DE19612967A1 - Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren - Google Patents
Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen InfluenzavirenInfo
- Publication number
- DE19612967A1 DE19612967A1 DE19612967A DE19612967A DE19612967A1 DE 19612967 A1 DE19612967 A1 DE 19612967A1 DE 19612967 A DE19612967 A DE 19612967A DE 19612967 A DE19612967 A DE 19612967A DE 19612967 A1 DE19612967 A1 DE 19612967A1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- influenza viruses
- influenza
- virus
- viruses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Description
Vermehrung von Influenzastämmen, gemessen als Antigengehalt (HA-Einheiten) in Rollflaschen (MDCK-Zellinie MDCK 33016) nach Infektion einer Zellkultur ohne Mediumwechsel | |
HA-Gehalt 5 Tage nach Infektion | |
Influenzastamm | |
HA-Gehalt | |
A/Singapore|1 : 1024 | |
A/Sichuan | 1 : 256 |
A/Shanghai | 1 : 256 |
A/Guizhou | 1 : 128 |
A/Beÿing | 1 : 512 |
B/Beÿing | 1 : 256 |
B/Yamagata | 1 : 512 |
A/PR/8/34 | 1 : 1024 |
A/Equi 1/Prag | 1 : 512 |
A/Equi 2/Miami | 1 : 256 |
A/Equi 2/Fontembleau | 1 : 128 |
A/Swine/Gent | 1 : 512 |
A/Swine/Iowa | 1 : 1024 |
A/Swine/Arnsberg | 1 : 512 |
Claims (22)
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19612967A DE19612967A1 (de) | 1996-04-01 | 1996-04-01 | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
EP97915628.8A EP0891420B2 (de) | 1996-04-01 | 1997-04-01 | Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
EP05075182A EP1526172B1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die Replikation von Influenza in Zellkultur, und die bei diesem Verfahren hergestellten Influenza Viren |
PCT/IB1997/000404 WO1997037001A1 (en) | 1996-04-01 | 1997-04-01 | Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
DK05075182.5T DK1526172T3 (da) | 1996-04-01 | 1997-04-01 | Fremgangsmåde til replikation af influenzavira i cellekultur og ved fremgangsmåden opnåelige influenzavira |
ES05075182T ES2367081T3 (es) | 1996-04-01 | 1997-04-01 | Procedimiento para la replicación de virus de la gripe en cultivo celular y los virus de la gripe que pueden obtenerse por el procedimiento. |
DE69732407.9T DE69732407T3 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren |
AT97915628T ATE288479T1 (de) | 1996-04-01 | 1997-04-01 | Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
AT05075182T ATE513905T1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur, und die bei diesem verfahren hergestellten influenza viren |
DE122007000082C DE122007000082I1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
PT05075182T PT1526172E (pt) | 1996-04-01 | 1997-04-01 | Processo para a replicação de vírus influenza em cultura celular e os vírus influenza que podem ser obtidos pelo processo |
JP53509097A JP4447054B2 (ja) | 1996-04-01 | 1997-04-01 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
ES09011476T ES2435726T3 (es) | 1996-04-01 | 1997-04-01 | Procedimiento para la replicación de virus de la gripe en cultivo celular y los virus de la gripe que pueden obtenerse por el procedimiento |
EP09011476.0A EP2172543B1 (de) | 1996-04-01 | 1997-04-01 | Verfahren zur Replikation von Influenzaviren in Zellkultur und die mit dem Verfahren erhältlichen Influenzaviren |
DK97915628.8T DK0891420T4 (da) | 1996-04-01 | 1997-04-01 | Fremgangsmåde til replikation af influenzavirus i cellekultur samt de ved fremgangsmåden opnåelige influenzavirus |
ES97915628T ES2236799T5 (es) | 1996-04-01 | 1997-04-01 | Procedimientos de replicación de virus de influenza en cultivo celular y virus de influenza obtenibles por el procedimiento |
CA002250078A CA2250078C (en) | 1996-04-01 | 1997-04-01 | Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
PT97915628T PT891420E (pt) | 1996-04-01 | 1997-04-01 | Processos para a replicacao dos virus influenza numa cultura celular e os virus influenza que se podem obter atraves do processo |
US10/245,037 US20030119183A1 (en) | 1996-04-01 | 2002-09-16 | Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
HK05109564.2A HK1075467A1 (en) | 1996-04-01 | 2005-10-27 | Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
JP2006189769A JP2006296437A (ja) | 1996-04-01 | 2006-07-10 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
US11/592,336 US20070117131A1 (en) | 1996-04-01 | 2006-11-03 | Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
NL300307C NL300307I1 (nl) | 1996-04-01 | 2007-11-28 | Werkwijzen voor de replicatie van influenzavirussen in celkweek en de influenzavirussen die verkrijgbaar zijn met behulp van de werkwijze |
LU91381C LU91381I2 (fr) | 1996-04-01 | 2007-11-30 | OPTAFLU-Définition du produit: Vaccin grippal préparé à partir du virus de la grippe dans une culture celluluaire ou les cellules sont cultivées à unetempérature comprise entre 30°C et 36°C pour la r éplication des virus |
JP2008169656A JP2008245659A (ja) | 1996-04-01 | 2008-06-27 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
