulations of rabies virus immunogens |
LT2822947T (lt) * | 2012-03-07 | 2016-10-10 | Glaxosmithkline Biologicals Sa | Tlr7 agonisto arginino druskos |
CN104519910B (zh) * | 2012-03-07 | 2017-05-03 | 诺华股份有限公司 | 肺炎链球菌抗原的含佐剂制剂 |
WO2013132041A2 (en) * | 2012-03-08 | 2013-09-12 | Novartis Ag | Adjuvanted formulations of booster vaccines |
EP2674170B1 (en) | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
CA2875391A1 (en) | 2012-07-27 | 2014-01-30 | Institut National De La Sante Et De La Recherche Medicale | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
CN104736165A (zh) * | 2012-08-31 | 2015-06-24 | 诺华股份有限公司 | 用于针对金黄色葡萄球菌的免疫的稳定化的蛋白质 |
EP2732825B1 (en) | 2012-11-19 | 2015-07-01 | Invivogen | Conjugates of a TLR7 and/or TLR8 agonist and a TLR2 agonist |
CN103845731B (zh) * | 2012-12-05 | 2015-12-02 | 复旦大学 | 抗st2/il-1r4抗体在制备防治瘙痒药物中的应用 |
WO2014108515A1 (en) * | 2013-01-10 | 2014-07-17 | Novartis Ag | Influenza virus immunogenic compositions and uses thereof |
JP6411378B2 (ja) * | 2013-02-01 | 2018-10-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Toll様受容体アゴニストを含む免疫学的組成物の皮内送達 |
EP2769738B1 (en) | 2013-02-22 | 2016-07-20 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
CN105828835A (zh) | 2013-05-10 | 2016-08-03 | 诺华股份有限公司 | 避免流感疫苗中的发作性嗜睡病风险 |
CN104338129B (zh) * | 2013-07-26 | 2017-05-24 | 中国科学院上海巴斯德研究所 | 雷帕霉素作为疫苗佐剂的用途及制备方法 |
JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ, インコーポレイテッド | Hivを治療するためのトール様受容体の調節因子 |
JP2017526730A (ja) | 2014-09-16 | 2017-09-14 | ギリアード サイエンシーズ, インコーポレイテッド | Toll様受容体モジュレーターの固体形態 |
EP3061826A1 (en) * | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
CN109415429B (zh) * | 2016-06-30 | 2023-04-28 | 美国政府(由卫生和人类服务部的部长所代表) | Herv-e反应性t细胞受体及使用方法 |
WO2018047888A1 (ja) * | 2016-09-09 | 2018-03-15 | 武田薬品工業株式会社 | 環状化合物 |
AR111760A1 (es) * | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
JP7351859B2 (ja) * | 2018-06-04 | 2023-09-27 | アプロス セラピューティクス, インコーポレイテッド | Tlr7の調節に関係する疾患を処置するのに有用な酸性基を含むピリミジン化合物 |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
KR20210106437A (ko) | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
BR112021015577A8 (pt) | 2019-02-08 | 2021-10-05 | Research & Business Found Sungkyunkwan Univ | Complexo-colesterol agonista do receptor toll-like 7/8, composição de nanopartícula, composição adjuvante, composição de vacina, composição para regular uma função imunológica, composição farmacêutica e uso do complexo |
EP3924054A1 (en) | 2019-02-15 | 2021-12-22 | Novartis AG | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
CA3123519A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
US20230057071A1 (en) | 2019-12-20 | 2023-02-23 | Novartis Ag | Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome |
CN114901275A (zh) | 2019-12-20 | 2022-08-12 | 纳米医疗有限公司 | 可用于治疗癌症的含有Toll样受体(“TLR”)激动剂前药的配制和/或共同配制的脂质体组合物及其方法 |
WO2021177679A1 (ko) | 2020-03-02 | 2021-09-10 | 성균관대학교산학협력단 | 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법 |
CA3182346A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
WO2022009157A1 (en) | 2020-07-10 | 2022-01-13 | Novartis Ag | Lhc165 and spartalizumab combinations for treating solid tumors |
EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
US20230277525A1 (en) | 2020-08-04 | 2023-09-07 | Progeneer Inc | Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof |
CN116322751A (zh) | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
WO2022031011A1 (ko) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | 동력학적으로 작용하는 아주번트 앙상블 |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
CN116262750A (zh) * | 2021-12-15 | 2023-06-16 | 上海翊石医药科技有限公司 | 一种芳杂环类化合物及其制备方法和用途 |
WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2848965A1 (de) | 1978-11-11 | 1980-05-22 | Behringwerke Ag | Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine |
US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
US6180111B1 (en) | 1995-05-18 | 2001-01-30 | University Of Maryland | Vaccine delivery system |
JP2000511769A (ja) | 1996-04-02 | 2000-09-12 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
EP0914330A4 (en) | 1996-05-14 | 2002-01-09 | Smithkline Beecham Corp | NEW TYPE COMPOUNDS |
EP0942983B2 (en) | 1996-10-31 | 2014-09-10 | Human Genome Sciences, Inc. | Streptococcus pneumoniae antigens and vaccines |
GB9711964D0 (en) | 1997-06-09 | 1997-08-06 | Medical Res Council | Live attenuated vaccines |
US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
CA2300854C (en) | 1997-08-21 | 2011-04-05 | Peter Andre Van Der Ley | Novel mutants of gram negative mucosal bacteria and application thereof in vaccines |
JPH1180156A (ja) * | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | 1−(置換アリール)アルキル−1h−イミダゾピリジン−4−アミン誘導体 |
DE69841807D1 (de) | 1997-11-06 | 2010-09-16 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
EP1034277B1 (en) | 1997-11-26 | 2012-06-27 | Inhibitex, Inc. | Extracellular matrix-binding proteins from Staphylococcus aureus |
AU1979599A (en) | 1998-01-14 | 1999-08-02 | Chiron S.P.A. | (neisseria meningitidis) antigens |
EP1073450A4 (en) | 1998-04-23 | 2003-04-23 | Uab Research Foundation | PNEUMOCOCCAL SURFACE PROTEIN C (PSPC), EPITOPIC REGIONS, SELECTION OF CORRESPONDING STRES AND USES |
EP1093517B1 (en) | 1998-05-01 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
GB9810193D0 (en) | 1998-05-12 | 1998-07-08 | Smithkline Beecham Biolog | Novel compounds |
DE69935986D1 (de) | 1998-07-27 | 2007-06-14 | Sanofi Pasteur Ltd | Streptococcus pneumoniae proteine und nukleinsäuren |
EP1144640A3 (en) | 1998-07-27 | 2001-11-28 | Microbial Technics Limited | Nucleic acids and proteins from streptococcus pneumoniae |
AU771426B2 (en) | 1998-08-31 | 2004-03-18 | Inhibitex, Inc. | Multicomponent vaccines |
IL141691A0 (en) | 1998-08-31 | 2002-03-10 | Trinity College Dublin | Polypeptides and polynucleotides from coagulase-negative staphylococci |
CA2346713A1 (en) | 1998-10-09 | 2000-04-20 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
GB9823978D0 (en) | 1998-11-02 | 1998-12-30 | Microbiological Res Authority | Multicomponent meningococcal vaccine |
GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
JP4689044B2 (ja) | 1998-12-21 | 2011-05-25 | メディミューン,インコーポレーテッド | ワクチン用の肺炎連鎖球菌タンパク質と免疫原断片 |
EP1165795A2 (en) | 1999-03-26 | 2002-01-02 | Provalis UK Limited | Streptococcus pneumoniae antigens |
WO2000076540A2 (en) | 1999-06-10 | 2000-12-21 | Med Immune, Inc. | Streptococcus pneumoniae proteins and vaccines |
EP1075841A1 (en) | 1999-08-13 | 2001-02-14 | Erasmus Universiteit Rotterdam | Pneumococcal vaccines |
WO2001034642A2 (en) | 1999-11-12 | 2001-05-17 | University Of Iowa Research Foundation | Control of neisserial membrane synthesis |
