MX2022003939A - Composicion farmaceutica de estabilidad mejorada. - Google Patents
Composicion farmaceutica de estabilidad mejorada.Info
- Publication number
- MX2022003939A MX2022003939A MX2022003939A MX2022003939A MX2022003939A MX 2022003939 A MX2022003939 A MX 2022003939A MX 2022003939 A MX2022003939 A MX 2022003939A MX 2022003939 A MX2022003939 A MX 2022003939A MX 2022003939 A MX2022003939 A MX 2022003939A
- Authority
- MX
- Mexico
- Prior art keywords
- lactate
- conjugate
- pharmaceutical composition
- based polymer
- less
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Pregnancy & Childbirth (AREA)
- Biotechnology (AREA)
- Gynecology & Obstetrics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición inyectable para la administración de fármacos por liberación controlada y el proceso de fabricación del mismo, donde la composición comprende: un polímero a base de lactato que tiene un peso molecular promedio en peso de entre 5.000 y 50.000 dalton, un número ácido menor de 3 mg de KOH/g y un contenido de monómeros de lactida residual en el polímero a base de lactato menor de aproximadamente 0,3% en peso; un solvente orgánico farmacéuticamente aceptable; y una sustancia bioactiva o una sal de la misma que contiene un aminoácido serina en su estructura molecular, que es capaz de reaccionar con el monómero lactida para formar un conjugado; y donde la composición reduce la formación del conjugado.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462064008P | 2014-10-15 | 2014-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022003939A true MX2022003939A (es) | 2022-04-25 |
Family
ID=55747307
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017005235A MX2017005235A (es) | 2014-10-15 | 2015-10-15 | Composición farmacéutica de estabilidad mejorada. |
MX2022003939A MX2022003939A (es) | 2014-10-15 | 2017-04-21 | Composicion farmaceutica de estabilidad mejorada. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017005235A MX2017005235A (es) | 2014-10-15 | 2015-10-15 | Composición farmacéutica de estabilidad mejorada. |
Country Status (20)
Country | Link |
---|---|
US (2) | US20160106804A1 (es) |
EP (1) | EP3207149B1 (es) |
JP (2) | JP6717839B2 (es) |
KR (2) | KR102274420B1 (es) |
CN (2) | CN113209009A (es) |
AU (2) | AU2015332456A1 (es) |
BR (1) | BR112017007669A2 (es) |
CA (1) | CA2964475C (es) |
ES (1) | ES2949827T3 (es) |
HR (1) | HRP20230716T1 (es) |
HU (1) | HUE062326T2 (es) |
IL (1) | IL251703B (es) |
MX (2) | MX2017005235A (es) |
NZ (1) | NZ730538A (es) |
PL (1) | PL3207149T3 (es) |
RS (1) | RS64339B1 (es) |
RU (1) | RU2728786C2 (es) |
SA (1) | SA517381298B1 (es) |
SG (1) | SG11201702535QA (es) |
WO (1) | WO2016061296A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160106804A1 (en) * | 2014-10-15 | 2016-04-21 | Yuhua Li | Pharmaceutical composition with improved stability |
CA3048499A1 (en) * | 2017-01-04 | 2018-07-12 | Pharmathen S.A. | Process for preparing biodegradable polymers of high molecular weight |
KR20190110567A (ko) * | 2017-01-31 | 2019-09-30 | 베루 인코퍼레이티드 | 성선 자극 호르몬-방출 호르몬(GnRH) 길항제의 장기간 방출을 위한 조성물 및 방법 |
US20200282008A1 (en) * | 2017-01-31 | 2020-09-10 | Veru Inc. | COMPOSITIONS AND METHODS FOR LONG TERM RELEASE OF GONADOTROPIN-RELEASING HORMONE (GnRH) ANTAGONISTS |
EP3727421A4 (en) * | 2017-12-18 | 2021-07-28 | Foresee Pharmaceuticals Co., Ltd. | PHARMACEUTICAL COMPOSITIONS WITH A CHOSEN DISCHARGE DURATION |
BR112024002231A2 (pt) | 2021-08-05 | 2024-04-30 | Medincell S A | Composição farmacêutica |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
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US4443340A (en) | 1981-10-09 | 1984-04-17 | Betz Laboratories, Inc. | Control of iron induced fouling in water systems |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
DE3708916A1 (de) | 1987-03-19 | 1988-09-29 | Boehringer Ingelheim Kg | Verfahren zur reinigung resorbierbarer polyester |
US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US5487897A (en) | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
ATE168391T1 (de) | 1990-04-13 | 1998-08-15 | Takeda Chemical Industries Ltd | Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung |
USRE37950E1 (en) | 1990-04-24 | 2002-12-31 | Atrix Laboratories | Biogradable in-situ forming implants and methods of producing the same |
AU2605592A (en) | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
EP0572675B1 (en) | 1991-12-19 | 1999-09-22 | Mitsui Chemicals, Inc. | Polyhydroxy carboxylic acid and production thereof |
EP0560014A1 (en) | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
US5242910A (en) | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
US5681873A (en) | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
WO1995027481A1 (en) | 1994-04-08 | 1995-10-19 | Atrix Laboratories, Inc. | Liquid delivery compositions |
US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
AR012448A1 (es) * | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
FR2776516B1 (fr) * | 1998-03-25 | 2001-05-25 | Pharma Biotech | Compositions presentant une liberation prolongee et leur procede de preparation |
US6261583B1 (en) | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
PT1158014E (pt) | 1998-12-15 | 2005-04-29 | Takeda Pharmaceutical | Processo para a producao de poliesteres biodegradaveis |
US6355657B1 (en) | 1998-12-30 | 2002-03-12 | Atrix Laboratories, Inc. | System for percutaneous delivery of opioid analgesics |
US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
US8470359B2 (en) | 2000-11-13 | 2013-06-25 | Qlt Usa, Inc. | Sustained release polymer |
DK1660039T3 (en) * | 2003-07-18 | 2017-01-16 | Oakwood Laboratories L L C | PREVENTION OF REDUCTION OF THE POLYMER MOLECULE WEIGHT, THE PREPARATION OF PURPOSES AND GELING IN POLYMER COMPOSITIONS |
US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
DK1824460T3 (en) | 2004-11-10 | 2015-01-19 | Tolmar Therapeutics Inc | Stabilized polymeric delivery system |
WO2007084460A2 (en) * | 2006-01-18 | 2007-07-26 | Qps, Llc | Pharmaceutical compositions with enhanced stability |
KR101466933B1 (ko) * | 2006-07-11 | 2014-12-01 | 큐피에스 엘엘씨 | 펩타이드의 지속 방출 전달을 위한 의약 조성물 |
PL2115029T3 (pl) * | 2007-02-15 | 2016-01-29 | Tolmar Therapeutics Inc | Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów |
WO2009064442A1 (en) * | 2007-11-13 | 2009-05-22 | Brookwood Pharmaceuticals, Inc. | Viscous terpolymers as drug delivery platform |
CN102958512B (zh) | 2008-08-29 | 2015-04-29 | 健赞股份有限公司 | 控释肽制剂 |
US20160106804A1 (en) * | 2014-10-15 | 2016-04-21 | Yuhua Li | Pharmaceutical composition with improved stability |
-
2015
- 2015-10-14 US US14/883,183 patent/US20160106804A1/en not_active Abandoned
- 2015-10-15 KR KR1020197007340A patent/KR102274420B1/ko active IP Right Grant
- 2015-10-15 HR HRP20230716TT patent/HRP20230716T1/hr unknown
- 2015-10-15 BR BR112017007669A patent/BR112017007669A2/pt not_active Application Discontinuation
- 2015-10-15 CA CA2964475A patent/CA2964475C/en active Active
- 2015-10-15 RU RU2017111079A patent/RU2728786C2/ru not_active Application Discontinuation
- 2015-10-15 KR KR1020177013085A patent/KR102134873B1/ko active IP Right Grant
- 2015-10-15 CN CN202110616661.7A patent/CN113209009A/zh active Pending
- 2015-10-15 RS RS20230541A patent/RS64339B1/sr unknown
- 2015-10-15 ES ES15850568T patent/ES2949827T3/es active Active
- 2015-10-15 CN CN201580055836.4A patent/CN107075541B/zh active Active
- 2015-10-15 AU AU2015332456A patent/AU2015332456A1/en not_active Abandoned
- 2015-10-15 MX MX2017005235A patent/MX2017005235A/es unknown
- 2015-10-15 WO PCT/US2015/055634 patent/WO2016061296A1/en active Application Filing
- 2015-10-15 SG SG11201702535QA patent/SG11201702535QA/en unknown
- 2015-10-15 JP JP2017539512A patent/JP6717839B2/ja active Active
- 2015-10-15 HU HUE15850568A patent/HUE062326T2/hu unknown
- 2015-10-15 EP EP15850568.5A patent/EP3207149B1/en active Active
- 2015-10-15 PL PL15850568.5T patent/PL3207149T3/pl unknown
- 2015-10-15 NZ NZ730538A patent/NZ730538A/en unknown
-
2017
- 2017-04-12 IL IL251703A patent/IL251703B/en active IP Right Grant
- 2017-04-12 SA SA517381298A patent/SA517381298B1/ar unknown
- 2017-04-21 MX MX2022003939A patent/MX2022003939A/es unknown
-
2019
- 2019-12-09 AU AU2019279929A patent/AU2019279929B2/en active Active
-
2020
- 2020-06-11 JP JP2020101632A patent/JP6928695B2/ja active Active
-
2021
- 2021-12-16 US US17/552,748 patent/US20220160817A1/en active Pending
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