BR112017027985A2 - peptídeos terapêuticos e métodos de uso dos mesmos - Google Patents

peptídeos terapêuticos e métodos de uso dos mesmos

Info

Publication number
BR112017027985A2
BR112017027985A2 BR112017027985A BR112017027985A BR112017027985A2 BR 112017027985 A2 BR112017027985 A2 BR 112017027985A2 BR 112017027985 A BR112017027985 A BR 112017027985A BR 112017027985 A BR112017027985 A BR 112017027985A BR 112017027985 A2 BR112017027985 A2 BR 112017027985A2
Authority
BR
Brazil
Prior art keywords
targeted
peptides
peptide
directed
brain
Prior art date
Application number
BR112017027985A
Other languages
English (en)
Inventor
David Strand Andrew
James Mhyre Andrew
Mehlin Christopher
Correnti Colin
June Girard Emily
Olson James
Brusniak Mi-Youn
Strong Roland
Sottero Theo
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of BR112017027985A2 publication Critical patent/BR112017027985A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Insects & Arthropods (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)

Abstract

a presente invenção refere-se aos peptídeos que são endereçados, se distribuem, se direcionam, são direcionados a ou se acumulam em tumores, cânceres ou células doentes. peptídeos que atravessam a barreira sangue-cérebro e são endereçados, se distribuem, se direcionam, são direcionados a ou se acumulam no cérebro e em uma região específica do cérebro são também divulgados. composições farmacêuticas e usos para os peptídeos ou complexos de peptídeo-agente ativo que compreendem tais peptídeos são adicionalmente divulgados. tais composições podem ser formuladas para entrega direcionada ou não direcionada de um fármaco a uma região, tecido, estrutura ou célula-alvo. as composições direcionadas da invenção podem entregar peptídeo ou complexos de peptídeo-agente ativo a regiões, tecidos, estruturas ou células-alvo direcionadas pelo peptídeo.
BR112017027985A 2015-06-26 2016-06-24 peptídeos terapêuticos e métodos de uso dos mesmos BR112017027985A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562185527P 2015-06-26 2015-06-26
US201562185529P 2015-06-26 2015-06-26
US201562239743P 2015-10-09 2015-10-09
US201562239739P 2015-10-09 2015-10-09
US201662322724P 2016-04-14 2016-04-14
US201662354642P 2016-06-24 2016-06-24
PCT/US2016/039431 WO2016210376A2 (en) 2015-06-26 2016-06-24 Therapeutic peptides and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112017027985A2 true BR112017027985A2 (pt) 2018-08-28

Family

ID=57586477

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017027985A BR112017027985A2 (pt) 2015-06-26 2016-06-24 peptídeos terapêuticos e métodos de uso dos mesmos

Country Status (7)

Country Link
US (1) US20180371033A1 (pt)
JP (1) JP2018521994A (pt)
AU (1) AU2016283391A1 (pt)
BR (1) BR112017027985A2 (pt)
CA (1) CA2987636A1 (pt)
IL (1) IL256515A (pt)
WO (1) WO2016210376A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
JP6966424B2 (ja) * 2015-09-09 2021-11-17 フレッド ハッチンソン キャンサー リサーチ センター 軟骨ホーミングペプチド
EP3571215A4 (en) 2017-01-18 2020-12-30 Fred Hutchinson Cancer Research Center PEPTIDE COMPOSITIONS AND METHOD OF USE THEREOF TO INTERRUPT TEAD INTERACTIONS
EP3595699A4 (en) * 2017-03-16 2020-12-23 Blaze Bioscience, Inc. CARTILLE HOMING PEPTIDE CONJUGATES AND METHOD OF USING THEREOF
CN107286231A (zh) * 2017-05-18 2017-10-24 长沙沁才生物科技有限公司 一种动物来源活性多肽spgp‑v
US11331393B2 (en) 2017-06-15 2022-05-17 Blaze Bioscience, Inc. Renal-homing peptide conjugates and methods of use thereof
EP3727146A4 (en) 2017-12-19 2021-10-06 Blaze Bioscience, Inc. CELL PENETRATION PEPTIDE TUMOR AND IMMUNO-ONCOLOGY ADDRESSING AGENT COMPLEXES AND METHODS OF USE
CN111744020A (zh) * 2019-03-27 2020-10-09 中国科学院宁波材料技术与工程研究所 一种主动靶向响应型多肽药物、其制备方法和应用
CA3138933A1 (en) * 2019-05-22 2020-11-26 The Board Of Trustees Of The Leland Stanford Junior University Drug conjugates and methods of using same
EP4048786A1 (en) * 2019-10-22 2022-08-31 Genethon Chimeric polypeptides and uses thereof
WO2023107428A1 (en) * 2021-12-07 2023-06-15 The Regents Of The University Of California Methods for treating traumatic brain injury