BR0107679A (pt) | 2000-01-17 | 2004-07-06 | Chiron Spa | Vacina de vesìcula de membrana externa (omv) compreendendo proteìnas de membrana externa do grupo sérico b de neisseria meningitidis |
WO2001064922A2 (en) | 2000-02-28 | 2001-09-07 | Chiron Spa | Heterologous expression of neisserial proteins |
KR20020097200A (ko) | 2000-03-21 | 2002-12-31 | 엘리트라 파마슈티컬즈, 인코포레이티드 | 원핵세포에서의 필수유전자의 동정 |
CA2407455A1 (en) | 2000-04-27 | 2001-11-01 | Medimmune, Inc. | Immunogenic pneumococcal protein and vaccine compositions thereof |
NO20002828D0 (no) | 2000-06-02 | 2000-06-02 | Statens Inst For Folkehelse | Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav |
US6495079B1 (en) | 2000-06-28 | 2002-12-17 | Prisma Fibers, Inc. | Process to prepare polymeric fibers with improved color and appearance |
WO2002002606A2 (en) | 2000-07-03 | 2002-01-10 | Chiron S.P.A. | Immunisation against chlamydia pneumoniae |
WO2002008426A2 (en) | 2000-07-20 | 2002-01-31 | Hansa Medical Ab | Fh-binding protein of streptococcus pneumoniae |
BRPI0112928B1 (pt) | 2000-07-27 | 2017-08-29 | Children's Hospital & Research Center At Oakland | A composition comprising preparations comprising outer membrane vesicles (OMV), microvesicles (MV) or both MVO and MV |
GB0103170D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
AU8743001A (en) | 2000-08-28 | 2002-03-13 | Aventis Pasteur | Moraxella polypeptides and corresponding dna fragments and uses thereof |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
WO2002034773A2 (en) | 2000-10-26 | 2002-05-02 | Imperial College Innovations Ltd. | Streptococcal genes |
JP4254931B1 (ja) | 2000-10-27 | 2009-04-15 | カイロン ソチエタ ア レスポンサビリタ リミタータ | A群連鎖球菌およびb群連鎖球菌由来の核酸およびタンパク質 |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
GB0103424D0 (en) | 2001-02-12 | 2001-03-28 | Chiron Spa | Gonococcus proteins |
WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
GB0108079D0 (en) | 2001-03-30 | 2001-05-23 | Microbial Technics Ltd | Protein |
ATE557041T1 (de) | 2001-05-18 | 2012-05-15 | Us Gov Health & Human Serv | Peptid-vakzinen gegen streptokokken der gruppe a |
EP1423701B1 (en) | 2001-06-15 | 2012-07-25 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
ATE542829T1 (de) | 2001-08-02 | 2012-02-15 | Univ Sheffield | Impfstoff |
EP2335724A1 (en) | 2001-12-12 | 2011-06-22 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation against chlamydia trachomatis |
GB0203403D0 (en) | 2002-02-13 | 2002-04-03 | Chiron Spa | Chlamydia cytotoxic-T cell epitopes |
WO2003082183A2 (en) | 2002-04-02 | 2003-10-09 | Ben-Gurion University Of The Negev Research And Development Authority | Protein-based streptococcus pneumoniae vaccines |
GB0210128D0 (en) | 2002-05-02 | 2002-06-12 | Chiron Spa | Nucleic acids and proteins from streptococcus groups A & B |
ATE359295T1 (de) | 2002-06-11 | 2007-05-15 | Glaxosmithkline Biolog Sa | Immunogene zusammensetzungen |
GB0213622D0 (en) | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
EP2481419A3 (en) | 2002-08-02 | 2013-04-10 | GlaxoSmithKline Biologicals S.A. | Neisserial vaccines |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
ES2504166T3 (es) | 2002-09-13 | 2014-10-08 | Novartis Vaccines And Diagnostics, Inc. | Vacuna de estreptococo del grupo B |
