MX353567B - Composiciones de nanoparticulas de lipidos para la entrega de oligonucleotidos antisentido. - Google Patents

Composiciones de nanoparticulas de lipidos para la entrega de oligonucleotidos antisentido.

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Publication number
MX353567B
MX353567B MX2014014251A MX2014014251A MX353567B MX 353567 B MX353567 B MX 353567B MX 2014014251 A MX2014014251 A MX 2014014251A MX 2014014251 A MX2014014251 A MX 2014014251A MX 353567 B MX353567 B MX 353567B
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MX
Mexico
Prior art keywords
modulates
expression
lipid nanoparticle
nucleic acid
aso
Prior art date
Application number
MX2014014251A
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English (en)
Other versions
MX2014014251A (es
Inventor
J Lee Robert
Bok Lee Young
Joong Kim Deog
Ho Ahn Chang
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Univ Ohio State
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Publication date
Application filed by Univ Ohio State filed Critical Univ Ohio State
Publication of MX2014014251A publication Critical patent/MX2014014251A/es
Publication of MX353567B publication Critical patent/MX353567B/es

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Abstract

La presente invención se refiere a una composición de nanopartículas de lípidos que incluye una macromolécula conjugada con un polímero y un agente de direccionamiento. La composición puede incluir un agente terapéutico. El agente terapéutico puede ser un oligonucleótido antisentido (ASO). ASOs de ejemplo apuntan a una porción de un ácido nucleico que codifica Akt-1 y que modula la expresión of Akt-1; o apunta a una porción de un ácido nucleico que codifica HIF-1 y que modula la expresión de HIF-1. También se describe una composición de nanopartículas de lípidos que incluye una macromolécula conjugada con un polímero y un agente terapéutico que es un ASO tal como un ASO apuntado a una porción de un ácido nucleico que codifica Akt-1 y que modula la expresión de Akt-1 o un ASO apuntado a una porción de un ácido nucleico que codifica HIF-1 y que modula la expresión de HIF-1. Se describen también formulaciones farmacéuticas, métodos para hacer la nanopartícula de lípidos y métodos para usar la nanopartícula de lípidos, por ejemplo para tratar cánceres.
MX2014014251A 2012-05-23 2013-05-23 Composiciones de nanoparticulas de lipidos para la entrega de oligonucleotidos antisentido. MX353567B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650729P 2012-05-23 2012-05-23
US201361784892P 2013-03-14 2013-03-14
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CA2871477A1 (en) 2013-11-28
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JP2015523969A (ja) 2015-08-20
AU2017245294A1 (en) 2017-11-02
AU2013266238A1 (en) 2014-12-18
JP2015525209A (ja) 2015-09-03
EP2852380A2 (en) 2015-04-01
MX2014014251A (es) 2015-06-17
WO2013177421A3 (en) 2014-02-27
AU2013266232B2 (en) 2017-08-03
US20130315937A1 (en) 2013-11-28
WO2013177419A3 (en) 2014-02-20
CN105163721A (zh) 2015-12-16
CA2874490A1 (en) 2013-11-28
CN105163721B (zh) 2018-05-22
CN104428005B (zh) 2019-05-10
WO2013177415A1 (en) 2013-11-28
CA2874490C (en) 2021-11-16
US20150118288A1 (en) 2015-04-30
KR102169891B1 (ko) 2020-10-26
CN104582691A (zh) 2015-04-29
JP2018002727A (ja) 2018-01-11
AU2013266238B2 (en) 2017-07-27
BR112014029247A2 (pt) 2017-06-27
AU2017245294B2 (en) 2019-09-12
JP6220389B2 (ja) 2017-10-25
AU2013266236A1 (en) 2014-12-18

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