AR125874A1 - COMBINATION THERAPIES - Google Patents

COMBINATION THERAPIES

Info

Publication number
AR125874A1
AR125874A1 ARP220101284A ARP220101284A AR125874A1 AR 125874 A1 AR125874 A1 AR 125874A1 AR P220101284 A ARP220101284 A AR P220101284A AR P220101284 A ARP220101284 A AR P220101284A AR 125874 A1 AR125874 A1 AR 125874A1
Authority
AR
Argentina
Prior art keywords
inhibitor
pharmaceutical combination
hif2a
bgb
combination therapies
Prior art date
Application number
ARP220101284A
Other languages
Spanish (es)
Inventor
Glenn Dranoff
Wolfgang Hackl
Javier Otero
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR125874A1 publication Critical patent/AR125874A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a composiciones farmacéuticas que comprenden inhibidores del factor inducible por hipoxia-2a (HIF2a). Las terapias de combinación pueden ser utilizadas para tratar o prevenir afecciones y trastornos cancerosos. Reivindicación 1: Una combinación farmacéutica que comprende un inhibidor de HIF2a, un inhibidor de PD-1, y opcionalmente un antagonista de A2aR. Reivindicación 2: La combinación farmacéutica de la reivindicación 1, en donde el inhibidor de HIF2α es un compuesto que tiene la estructura general (1). Reivindicación 3: La combinación farmacéutica de la reivindicación 1, en donde el inhibidor de PD-1 se selecciona entre spartalizumab, nivolumab, pembrolizumab, pidilizumab, MEDI0680, REGN2810, TSR-042, PF-06801591, tislelizumab (BGB-A317), BGB-108, INCSHR1210, o AMP-224.The present invention relates to pharmaceutical compositions comprising inhibitors of hypoxia-inducible factor-2a (HIF2a). Combination therapies can be used to treat or prevent cancerous conditions and disorders. Claim 1: A pharmaceutical combination comprising a HIF2a inhibitor, a PD-1 inhibitor, and optionally an A2aR antagonist. Claim 2: The pharmaceutical combination of claim 1, wherein the HIF2α inhibitor is a compound having the general structure (1). Claim 3: The pharmaceutical combination of claim 1, wherein the PD-1 inhibitor is selected from spartalizumab, nivolumab, pembrolizumab, pidilizumab, MEDI0680, REGN2810, TSR-042, PF-06801591, tislelizumab (BGB-A317), BGB -108, INCSHR1210, or AMP-224.

ARP220101284A 2021-05-18 2022-05-13 COMBINATION THERAPIES AR125874A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163189972P 2021-05-18 2021-05-18

Publications (1)

Publication Number Publication Date
AR125874A1 true AR125874A1 (en) 2023-08-23

Family

ID=82163537

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220101284A AR125874A1 (en) 2021-05-18 2022-05-13 COMBINATION THERAPIES

Country Status (3)

Country Link
AR (1) AR125874A1 (en)
TW (1) TW202313033A (en)
WO (1) WO2022243846A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025031393A1 (en) * 2023-08-08 2025-02-13 杭州安道药业有限公司 Spiro compound and use thereof in the field of medicine

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