CA2501812C (en) | 2002-10-11 | 2012-07-10 | Mariagrazia Pizza | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
ES2529736T3 (es) | 2003-04-10 | 2015-02-25 | Novartis Vaccines And Diagnostics, Inc. | Composición inmunogénica que comprende una proteína espicular del coronavirus del SARS |
EP2311989A1 (en) | 2003-04-15 | 2011-04-20 | Intercell AG | S. pneumoniae antigens |
DE10327439A1 (de) * | 2003-06-18 | 2005-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazopyridazinon- und Imidazopyridonderivate, deren Herstellung und deren Verwendung als Arzneimittel |
BRPI0411857A (pt) | 2003-06-26 | 2006-05-23 | Chiron Corp | composições imunogênicas para chlamydia trachomatis |
GB0316560D0 (en) | 2003-07-15 | 2003-08-20 | Chiron Srl | Vesicle filtration |
PT1648500E (pt) | 2003-07-31 | 2014-10-10 | Novartis Vaccines & Diagnostic | Composições imunogénicas para estreptococos piogenes |
AU2005214061B2 (en) | 2004-02-18 | 2010-02-04 | Merck Sharp & Dohme Corp. | Polypeptides for inducing a protective immune response against Staphylococcus aureus |
GB0419627D0 (en) | 2004-09-03 | 2004-10-06 | Chiron Srl | Immunogenic bacterial vesicles with outer membrane proteins |
JP2008513406A (ja) | 2004-09-22 | 2008-05-01 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
NZ555937A (en) | 2005-01-27 | 2009-05-31 | Childrens Hosp & Res Ct Oak | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
AU2006342053A1 (en) | 2005-12-27 | 2007-10-25 | Obetech, Llc | Adipogenic adenoviruses as a biomarker for disease |
EP2368570A3 (en) | 2006-01-18 | 2012-05-02 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
EP1994047A2 (en) | 2006-02-17 | 2008-11-26 | Novartis AG | Purification and use of streptococcus pneumoniae pili and pilus proteins |
EP2010537B1 (en) * | 2006-03-23 | 2011-12-28 | Novartis AG | Imidazoquinoxaline compounds as immunomodulators |
AR060187A1 (es) | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Composicion inmunogenica |
BRPI0710210A2 (pt) | 2006-03-30 | 2011-05-24 | Glaxomithkline Biolog S A | composição imunogênica, vacina, métodos para preparar a vacina, e para prevenir ou tratar infecção estafilocócica, uso da composição imunogênica, e, processo para conjugar oligassacarìdeo ou polissacarìdeo capsular |
EA018068B1 (ru) * | 2008-03-03 | 2013-05-30 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности tlr |
ES2658863T3 (es) * | 2009-06-10 | 2018-03-12 | Glaxosmithkline Biologicals Sa | Vacunas que contienen benzonaftiridina |
CN102760226B (zh) * | 2011-04-29 | 2015-07-01 | 贵州师范大学 | 一种基于实心正方形的试卷客观题答题卡定位方法 |
-
2010
- 2010-08-31 JO JOP/2010/0304A patent/JO3257B1/ar active
- 2010-08-31 TW TW099129346A patent/TWI445708B/zh active
- 2010-09-01 BR BR112012004696A patent/BR112012004696B8/pt active IP Right Grant
- 2010-09-01 MX MX2012002654A patent/MX2012002654A/es unknown
- 2010-09-01 ES ES10807754.6T patent/ES2627669T3/es active Active
- 2010-09-01 LT LTEP10807754.6T patent/LT2473508T/lt unknown
- 2010-09-01 PE PE2012000285A patent/PE20121156A1/es active IP Right Grant
- 2010-09-01 CN CN201080049422.8A patent/CN102712636B/zh active Active
- 2010-09-01 SI SI201031468A patent/SI2473508T1/sl unknown
- 2010-09-01 WO PCT/US2010/047587 patent/WO2011049677A1/en active Application Filing
- 2010-09-01 CA CA2772657A patent/CA2772657C/en active Active
