ES2281409T3 - Expresion heterologa de proteinas de neisseria. - Google Patents
Expresion heterologa de proteinas de neisseria. Download PDFInfo
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- ES2281409T3 ES2281409T3 ES01914109T ES01914109T ES2281409T3 ES 2281409 T3 ES2281409 T3 ES 2281409T3 ES 01914109 T ES01914109 T ES 01914109T ES 01914109 T ES01914109 T ES 01914109T ES 2281409 T3 ES2281409 T3 ES 2281409T3
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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Abstract
Un procedimiento para expresión heteróloga de la proteína ''961'' de N. meningitidis, en el que (a) la proteína 961 de la cepa MC58 tiene la secuencia "961" de aminoácidos: y en el que (b) al menos un dominio de la proteína está suprimido, en el que los dominios de ''961'' de la cepa MC58 son como sigue: (1) aminoácidos 1-23; (2) aminoácidos 24-268; (3) aminoácidos 269-307 y (4) aminoácidos 308-364 y en el que las proteína ''961'' se expresa en una célula hospedadora.
Description
Expresión heteróloga de proteínas de
Neisseria.
Esta invención corresponde al campo de la
expresión de proteínas. En particular se refiere a la expresión
heteróloga de proteínas de Neisseria (por ejemplo
N.gonorrhoeae o, preferiblemente, N.
meningitidis).
Las solicitudes de patente internacional WO
99/24578, WO 99/36544, WO 99/57280 y WO 00/22430 describen proteínas
de Neisseria meningitidis y Neisseria gonorrhoeae.
Típicamente estas proteínas se describen como expresadas en E.
coli (esto es, expresión heteróloga) como fusiones GST
N-terminales o fusiones His-tag
C-terminales, aunque también se describen otros
sistemas de expresión, incluida la expresión en Neisseria
nativa. El documento FR-A-2720408
describe la producción heteróloga de una proteína de N.
meningitidis en la que se ha suprimido al menos un dominio.
Es un objetivo de la presente invención
proporcionar enfoques alternativos y mejorados para la expresión
heteróloga de estas proteínas. Estos enfoques afectarán típicamente
al nivel de expresión, la facilidad de purificación, la
localización celular de expresión y/o las propiedades inmunológicas
de la proteína expresada.
La invención se refiere a la proteína "961"
descrita en el documento WO 99/57280.
En esta memoria se usan las convenciones de
denominación usadas en los documentos WO 99/24578, WO 99/36544 y WO
99/57280 (por ejemplo, "ORF4", "ORF40",
"ORF40-I", etc., como las usadas en WO 99/24578
y WO 99/36544; "m919", "g919" y "a919", etc. usadas
en el documento WO 99/57280.
La proteína preferida "961" de la invención
se encuentra en el serogrupo B de N. meningitidis.
La proteína preferida "961" para uso de
acuerdo con la invención es del serogrupo B de la cepa 2996 de N.
menigitidis o de la cepa 394/98 (una cepa de Nueva Zelanda). A
no ser que se indique lo contrario, las proteínas que se mencionan
en esta memoria son de la cepa 2996 de N. menigitidis. Se
apreciará, sin embargo, que en general la invención no está
limitada por la cepa. Las referencias a una proteína particular (por
ejemplo, "287", "919", etc.) se pueden tomar para incluir
esa proteína de cualquier cepa.
En este enfoque para la expresión heteróloga, la
proteína 961 se expresa como dominios. Ésta se puede usar en
asociación con sistemas de fusión (por ejemplo, fusiones GST o
His-tag).
Así, la invención proporciona un procedimiento
para expresión heteróloga de la proteína "961" de N.
meningitidis, en el que
(a) la proteína "961" tiene la secuencia de
aminoácidos "961" en la cepa MC58:
\vskip1.000000\baselineskip
y en el
que
(b) está suprimido al menos un dominio de la
proteína en la que los dominios "961" en la cepa MC58 son como
sigue: (1) aminoácidos 1-23; (2) aminoácidos
24-268; (3) aminoácidos 269-307, y
(4) aminoácidos 308-364,
y en el que la proteína "961"
se expresa en una célula
hospedadora.
El procedimiento típicamente implica las etapas
de: obtener ácido nucleico que codifica una proteína de la
invención; manipular el mencionado ácido nucleico para eliminar al
menos un dominio del interior de la proteína. El ácido nucleico
resultante se puede insertar en un vector de expresión o puede ser
ya parte de un vector de expresión. Cuando no se usan partícipes de
fusión, el primer aminoácido de la proteína expresada será el de un
dominio de la proteína.
Típicamente, una proteína se divide en dominio
nocionales alineándola con secuencias conocidas de bases de datos y
determinando luego regiones determinantes de la proteína que
presentan diferentes configuraciones de alineamiento entre sí.
Una vez que una proteína se ha dividido en
dominios, éstos se pueden (a) expresar individualmente, (b) suprimir
de la proteína, por ejemplo proteína ABCD \rightarrowABD, ACD,
BCD, etc., o (c) reordenar por ejemplo, proteína ABC \rightarrow
ACB, CAB, etc. Estas tres estrategias se pueden combinar con
partícipes de fusión, si se desea.
Los dominios de la proteína 961 se ilustran en
la Figura 12.
La proteína 961 puede ser parte de un híbrido de
dos o más (por ejemplo, 3, 4, 5, 6 o más) proteínas de
Neisseria expresada como proteína individual. Se prefiere
usar un partícipe de fusión no neisserial (por ejemplo, GST o
poli-His).
Esto ofrece dos ventajas. Primera, una proteína
que pueda ser inestable o expresarse deficientemente en sí puede
ser ayudada añadiendo un partícipe de fusión que eluda el problema.
Segunda, la producción industrial se simplifica; sólo es necesario
emplear una expresión y purificación para producir dos proteínas
útiles separadamente.
Así, la invención proporciona un procedimiento
para la expresión heteróloga simultánea de la proteína 961 con una
o más proteínas de Neisseria en la que las mencionada
proteínas están fusionadas (esto es, se traducen como una cadena
individual de polipéptido).
Típicamente, el procedimiento implicará las
etapas de: obtener un primer ácido nucleico que codifica una primera
proteína de la invención; obtener un segundo ácido nucleico que
codifica una segunda proteína de la invención; ligar los ácidos
nucleicos primero y segundo. El ácido nucleico resultante se puede
expresar en un vector de expresión, o puede ser ya parte de un
vector de expresión.
Preferiblemente, las proteínas constitutivas de
una proteína híbrida de acuerdo con la invención serán de la misma
cepa.
Las proteínas fusionadas en el híbrido se pueden
unir directamente o se pueden unir a través de un péptido conector,
por ejemplo, a través de un conector de poliglicina (esto es,
G_{n} en el que n = 3, 4, 5, 6, 7, 8, 9, 10 o más) o a través de
una secuencia peptídica corta que facilita la clonación.
Evidentemente se prefiere no unir una proteína \DeltaG al
término C de un conector de poliglicina.
Las proteínas fusionadas pueden carecer de
péptidos líder nativos o pueden incluir la secuencia de péptido
líder del partícipe de fusión N-terminal.
Se prefieren los híbridos marcados X en la
tabla siguiente para formar
NH_{2}-A-B-COOH:
Las proteínas preferidas a ser expresadas como
híbridos con la proteína "961" son así ORF46.1, 287, 741, 919,
953 y 983. Éstas se pueden usar en su forma de longitud
sustancialmente entera, o se pueden usar las formas con supresión
de poliglicina (\DeltaG) (por ejemplo,
\DeltaG-287, \DeltaGTbb2, \DeltaG741,
\DeltaG983, etc.), o formas truncadas
(\Delta1-287, \Delta2-287, etc),
o versiones de dominio suprimido (por ejemplo, 287B, 287C, 287BC,
ORF46_{1-433}, ORF_{433-608},
ORF46, 961c, etc).
Cuando se usa 287, preferiblemente está en el
extremo C-terminal; si se ha de usar en el término
N, se prefiere usar una forma \DeltaG de 287 (por ejemplo, como
el término N de un híbrido con 961).
Cuando se usa 287, preferiblemente es de la cepa
2996 o de la cepa 394/98.
Preferiblemente, 961 está en el término N.
Preferiblemente, en tales híbridos se usan las formas de dominio de
961.
Los alineamientos de formas polimórficas de
ORF46, 287, 919 y 953 se describen en el documento WO 00/66741. Se
puede usar de acuerdo con la presente invención cualquiera de estos
polimorfos.
Si bien la expresión de la proteína 961 o su
híbrido puede tener lugar en el hospedador nativo (esto es, el
organismo en el que la proteína se expresa naturalmente), la
presente invención utiliza un hospedador heterólogo. El hospedador
heterólogo puede ser procariótico o eucariótico. Preferiblemente es
E. coli, pero entre otros hospedadores adecuados están
incluidos Bacillus subtilis, Vibrio cholerae, Salmonella typhi,
Salmonella typhimurium, Neisseria meningitidis, Neisseria
gonorrhoeae, Neisseria lactamica, Neisseria cinerea,
Mycobacteria (por ejemplo, M. tuberculosis), levadura,
etc.
Además de los procedimientos descritos antes, la
invención proporciona (a) ácido nucleico y vectores útiles en estos
procedimientos, (b) células hospedadoras que contienen los
mencionados vectores, (c) proteínas expresadas o expresables por
los procedimientos, (d) composiciones que comprenden estas
proteínas, que pueden ser adecuadas como vacunas, por ejemplo, o
como reactivos diagnósticos, (e) estas composiciones para uso como
medicamentos (por ejemplo, vacunas), (f) el uso de estas
composiciones en la fabricación de (1) un medicamento para tratar o
prevenir una infección debida a bacterias Neisseria, (2) un
reactivo diagnóstico para detectar la presencia de bacterias
Neisseria o de anticuerpos generados contra bacterias
Neisseria, y/o (3) un reactivo que puede generar anticuerpos
contra bacterias Neisseria y (g) un procedimiento para tratar
un paciente, que comprende administrar al paciente una cantidad
terapéuticamente eficaz de estas composiciones.
La invención proporciona también una proteína o
un ácido nucleico que tiene cualquiera de las secuencias que se
presentan en los ejemplos siguientes. También proporciona proteínas
y ácido nucleico que tienen identidad de secuencia con las
anteriores. Como se ha descrito antes, el grado de identidad de la
secuencia es mayor que 50% (por ejemplo, 60%, 70%, 80%, 90%, 95%,
99% o más).
Además, la invención proporciona ácido nucleico
que puede hibridizar con el ácido nucleico descrito en los
ejemplos, preferiblemente en condiciones de "alta rigurosidad"
(por ejemplo, 65ºC en una solución 01xSSC, 05% de SDS.
La invención también usa ácido nucleico que
codifica proteínas usadas en la invención.
Debe apreciarse también que la invención
proporciona ácido nucleico que comprende secuencias complementarias
de las descritas antes (por ejemplo, de antisentido o a fines de
sonda).
El ácido nucleico de acuerdo con la invención se
puede preparar, obviamente, de varias maneras (por ejemplo, por
síntesis química, a partir de bibliotecas genómicas o de cDNA, a
partir del propio organismo, etc.) y puede tomar varias formas (por
ejemplo, de cadena simple, cadena doble, vectores, sondas,
etc.).
Además, el término "ácido nucleico" incluye
DNA y RNA y también sus análogos, tales como los que contienen
espinazos modificados, y también ácidos nucleicos peptídicos (PNA)
etc.
La Figura 4 presenta datos de expresión para la
proteína 961.
La Figura 12 presenta dominios de la proteína
961.
La Figura 14 presenta 26 proteínas híbridas de
acuerdo con la invención.
La proteína 953 con su péptido líder nativo y
sin partícipes de fusión se expresó a partir del vector pET y
también de pSM214 [Velati Bellini y otros, (1991), J. Biotechnol.
18, 177-192].
La secuencia de 953 se clonó como gen de
longitud total en pSM214 usando la cepa MM294-1 de
E. coli como hospedador. Para hacerlo, se amplificó por
reacción en cadena de polimerasa (PCR) la secuencia entera de DNA
del gen de 953 /de ATG al codón STOP) usando los cebadores
siguientes:
que contienen los sitios de
restricción EcoRI y HindIII, respectivamente. El fragmento
amplificado se digirió con ECORI y HindIII y se ligó con el vector
pSM214 digerido con las mismas dos enzimas. El plásmido ligado se
transformó en células MM294-1 de E. coli (por
incubación en hielo durante 65 min a 37ºC) y las células
bacterianas se cultivaron en agar LB que contenía 20 \mug/ml de
cloranfenicol.
