CY1122771T1 - Φαρμακοτεχνικες μορφες παρατεταμενης αποδεσμευσης για τη χορηγηση πρωτεϊνων στον οφθαλμο και μεθοδοι για την παρασκευη αυτων - Google Patents
Φαρμακοτεχνικες μορφες παρατεταμενης αποδεσμευσης για τη χορηγηση πρωτεϊνων στον οφθαλμο και μεθοδοι για την παρασκευη αυτωνInfo
- Publication number
- CY1122771T1 CY1122771T1 CY20201100042T CY201100042T CY1122771T1 CY 1122771 T1 CY1122771 T1 CY 1122771T1 CY 20201100042 T CY20201100042 T CY 20201100042T CY 201100042 T CY201100042 T CY 201100042T CY 1122771 T1 CY1122771 T1 CY 1122771T1
- Authority
- CY
- Cyprus
- Prior art keywords
- administration
- eye
- sustained
- proteins
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ενέσιμες φαρμακοτεχνικές μορφές παρατεταμένης αποδέσμευσης για τη χορήγηση δραστικών παραγόντων, ιδιαίτερα θεραπευτικών πρωτεϊνών, στον οφθαλμό. Οι φαρμακοτεχνικές μορφές είναι βιοσυμβατές, βιοαποικοδομήσιμες φαρμακοτεχνικές μορφές παρατεταμένης αποδέσμευσης που περιλαμβάνουν υγρά έκδοχα χαμηλής διαλυτότητας και σχετικά μικρές ποσότητες (λιγότερο από περίπου 10%) βιοσυμβατού, βιοαποικοδομήσιμου πολυμερούς όπως τα πολυμερή PLA ή PLGA. Μία μοναδιαία δόση των 5μL έως 100μL της φαρμακοτεχνικής μορφής παρέχει παρατεταμένη αποδέσμευση του παράγοντα για τουλάχιστον 14 ημέρες.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161495672P | 2011-06-10 | 2011-06-10 | |
PCT/US2012/041950 WO2013036309A2 (en) | 2011-06-10 | 2012-06-11 | Sustained release formulations for delivery of proteins to the eye and methods of preparing same |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122771T1 true CY1122771T1 (el) | 2021-05-05 |
Family
ID=47832748
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100042T CY1122771T1 (el) | 2011-06-10 | 2020-01-17 | Φαρμακοτεχνικες μορφες παρατεταμενης αποδεσμευσης για τη χορηγηση πρωτεϊνων στον οφθαλμο και μεθοδοι για την παρασκευη αυτων |
Country Status (21)
Country | Link |
---|---|
US (1) | US9814773B2 (el) |
EP (1) | EP2717914B1 (el) |
JP (1) | JP6339011B2 (el) |
KR (1) | KR20140060274A (el) |
CN (1) | CN103945865B (el) |
AU (1) | AU2012304909B2 (el) |
BR (1) | BR112013031685B1 (el) |
CA (1) | CA2838289C (el) |
CY (1) | CY1122771T1 (el) |
DK (1) | DK2717914T3 (el) |
ES (1) | ES2761340T3 (el) |
HR (1) | HRP20192276T1 (el) |
HU (1) | HUE047737T2 (el) |
IN (1) | IN2013MN02384A (el) |
LT (1) | LT2717914T (el) |
MX (1) | MX359119B (el) |
PL (1) | PL2717914T3 (el) |
PT (1) | PT2717914T (el) |
RS (1) | RS60051B1 (el) |
SI (1) | SI2717914T1 (el) |
WO (1) | WO2013036309A2 (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2913336C (en) * | 2013-05-24 | 2020-12-15 | Icon Bioscience, Inc. | Use of sustained release dexamethasone in post-cataract surgery inflammation |
SG11201608835VA (en) * | 2014-05-08 | 2016-11-29 | Panoptes Pharma Ges M B H | Compounds for treating ophthalmic diseases and disorders |
EP3272362B1 (en) * | 2015-03-18 | 2023-12-13 | Santen Pharmaceutical Co., Ltd. | Sustained-release pharmaceutical composition |
CA2991015A1 (en) * | 2015-07-01 | 2017-01-05 | Santen Pharmaceutical Co., Ltd. | Depot preparation containing citric acid ester |
EA036951B1 (ru) * | 2015-08-03 | 2021-01-19 | Толмар Интернэшнл Лимитед | Жидкая полимерная система доставки для длительного введения лекарственных средств |
HUE063850T2 (hu) | 2015-09-21 | 2024-02-28 | Teva Pharmaceuticals Int Gmbh | Hosszan tartó felszabadulású olanzapin készítmények |
CA3057438A1 (en) | 2017-03-20 | 2018-09-27 | Teva Pharmaceuticals International Gmbh | Sustained release olanzapine formulaitons |
KR101957599B1 (ko) | 2017-10-23 | 2019-03-13 | 김상현 | 훈제 단무지 제조 방법, 이에 의해 제조된 훈제 단무지 |
EP3749386A4 (en) | 2018-02-09 | 2021-10-27 | Icon Bioscience, Inc. | SYSTEMS, KITS AND METHODS FOR LOADING AND DISPENSING A SMALL VOLUME DOSE FROM A SYRINGE |
JP2021523223A (ja) | 2018-05-01 | 2021-09-02 | チビ,インコーポレイティド | 眼への薬物の非侵襲的な持続型送達のための液体デポー |
AU2019262061A1 (en) | 2018-05-01 | 2020-11-26 | Chibi, Inc. | Eye drop formulation and method for sustained delivery of medicament to the retina |
EP4153214A4 (en) * | 2020-05-22 | 2024-06-26 | Trustees of Boston University | METHODS AND COMPOSITIONS FOR TREATING FIBROTIC DISEASE |
US20240100012A1 (en) | 2021-01-18 | 2024-03-28 | Mark Hasleton | Pharmaceutical dosage form |
