BR112014027834A2 - composições de nanopartícula lipídica para entrega de oligonucleotídeos antissenso - Google Patents

composições de nanopartícula lipídica para entrega de oligonucleotídeos antissenso

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Publication number
BR112014027834A2
BR112014027834A2 BR112014027834A BR112014027834A BR112014027834A2 BR 112014027834 A2 BR112014027834 A2 BR 112014027834A2 BR 112014027834 A BR112014027834 A BR 112014027834A BR 112014027834 A BR112014027834 A BR 112014027834A BR 112014027834 A2 BR112014027834 A2 BR 112014027834A2
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BR
Brazil
Prior art keywords
lipid nanoparticle
akt
nucleic acid
directed
aso
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BR112014027834A
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English (en)
Inventor
Ho Ahn Chang
Joong Kim Deog
J Lee Robert
Bok Lee Young
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Univ Ohio State
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Publication date
Application filed by Univ Ohio State filed Critical Univ Ohio State
Publication of BR112014027834A2 publication Critical patent/BR112014027834A2/pt

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Abstract

resumo patente de invenção: "composições de nanopartícula lipídica para entrega de oligonucleotídeos antis-senso". a presente invenção refere-se a um a uma composição de nanopartícula lipídica que inclui uma macromolécula conjugada a um polímero e um agente de direcionamento. a composição pode incluir um agente terapêutico. o agente terapêutico pode ser um oligonucleotídeo antissenso (aso). os asos exemplificados são direcionados a uma parte de um ácido nucleico codificando akt-1, e que modula a expressão de akt-1, ou são direcionados para uma parte de um ácido nucleico codificando hif-1, e que modula a expressão de hfi-1. também é descrita uma composição de nanopartícula lipídica que inclui uma macromolécula conjugada a um polímero e a um agente terapêutico que é um aso, tal como um aso direcionado para uma parte de um ácido nucleico codificando akt-1, e que modula a expressão de akt-1 ou um aso direcionado a uma parte de um ácido nucleico codificando hif-1, e que modula a expressão de hif-1. formulações farmacêuticas, métodos de fabricação de nanopartículas lipídicas e métodos de uso das ditas nanopartículas lipídicas, por exemplo, para o tratamento do câncer, também são descritos.
BR112014027834A 2012-05-23 2013-05-23 composições de nanopartícula lipídica para entrega de oligonucleotídeos antissenso BR112014027834A2 (pt)

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