PE20141702A1 - Compuestos de carbamato y preparacion y uso de los mismos - Google Patents

Compuestos de carbamato y preparacion y uso de los mismos

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Publication number
PE20141702A1
PE20141702A1 PE2014001068A PE2014001068A PE20141702A1 PE 20141702 A1 PE20141702 A1 PE 20141702A1 PE 2014001068 A PE2014001068 A PE 2014001068A PE 2014001068 A PE2014001068 A PE 2014001068A PE 20141702 A1 PE20141702 A1 PE 20141702A1
Authority
PE
Peru
Prior art keywords
hexafluoropropan
ilo
carboxylate
bis
alkyl
Prior art date
Application number
PE2014001068A
Other languages
English (en)
Inventor
Justin S Cisar
Chery A Grice
Todd K Jones
Micah J Niphakis
Jae Won Chang
Kenneth M Lum
Benjamin F Cravatt
Original Assignee
Abide Therapeutics Inc
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abide Therapeutics Inc, Scripps Research Inst filed Critical Abide Therapeutics Inc
Publication of PE20141702A1 publication Critical patent/PE20141702A1/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE CARBAMATO DE FORMULA (I) DONDE T ES CX3 O CO-V-Rv, EN DONDE X ES H, F, Cl O Br; Rv ES H, ALQUILO(C1-C6), FENILO, ENTRE OTROS; V ES O U NRa, DONDE Ra ES H, ALQUILO(C1-C3), ENTRE OTROS; R1 ES L1-R6, ENTRE OTROS, EN DONDE L1 ES ALQUILENO(C1-C6) O UN ENLACE; R6 ES FENILO, NAFTILO, HETEROARILO, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4-[BIS(4-CLOROFENIL)METIL]-3-METILPIPERAZIN-1-CARBOXILATO DE 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-ILO; 4-(BIS(OXAZOL-4-IL)METIL)PIPERAZIN-1-CARBOXILATO DE 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-ILO; 4-(BIS(4-CLORO-2-METILFENIL)METIL)PIPERAZIN-1-CARBOXILATO DE 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-ILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LA MONOACILGLICEROL LIPASA (MAGL) Y DEL DOMINIO 6 DE SERINA HIDROLASA a-B-HIDROLASA (ABHD6) SIENDO UTILES EN EL TRATAMIENTO DE DOLOR, CANCER POR TUMOR SOLIDO, OBESIDAD
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