KR20240117521A (ko) | 2021-07-06 | 2024-08-01 | 마크 하슬레톤 | 세로토닌 재흡수 억제제 금단 증후군의 치료 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
NZ523385A (en) * | 2000-06-28 | 2005-09-30 | Atul J | Biodegradable vehicles and BAS-loaded delivery systems for use as biodegradable fillers and/or spacers, e.g. artificial skin |
US20040001889A1 (en) * | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
AR039729A1 (es) * | 2002-06-25 | 2005-03-09 | Alza Corp | Formulaciones de deposito de corta duracion |
US20050079202A1 (en) * | 2003-05-30 | 2005-04-14 | Guohua Chen | Implantable elastomeric depot compositions and uses thereof |
US7727969B2 (en) * | 2003-06-06 | 2010-06-01 | Massachusetts Institute Of Technology | Controlled release nanoparticle having bound oligonucleotide for targeted delivery |
US7771742B2 (en) * | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
US20050244472A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Intraocular drug delivery systems containing excipients with reduced toxicity and related methods |
US8685435B2 (en) * | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
US20080038316A1 (en) * | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
MX366832B (es) * | 2004-10-01 | 2019-07-24 | Ramscor Inc | Composiciones de farmaco de liberacion sostenida convenientemente implantables. |
AU2005294382A1 (en) * | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
US8039010B2 (en) * | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
CA2792484C (en) * | 2009-03-12 | 2017-10-31 | Delpor, Inc. | Implantable device for long-term delivery of drugs |
ES2672806T3 (es) * | 2009-07-03 | 2018-06-18 | Armbruster Biotechnology Gmbh | Injerto óseo y material biocompuesto |
-
2012
- 2012-06-11 LT LTEP12829655.5T patent/LT2717914T/lt unknown
- 2012-06-11 ES ES12829655T patent/ES2761340T3/es active Active
- 2012-06-11 AU AU2012304909A patent/AU2012304909B2/en active Active
- 2012-06-11 BR BR112013031685-3A patent/BR112013031685B1/pt active IP Right Grant
- 2012-06-11 CA CA2838289A patent/CA2838289C/en active Active
- 2012-06-11 PL PL12829655T patent/PL2717914T3/pl unknown
- 2012-06-11 DK DK12829655.5T patent/DK2717914T3/da active
- 2012-06-11 MX MX2013014461A patent/MX359119B/es active IP Right Grant
- 2012-06-11 IN IN2384MUN2013 patent/IN2013MN02384A/en unknown
- 2012-06-11 JP JP2014514933A patent/JP6339011B2/ja active Active
- 2012-06-11 RS RS20191574A patent/RS60051B1/sr unknown
- 2012-06-11 KR KR1020147000443A patent/KR20140060274A/ko not_active Application Discontinuation
- 2012-06-11 CN CN201280028816.4A patent/CN103945865B/zh active Active
- 2012-06-11 HU HUE12829655A patent/HUE047737T2/hu unknown
- 2012-06-11 EP EP12829655.5A patent/EP2717914B1/en active Active
- 2012-06-11 SI SI201231706T patent/SI2717914T1/sl unknown
- 2012-06-11 PT PT128296555T patent/PT2717914T/pt unknown
- 2012-06-11 WO PCT/US2012/041950 patent/WO2013036309A2/en active Application Filing
- 2012-06-11 US US14/124,631 patent/US9814773B2/en active Active
-
2019
- 2019-12-17 HR HRP20192276TT patent/HRP20192276T1/hr unknown
-
2020
- 2020-01-17 CY CY20201100042T patent/CY1122771T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO2013036309A3 (en) | 2013-05-10 |
KR20140060274A (ko) | 2014-05-19 |
US20140140992A1 (en) | 2014-05-22 |
EP2717914A4 (en) | 2015-05-13 |
CA2838289A1 (en) | 2013-03-14 |
AU2012304909A1 (en) | 2013-12-19 |
MX2013014461A (es) | 2014-05-14 |
NZ619707A (en) | 2015-01-30 |
BR112013031685B1 (pt) | 2021-04-06 |
US9814773B2 (en) | 2017-11-14 |
JP6339011B2 (ja) | 2018-06-06 |
BR112013031685A2 (pt) | 2017-02-07 |
IN2013MN02384A (el) | 2015-06-12 |
EP2717914B1 (en) | 2019-10-30 |
PL2717914T3 (pl) | 2020-05-18 |
MX359119B (es) | 2018-09-14 |
LT2717914T (lt) | 2020-03-25 |
JP2014516087A (ja) | 2014-07-07 |
WO2013036309A2 (en) | 2013-03-14 |
HUE047737T2 (hu) | 2020-05-28 |
ES2761340T3 (es) | 2020-05-19 |
HRP20192276T1 (hr) | 2020-05-15 |
DK2717914T3 (da) | 2020-01-20 |
CA2838289C (en) | 2019-09-10 |
EP2717914A2 (en) | 2014-04-16 |
SI2717914T1 (sl) | 2020-07-31 |
RS60051B1 (sr) | 2020-04-30 |
AU2012304909B2 (en) | 2017-06-08 |
CN103945865B (zh) | 2016-10-26 |
PT2717914T (pt) | 2019-12-18 |
CN103945865A (zh) | 2014-07-23 |
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