IN2012DN02736A - "compounds and compositions as tlr activity modulators" - Google Patents

"compounds and compositions as tlr activity modulators" Download PDF


Publication number
IN2012DN02736A IN2736/DELNP/2012A IN2736DEN2012A IN2012DN02736A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A IN 2736DEN2012 A IN2736DEN2012 A IN 2736DEN2012A IN 2012DN02736 A IN2012DN02736 A IN 2012DN02736A
Prior art keywords
activity modulators
tlr activity
Prior art date
Application number
Alex Cortez
Yongkai Li
Manmohan Singh
David Skibinski
Tom Yao Hsiang Wu
Kathy Yue
Xiaoyue Zhang
Original Assignee
Irm Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US23921709P priority Critical
Priority to US20090239217P priority
Priority to US20100874153 priority
Priority to PCT/US2010/047587 priority patent/WO2011049677A1/en
Priority to WO2010US47587 priority
Application filed by Irm Llc, Novartis Ag filed Critical Irm Llc
First worldwide family litigation filed litigation Critical "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of IN2012DN02736A publication Critical patent/IN2012DN02736A/en



    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems


The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
IN2736/DELNP/2012A 2009-09-02 2012-03-29 "compounds and compositions as tlr activity modulators" IN2012DN02736A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US23921709P true 2009-09-02 2009-09-02
US20090239217P 2009-09-02
US20100874153 2010-09-01
PCT/US2010/047587 WO2011049677A1 (en) 2009-09-02 2010-09-01 Compounds and compositions as tlr activity modulators
WO2010US47587 2010-09-01

Publications (1)

Publication Number Publication Date
IN2012DN02736A true IN2012DN02736A (en) 2015-09-11



Family Applications (1)

Application Number Title Priority Date Filing Date
IN2736/DELNP/2012A IN2012DN02736A (en) 2009-09-02 2012-03-29 "compounds and compositions as tlr activity modulators"

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US (2) US9045470B2 (en)
EP (1) EP2473508B1 (en)
JP (1) JP5525614B2 (en)
CN (1) CN102712636B (en)
AR (1) AR078153A1 (en)
AU (1) AU2010308524B2 (en)
BR (1) BR112012004696A2 (en)
CA (1) CA2772657C (en)
CY (1) CY1119618T1 (en)
DK (1) DK2473508T3 (en)
EA (1) EA020962B1 (en)
ES (1) ES2627669T3 (en)
HR (1) HRP20170707T1 (en)
HU (1) HUE032323T2 (en)
IN (1) IN2012DN02736A (en)
JO (1) JO3257B1 (en)
LT (1) LT2473508T (en)
MX (1) MX2012002654A (en)
PE (1) PE11562012A1 (en)
PL (1) PL2473508T3 (en)
PT (1) PT2473508T (en)
SI (1) SI2473508T1 (en)
TW (1) TWI445708B (en)
UY (1) UY32874A (en)
WO (1) WO2011049677A1 (en)

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Publication number Publication date
BR112012004696A2 (en) 2017-05-23
CA2772657C (en) 2015-11-24
HUE032323T2 (en) 2017-09-28
AU2010308524B2 (en) 2014-03-20
CY1119618T1 (en) 2018-04-04
EP2473508A1 (en) 2012-07-11
PT2473508T (en) 2017-05-29
WO2011049677A1 (en) 2011-04-28
JP5525614B2 (en) 2014-06-18
UY32874A (en) 2011-04-29
DK2473508T3 (en) 2017-06-06
HRP20170707T1 (en) 2017-07-14
PE11562012A1 (en) 2012-08-23
AU2010308524A1 (en) 2012-04-19
CN102712636A (en) 2012-10-03
US20110053893A1 (en) 2011-03-03
TW201113281A (en) 2011-04-16
US9045470B2 (en) 2015-06-02
JP2013503884A (en) 2013-02-04
PL2473508T3 (en) 2017-08-31
EA201200406A1 (en) 2012-09-28
JO3257B1 (en) 2018-09-16
EA020962B1 (en) 2015-03-31
AR078153A1 (en) 2011-10-19
CN102712636B (en) 2014-11-05
CA2772657A1 (en) 2011-04-28
TWI445708B (en) 2014-07-21
SI2473508T1 (en) 2017-07-31
US20150225432A1 (en) 2015-08-13
MX2012002654A (en) 2012-03-26
ES2627669T3 (en) 2017-07-31
EP2473508B1 (en) 2017-03-08
LT2473508T (en) 2017-06-12

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