Se hicieron crecer colonias recombinantes
durante la noche, a 37ºC en 4 ml de caldo LB que contenía 20
\mug/ml de cloranfenicol; se centrifugaron las células
microbianas y se extrajo DNA del plásmido y se analizó por
restricción con EcoRI y HindIII. Para analizar la capacidad de las
colonias recombinantes de expresar la proteína, se inocularon con
caldo de LB que contenía 20 \mug/ml de cloranfenicol y se dejaron
crecer durante 16 horas a 37ºC. Se centrifugaron las células
bacterianas y ase pusieron en suspensión PBS. La expresión de la
proteína se analizó por SDS-PAGE y tinción con azul
Coomassie.
Los niveles de expresión fueron inesperadamente
altos desde el plásmido pSM214.
Los oligonucleótidos usados para clonar
secuencias de "961" en vectores pSM214 fueron los
siguientes:
Estas secuencias se manipularon, clonaron y
expresaron como se ha descrito para 953L.
Para el vector pET-24, se
clonaron las secuencias y las proteínas se expresaron en
pET-24 como se describe más adelante para pET21.
pET2 tiene la misma secuencia que pET-21, pero con
la casete de resistencia a la kanamicina en vez de la casete de
ampicilina.
Los oligonucleótidos usados para clonar
secuencias en el vector pET24b fueron las siguientes:
- * Este cebador se usó como cebador inverso para todas las 287 formas
- ** Cebadores de avance usados en combinación con el cebador inverso \DeltaG278 K.
La proteína 961 entera de N. meningitidis
(serogrupo B, cepa MC58) tiene la siguiente secuencia:
La secuencia líder del péptido está
subrayada.
Se usaron tres enfoques a la expresión de
961:
- (1)
- usando una proteína de fusión de GST, según WO 99/57280 ("GST961")
- (2)
- 961 con su propia secuencia líder pero sin partícipe de fusión ("961L"), y
- (3)
- 961 sin su secuencia líder y sin partícipe de fusión ("961^{no \ etiquetada}"), con la frecuencia líder omitida por diseñar el cebador de PCR del extremo 5’ aguas abajo de la secuencia líder prevista.
Se expresaron las tres formas de la proteína. Se
pudo purificar la proteína de fusión GST y los anticuerpos contra
ella confirmaron que 961 es de superficie expuesta (Figura 4). La
proteína se usó para inmunizar ratones y los sueros resultantes
dieron excelentes resultados en el ensayo bactericida. También se
pudo purificar 961L y dio títulos por ELISA muy altos.
Parece que la proteína 961 es de fase variable.
Además, no se encuentra en todas las cepas de N.
meningitidis.
Como se ha descrito en el ejemplo 7 anterior, la
fusión GST de 961 se expresó óptimamente en E. coli. Para
mejorar la expresión, la proteína se dividió en dominios. (Figura
12).
Los dominios de 961 se diseñaron sobre la base
de YadA (una adhesina producida por Yersinia que se había
demostrado que es una adhesina localizada sobre la superficie
bacteriana que forma oligómeros que generan proyección de la
superficie [Hoiczyk y otros (2000). EMBO J.
19:5989-99]) y son: péptido líder, dominio de
cabecera, región de la bobina enrollada (tronco) y dominio de
anclaje de membrana. Estos dominios se expresaron con o sin péptido
líder y opcionalmente se fusionaron a His-tag
C-terminal o GST N-terminal. Los
clones de E. coli que expresaban diferentes dominios de 961
se analizaron por SDS-PAGE y transferencia western
para la producción y localización de la proteína expresada, desde
cultivo durante la noche (o/n) o después de 3 horas de inducción
con IPTG. Los resultados fueron:
Los resultados revelan que, en E.
coli:
\bullet 961-L se expresa
altamente y se localiza en la membrana exterior. Por análisis de
transferencia western se han detectado dos bandas específicas: una
a \approx45 kDa (el peso molecular previsto) y una a \approx180
kDa, lo que indica que 961-L puede formar
oligómeros. Además, estos agregados se expresan más en el cultivo
nocturno (sin inducción por IPTG). Se usaron preparaciones de OMV de
este clon para inmunizar ratones y se obtuvo suero. Usando cultivo
nocturno (predominantemente en forma oligómera), el suero era
bactericida; el cultivo inducido por IPTG (predominantemente
monómero) no era bactericida;
\bullet 961\Delta_{1}-L
(con supresión parcial en la región de anclaje) se expresa altamente
y se localiza en la membrana exterior, pero no forma
oligómeros;
\bullet el 961c-L (sin la
región de anclaje) es produce en forma soluble y se exporta al
material sobrenadante.
Los títulos en ELISA y el ensayo bactericida en
suero usando fusiones His fueron los siguientes:
Se usaron clones de E. coli que expresan
diferentes formas de 961 (961, 961-L, 961
\Delta_{1}L y 961c-L) para investigar si l961
es una adhesina (c.f. YadA). Se hizo un ensayo de adhesión usando
(a) las células epiteliales humanas y (b) clones de E. coli
después de cultivo nocturno o 3 horas de inducción por IPTG.
961-L crecido durante la noche
(961\Delta_{1}-L) y 961c-L (los
clones que expresan proteína sobre la superficie) se adhieren a
células epiteliales humanas.
También se usó 961c en proteínas híbridas (véase
antes). Como 961 y sus variantes de dominio dirigen la expresión
eficiente, son idealmente adecuadas como porción
N-terminal de un proteína híbrida.
Seguidamente es presentan otras proteínas
híbridas de la invención (véase también la Figura 14). Éstas son
ventajosas cuando se comparan con proteínas individuales
Se entenderá que la invención se ha descrito
sólo a modo de ejemplo y que se pueden hacer modificaciones dentro
del ámbito de la invención. Por ejemplo, se contempla el uso de
proteínas de otras cepas [por ejemplo, véase el documento WO
00/66741 para las secuencias polimórficas para ORF4, ORF40, ORF46,
225, 235, 287, 519, 726, 919 y 953].
Se amplificaron por PCR genes que codifican
antígenos de interés diseñados sobre la base de la secuencia
genómica de B MC58 de N. meningitidis. Se usó siempre DNA
genómico de la cepa 2996 como plantilla en reacciones de PCR a no
ser que se especifique lo contrario, y se clonaron los fragmentos
amplificados en el vector de expresión pET21b+ (Novagen) para
expresar la proteína como producto C-terminal
etiquetado His, o en pET-24b+ (Novagen) para
expresar la proteína en forma "no etiquetada" (por ejemplo,
\DeltaG 287K).
Cuando se expresó una proteína sin un partícipe
de fusión y con su propio péptido líder (si estaba presente), se
realizó la amplificación del marco de lectura abierta (codones ATG a
STOP).
Cuando se expresó una proteína en forma "no
etiquetada", se omitió la secuencia líder diseñando el cebador
de amplificación de extremo 5’ aguas abajo de la secuencia líder
predicha.
La temperatura de fusión de los cebadores usados
en la PCR dependía del número y el tipo de nucleótidos de
hibridación en el cebador global, y se determinó usando las
fórmulas:
- T_{m1} = 4 (G + c) + 2 (A + T)
- excluida la cola
- T_{m2} = 64,9 + 0,41 (% de GC) - 600/N
- cebador entero
Las temperaturas de fusión de los
oligonucleótidos seleccionados usualmente eran de
65-70ºC para los oligonucleótidos enteros y de
50-60ºC para la región de hibridación sola.
Los oligonucleótidos se sintetizaron usando un
sintetizador Perkin Elmer 394 DNA/RNA eluyendo de las columnas en
2,0 ml de NH_{4}OH y desprotegiendo por incubación durante 5 horas
a 56ºC. Los oligonucleótidos se precipitaron añadiendo acetato
sódico 0,3 M y dos volúmenes de etanol. Se centrifugaron las
muestras y las pellas se volvieron a poner en suspensión.
Los oligonucleótidos usados para hacer las
proteínas 961 e híbridos de la invención incluyen:
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
(Tabla pasa a página
siguiente)
En todas las construcciones que empiezan con un
ATG no seguido por un sitio individual NheI, el codón ATG es parte
del sitio NdeI usado para clonar. Las construcciones hechas usando
NheI como sitio de clonación en el terminal 5’ (por ejemplo, los
que contienen 287 en el término N) tienen dos codones adicionales
(GCT AGC) fusionados a la secuencia de codificación del
antígeno.
Las cepas de N. meningitidis 2996, MC58,
394.98, 1000 y BZ232 (y otras) se hicieron crecer a fase exponencial
en 100 ml de medio GC, se cosecharon por centrifugación y se
volvieron a poner en suspensión en 5 ml de tampón (20% p/v de
sacarosa, Tris-HCl 50 mM, EDTA 50 mM, pH 8). Después
de 10 minutos de incubación sobre hielo, las bacterias se lisaron
añadiendo 10 ml de solución de lisis (NaCl 50 mM, 1% de
Na-sacarosil, 50 \mug/ml de proteinasa K) y la
suspensión se incubó a 37ºC durante 2 horas. Se realizaron dos
extracciones con fenol (equilibrado a pH 8) y una extracción con
CHCl_{3}/alcohol isoamílico, se precipitó DNA añadiendo acetato
sódico 0,3 M y dos volúmenes de etanol y se recogió por
centrifugación. La pella es lavó una vez con etanol (70% v/v) y se
redisolvió en 4,0 ml de tampón TE (Tris-HCl 10 mM,
EDTA 1 mM, pH 8,0). La concentración de DNA se midió por lectura de
OD _{260}.
El protocolo estándar de PCR fue el siguiente:
se usaron como plantillas 200 ng de DNA genómico de cepas 2996,
MC58, 1000 o BZ232, o 10 ng de preparación de DNA de plásmido de
clones recombinantes en presencia de 40 \muM de cada cebador de
nucleótido, 400-800 \muM de solución de dNTPs,
tampón lx de PCR (que incluye MgCl_{2} 1,5 mM), 2,5 unidades de
Taq/polimerasa de DNA (usando Perkin-Elmer AmpliTaQ,
plantilla larga Boehringer Mannheim Expand^{MC}).
Después de una incubación preliminar de 3
minutos de la totalidad de la mezcla a 95ºC, cada muestra
experimentó una amplificación en dos etapas: los primeros 5 ciclos
es realizaron usando la temperatura de hibridación que excluía la
cola de la enzima de restricción del cebador (T_{m1}). A esto
siguieron 5 ciclos de de acuerdo con la temperatura de hibridación
calculada para oligonucleótidos de longitud entera (T_{m2}). Los
tiempos de alargamiento, realizados a 68ºC o 72ºC, variaban de
acuerdo con la longitud de Orf a amplificar. En el caso de Orf1, el
tiempo de alargamiento, empezando desde 3 minutos, se aumentó en 15
segundos cada ciclo. Los ciclos se completaron con una etapa de
extensión de 10 minutos a 72ºC.
El DNA amplificado se cargó directamente en gel
de agarosa al 1%. El fragmento de DNA correspondiente a la banda de
tamaño correcto se purificó desde gel usando el kit Qiagen Gel
Extraction.
El DNA purificado correspondiente al fragmento
ampliado se digirió con enzimas de restricción apropiadas en
pET-21b, pET22b+ o pET-24b-. Los
fragmentos digeridos se purificaron usando el kit de purificación
QIAquick (siguiendo las instrucciones del fabricante) y se eluyó
con H_{2}O o Tris 10 mM, pH 8,5. Los vectores de plásmido se
digirieron con las enzimas de restricción apropiadas, se cargaron en
gel de agarosa al 1,0% y la banda correspondiente al vector
digerido se purificó usando el kit Qiagen QIAquack Gel
Extraction.
Los fragmentos correspondientes a cada gen,
previamente digeridos y purificados, se ligaron a pRT21b+, pET22b+
o pEt-24b+. Se usó una relación 3:1 de
fragmento/vector con T4 DNA ligasa en el tampón de ligación
suministrado por el fabricante.
Se transformó plásmido recombinante en DH5 o
HB101 competente de E. coli incubando la solución de reacción
de ligasa y bacterias durante 40 minutos sobre hielo, luego a 37ºC
durante 3 minutos.
Seguidamente se añadieron 800 \mul de caldo LB
y se incubó a 37ºC durante 20 minutos. Las células se centrifugaron
a la velocidad máxima en una microcentrifugadora Eppendorf y se
pusieron nuevamente en suspensión en aproximadamente 200 \mul de
material sobrenadante y se cultivaron sobre agar de ampicilina LB
(100 mg/ml). La exploración de clones recombinantes se realizó
haciendo crecer al azar colonias seleccionadas durante la noche a
37ºC en 4,0 ml de caldo LB + 100 \mug/ml de ampicilina. Se
peletizaron las células y se extrajo el DNA de plásmido usando el
kit Qiagen QIAprep Spin Miniprep siguiendo las instrucciones del
fabricante. Se digirió aproximadamente 1 \mug de cada
minipreparado individual con las enzimas de restricción apropiadas y
el digerido se cargó en gel de agarosa al 1-1,5%
(dependiendo del tamaño esperado del inserto) paralelamente con el
marcado del peso molecular (1 kb DNA Ladder, GIBCO). Se
seleccionaron clones positivos sobre la base del tamaño del
inserto.
Después de clonar cada gen en el vector de
expresión, se transformaron plásmidos recombinantes en cepas de
E. coli adecuadas para expresión de la proteína recombinante.
Para transformar BL21-DE3 de E. coli se usó
1 \mul de cada construcción como se ha descrito antes. Se
inocularon colonias recombinantes individuales en 2 ml de LB+Amp
(100 \mug/ml), se incubó a 37ºC durante la noche, luego se diluyó
1:30 en 20 ml de LB+Amp (100 \mug/ml) en matraces de 100 ml para
obtener un OD_{600} entre 0,1 y 0,2. Los matraces se incubaron a
30ºC o a 37ºC en un agitador giratorio de baño de agua hasta que
IO_{600} indicó un crecimiento exponencial adecuado para inducir
la expresión (0,4-0,8 OD). La expresión de proteína
se indujo añadiendo IPTG 1,0 mM. Después de 3 horas de incubación a
30ºC o 37ºC, se midió OD_{600} y se examinó la expresión. Se
centrífugo 1,0 ml de cada muestra en una microcentrifugadora, se
volvió a poner en suspensión la pella en PBS y se analizó por
SDS-PAGE y tinción con azul Coomassie.
Las secuencias marcadas GATE se clonaron y
expresaron usando la tecnología de clonación GATEWAY
(GIBCO-BRL). La clonación por recombinación (RC)
está basada en reacciones de recombinación que median la
integración y escisión de fago en y de, respectivamente, E.
coli. La integración implica recombinación del sitio attP del
DNA del fago dentro del sitio attB situado en el genoma bacterial
(reacción de BP) y genera un genoma de fago integrado flanqueado
por los sitios attL y attR. La escisión recombina los sitios attL y
attR (reacción LR). La reacción de integración requiere dos enzimas
[la integrasa de proteína de fago (Int) y el factor de hospedador
de integración de proteína bacteriana (IHF)] (BP clonasa). La
reacción de escisión requiere Int, IHF y una enzima de fago
adicional, escisionasa (Xis) (RL clonasa). Al extremo 5’ de los
cebadores usados en las reacciones PCR para amplificar ORFs de
Neisseria se añadieron derivados artificiales del sitio de
recombinación attB bacteriana de 25 bp, denominados B1 y B2. Los
productos resultantes se clonaron por BP en el "vector dador"
que contenía derivados complementarios del sitio de recombinación
(P1 y P2) attP del fago usando BO clonasa. Los "clones de
entrada" resultantes contenían ORFs flanqueadas por derivados del
sitio attL (L1 y L2) y se subclonaron en los "vectores de
destino" de expresión que contienen derivados de los sitios attR
compatibles con attL.(R1 y R2) usando LR clonasa. Esto dio por
resultado "clones de expresión" en los que las ORFs están
flanqueadas por B1 y B2 y fusionadas en el marco a GST o etiquetas
His N terminales. La cepa de E. coli usada para expresión
GATEWAY es BL21-SI. Las células de esta cepa se
inducen para expresión de la T7 RNA polimerasa por crecimiento en
un medio que contiene sal (NaCl 0,3M). Nótese que este sistema da
etiquetas His de término N.
Con el fin de obtener proteínas recombinantes
expresadas con secuencias líder de localización de membrana, se
aislaron fracciones compuestas principalmente por membrana interior,
exterior o membrana completa. El procedimiento de preparación de
fracciones de membrana, enriquecidas para proteínas recombinantes,
se adaptó de Filip y otros (J. Bact. (1973)
115:717-722) y Davies y otros [J. Immunol. Meth.
(1990) 143:215-225]. Se hicieron crecer colonias
individuales que alojan el plásmido durante la noche a 37ºC en 20 ml
de cultivo líquido de LB/Amp (100 \mug/ml). Las bacterias se
diluyeron 1:30 en 1,0 l de medio de cultivo recientemente preparado
y se hicieron crecer a 30ºC o 37ºC hasta que OD_{550} alcanzó
0,6-0,8. La expresión de bacterias recombinantes se
indujo con ITPG a una concentración final de 1,0 mM. Después de una
incubación durante 3 horas, las bacterias se cosecharon por
centrifugación a 8000 g durante 15 minutos a 4ºC y se volvieron a
poner en suspensión en 20 ml de Tris-HCl 20 mM (pH
7,5) e inhibidores de proteasa entera (Boehringer Mannheim). Todos
los procedimientos posteriores se realizaron a 4ºC sobre hielo.
Las células se rompieron por sonicación usando
un Branson Sonifier 450 y se centrifugaron a 5000 g durante 20 min
para sedimentar células no rotas y cuerpos de inclusión. El material
sobrenadante, que contenía membranas y residuos celulares, se
centrífugo a 50000 g (Beckman Ti50, 29000 rpm) durante 75 min, se
lavó con bis-tris-propano 20 mM (pH
6,5), NaCl 1,0 M, 10% de glicerol (v/v) y se sedimentó nuevamente a
50000 g durante 75 min. La pella se volvió a poner en suspensión en
Tris.-HCl 20 mM (pH 7,5), 2% (v/v) de Sarkosyl, inhibidor de
proteasa completa (concentración final en EDTA 1,0 mM) y se incubó
durante 20 minutos para disolver la membrana interior. Los residuos
celulares se peletizaron por centrifugación a 5000 g durante 10 min
y el material sobrenadante se centrífugo a 75000 g durante 75 min
(Beckman Ti50, 33000 rpm). En el material sobrenadante se
encontraron proteínas 008L y 519L, lo que sugirió la localización
de la membrana interior. Para estas proteínas se usaron fracciones
de membrana interior y de membrana total (lavadas como antes con
NaCl) con el fin de inmunizar ratones. Se lavaron con
Tris-HCl (pH 7,5) vesículas de membrana exterior
obtenidas de la pella de 75000 g y se centrifugaron a 75000 g
durante 75 minutos o durante la noche. El OMV se volvió a poner
finalmente en suspensión en 500 \mul de Tris-HCl
20 mM (pH 7,5), 10% v/v de glicerol. Se localizaron Orf1L y Orf4L y
se enriquecieron en la fracción de membrana exterior que se usó
para inmunizar ratones. La concentración de proteína se estimó por
la norma Bradford Assay (Bio-Rad), mientras que la
concentración de proteína en la fracción de membrana interior se
determinó con el ensayo DC de proteínas (Bio-Rad).
Se ensayaron por SDS-PAGE varias fracciones del
procedimiento de aislamiento.
Se clonaron varias formas de 287 de las cepas
2996 y MC58. Se construyeron con una fusión etiquetada His de
término C y se incluyeron en una forma madura (aa
18-427), construcciones con supresiones (\Delta1,
\Delta2, \Delta3 y \Delta4) y clones compuestos por dominios
B o C. Para cada clon purificado como una fusión His, se tomó una
porción de una colonia individual y se hizo crecer durante la noche
a 37ºC sobre placa de agar con LB/Amp (100 \mug/ml). Se inoculó
una colonia aislada de esta placa en 20 ml de medio líquido de
LB/Amp (100 \mug/ml) y se hizo crecer durante la noche a 37ºC. El
cultivo nocturno se diluyó 1:30 en 1,0 l de medio líquido de LB/Amp
(100 \mug/ml) y se dejó que creciera a la temperatura óptima (30 o
37ºC) hasta que OD_{550} alcanzó el valor de
0,6-0,8. La expresión de proteína recombinante se
indujo añadiendo IPTG (concentración final, 1,0 mM) y el cultivo se
incubó durante 3 horas más. Las bacterias se cosecharon por
centrifugación a 8000 g durante 15 min a 4ºC. La pella bacteriana
se volvió a poner en suspensión en 7,5 ml de (i) tampón A frío
(NaCl 300 mM, tampón de fosfato 50 mM, imidazol 10 mM, pH 8,0) para
proteínas solubles, o (ii) tampón B (Tris-HCl 10
mM, tampón de fosfato 100 mM, pH 8,8 y, opcionalmente, urea 8 M)
para proteínas insolubles. Las proteínas purificadas en forma
soluble incluían 287-His, \Delta1, \Delta2,
\Delta3 y \Delta4287-His,
\Delta4287MC58-His, 287c-His y
287cMC58-His. La proteína
287bMC58-His era insoluble y se purificó como
correspondía. Las células se rompieron por sonicación sobre hielo
cuatro veces durante 30 s a 40 W usando un sonicador Branson 450 y
se centrifugaron a 13000xg durante 30 min a 4ºC. Para las proteínas
insolubles, las pellas se pusieron nuevamente en suspensión en 2,0
ml de tampón C (hidrocloruro de guanidina 6M, tampón de fosfato 100
mM, Tris-HCl 10 mM, pH 7,5) y se trataron con 10
pasadas de un homogeneizador de mano de mortero (Dounce). El
homogeneizado se centrífugo a 13000 g durante 30 min y se retuvo el
material sobrenadante. El material sobrenadante tanto de la
preparación soluble como de la insoluble se mezcló con 150 \mul de
resina Ni^{2+} (equilibrada previamente con tampón A o tampón B,
como procediera) y se incubó a temperatura ambiente con una
agitación suave durante 30 min. La resina era Chelating Sepharose
Fast Flow (Pharmacia), preparada de acuerdo con el protocolo del
fabricante. La preparación por lotes se centrífugo a 700 g durante 5
min a 4ºC y se desechó el material sobrenadante. La resina se lavó
dos veces (a modo de lote) con 10 ml de tampón A o B durante 10 min,
se puso en suspensión en 1,0 ml de tampón A o B y se cargó en una
columna desechable. Se continuó lavando la resina con (i) tampón A
a 4ºC o (ii) tampón B a temperatura ambiente hasta que OD_{280} de
la corriente de paso alcanzó el valor de 0,02-0,01.
La resina se lavó más con (i) tampón C frío (NaCl 300 mM, tampón de
fosfato 50 mM, imidazol 20 mM, pH 8,0) o (ii) tampón D
(tris-HCl 10 mM, tampón de fosfato 100 mM, pH 6,3 y,
opcionalmente, urea 8M) hasta que el OD_{280} de la corriente de
paso alcanzó el valor de 0,02-0,01. La proteína de
fusión His se eluyó añadiendo 700 \mul de (i) tampón de elusión A
frío (NaCl 300 mM, tampón de fosfato 50 mM, imidazol 250 mM, pH
8,0) o (ii) tampón de elución B (Tris-HCl 10 mM,
tampón de fosfato 100 mM, pH 4,5 y, opcionalmente, urea 8M) y se
recogieron las fracciones hasta que OD_{260} indicó que se había
obtenido la totalidad de proteína recombinante. Se analizaron por
SDS-PAGE partes alícuotas de 20 \mul de cada
fracción de elución. Las concentraciones de proteína se estimaron
usando el ensayo Bradford.
La desnaturalización era necesaria para
solubilizar 287bMC8, por lo que se empleó una etapa de
renaturalización antes de la inmunización. Se añadió glicerol a las
fracciones desnaturalizadas obtenidas antes para obtener una
concentración final de 10% v/v. Las proteínas se diluyeron a 200
\mug/ml usando tampón de diálisis I (glicerol al 10% v/v,
arginina 0,5M, tampón de fosfato 50 mM, glutationa reducida 5,0 mM.
glutationa oxidada 0,5 mM, urea 2,0 mM, pH 8,8) y se dializó contra
el mismo tampón durante 12-14 horas a 4ºC. Se
dializó además con tampón II (glicerol al 10% v/v, arginina 0,5 mM,
tampón de fosfato 50 mM, glutationa reducida 5,0 mM, glutationa
oxidada 0,5 mM, pH 8,8) durante 12-14 horas a 4ºC.
La concentración de proteína se estimó usando la fórmula:
Proteína
(mg/ml) = (1,55 x OD_{280}) - (0,76 x
OD_{260})
El análisis automatizado de secuencias del
término NH_{2} de proteínas se realizó con un secuenciador Beckman
(LF 3000) equipado con analizador en linea de
feniltioindantoin-aminoácidos (sistema Gold) de
acuerdo con las recomendaciones del fabricante.
Se inmunizaron ratones Balb/C con antígenos los
días 0, 21 y 35 y se analizaron los sueros el día 49.
Las cepas acapsuladas MenB M7 y las capsuladas
se cultivaron sobre placas de agar de chocolate y se incubaron
durante la noche a 37ºC con 5% de CO_{2}. Se recogieron de las
placas de agar colonias de bacterias usando un trapo de dracón
estéril y se inocularon en caldo Mueller-Hinton
(Difco) que contenía 0,25% de glucosa. El crecimiento de bacterias
se controló cada 30 minutos siguiendo el valor de OD_{620}. Se
dejó que crecieran las bacterias hasta que OD alcanzó el valor de
0,4-0,5. Se centrífugo el cultivo a 4000 rpm durante
10 minutos. Se desechó el material sobrenadante y las bacterias se
lavaron dos veces con PBS, se pusieron en suspensión en PBS que
contenía 0,025% de formaldehído y se incubó durante 1 hora a 37ºC y
luego durante la noche a 4ºC con agitación. Se añadieron 100 \mul
de células de bacterias a cada pocillo de una placa Greiner de 96
pocillos y se incubó a 4ºC durante la noche. Luego se lavaron los
pocillos tres veces con tampón de lavado de PBS
(Tween-20 al 0,1% en PBS). A cada pocillo se
añadieron 200 \mul de tampón de saturación (polivinilpirrolidona
10 al 2,7% en agua) y las placas se incubaron durante 2 horas a
37ºC. Los pocillos se lavaron luego tres veces con tampón de PBT. A
cada pocillo se añadieron 200 200 \mul de suero de dilución
(tampón de dilución: 1% de BSA, 0,1% de Tween-20,
0,1% de NaN_{3} en PBS) y las placas se incubaron durante 2 horas
a 37ºC. Los pocillos se lavaron tres veces con PBT).Se añadieron a
cada pocillo 100 \mul de suero antirratón (Dako) de ratón
HRP-conjugado diluido 1:2000 en tampón de dilución y
las placas se incubaron durante 90 minutos a 37ºC. Los pocillos se
lavaron tres veces con tampón de PBT. Se añadieron a cada pocillo
100 \mul de tampón de sustrato para HPR (25 ml de tampón de
citrato pH 5, 10 mg de O-fenildiamina y 10 \mul de
H_{2}O_{2}) y las placas se dejaron a temperatura ambiente
durante 20 minutos. Se añadieron 100 \mul de H_{2}SO_{4} al
12% a cada pocillo y se siguió OD_{400}. Los títulos de ELISA se
calcularon arbitrariamente como la dilución de suero que daba un
valor de OD_{490} de 0,4 por encima de sueros preinmunes. Se
consideró que ELISA era positivo cuando la dilución del suero con
un OD_{490} de 0,4 era mayor que 1:400.
La cepa acapsulada MenB M7 se cultivó sobre
placas de agar con chocolate y se incubó durante la noche a 37ºC
con 5% de CO_{2}. De las placas de agar se recogieron colonias de
bacterias usando un trapo estéril de dracon y se inocularon en 4
tubos que contenían 8 ml cada una de caldo
Mueller-Hinton (Difco) que contenía 0,25% de
glucosa. El crecimiento de bacterias se controló cada 30 minutos
siguiendo OD_{620}. Se dejó que las bacterias crecieran hasta que
OD alcanzó el valor de 0,35-0,5. El cultivo se
centrifugó a 4000 rpm durante 10 min. Se desechó el material
sobrenadante y la pella se puso en suspensión en tampón de bloqueo
(1% de BSA en PBS, 0,4% de NaN_{3}) y se centrífugo a 4000 rpm
durante 5 minutos. Se volvió a poner en suspensión las células en
tampón de bloqueo para alcanzar un valor de OD_{620} de 0,05. Se
añadieron 100 \mul de células de bacterias a cada pocillo de una
placa Costar de 96 pocillos. A cada pocillo se añadieron 100 \mul
de suero diluido (1:100, 1:200, 1:400) (en tapón de bloqueo) y las
placas se incubaron a 4ºC durante 2 horas. Se centrifugaron las
células durante 5 minutos a 4000 rpm, se aspiró el material
sobrenadante y las células se lavaron añadiendo 200 \mul/pocillo
de tampón de bloqueo en cada pocillo. Se añadieron a cada pocillo
de antirratón de cabra conjugado F(ab)_{2} a
R-ficoeritrina, diluido 1:100 y las placas se
incubaron durante 1 hora a 4ºC. Las células se sedimentaron por
centrifugación a 4000 rpm durante 5 minutos y se lavaron añadiendo
200 \mul/pocillo de tampón de bloqueo. Se aspiró el material
sobrenadante y las células se pusieron nuevamente en suspensión en
200 \mul/pocillo de PBS, 0,25% de formaldehído. Se pasaron las
muestras a tubos para FACscan y se hicieron las lecturas. Los
parámetros experimentales para FACScan (potencia del láser 15 mW)
fueron: FL2 conect.; umbral de FSC-H: 92; voltaje
de FSC PMT: E 01; SSC PMT: 474; aumentos del amp. 6:1;
FL-2-PMT: 586; valores de
compensación: 0.
Se hizo crecer durante la noche a 37ºC, la cepa
2996 de N. meningitidis sobre placas de agar con chocolate
(a partir de un acopio congelado) con 5% de CO_{2}. Se recogieron
colonias y se usaron para inocular 7 ml de caldo
Mueller-Hinton que contenía 0,25% de glucosa para
alcanzar un OD_{620} de 0,05-0,08. El cultivo se
incubó durante aproximadamente 1,5 horas a 37ºC con sacudidas hasta
que OD_{620} alcanzó el valor de 0,23-0,24. Las
bacterias se diluyeron en tampón de fosfato 50 mM, pH 7,2, que
contenía MgCl_{2} 10 mM, CaCl_{2} 10 mM y 0,5% (p/v) de BSA
(tampón de ensayo) a una dilución de trabajo de 10^{5} CFU/ml. El
volumen total de la mezcla de reacción final era de 50 \mul con
25 \mul de suero de ensayo con dilución serial de dos veces, 12,5
\mul de bacterial a la dilución de trabajo, 12,5 \mul de
complemento de conejo joven (concentración final 25%).
Los controles incluían bacterias incubadas con
suero complementario, sueros inmunes incubados con bacterias y con
complemento inactivados por calentamiento a 55ºC durante 30 minutos.
Inmediatamente después de añadir el complemento de conejo joven, se
cultivaron 10 \mul de los controles sobre placas de agar
Mueller-Hinton usando el procedimiento de
inclinación (tiempo 0). Las placas de agar de 96 pocillos se
incubaron durante 1 hora a 37ºC con rotación. Se cultivaron 7
\mul de cada muestra sobre placas de agar
Mueller-Hinton como manchas, mientras que se
cultivaron 10 \mul de los controles sobre placas de agar
Mueller-usando el procedimiento de inclinación
(tiempo 1. Las placas
de agar se incubaron a 37ºC durante 18 horas y se contaron las colonias correspondientes al tiempo 0 y el tiempo 1.
de agar se incubaron a 37ºC durante 18 horas y se contaron las colonias correspondientes al tiempo 0 y el tiempo 1.
Proteínas purificadas (500 ng/hilera), vesículas
de membrana exterior (5 \mug) y extractos de células totales (25
\mug) derivados de la cepa 2996 de MenB se cargaron en gel de SDS
al 12%-poliacrilamida y se pasaron a una membrana de nitrocelulosa.
La transferencia se hizo durante 2 horas a 150 mA y 4ºC usando
tampón de transferencia (0,3% de Tris base, 1,44% de glicina, 20%
(v/v) de metanol. La membrana se saturó por incubación nocturna a
4ºC en tampón de saturación (10% de leche desnatada, 0,1% de Triton
X100 en PBS). La membrana se lavó dos veces con tampón de lavado
(3% de leche desnatada, 0,1% de TritónX100 en PBS) y se incubó
durante 2 horas a 37ºC con suero de ratón diluido 1:200 en tampón
de lavado. La membrana se lavó dos veces y se incubó durante 90
minutos con una dilución 1:2000 de Ig antirratón marcada con
peroxidasa de rábano amargo. La membrana se lavó dos veces con 0,1%
de Triton X100 en PBS y se reveló con el kit
Opti-4CN Substrate (Bio-Rad). La
reacción se paró añadiendo agua.
Los OMVs se prepararon como sigue: Se hizo
crecer durante la noche la cepa 2996 de N. meningitidis a
37ºC con 5% de CO_{2} sobre placas 5 GC, se cosechó con un bucle
y se volvió a poner en suspensión en 10 ml de
Tris-HCl 20 mM, pH 5,2, EDTA 2 mM. La inactivación
por calor se realizó a 56ºC durante 45 min y las bacterias se
rompieron por sonicación durante 5 min sobre hielo (50% de ciclo
debido, 50% de producción, sonificador Branson con micropunta de 3
mm). Las células no rotas se eliminaron por centrifugación a 5000 g
durante 10 min, se recuperó la parte sobrenadante que contenía la
fracción de envoltura de la célula entera y se centrífugo más
durante la noche a 50000 g a la temperatura de 4ºC. La pella que
contenía las membranas se volvió a poner en suspensión en 2% de
sarkosyl, Tris-HCl 20 mM, pH 7,5, EDTA 2 mM y se
incubó a temperatura ambiente durante 20 minutos para solubilizar
las membranas interiores. La suspensión se centrífugo a 10000 para
eliminar agregados, se centrífugo luego el material sobrenadante a
50000 g durante 3 horas. La pella, que contenía las membranas
externas, se lavó en PBS y se volvió a poner en suspensión en el
mismo tampón. La concentración de proteína se midió por el ensayo
de proteínas D.C. Bio-Rad (procedimiento de Lowry
modificado) usando BSA como patrón.
Se prepararon como sigue extractos de células
completas: se hizo crecer durante la noche la cepa 2996 de N.
meningitidis sobre una placa GC, se cosechó con un bucle y se
volvió a poner en suspensión en 1 ml de Tris-HCl 20
mM. La inactivación por calor se realizó a 56ºC durante 30
minutos.
Preparación de fracciones celulares. Se
prepararon lisado total, periplasma, material sobrenadante y OMV de
clones de E. coli que expresan diferentes dominios de 961
usando bacterias de cultivos nocturnos o después de tres horas de
inducción con IPTG. En resumen, el periplasma se obtuvo poniendo en
suspensión bacterias en sacarosa al 25% y Tris 50 mM (pH 8) con 100
\mug/ml de poliximina. Después de 1 hora a temperatura ambiente,
se centrifugaron las bacterias a 13000 rpm durante 15 min y se
recogió el material sobrenadante. El material sobrenadante del
cultivo se filtró con 0,2 \mum y se precipitó con TCA al 50% en
baño de hielo durante 2 horas. Después de centrifugación (30 min a
13000 rpm), la pella se enjuagó dos veces con etanol al 70% y se
volvió a poner en suspensión en PBS. La preparación de OMV se
realizó como se ha descrito previamente. Cada fracción celular se
analizó por SDS-PAGE o transferencia western usando
el antisuero policlonal generado contra
GST-961.
Ensayo de adhesión. Se mantuvieron
células epiteliales Chang (derivadas de
Wong-Kibourne, clon
1-5c-4, de conjuntiva humana) en
DMEM (Gibco) suplementado con 10% de FCS inactivado por calor,
L-glutamina 15 mM y antibióticos.
Para el ensayo de adherencia, se enjuagaron con
PBS cultivos sub-confluentes de células epiteliales
Chang y se trataron con tripsina-EDTA (Gibco) para
liberarlas del soporte de plástico. Las células se pusieron luego
en suspensión en PBS a 5 x 10^{5} células/ml.
Se peletizaron bacterias procedentes de cultivos
nocturnos o después de inducidas por IPTG y se lavaron dos veces
con PBS por centrifugación a 13000 durante 5 minutos. Se incubaron
aproximadamente (2-3) x10^{8} (cfu) con 0,5 mg/ml
de FITC (Sigma) en 1 ml de tampón que contenía NaHCO_{3} 50 mM y
NaCl 100 mM, pH 8, durante 30 minutos a temperatura ambiente en la
oscuridad. Bacterias marcadas por IFTC se lavaron 3 veces y se
pusieron en suspensión en PBS a (1-5) x10^{9}/ml.
Se incubaron 200 \mul de esta suspensión
((2-3)x10^{8}) con 200 \mul (1x10^{5})
células epiteliales durante 30 minutos a 37ºC. Las células se
centrifugaron luego a 2000 rpm durante 5 minutos para eliminar
bacterias no adherentes, se pusieron en suspensión en 200 \mul de
PBS, se pasaron a tubos de FACScan y se hicieron las lecturas.
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<210> 11
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia Artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 11
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgtgcataaaa aaaagaccga cggggtct
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 12
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia Artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 12
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipaacgcctcgc cggtgtttg ggtca
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 13
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 13
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskiptttgacccaa aacaccggcg aggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 14
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 14
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskiptgccggcgca gtcggtcggc actaca
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 15
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 15
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskiptaatgtagtg ccgaccgact gcgccg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 16
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 16
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskiptgattgaggt gggtagcgcg ttccg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 17
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 17
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggcgggaacgc gctacccacc tcaat
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 18
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 18
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgaaaaaa atcatcttcg ccgc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 19
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 19
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttattgtttg gctgcctcga tt
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 20
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 20
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgtcgccc gatgttaaat cggcgga
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 21
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 21
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaatcctgc tcttttttgc cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 22
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 22
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgagccaa gatatggcgg cagt
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 23
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 23
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaatcctgc tctttttt cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 24
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 24
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgtccgcc gaatccgcaa atca
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 25
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaatcctgc tcttttttgc cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 26
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgggaagg gttgatttgg ctaatg
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 27
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaatcctgc tcttttttgc cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 28
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<213> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgtcagat ttggcaacg attctt
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 29
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttacgtatca tatttcacgt gcttc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 30
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgtcgccc gatgttaaat cggcgga
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 31
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttacgtatca tatttcacgt gcttc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 32
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia arificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgcaaagc aagagcatcc aaacct
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 33
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttacgggcgg tattcgggct
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 34
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattca tatgaaacac tttccatcc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 35
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 36
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattca tatggccaca agcgacgac
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 37
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 38
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatgaaacac tttccatccc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 39
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 39
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaacccacg ttgtaaggtt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 40
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatggccaca aacgacgacg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 41
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcaacccacg ttgtaaggtt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 42
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccggaattct tatggccacc tacaaagtgg acga
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 43
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 43
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttattgttg gctgcctcga tt
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 44
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 44
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 45
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 46
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 46
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccaaga tatggcggca gt
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 47
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 47
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcgccga atccgcaaat ca
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 48
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 48
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgctagcg gaagggttga ttggctaat gg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 49
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 49
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgggcatt tcccgcaaaa tata
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 50
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 50
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgtatca tatttcacgt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 51
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 51
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgggcatt tcccgcaaaa tatc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 52
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 52
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattctatg ccttgtgcgg cat
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 53
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 53
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aagcgacgac ga
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 54
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 54
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 55
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 55
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 56
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 56
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcatttagca atattatctt tgttc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 457
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 57
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaagc aaacagtgcc gac
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 58
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 58
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 59
\vskip0.400000\baselineskip
<211> 328
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 59
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 60
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaacccacg ttgtaaggt
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 61
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 61
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa acactttcca tcc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 62
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 62
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaacccacg ttgtaaggt
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 63
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 63
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 64
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 64
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagtctgac actgttttat cc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 65
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 65
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 66
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 66
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgggcgg tattcgg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 67
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 67
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 68
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 68
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgtatca tatttcacgt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 69
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 69
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 70
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 70
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 71
\vskip0.400000\baselineskip
<211> 1457
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 71
\vskip0.400000\baselineskip
<210> 72
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Escherichia coli
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 72
\vskip1.000000\baselineskip
\sa{Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala
Leu Ala Gly Phe Ala}
\sac{Thr Val Ala Gln Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 73
\vskip0.400000\baselineskip
<211> 1439
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 73
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 74
\vskip0.400000\baselineskip
<211> 164
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 74
\vskip0.400000\baselineskip
<210> 75
\vskip0.400000\baselineskip
<211> 21
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Erwinia carotovora
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 75
\vskip1.000000\baselineskip
\sa{Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly
Leu Leu Leu Ala Ala}
\sac{Gln Pro Ala Met Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 76
\vskip0.400000\baselineskip
<211> 608
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
ORF46
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 76
\vskip0.400000\baselineskip
<210> 77
\vskip0.400000\baselineskip
<211> 584
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46-2
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 77
\vskip0.400000\baselineskip
<210> 78
\vskip0.400000\baselineskip
<211> 364
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 78
\vskip0.400000\baselineskip
<210> 79
\vskip0.400000\baselineskip
<211> 427
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Neisseria meningitidis
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 79
\vskip0.400000\baselineskip
<210> 80
\vskip0.400000\baselineskip
<211> 410
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 287 no marcado
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 80
\vskip0.400000\baselineskip
<210> 81
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 920L N-terminal
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 81
\vskip1.000000\baselineskip
\sa{His Arg Val Trp Val Glu Thr Ala His}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 82
\vskip0.400000\baselineskip
<211> 16
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 953L N-terminal
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 82
\vskip1.000000\baselineskip
\sa{Ala Thr Tyr Lys Val Asp Glu Tyr His Ala Asn
Ala Arg Phe Ala Phe}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 83
\vskip0.400000\baselineskip
<211> 16
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 519,1L
N-terminal
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 83
\vskip1.000000\baselineskip
\sa{Met Glu Phe Phe Ile Ile Leu Leu Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 84
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 84
\vskip0.400000\baselineskip
<210> 85
\vskip0.400000\baselineskip
<211> 712
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> TBP2
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 85
\vskip0.400000\baselineskip
<210> 86
\vskip0.400000\baselineskip
<211> 274
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 741
\newpage
\vskip0.400000\baselineskip
<400> 86
\vskip0.400000\baselineskip
<210> 87
\vskip0.400000\baselineskip
<211> 1082
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 87
\vskip0.400000\baselineskip
<210> 88
\vskip0.400000\baselineskip
<211> 2505
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> delta G287-919
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 88
\vskip0.400000\baselineskip
<210> 89
\vskip0.400000\baselineskip
<211> 832
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287-919
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 89
\vskip0.400000\baselineskip
<210> 90
\vskip0.400000\baselineskip
<211> 1746
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> delta G287-953
\newpage
\vskip0.400000\baselineskip
<400> 90
\vskip0.400000\baselineskip
<210> 91
\vskip0.400000\baselineskip
<211> 579
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287-953
\newpage
\vskip0.400000\baselineskip
<400> 91
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 92
\vskip0.400000\baselineskip
<211> 2388
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287-961
\newpage
\vskip0.400000\baselineskip
<400> 92
\vskip0.400000\baselineskip
<210> 93
\vskip0.400000\baselineskip
<211> 793
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> delta G287-961
\newpage
\vskip0.400000\baselineskip
<400> 93
\vskip0.400000\baselineskip
<210> 94
\vskip0.400000\baselineskip
<211> 2700
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> delta G287NZ-919
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 94
\vskip0.400000\baselineskip
<210> 95
\vskip0.400000\baselineskip
<211> 897
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287NZ-919
\newpage
\vskip0.400000\baselineskip
<400> 95
\vskip0.400000\baselineskip
<210> 96
\vskip0.400000\baselineskip
<211> 1941
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287NZ-953
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 96
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 97
\vskip0.400000\baselineskip
<211> 644
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG827NZ-953
\newpage
\vskip0.400000\baselineskip
<400> 97
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 98
\vskip0.400000\baselineskip
<211> 2583
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia arficial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287NZ-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 98
\newpage
\vskip0.400000\baselineskip
<210> 99
\vskip0.400000\baselineskip
<211> 858
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG287NZ-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 99
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 100
\vskip0.400000\baselineskip
<211> 4425
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223>
deltaG983-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 100
\vskip0.400000\baselineskip
<210> 101
\vskip0.400000\baselineskip
<211> 1474
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223>
deltaG983-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 101
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 102
\vskip0.400000\baselineskip
<211> 3939
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 102
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 103
\vskip0.400000\baselineskip
<211> 1312
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 103
\vskip0.400000\baselineskip
<210> 104
\vskip0.400000\baselineskip
<211> 4344
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 104
\vskip0.400000\baselineskip
<210> 105
\vskip0.400000\baselineskip
<211> 1447
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 105
\vskip0.400000\baselineskip
<210> 106
\vskip0.400000\baselineskip
<211> 4179
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-961c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 106
\vskip0.400000\baselineskip
<210> 107
\vskip0.400000\baselineskip
<211> 1392
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG983-961c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 107
\vskip0.400000\baselineskip
<210> 108
\vskip0.400000\baselineskip
<211> 1947
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 108
\vskip0.400000\baselineskip
<210> 109
\vskip0.400000\baselineskip
<211> 648
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 109
\vskip0.400000\baselineskip
<210> 110
\vskip0.400000\baselineskip
<211> 1782
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia superficial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-961c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 110
\vskip0.400000\baselineskip
<210> 111
\vskip0.400000\baselineskip
<211> 593
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-961c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 111
\vskip0.400000\baselineskip
<210> 112
\vskip0.400000\baselineskip
<211> 3939
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 112
\vskip0.400000\baselineskip
<210> 113
\vskip0.400000\baselineskip
<211> 1312
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> deltaG741-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 113
\vskip0.400000\baselineskip
<210> 114
\vskip0.400000\baselineskip
<211> 2028
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223>
deltaG741-ORF46.1
\newpage
\vskip0.400000\baselineskip
<400> 114
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 115
\vskip0.400000\baselineskip
<211> 675
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223>
deltaG741-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 115
\vskip0.400000\baselineskip
<210> 116
\vskip0.400000\baselineskip
<211> 249
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Proteína nueva
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 116
\vskip0.400000\baselineskip
<210> 117
\vskip0.400000\baselineskip
<211> 66
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Unión L1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> N
\vskip0.400000\baselineskip
<222> 13
\vskip0.400000\baselineskip
<223> A, T/U, G o C
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 117
\vskip0.400000\baselineskip
<210> 118
\vskip0.400000\baselineskip
<211> 69
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Unión S1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<221> N
\vskip0.400000\baselineskip
<222> 25, 28
\vskip0.400000\baselineskip
<223> A, T/U, G o C
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 118
\vskip0.400000\baselineskip
<210> 119
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9LI-a
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 119
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaagaagt accttttcag cgccgcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 120
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9L1-e
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 120
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat actttttccg cgccgcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 121
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9LI-d
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 121
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat actttttccg cgccgcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 122
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9L1-f
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 122
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat atctctttag cgccgccctg tacggcatcg ccgccgccat cctcgccgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 123
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 919sp
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 123
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat acctattccg cgccgccctg tacggcatcg ccgccgccat cctcgccgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 124
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9Lla
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 124
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Ser Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 125
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9L1e
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 125
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Phe Phe Arg Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 126
\vskip0.400000\baselineskip
<211> 9
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9LId
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 126
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Phe Phe Arg Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 127
\vskip0.400000\baselineskip
<211> 20
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9L1f
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 127
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Ser Ala Ala Leu Tyr
Gly Ile Ala Ala Ala}
\sac{Ile Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 128
\vskip0.400000\baselineskip
<211> 20
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9Llsp
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 128
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Arg Ala Ala Leu Tyr
Gly Ile Ala Ala Ala}
\sac{Ile Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 129
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1-e
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 129
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat acctattcat cgccgccgcc atcctcgccg cc
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 130
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1-c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 130
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat acctattccg agctgcccaa tacggcatcg ccgccgccat cctcgccgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 131
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1-b
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 131
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat acctattccg ggccgcccaa tacggcatcg ccgccgccat cctcgccgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 132
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1-i
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 132
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipatgaaaaaat acctattccg ggcggctttg tacgggatcg ccgccgccat cctcgccgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 133
\vskip0.400000\baselineskip
<211> 14
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1e
\newpage
\vskip0.400000\baselineskip
<400> 133
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Ile Ala Ala Ala Ile
Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 134
\vskip0.400000\baselineskip
<211> 120
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9S1c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 134
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Arg Ala Ala Gln Tyr
Gly Ile Ala Ala Ala}
\sac{Ile Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 135
\vskip0.400000\baselineskip
<211> 20
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9SIb
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 135
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Arg Ala Ala Gln Tyr
Gly Ile Ala Ala Ala}
\sac{Ile Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 136
\vskip0.400000\baselineskip
<211> 20
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 9SLi
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 136
\vskip1.000000\baselineskip
\sa{Met Lys Lys Tyr Leu Phe Arg Ala Ala Leu Tyr
Gly Ile Ala Ala Ala}
\sac{Ile Leu Ala Ala}
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 137
\vskip0.400000\baselineskip
<211> 467
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 730
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 137
\vskip0.400000\baselineskip
<210> 139
\vskip0.400000\baselineskip
<211> 377
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 730-C1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 138
\vskip0.400000\baselineskip
<210> 139
\vskip0.400000\baselineskip
<211> 353
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 730-C2
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 139
\vskip0.400000\baselineskip
<210> 140
\vskip0.400000\baselineskip
<211> 2019
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 140
\vskip0.400000\baselineskip
<210> 141
\vskip0.400000\baselineskip
<211> 672
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 141
\vskip0.400000\baselineskip
<210> 142
\vskip0.400000\baselineskip
<211> 2421
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 142
\vskip0.400000\baselineskip
<210> 143
\vskip0.400000\baselineskip
<211> 806
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-961
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 143
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 144
\vskip0.400000\baselineskip
<211> 2256
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-961c
\newpage
\vskip0.400000\baselineskip
<400> 144
\vskip0.400000\baselineskip
<210> 145
\vskip0.400000\baselineskip
<211> 751
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> ORF46.1-961c
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 145
\vskip0.400000\baselineskip
<210> 146
\vskip0.400000\baselineskip
<211> 2421
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-ORF46.1
\newpage
\vskip0.400000\baselineskip
<400> 146
\vskip0.400000\baselineskip
<210> 147
\vskip0.400000\baselineskip
<211> 806
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-ORF46.1
\newpage
\vskip0.400000\baselineskip
<400> 147
\vskip0.400000\baselineskip
<210> 148
\vskip0.400000\baselineskip
<211> 1938
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 148
\vskip0.400000\baselineskip
<210> 149
\vskip0.400000\baselineskip
<211> 649
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 149
\vskip0.400000\baselineskip
<210> 150
\vskip0.400000\baselineskip
<211> 4335
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 150
\vskip0.400000\baselineskip
<210> 151
\vskip0.400000\baselineskip
<211> 1444
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 151
\vskip0.400000\baselineskip
<210> 152
\vskip0.400000\baselineskip
<211> 2256
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 152
\vskip0.400000\baselineskip
<210> 153
\vskip0.400000\baselineskip
<211> 751
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 153
\vskip0.400000\baselineskip
<210> 154
\vskip0.400000\baselineskip
<211> 1773
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 154
\vskip0.400000\baselineskip
<210> 155
\vskip0.400000\baselineskip
<211> 590
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-741
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 155
\vskip0.400000\baselineskip
<210> 156
\vskip0.400000\baselineskip
<211> 4170
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 156
\vskip0.400000\baselineskip
<210> 157
\vskip0.400000\baselineskip
<211> 1389
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961c-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 157
\vskip0.400000\baselineskip
<210> 158
\vskip0.400000\baselineskip
<211> 2304
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961cL-ORF46.1
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 158
\vskip0.400000\baselineskip
<210> 159
\vskip0.400000\baselineskip
<211> 765
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961cL-ORF46.1
\newpage
\vskip0.400000\baselineskip
<400> 159
\vskip0.400000\baselineskip
<210> 160
\vskip0.400000\baselineskip
<211> 1839
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961 cL-741
\newpage
\vskip0.400000\baselineskip
<400> 160
\vskip0.400000\baselineskip
<210> 161
\vskip0.400000\baselineskip
<211> 612
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961cL-741
\newpage
\vskip0.400000\baselineskip
<400> 161
\vskip0.400000\baselineskip
<210> 162
\vskip0.400000\baselineskip
<211> 4218
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961cL-983
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 162
\vskip0.400000\baselineskip
<210> 163
\vskip0.400000\baselineskip
<211> 1403
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 961cL-983
\newpage
\vskip0.400000\baselineskip
<400> 163
\vskip0.400000\baselineskip
<210> 164
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 164
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcaaaac aaccgacaaa cgg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 165
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 165
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccagcgg tagccta
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 166
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 166
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagcg gacacactta tttcggcatc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 167
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 167
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccagcgg tagcctaatt tg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 168
