EA201491299A1 - Карбаматные соединения, их получение и применение - Google Patents

Карбаматные соединения, их получение и применение

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Publication number
EA201491299A1
EA201491299A1 EA201491299A EA201491299A EA201491299A1 EA 201491299 A1 EA201491299 A1 EA 201491299A1 EA 201491299 A EA201491299 A EA 201491299A EA 201491299 A EA201491299 A EA 201491299A EA 201491299 A1 EA201491299 A1 EA 201491299A1
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EA
Eurasian Patent Office
Prior art keywords
carbamatic
connections
production
application
provides
Prior art date
Application number
EA201491299A
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English (en)
Other versions
EA028085B1 (ru
Inventor
Джастие С. Сизар
Шерил А. Грайс
Тодд К. Джонс
Миса Дж. Нипхакис
Цзае Вон Чан
Кеннет М. Лум
Бенджамин Ф. Краватт
Original Assignee
Эбайд Терапьютикс, Инк.
Дзе Скриппс Рисерч Инститьют
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Publication of EA201491299A1 publication Critical patent/EA201491299A1/ru
Publication of EA028085B1 publication Critical patent/EA028085B1/ru

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Данное изобретение обспечивает соединения и композиции, которые могут представлять собой модуляторы MAGL и/или ABHD6, и их применение в качестве лекарственных средств, способы их получения, а также фармацевтические композиции, которые включают раскрытые соединения в качестве по меньшей мере одного активного агента. Также изобретение обеспечивает способ лечения пациента, нуждающегося в этом, при этом пациент страдает такими симптомами, как боль, солидной злокачественной опухолью и/или ожирением, включающий введение раскрытого соединения или композиции.
EA201491299A 2012-01-06 2013-01-07 Карбаматные соединения и их применение EA028085B1 (ru)

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UA109991C2 (xx) 2015-10-26
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CY1122984T1 (el) 2021-10-29
LT2800565T (lt) 2020-07-27
JP2019142891A (ja) 2019-08-29
US20150148330A1 (en) 2015-05-28
US20170073320A1 (en) 2017-03-16
IL233476B (en) 2018-01-31
US20230312499A1 (en) 2023-10-05
BR112014016672B1 (pt) 2022-06-28
CR20140365A (es) 2014-12-03
EP2800565B1 (en) 2020-03-25
US20180208568A1 (en) 2018-07-26
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ZA201405541B (en) 2017-04-26
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US11530189B2 (en) 2022-12-20
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JP2015508407A (ja) 2015-03-19
SI2800565T1 (sl) 2020-10-30
EP2800565A4 (en) 2015-04-29
WO2013103973A1 (en) 2013-07-11
PH12014501560B1 (en) 2014-10-08
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PH12014501560A1 (en) 2014-10-08
US11021453B2 (en) 2021-06-01
AU2013207252B2 (en) 2016-06-09
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CN107982266A (zh) 2018-05-04
CN107982266B (zh) 2021-07-30
JP2018065837A (ja) 2018-04-26
PE20141702A1 (es) 2014-11-19
US20150018335A1 (en) 2015-01-15
ES2793148T3 (es) 2020-11-13
MX350788B (es) 2017-09-13
US20200270223A1 (en) 2020-08-27
EP3698782A1 (en) 2020-08-26
MX2014008279A (es) 2014-11-10
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BR112014016672A8 (pt) 2021-03-09
JP2017125039A (ja) 2017-07-20
US9957242B2 (en) 2018-05-01
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