BR112015024271A2 - sistema de fornecimento transdérmico - Google Patents
sistema de fornecimento transdérmicoInfo
- Publication number
- BR112015024271A2 BR112015024271A2 BR112015024271A BR112015024271A BR112015024271A2 BR 112015024271 A2 BR112015024271 A2 BR 112015024271A2 BR 112015024271 A BR112015024271 A BR 112015024271A BR 112015024271 A BR112015024271 A BR 112015024271A BR 112015024271 A2 BR112015024271 A2 BR 112015024271A2
- Authority
- BR
- Brazil
- Prior art keywords
- molecular weight
- delivery system
- transdermal delivery
- drug
- weight
- Prior art date
Links
- 230000037317 transdermal delivery Effects 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- 229920002367 Polyisobutene Polymers 0.000 abstract 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 229960003530 donepezil Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
sistema de fornecimento transdérmico resumo a presente invenção fornece um sistema de fornecimento transdérmico que consiste numa camada de suporte, uma camada de matriz que contém fármaco e uma camada de liberação, em que a camada de matriz que contém fármaco compreende (a) donepezil ou um sal farmaceuticamente aceitável do mesmo como um ingrediente ativo, (b) uma mistura de poliisobutileno de peso molecular alto que possui um peso molecular em peso médio que varia desde 400.000 até 3.000.000 e poliisobutileno de peso molecular baixo que possui um peso molecular em peso médio que varia desde 25.000 até 300.000 como um adesivo e (c) um intensificador de permeação em não mais que 3 % em peso com base no peso total da camada de matriz que contém fármaco. 1/1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140007556A KR101485822B1 (ko) | 2014-01-22 | 2014-01-22 | 도네페질 또는 그의 염을 함유하는 경피흡수제제 |
| KR10-2014-0007556 | 2014-01-22 | ||
| PCT/KR2015/000277 WO2015111862A1 (en) | 2014-01-22 | 2015-01-12 | Transdermal delivery system comprising donepezil or its salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015024271A2 true BR112015024271A2 (pt) | 2017-07-18 |
| BR112015024271B1 BR112015024271B1 (pt) | 2023-10-31 |
Family
ID=52592456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015024271-5A BR112015024271B1 (pt) | 2014-01-22 | 2015-01-12 | Sistema de fornecimento transdérmico |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9931307B2 (pt) |
| EP (1) | EP3096745B1 (pt) |
| JP (1) | JP6405391B2 (pt) |
| KR (1) | KR101485822B1 (pt) |
| CN (1) | CN105025890B (pt) |
| AU (1) | AU2015209915B2 (pt) |
| BR (1) | BR112015024271B1 (pt) |
| CA (1) | CA2908340C (pt) |
| ES (1) | ES2874508T3 (pt) |
| PH (1) | PH12015502280A1 (pt) |
| WO (1) | WO2015111862A1 (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180112768A (ko) * | 2015-12-10 | 2018-10-12 | 케이엠 트랜스덤 엘티디 | 경피 흡수 제제 |
| US10835499B2 (en) | 2015-12-30 | 2020-11-17 | Corium, Inc. | Systems and methods for long term transdermal administration |
| CN109922796B (zh) | 2016-06-23 | 2023-04-07 | 考里安有限责任公司 | 具有亲水和疏水域的粘合剂基质和治疗剂 |
| KR102424270B1 (ko) | 2016-07-27 | 2022-07-25 | 코리움, 인크. | 경구 전달과 생물학적으로 동등한 약물동역학을 가진 경피 전달 시스템 |
| RU2764764C2 (ru) | 2016-07-27 | 2022-01-21 | Кориум Интернэшнл, Инк. | Трансдермальные системы доставки мемантина |
| EP3490541A2 (en) | 2016-07-27 | 2019-06-05 | Corium International, Inc. | Transdermal formulation and delivery method of low solubility or unstable unionized neutral drugs byin situ |
| WO2019126531A1 (en) | 2017-12-20 | 2019-06-27 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| KR102024996B1 (ko) | 2017-12-27 | 2019-09-25 | 동아에스티 주식회사 | 도네페질을 함유하는 치매 치료용 경피흡수제제 |
| KR102372630B1 (ko) | 2019-05-15 | 2022-03-14 | 주식회사 대웅제약 | 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제 |
| KR102218593B1 (ko) * | 2020-05-13 | 2021-02-22 | 동아에스티 주식회사 | 안정성이 향상된 도네페질 함유 경피 흡수제제 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
| KR100342388B1 (ko) * | 1999-11-03 | 2002-07-04 | 김충섭 | 경피 투과용 약물 전달 시스템 |
| JP4394443B2 (ja) | 2001-10-17 | 2010-01-06 | 久光製薬株式会社 | 経皮吸収型製剤 |
| KR100623077B1 (ko) * | 2002-08-26 | 2006-09-18 | 지상철 | 에스(+)-이부프로펜을 함유하는 경피투여용 조성물 및이를 함유하는 경피투여용 패취제 |
| WO2005123046A1 (en) | 2004-06-15 | 2005-12-29 | Amorepacific Corporation | Novel transdermal preparation and its producing method |
| US20060257461A1 (en) * | 2005-05-13 | 2006-11-16 | Jansen Rolf R | Multilayer galantamine delivery system with barrier against reservoir material flow |
| JP5097359B2 (ja) * | 2006-05-09 | 2012-12-12 | 久光製薬株式会社 | ドネペジル経皮吸収型製剤 |
| US9248104B2 (en) * | 2006-08-17 | 2016-02-02 | Core Tech Solutions, Inc. | Transdermal methods and systems for treating Alzheimer's disease |
| KR101454362B1 (ko) | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
| EP2328582A4 (en) | 2008-09-30 | 2012-02-22 | Teikoku Pharma Usa Inc | DERPEZIL COMPOSITIONS WITH EXTENDED TRANSDERMAL DELIVERY AND METHODS OF USE |
| EP2399607B1 (en) | 2009-02-18 | 2017-11-29 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal preparation |
| WO2011034323A2 (en) | 2009-09-16 | 2011-03-24 | Samyang Corporation | Transdermal delivery system, method for manufacturing the same, and transdermal delivery method using the system |
| RU2545696C2 (ru) | 2009-10-21 | 2015-04-10 | Тейкоку Сейяку Ко., Лтд. | Трансдермально абсорбируемый состав, содержащий донепезил |
| JP5766475B2 (ja) * | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
| KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
| TWI433904B (zh) * | 2011-01-12 | 2014-04-11 | Taiwan Biotech Co Ltd | 多奈哌齊經皮貼片 |
| KR101239150B1 (ko) * | 2012-02-28 | 2013-03-06 | 에스케이케미칼주식회사 | 도네페질-함유 경피흡수제제 및 그의 제조방법 |
| CN102895217A (zh) * | 2012-11-13 | 2013-01-30 | 沈阳药科大学 | 长效多奈哌齐经皮吸收贴剂 |
-
2014
- 2014-01-22 KR KR20140007556A patent/KR101485822B1/ko active IP Right Grant
-
2015
- 2015-01-12 AU AU2015209915A patent/AU2015209915B2/en not_active Ceased
- 2015-01-12 CN CN201580000338.XA patent/CN105025890B/zh active Active
- 2015-01-12 US US14/779,649 patent/US9931307B2/en active Active
- 2015-01-12 JP JP2016566588A patent/JP6405391B2/ja active Active
- 2015-01-12 BR BR112015024271-5A patent/BR112015024271B1/pt active IP Right Grant
- 2015-01-12 ES ES15739978T patent/ES2874508T3/es active Active
- 2015-01-12 EP EP15739978.3A patent/EP3096745B1/en active Active
- 2015-01-12 WO PCT/KR2015/000277 patent/WO2015111862A1/en active Application Filing
- 2015-01-12 CA CA2908340A patent/CA2908340C/en active Active
- 2015-09-30 PH PH12015502280A patent/PH12015502280A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015209915A1 (en) | 2015-08-27 |
| PH12015502280B1 (en) | 2016-02-01 |
| KR101485822B1 (ko) | 2015-01-23 |
| WO2015111862A1 (en) | 2015-07-30 |
| CN105025890A (zh) | 2015-11-04 |
| EP3096745A4 (en) | 2017-08-02 |
| CA2908340A1 (en) | 2015-07-30 |
| ES2874508T3 (es) | 2021-11-05 |
| EP3096745A1 (en) | 2016-11-30 |
| JP2017503865A (ja) | 2017-02-02 |
| CN105025890B (zh) | 2020-03-10 |
| US9931307B2 (en) | 2018-04-03 |
| JP6405391B2 (ja) | 2018-10-17 |
| US20160051486A1 (en) | 2016-02-25 |
| PH12015502280A1 (en) | 2016-02-01 |
| AU2015209915B2 (en) | 2019-09-12 |
| EP3096745B1 (en) | 2021-05-12 |
| CA2908340C (en) | 2021-11-30 |
| BR112015024271B1 (pt) | 2023-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/01/2015, OBSERVADAS AS CONDICOES LEGAIS |