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 168
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag
\hfill10
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 169
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 169
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaac cttcttcaaa acc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 170
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 170
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttggct gcgccttc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 171
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 171
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcattaa tatgttgaga aaattgttga aatgg
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 172
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 172
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttttt caaaatatat ttgc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 173
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 173
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gttacctaac cgtttcaaaa tgt
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 174
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 174
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttccg aggttttcgg g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 175
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 175
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgacacg cttcaaatat tc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 176
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 176
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttaaac cgataggtaa a
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 177
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 177
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcag ggaagaaccg c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 178
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 178
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt atcgatggaa tagccgcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 179
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 179
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcaacgg tttggatgcc cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 180
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 180
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttgtctaag ttcctgatat
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 181
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 181
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag attcccacct gccatc
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 182
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 182
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcatgaa tttgcctatt caaaaat
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 183
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 183
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaattccca cctgccatc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 184
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 184
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcatgaa tttgcctatt caaaaat
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 185
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 185
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttggacgatg cccgcga
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 186
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 186
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcatgaa tttgcctatt caaaaat
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 187
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 187
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattggacg atgcccgc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 188
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 188
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtatcg caaactgatt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 189
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 189
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ctaatcgatg gaatagcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 190
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 190
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaca gacagtcaaa tg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 191
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 191
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaataaccc gccttcag
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 192
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 192
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgttacg tttgactgct ttagccgtat gcacc
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 193
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 193
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattttgcc gcgttaaag cgtcggcaac
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 194
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 194
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacaa aatataccgc at
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 195
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 195
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactga taaccgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 196
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 196
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaccga tgacgacgat ttat
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 197
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 197
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ccactgataa ccgacaga
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 198
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 198
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacaa aatatccgc at
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 199
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 199
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttaccactga taaccgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 200
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 200
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgggcatt tcccgcaaaa tatc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 201
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 201
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttactc ctataacgag gtctcttaac
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 202
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 202
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgtcagat ttggcaaacg attctt
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 203
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 203
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttactc ctataacgag gtctcttaac
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 204
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 204
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgggcatt tcccgcaaaa tatc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 205
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 205
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgtatca tatttcacgt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 206
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 206
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgcacgtg aaatatgata cgaag
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 207
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 207
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttactcct taacgaggtc tcttaac
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 208
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 208
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgtcagat ttggcaaacg attctt
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 209
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 209
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 210
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 210
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgtcagat ttggcaaacg attctt
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 211
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 211
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttactccta taacgaggtc tcttaac
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 212
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 212
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaaaa tgcgttcaaa atccc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 213
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 213
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacaa aatataccgc at
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 214
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 214
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttgctttcg atagaacgg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 215
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 215
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggtcataaaa tatacaaatt tgaa
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 216
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 216
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttagcctga gacctttgca aatt
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 217
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 217
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaaacagaaa aaaaccgctg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 218
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 218
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttacggttt gacaccgttt tc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 219
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 219
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaac cctgctcctc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 220
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 220
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatcctcct ttgcggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 221
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 221
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggcaaaaatg atgaaatggg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 222
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 222
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga ggttatcggcg cggcgggcc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 223
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 223
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaaaaaatcc tccctcatca
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 224
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 224
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttgcc gccgtttttg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 225
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 225
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggcccctgcc gacgcggtaa g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 226
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 226
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtttgccgcc gtttttggct ttc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 227
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 227
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaaacacata ctccccctga
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 228
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 228
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttattcgcc tacggttttt tg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 229
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 229
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gatttacatc gtactgtttc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 230
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 230
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaggagaa caggcgcaat gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 231
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 231
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gtacaacatg tatcaggaaa ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 232
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 232
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggagaacag gcgcaatgcg g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 233
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 233
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagctgcgg cacggcggg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 234
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 234
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ataacggtat gccgccag
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 235
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 235
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggaatc aacactttca c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 236
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 236
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacacgcgg ttgctgt
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 237
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 237
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacaa cagacatttt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 238
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 238
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacctgtcc ggtaaaag
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 239
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 239
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcaccgt catcaaacag gaa
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 240
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 240
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaagattcg acgggga
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 241
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 241
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtccgc aaacgaatac g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 242
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 242
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagtgttct gccagttt
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 243
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 243
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgccgtc tgaaacacg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 244
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 244
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttagcggagc agtttttc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 245
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 245
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaccgc catcagcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 246
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 246
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaaagccgg gtaacgc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 247
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 247
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggaaacacag ctttacatcg g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 248
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 248
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcaataata atatcccgcg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 249
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 249
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gattaaaatc cgcaatatcc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 250
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 250
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaaatctt ggtagattgg atttgg
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 251
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 251
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gactgacaac gcactgctcc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 252
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 252
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcagaccgc gttgtcgaaa c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 253
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 253
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcgtt aaaaacatca aa
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 254
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 254
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagcccttc atacagc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 255
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 255
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcattaa tggcacaaac tacactcaaa cc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 256
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 256
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaaaactt cacgttcacg ccg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 257
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 257
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcattaa tgcatgaaac tgagcaatcg gtgg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 258
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 258
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gaaacttcac gttcacgccg ccggtaaa
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 259
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 259
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcaa atccgaaaat acg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 260
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 260
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ataatggcgg cggcgg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 261
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 261
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtttcc ccccgacaa
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 262
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 262
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcattctgta aaaaaagtat g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 263
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 263
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcttca aagcgacagc ag
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 264
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 264
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttcggatttt tgcgtactc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 265
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 265
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcaat ggcagaaaac g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 266
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 266
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ctatacaatc cgtgccg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 267
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 267
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggattc ttttttcaaa cc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 268
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 268
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagttcaga aagcggg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 269
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 269
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaacc tttgatttta gg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 270
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 270
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttgggc tgctcttc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 271
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 271
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtaat cgtctggttg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 272
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 272
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ctacgacttg gttaccg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 273
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 273
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gagacgtaaa atgctaaagc tac
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 274
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 274
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcaaagtgt tctgtttgcg c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 275
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 275
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat gttgacttta acccgaaaaa
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 276
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 276
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga ggccggcggt caataccgcc cgaa
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 277
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 277
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcgca atgcgatttg ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 278
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 278
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttcggcggta aatgccg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 279
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 279
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggcggggccg atttttgt
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 280
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 280
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttgct ttcagtatta ttg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 281
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 281
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaactttgct ttatccgtca
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 282
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 282
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaacggca gtattgttt ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 283
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 283
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggttt gcgcttcggg c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 284
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 284
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttttcctttg ccgtttccg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 285
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 285
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccga cctttccgaa aa
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 286
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 286
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaagcgcgtt cccaagc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 287
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 287
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcacga cacccgtac
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 288
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 288
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttagaagcgc gttcccaa
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 289
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 289
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagct ttaaacgcag cgtaatcgca atgg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 290
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 290
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 291
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 291
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagcg ggggcggcgg tggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 292
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 292
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 293
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 293
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagcg ctcatcctcg ccgcctgcgg gggcggcggt
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 294
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 294
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 295
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 295
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcggggatccg ggggcggcgg tggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 296
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 296
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 297
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 297
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagcg ggggcggcgg tggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 298
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 298
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag atcctgctct tttttgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 299
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 299
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagct gcgggggcgg cggtggcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 300
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 300
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag atcctgctct tttttgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 301
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 301
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccgatgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 302
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 302
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccaaga tatggcggca gt
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 303
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 303
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcgccga atccgcaaat ca
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 304
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 304
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgctagcg gaagggttga tttggctaat gg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 305
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 305
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgctagcg gaagggttga tttggctaat gg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 306
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 306
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgccatatgt ttaaacgcag cgtaatcgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 307
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 307
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag aaaattgcta ccgccattcg cagg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 308
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 308
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgccatatgg gaagggttga tttggctaat gg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 309
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 309
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cttgtcttta taaatgatga catatttg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 310
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 310
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttataaaag ataatatatt gattgattcc
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 311
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 311
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgctagca tgccgctgat tcccgtcaat c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 312
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 312
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipctagctagcg ggggcggcgg tggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 313
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 313
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 314
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 314
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 315
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 315
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag atcctgctct tttttgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 316
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 316
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 317
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 317
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 318
\vskip0.400000\baselineskip
<211> 87
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 318
\vskip0.400000\baselineskip
<210> 319
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 319
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 320
\vskip0.400000\baselineskip
<211> 90
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 320
\vskip0.400000\baselineskip
<210> 321
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 321
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 322
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 322
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaac caagttaatc aaa
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 323
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 323
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattgattt ttgcggatga
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 324
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 324
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgttaaa tcgggtattt tatc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 325
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 325
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaatccgcc attccctg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 326
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 326
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaaattacaa caattggctg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 327
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 327
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaccttac gtttttcaaa g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 328
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 328
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaagc acggctgct
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 329
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 329
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaaggttgt ccttgtcta
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 330
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 330
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa accgcacaac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 331
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 331
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagttgctc aacacgtc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 332
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 332
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtaga cgcgcttaag ca
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 333
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 333
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag agctgcatgg cggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 334
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 334
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcacg gtcgttatac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 335
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 335
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ctaccgcgca ttcctg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 336
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 336
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggaatttttc attatcttgt t
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 337
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 337
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttggc ggttttgctg c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 338
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 338
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaagtatgtc cggttatttt tc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 339
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 339
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatcggct tgtgcaacgg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 340
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 340
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagctccgg cagcaaaacc ga
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 341
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 341
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt acgcagttcg gaatggag
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 342
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 342
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat gttgaatatt aaactgaaaa ccttg
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 343
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 343
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga gttatttctg atgccttttc cc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 344
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 344
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat ggacaataag accaaactg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 345
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 345
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga gttaacggtg cggacgtttc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 346
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 346
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacaa actgtttctt ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 347
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 347
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcattccgcc ttcagaaa
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 348
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 348
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaagg tatcgttgcc gacaaatccg cacct
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 349
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 349
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgcctcgag agctaattgt gcttggtttg cagataggag tt
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 350
\vskip0.400000\baselineskip
<211> 52
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 350
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaccg caccctgtac aaagttgtat ttaacaaaca tc
\hfill52
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 351
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 351
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaagctaat tgtgcttggt ttgcagatag gagtt
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 352
\vskip0.400000\baselineskip
<211> 46
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 352
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgacggg agaaaatcat gcggtttcac ttcatg
\hfill46
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 353
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 353
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag agctaattgt gcttggtttg cagataggag tt
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 354
\vskip0.400000\baselineskip
<211> 51
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 354
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtttc agacggccta tacaaccaac atggtgaaat t
\hfill51
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 355
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 355
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gcggtaactg ccgcttgacac tgaatccgta a
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 356
\vskip0.400000\baselineskip
<211> 46
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 356
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgacggg agaaaatcat gcggtttcac ttcatg
\hfill46
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 357
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 357
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gcggtaactg ccgcttgcac tgaatccgta a
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 358
\vskip0.400000\baselineskip
<211> 49
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 358
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaaag caaagtcaaa gcagcccatg cctccgtaa
\hfill49
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 359
\vskip0.400000\baselineskip
<211> 56
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 359
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcttttcctt tcaattataa ctttagtagg ttcaattttg gtcccc
\hfill56
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 360
\vskip0.400000\baselineskip
<211> 51
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 360
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtttc agacggccta tacaaccaac atggtgaaat t
\hfill51
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 361
\vskip0.400000\baselineskip
<211> 56
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 361
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcttttcctt tcaattataa ctttagtagg ttcaattttg gtccc
\hfill56
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 362
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 362
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gacccgtttg acccgcg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 363
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 363
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcagcgggc gttcatttct t
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 364
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 364
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaacac cattttcaaa atc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 365
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 365
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaatttact ttttgatgt cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 366
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 366
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggattcgccc aaggtcgg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 367
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 367
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gctacacttc ccccgaagtg g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 368
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 368
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatagt tgaccaaagc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 369
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 369
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttttcc gatttttcgg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 370
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 370
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gcttgaactg aacggact
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 371
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 371
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcagcggaa gcggacgatt
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 372
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 372
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtccaa actcaaaacc atcg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 373
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 373
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gcttccaatc agtttgacc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 374
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 374
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gagcgcaatc gttgatattt tc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 375
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 375
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttatttgcc cagttggtag aatg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 376
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 376
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggtgatacat ccgcactact tc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 377
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 377
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcaaaatcg agtttacac ca
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 378
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 378
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaccatctat ttcaaaaacg g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 379
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 379
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcagccgat gtttagcgtc catt
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 380
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 380
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgagcag cggagggggt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 381
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 381
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaaggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 382
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 382
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtcgc cgccgacatc g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 383
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 383
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaaggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 384
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 384
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcgg ttcggaaggc g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 385
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 385
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgaacactg atgtcttttc cga
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 386
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 386
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcaaact gtcgttggtg ttaac
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 387
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 387
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgacccgct ccacgg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 388
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 388
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat ggcggacttg gcgcaagacc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 389
\vskip0.400000\baselineskip
<211> 39
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 389
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga gatctcctaa acctgtttta acaatgccg
\hfill39
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 390
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 390
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat ggcggacttg gcgcaagacc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 391
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 391
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gctccatgct gttgccccag c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 392
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 392
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat ggcggacttg gcgcaagacc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 393
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 393
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gaaaatcccc gctaaccgca g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 394
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 394
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgagcag cggagggggt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 395
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 395
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaaggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 396
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 396
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtcgc cgccgacatc g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 397
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 397
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaaggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 398
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 398
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggacgg tgttgtgcct gtt
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 399
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 399
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cttacggatc aaattgacg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 400
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 400
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcag ccaatctgaa gaa
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 401
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 401
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ctcagctttt gccgtcaa
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 402
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 402
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagctactc atccattgtc cgc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 403
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 403
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ccagttgtag cctattttg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 404
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 404
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcatgcg cttcacacac ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 405
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 405
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccagttg tagcctattt
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 406
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 406
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat ggcacaaacg gaaggtttgg aa
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 407
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 407
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga gaaaactgta acgcaggttt gccgtc
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 408
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 408
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggaagaaaca ccgcgcgaac cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 409
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 409
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga ggaacgtttt attaaactg ac
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 410
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 410
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gagaaaaccg accgataccc ta
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 411
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 411
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gtcaacgcca ctgccagcgg ttg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 412
\vskip0.400000\baselineskip
<211> 48
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 412
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaagaa gaacatattg gaattttggg tcggactg
\hfill48
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 413
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 413
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattcggcg gctttttccg cattgccg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 414
\vskip0.400000\baselineskip
<211> 103
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 414
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 415
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 415
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattcggcg gctttttccg cattgccg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 416
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\newpage
\vskip0.400000\baselineskip
<400> 416
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcatgccatgg ctttccgcgt ggccggcggt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 417
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 417
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattcggcg gctttttccg cattgccg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 418
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 418
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtttgc cgaaacccgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 419
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 419
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag aggttgtgtt ccaggttg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 420
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 420
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaaa aaccgcctat g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 421
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 421
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaaggttgt gttccagg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 422
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 422
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaaa atacctattc cgc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 423
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 423
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgggcgg tattcgg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 424
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 424
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaaag caagagcatc caaa
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 425
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 425
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgggcgg tattcgg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 426
\vskip0.400000\baselineskip
<211> 86
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 426
\vskip0.400000\baselineskip
<210> 427
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 427
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgggcgg tattcgggct tcataccg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 428
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 428
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg tcgactgtgg gggcggcggt ggc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 429
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 429
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcaatcctgc tcttttttgc c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 430
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 430
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat gaagaaaaca ttgacactgc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 431
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 431
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttaatggtg cgaatgaccg at
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 432
\vskip0.400000\baselineskip
<211> 46
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 432
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggacaagt ttgtacaaaa aagcaggctt gcggcaagga tgccgg
\hfill46
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 433
\vskip0.400000\baselineskip
<211> 47
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 433
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggaccact ttgtacaaga aagctgggtc taaagcaaca atgccgg
\hfill47
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 434
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 434
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaca caccgtatcc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 435
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 435
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatctcgtg cgcgcc
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 436
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 436
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgagccc cgcgccgatt
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 437
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 437
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttttgtgcg gtcaggcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 438
\vskip0.400000\baselineskip
<211> 62
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 438
\vskip0.400000\baselineskip
<210> 439
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 439
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcgga tgcgcccgcg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 440
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 440
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag aaaccgccaa tccgcc
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 441
\vskip0.400000\baselineskip
<211> 61
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 441
\vskip0.400000\baselineskip
<210> 442
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 442
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaacc caaaccgcac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 443
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 443
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatgaaaaaa atcatcttcg ccg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 444
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 444
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattgtttg gctgcctcga t
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 445
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 445
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgggaattcca tatggccacc tacaaagtgg acg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 446
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 446
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcggggatcct tgtttggctg cctcgatttg
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 447
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 447
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaaga acaatcgcag aaag
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 448
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 448
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttttttcggc aaattggctt
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 449
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 449
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggacaagt ttgtacaaaa aagcaggctg ccgatgccgt tgcgg
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 450
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 450
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggaccact ttgtacaaga aagctgggtt cagggtcgtt tgttgcg
\hfill47
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 451
\vskip0.400000\baselineskip
<211> 47
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 451
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaca ctttccatcc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 452
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 452
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaca ctttccatcc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 453
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 453
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 454
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 454
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aagcgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 455
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 455
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaccactcg taattgac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 456
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 456
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 457
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 457
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag acccacgttg taaggttg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 458
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 458
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aagcgacgac ga
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 459
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 459
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag acccacgttg taaggttg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 460
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 460
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa acactttcca tcc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 461
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 461
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaacccacg ttgtaaggt
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 462
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 462
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa acactttcca tcc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 463
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 463
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttaacccacg ttgtaaggt
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 464
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 464
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 465
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 465
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gtctgacact gttttatcc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 466
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 466
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa acactttcca tcc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 467
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 467
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatgctttg gcggcaaag
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 468
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 468
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 469
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 469
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc cactcgtaat tgacgcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 470
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 470
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aagcgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 471
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 471
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc cactcgtaat tgacgcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 472
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 472
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 473
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 473
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatcca cccacgttgt aaggttg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 474
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 474
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgatgaa acactttcca tcc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 475
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 475
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatcca cccacgttgt aaggttg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 476
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 476
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gagggggtgg tgtcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 477
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 477
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaaggc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 478
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 478
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gcggaggcgg cactt
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 479
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 479
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 480
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 480
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg ttcagatttg gcaaacgatt c
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 481
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 481
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 482
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 482
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gagggggtgg tgtcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 483
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 483
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattgcttg gcggcaag
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 484
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 484
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gcggaggcgg cactt
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 485
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 485
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagaaccgg tagcctac
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 486
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 486
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg ttcagatttg gcaaacgatt c
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 487
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 487
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttacgtatca tatttcacgt gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 488
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 488
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aagcgacgac g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 489
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 489
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ccactcgtaa ttgacgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 490
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 490
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 491
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 491
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tgctttggcg gcaaagtt
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 492
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 492
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggccac aaacgacgac
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 493
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 493
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttagcaata ttatctttgt tcgtagc
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 494
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 494
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaagc aaaccgtgcc ga
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 495
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 495
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ccactcgtaa ttgacgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 496
\vskip0.400000\baselineskip
<211> 61
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 496
\vskip0.400000\baselineskip
<210> 497
\vskip0.400000\baselineskip
<211> 61
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 497
\vskip1.000000\baselineskip
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 498
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 498
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggccatat ggcagcaaaa gacgtacagt t
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 499
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 499
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gttacatcat gccgcccata cca
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 500
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 500
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcttagg cggcggcgga g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 501
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\newpage
\vskip0.400000\baselineskip
<400> 501
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 502
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 502
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccctagcta gcacttctgc gcccgactt
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 503
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 503
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 504
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 504
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcttagg cggcggcgga g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 505
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 505
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 506
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 506
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcacttc tgcgcccgac tt
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 507
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 507
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 508
\vskip0.400000\baselineskip
<211> 50
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 508
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccgaac gaccccaacc ttccctacaa aaactttcaa
\hfill50
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 509
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 509
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagaaccga cgtgccaagc cgttc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 510
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 510
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgccatat gcccccactg gaagaacgga cg
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 511
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 511
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgccgcctcga gtaataaacc ttctatgggc agcag
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 512
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 512
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtccgt ccacgcatcc g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 513
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 513
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttgaatttg taggtgtatt g
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 514
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 514
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgacccc ttccgcact
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 515
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 515
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttatttgaat ttgtaggtgt at
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 516
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 516
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaaaac caattcagaa gaa
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 517
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 517
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tccacagaga ttgtttcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 518
\vskip0.400000\baselineskip
<211> 17
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 518
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgatgcccgaa gggcggg
\hfill17
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 519
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 519
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcagaagaag acttcacgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 520
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 520
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaaac ccataaatac gctatt
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 521
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 521
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt gaagaagact tcacgccag
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 522
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 522
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggtctt tttcgacaat accga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 523
\vskip0.400000\baselineskip
<211> 10
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 523
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt
\hfill10
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 524
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 524
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgaataa aactttaaaa aggcgg
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 525
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 525
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt tcagaagaag acttcacgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 526
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 526
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgaatccc atatgttcga tcttgattct gtcga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 527
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 527
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcgcacaggc tgttggcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 528
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 528
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgaatccc atatgttggg cggaggcggc ag
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 529
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 529
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcgcacaggc tgttggcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 530
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 530
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcgaatccc atatgttggg cggaggcggc ag
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 531
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 531
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcgcacaggc tgttggcg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 532
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 532
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcaaa tttggaggtg cgc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 533
\vskip0.400000\baselineskip
<211> 327
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 533
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttcggagcgg ttgaagc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 534
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 534
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcaacg tcgtattata accc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 535
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 535
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttattcggag cggttgaag
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 536
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 536
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcat caaagtcgcc atcaacggct ac
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 537
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 537
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttgagcggg cgcacttcaa gtccg
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 538
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 538
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcgg cagcgaaaaa aac
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 539
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 539
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gttggtgccg actttgat
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 540
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 540
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcgg cggaagcgat a
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 541
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 541
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tttgcccgct ttgagcc
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 542
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 542
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggcaa atccgaaaat acg
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 543
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 543
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag catcccgtac tgtttcg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 544
\vskip0.400000\baselineskip
<211> 62
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 544
\vskip0.400000\baselineskip
<210> 545
\vskip0.400000\baselineskip
<211> 61
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 545
\vskip0.400000\baselineskip
<210> 546
\vskip0.400000\baselineskip
<211> 61
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 546
\vskip0.400000\baselineskip
<210> 547
\vskip0.400000\baselineskip
<211> 60
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 547
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggaccact ttgtacaaga aagctgggtc taggaaaaat cgtcatcgtt gaaattcgcc
\hfill60
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 548
\vskip0.400000\baselineskip
<211> 47
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 548
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggacaagt ttgtacaaaa aagcaggcta tgcaccccat cgaaacc
\hfill47
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 549
\vskip0.400000\baselineskip
<211> 47
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 549
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggggaccact ttgtacaaga aagctgggtc tagtcttgca gtgcctc
\hfill47
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 550
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 550
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgggaaa tttcttatat agaggcatta g
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 551
\vskip0.400000\baselineskip
<211> 40
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 551
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gttaatttct atcaactctt tagcaataat
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 552
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 552
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcctg ccaagacgac a
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 553
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 553
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggcaga gatctgtttg ataa
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 554
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 554
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cggttttccg cccaatg
\hfill27
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 555
\vskip0.400000\baselineskip
<211> 27
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 555
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcagcc ggatacggtc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 556
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 556
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgcagcc ggatacggtc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 557
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 557
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag aatcacttcc aacacaaaat
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 558
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 558
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgtggtt gctgatgaag ggc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 559
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 559
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gactgcttca tcttctgc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 560
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 560
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatggaact gatgactgtt ttgc
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 561
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 561
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag tcagactgct tcatcttct
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 562
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 562
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc atatgagcat taaagtagcg attaacggtt tcggc
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 563
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 563
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gattttgcct gcgaagtatt ccaaagtgcg
\hfill40
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 564
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 564
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 565
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 565
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcggggatcca tcctgctctt ttttgccgg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 566
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 566
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg tcaaagcaag agcatccaaa cc
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 567
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 567
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttt tcgggcggta ttcgggcttc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 568
\vskip0.400000\baselineskip
<211> 39
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 568
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg tgccacctac aaagtggac
\hfill39
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 569
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 569
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ttgtttggct gcctcgat
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 570
\vskip0.400000\baselineskip
<211> 34
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 570
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg tacaagcgac gacg
\hfill34
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 571
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 571
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcccaagctt ccactcgtaa ttgacgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 572
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 572
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg ttcagatttg gcaaacgatt c
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 573
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 573
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttc gtatcatatt tcacgtgc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 574
\vskip0.400000\baselineskip
<211> 44
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 574
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttg gtggtggtgg tggttcagat ttggcaaacg attc
\hfill44
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 575
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 575
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 576
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 576
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttg gtggtggtgg tggtcaaagc aagagcatcc aaacc
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 577
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 577
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgggcggtat tcgggctt
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 578
\vskip0.400000\baselineskip
<211> 32
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 578
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagccccga tgttaaatcg gc
\hfill32
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 579
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 579
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcggggatcca tcctgctctt ttttgccgg
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 580
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 580
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg ctagcggaca cacttatttc ggcatac
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 581
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 581
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc cagcggtagc ctaatttgat
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 582
\vskip0.400000\baselineskip
<211> 41
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 582
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg ttcagatttg gcaaacgatt c
\hfill41
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 583
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 583
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttc gtatcatatt tcacgtgc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 584
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 584
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcgtcga cggtggcgga ggcactggat cctcag
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 585
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 585
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatcctcaga tttggcaaac gattc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 586
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 586
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 587
\vskip0.400000\baselineskip
<211> 33
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 587
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaattccat atgtcagatt tggcaaacga ttc
\hfill33
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 588
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 588
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccc gtatcatatt tcacgtgc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 589
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 589
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcggggatccg ggggcggcgg tggcg
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 590
\vskip0.400000\baselineskip
<211> 30
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 590
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagctta tcctgctctt ttttgccggc
\hfill30
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 591
\vskip0.400000\baselineskip
<211> 42
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 591
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcgcggatccg gtggtggtgg tcaaagcaag agcatccaaa cc
\hfill42
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 592
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 592
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttc gggcggtatt cgggcttc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 593
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 593
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipccccaagctt gggggcggcg gtggcg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 594
\vskip0.400000\baselineskip
<211> 31
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 594
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag atcctgctct tttttgccgg c
\hfill31
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 595
\vskip0.400000\baselineskip
<211> 45
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 595
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccaagcttg gtggtggtgg tggtcaaagc aagagcatcc aaacc
\hfill45
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 596
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 596
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgggcggtat tcgggctt
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 597
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 597
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatccgcagc cacaaacgac gacga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 598
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 598
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggtggcgga ggcactggat ccgcag
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 599
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 599
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag acccagcttg taaggttg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 600
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 600
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatccgcagc cacaaacgac gacga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 601
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 601
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggtggcgga ggcactggat ccgcag
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 602
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 602
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ccactcgtaa ttgacgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 603
\vskip0.400000\baselineskip
<211> 38
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 603
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggatccggc ggaggcggca cttctgcg
\hfill38
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 604
\vskip0.400000\baselineskip
<211> 26
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 604
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag gaaccggtag cctacg
\hfill26
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 605
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 605
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatcctcaga tttggcaaac gattc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 606
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 606
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcgtcga cggtggcgga ggcactggat cctcaga
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 607
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 607
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 608
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 608
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggatccgga gggggtggtg tcgcc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 609
\vskip0.400000\baselineskip
<211> 25
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 609
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ttgcttggcg gcaag
\hfill25
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 610
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 610
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatccgcagc cacaaacgac gacga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 611
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 611
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggtggcgga ggcactggat ccgcag
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 612
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 612
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag acccagcttg taaggtg
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 613
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 613
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatccgcagc cacaaacgac gacga
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 614
\vskip0.400000\baselineskip
<211> 36
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 614
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcctcga gggtggcgga ggcactggat ccgcag
\hfill36
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 615
\vskip0.400000\baselineskip
<211> 28
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 615
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag ccactcgtaa ttgacgcc
\hfill28
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 616
\vskip0.400000\baselineskip
<211> 35
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 616
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipggaggcactg gatcctcaga tttggcaaac gattc
\hfill35
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 617
\vskip0.400000\baselineskip
<211> 37
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 617
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipgcggcgtcga cggtggcgga ggcactggat cctcaga
\hfill37
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 618
\vskip0.400000\baselineskip
<211> 29
\vskip0.400000\baselineskip
<212> ADN
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> Oligonucleótido
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 618
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
\hskip-.1em\dddseqskipcccgctcgag cgtatcatat ttcacgtgc
\hfill29
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<210> 619
\vskip0.400000\baselineskip
<211> 488
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> MC58
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 619
\vskip0.400000\baselineskip
<210> 620
\vskip0.400000\baselineskip
<211> 427
\vskip0.400000\baselineskip
<212> PRT
\vskip0.400000\baselineskip
<213> Secuencia artificial
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<220>
\vskip0.400000\baselineskip
<223> 2996
\vskip1.000000\baselineskip
\vskip0.400000\baselineskip
<400> 620
\vskip0.800000\baselineskip
-
240
Claims (6)
1. Un procedimiento para expresión
heteróloga de la proteína "961" de N. meningitidis, en
el que
(a) la proteína 961 de la cepa MC58 tiene
la secuencia "961" de aminoácidos:
y en el
que
(b) al menos un dominio de la proteína
está suprimido, en el que los dominios de "961" de la cepa MC58
son como sigue: (1) aminoácidos 1-23; (2)
aminoácidos 24-268; (3) aminoácidos
269-307 y (4) aminoácidos
308-364
y en el que las proteína "961"
se expresa en una célula
hospedadora.
2. El procedimiento de la reivindicación
1, en el que no se usa un partícipe de fusión para expresión de la
proteína.
3. El procedimiento de la reivindicación
1, en el que la proteína incluye una etiqueta His C terminal.
4. El procedimiento de la reivindicación
1, en el que la proteína incluye una GST N terminal.
5. El procedimiento de la reivindicación
1, en el que la proteína "961" es la porción N terminal de una
proteína híbrida.
6. Una proteína expresada por el
procedimiento de cualquier reivindicación precedente.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0004695A GB0004695D0 (en) | 2000-02-28 | 2000-02-28 | Protein expression |
| GB0004695 | 2000-02-28 | ||
| GB0027675 | 2000-11-13 | ||
| GB0027675A GB0027675D0 (en) | 2000-11-13 | 2000-11-13 | Protein Expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2281409T3 true ES2281409T3 (es) | 2007-10-01 |
Family
ID=26243750
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08075111T Expired - Lifetime ES2360746T3 (es) | 2000-02-28 | 2001-02-28 | Expresión híbrida de proteínas e neisseriales. |
| ES01914109T Expired - Lifetime ES2281409T3 (es) | 2000-02-28 | 2001-02-28 | Expresion heterologa de proteinas de neisseria. |
| ES01914098T Expired - Lifetime ES2299476T3 (es) | 2000-02-28 | 2001-02-28 | Expresion hibrida de proteinas de neisseria. |
| ES10178586T Expired - Lifetime ES2386534T3 (es) | 2000-02-28 | 2001-02-28 | Expresión heteróloga de proteínas de Neisseria |
| ES06076718T Expired - Lifetime ES2391153T3 (es) | 2000-02-28 | 2001-02-28 | Expresión heteróloga de proteínas de Neisseria |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08075111T Expired - Lifetime ES2360746T3 (es) | 2000-02-28 | 2001-02-28 | Expresión híbrida de proteínas e neisseriales. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01914098T Expired - Lifetime ES2299476T3 (es) | 2000-02-28 | 2001-02-28 | Expresion hibrida de proteinas de neisseria. |
| ES10178586T Expired - Lifetime ES2386534T3 (es) | 2000-02-28 | 2001-02-28 | Expresión heteróloga de proteínas de Neisseria |
| ES06076718T Expired - Lifetime ES2391153T3 (es) | 2000-02-28 | 2001-02-28 | Expresión heteróloga de proteínas de Neisseria |
Country Status (20)
| Country | Link |
|---|---|
| US (9) | US7803387B2 (es) |
| EP (6) | EP1947187B9 (es) |
| JP (8) | JP4763210B2 (es) |
| CN (7) | CN101906413A (es) |
| AT (3) | ATE387502T1 (es) |
| AU (4) | AU2001239478B2 (es) |
| BR (2) | BR0108711A (es) |
| CA (5) | CA2744921C (es) |
| CY (6) | CY1106532T1 (es) |
| DE (3) | DE60132978T2 (es) |
| DK (4) | DK1947187T5 (es) |
| ES (5) | ES2360746T3 (es) |
| HK (4) | HK1055993A1 (es) |
| LU (1) | LU92240I2 (es) |
| MX (2) | MXPA02008313A (es) |
| NL (1) | NL300605I2 (es) |
| NZ (2) | NZ521531A (es) |
| PT (4) | PT1947187E (es) |
| RU (2) | RU2299906C2 (es) |
| WO (2) | WO2001064920A2 (es) |
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