JP2010198362A JP5264843B2 (ja) | 1996-04-01 | 2010-09-03 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
HK10108428.3A HK1142093A1 (en) | 1996-04-01 | 2010-09-06 | Process for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process |
JP2011157202A JP2011212020A (ja) | 1996-04-01 | 2011-07-15 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
JP2013039239A JP2013116124A (ja) | 1996-04-01 | 2013-02-28 | 細胞培養におけるインフルエンザウイルスの複製の方法、および本方法によって入手可能なインフルエンザウイルス |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19612967A DE19612967A1 (de) | 1996-04-01 | 1996-04-01 | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19612967A1 true DE19612967A1 (de) | 1997-10-02 |
Family
ID=7790127
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19612967A Withdrawn DE19612967A1 (de) | 1996-04-01 | 1996-04-01 | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
DE122007000082C Pending DE122007000082I1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
DE69732407.9T Expired - Lifetime DE69732407T3 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122007000082C Pending DE122007000082I1 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren |
DE69732407.9T Expired - Lifetime DE69732407T3 (de) | 1996-04-01 | 1997-04-01 | Verfahren für die Replikation von Influenza in Zellkultur und die bei diesem Verfahren hergestellten Influenza-Viren |
Country Status (13)
Country | Link |
---|---|
US (2) | US20030119183A1 (de) |
EP (3) | EP0891420B2 (de) |
JP (6) | JP4447054B2 (de) |
AT (2) | ATE513905T1 (de) |
CA (1) | CA2250078C (de) |
DE (3) | DE19612967A1 (de) |
DK (2) | DK1526172T3 (de) |
ES (3) | ES2435726T3 (de) |
HK (2) | HK1075467A1 (de) |
LU (1) | LU91381I2 (de) |
NL (1) | NL300307I1 (de) |
PT (2) | PT1526172E (de) |
WO (1) | WO1997037001A1 (de) |
Families Citing this family (88)
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DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
JP2001521737A (ja) * | 1997-10-31 | 2001-11-13 | メルク エンド カムパニー インコーポレーテッド | 回転瓶内の水痘感染細胞培養物の混合増進方法 |
WO1999023204A1 (en) * | 1997-10-31 | 1999-05-14 | Merck & Co., Inc. | A method of improved mixing in roller bottles |
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CA2401117C (en) | 2000-03-03 | 2010-06-29 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
DE10144906B4 (de) | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
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DK1539921T3 (da) * | 2002-09-16 | 2008-04-14 | Pan Biotech Gmbh | Indretning til dyrkning af celler, især celler fra mennesker eller dyr |
ES2295465T3 (es) | 2002-09-16 | 2008-04-16 | Pan-Biotech Gmbh | Procedimiento para el cultivo de celulas, en especial de celulas humanas o de animales. |
US7270990B2 (en) | 2003-06-20 | 2007-09-18 | Microbix Biosystems, Inc. | Virus production |
CA2559371C (en) | 2004-03-09 | 2014-07-08 | Chiron Corporation | Influenza virus vaccines |
JP2007537760A (ja) * | 2004-05-20 | 2007-12-27 | アイディー バイオメディカル コーポレイション | インフルエンザワクチンを製造するためのプロセス |
EP2811027A1 (de) | 2004-05-21 | 2014-12-10 | Novartis Vaccines and Diagnostics, Inc. | Alphavirus-Vektoren für RSV- und PIV-Impfstoffe |
RS51665B (en) * | 2004-09-09 | 2011-10-31 | Novartis Vaccines And Diagnostics Gmbh. | Reduction of potential iatrogenic risks associated with influenza vaccines |
DK1824990T3 (en) | 2004-12-08 | 2015-05-26 | Medimmune Llc | Methods for the production of influenza vaccine compositions |
ES2526170T3 (es) | 2004-12-23 | 2015-01-07 | Medimmune, Llc | Línea celular MDCK no tumorigénica para propagar virus |
FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
ES2525518T3 (es) | 2005-11-01 | 2014-12-26 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
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JP2009514850A (ja) | 2005-11-04 | 2009-04-09 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | アジュバントとして減少した量の水中油型エマルションを有するインフルエンザワクチン |
ES2792398T3 (es) | 2005-11-04 | 2020-11-11 | Seqirus Uk Ltd | Vacunas adyuvantadas con antígenos de no virión preparadas a partir de virus de la gripe cultivados en cultivo celular |
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WO2007132763A1 (ja) * | 2006-05-11 | 2007-11-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | インフルエンザウイルスの増殖方法 |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
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WO2008068631A2 (en) | 2006-12-06 | 2008-06-12 | Novartis Ag | Vaccines including antigen from four strains of influenza virus |
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US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
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1996
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2002
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2007
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2008
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