- 2010-09-01 IN IN2736DEN2012 patent/IN2012DN02736A/en unknown
- 2010-09-01 PL PL10807754T patent/PL2473508T3/pl unknown
- 2010-09-01 AU AU2010308524A patent/AU2010308524B2/en active Active
- 2010-09-01 HU HUE10807754A patent/HUE032323T2/en unknown
- 2010-09-01 PT PT108077546T patent/PT2473508T/pt unknown
- 2010-09-01 EP EP10807754.6A patent/EP2473508B1/en active Active
- 2010-09-01 EA EA201200406A patent/EA020962B1/ru not_active IP Right Cessation
- 2010-09-01 JP JP2012528021A patent/JP5525614B2/ja active Active
- 2010-09-01 US US12/874,153 patent/US9045470B2/en active Active
- 2010-09-01 DK DK10807754.6T patent/DK2473508T3/en active
- 2010-09-02 UY UY0001032874A patent/UY32874A/es unknown
- 2010-09-02 AR ARP100103222A patent/AR078153A1/es active IP Right Grant
-
2012
- 2012-02-29 CL CL2012000535A patent/CL2012000535A1/es unknown
-
2015
- 2015-04-24 US US14/696,165 patent/US20150225432A1/en not_active Abandoned
-
2017
- 2017-05-11 HR HRP20170707TT patent/HRP20170707T1/hr unknown
- 2017-06-08 CY CY20171100605T patent/CY1119618T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JO3257B1 (ar) | مركبات وتركيبات كمعدلات لفاعلية tlr | |
SG178954A1 (en) | Immunogenic compositions including tlr activity modulators | |
JO3065B1 (ar) | مركبات وتركيبات كمعدلات لفاعلية tlr | |
MX341395B (es) | Compuestos (lipopeptidos basados en cisteina) y composiciones como agonistas de tlr2 usados para el tratamiento de infecciones, inflamaciones, enfermedades respiratorias, etc. | |
MX347471B (es) | Vacunas que comprenden colesterol y cpg como moleculas portadoras-adyuvantes unicas. | |
MX352324B (es) | Vacunas multivalentes de nanovehiculos sinteticos. | |
EA201390843A1 (ru) | Применение агониста toll-подобного рецептора для лечения рака | |
EP2563366A4 (en) | USE OF PHOSPHOLIPID CONJUGATES FROM SYNTHETIC TLR7 AGONISTS | |
AU2012253757A8 (en) | Partially saturated tricyclic compounds and methods of making and using same | |
MX2011012836A (es) | Adyuvantes sinteticos de glucopiranosil-lipido. | |
TN2010000122A1 (en) | Compounds and compositions as modulators of gpr119 activity | |
MX2009009491A (es) | Compuestos y composiciones como moduladores de la actividad del gpr119. | |
MY161415A (en) | A homeopathic formulation | |
MX2021004211A (es) | Composiciones vacuna. | |
MX2012004078A (es) | Compuestos y composiciones como moduladores de la actividad de gpr119. | |
PH12015501637A1 (en) | Inactivated dengue virus vaccine with aluminium-free adjuvant | |
MX2015000446A (es) | Composiciones de vacuna para la prevencion contra la infeccion por el virus del dengue. | |
SG178596A1 (en) | Methods of treatment using anti-oxidized ldl antibodies | |
EA201290319A1 (ru) | Применение источника l3 и/или l5 в качестве вакцины или диагностического средства для паразитарного заболевания | |
BR112013023354A2 (pt) | vacina para rinite equina | |
MX2013003454A (es) | Composiciones de vacuna mejoradas. | |
TN2010000398A1 (en) | Compounds and compositions as tlr activity modulators | |
TN2010000463A1 (en) | Compositions and methods for preparing and using same | |
UA97289C2 (ru) | Соединения и их композиция как модуляторы gpr119 активности | |
TN2010000338A1 (en) | Vaccine comprising a ribosomal protein extract (rpe) and optionally a th1-promoting adjuvant |