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
CA2788824C (en) * 2010-02-04 2019-03-12 Morphotek, Inc. Chlorotoxin polypeptides and conjugates and uses thereof
CN103097403B (zh) * 2010-05-11 2017-04-19 弗雷德哈钦森癌症研究中心 氯毒素变体、缀合物及其使用方法
CN105189540A (zh) * 2012-12-10 2015-12-23 弗莱德哈钦森癌症研究中心 含脂质运载蛋白融合伴侣

Also Published As

Publication number Publication date
WO2016210376A3 (en) 2017-03-02
AU2016283391A1 (en) 2017-11-30
JP2018521994A (ja) 2018-08-09
US20180371033A1 (en) 2018-12-27
CA2987636A1 (en) 2016-12-29
WO2016210376A2 (en) 2016-12-29
IL256515A (en) 2018-02-28

Similar Documents

Publication Publication Date Title
BR112017027985A2 (pt) peptídeos terapêuticos e métodos de uso dos mesmos
BR112018004536A2 (pt) peptídeos de endereçamento à cartilagem
BR212016030926U2 (pt) conjugados de alvo e partículas e formulações dos mesmos
BR112017025108A2 (pt) compostos seletivos de pyy e usos dos mesmos
CY1122771T1 (el) Φαρμακοτεχνικες μορφες παρατεταμενης αποδεσμευσης για τη χορηγηση πρωτεϊνων στον οφθαλμο και μεθοδοι για την παρασκευη αυτων
CY1119616T1 (el) Συζευγματα ανθρωπινου αντισωματος-φαρμακου κατα του ιστικου παραγοντα
ZA202002094B (en) Trispecific proteins and methods of use
BR112017007765A2 (pt) composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
BR112014018728A8 (pt) Compostos de purinonas como inibidores de quinase
BR112018006489A2 (pt) composições e métodos para inibir a expressão gênica de lpa
BR112016012538A2 (pt) peptídeos citotóxicos e conjugados dos mesmos
BR112018004078A2 (pt) composições farmacêuticas, usos de proteinas de fusão e métodos para tratar câncer e para inibir a metástase em um indivíduo
BR112016015818A2 (pt) Compostos e respectivos usos para tratar pacientes com células cancerosas mutantes em relação a ros1
BR112012026801B8 (pt) conjugados de pirrolobenzodiazepina direcionados, composição farmacêutica, uso dos mesmos para tratamento de uma doença proliferativa ou autoimune e ligante de medicamento
BR112019024747A2 (pt) formulações de dose fixa
MX2019013690A (es) Conjugados de farmaco-proteina con ciclodextrina.
EA201491299A1 (ru) Карбаматные соединения, их получение и применение
BR112015021222A2 (pt) inibidores de ras e usos dos mesmos
BR112012026213A8 (pt) Compostos de pirrolobenzodiazepinas, conjugado das mesmas, composição farmacêutica compreendendo o conjugado e uso do mesmo para o tratamento de uma doença proliferativa
BR112017025698A2 (pt) composições e métodos para inibir a expressão do gene de hif2alfa
BR112019001945A2 (pt) composição de conjugado de fármaco aglutinante, formulação farmaceuticamente aceitável, métodos para tratar uma doença ou afecção hiperproliferativa, para inibir a multiplicação de uma célula tumoral ou célula cancerígena e para preparar uma composição de conjugado de fármaco aglutinado, e, composto
BR112016004095A2 (pt) administração de enzimas de empobrecimento de quinurenina para a terapia contra tumores
WO2018081726A3 (en) Pharmaceutical compositions and methods of use for activation of human fibroblast and myofibroblast apoptosis
BR112016016202A2 (pt) Construtos de direcionamento de receptores e uso dos mesmos
BR112017016087A2 (pt) formulações para coxim articular adiposo e métodos de uso das mesmas

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements