MX2017004592A - Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos. - Google Patents
Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos.Info
- Publication number
- MX2017004592A MX2017004592A MX2017004592A MX2017004592A MX2017004592A MX 2017004592 A MX2017004592 A MX 2017004592A MX 2017004592 A MX2017004592 A MX 2017004592A MX 2017004592 A MX2017004592 A MX 2017004592A MX 2017004592 A MX2017004592 A MX 2017004592A
- Authority
- MX
- Mexico
- Prior art keywords
- peptide
- pharmaceutically acceptable
- complex
- pharmaceutical formulations
- oral delivery
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
La presente invención se refiere a formulaciones farmacéuticas mejoradas, usos y métodos para la administración por vía oral de fármacos peptídicos o proteínicos con biodisponibilidad, seguridad y rentabilidad ventajosamente altas. En particular, la invención proporciona un método para la administración por vía oral de un fármaco peptídico o proteínico que tiene un peso molecular menor o igual que aproximadamente 50 kDa, para uso como medicamento, en donde dicho fármaco peptídico o proteínico es para administración oral en combinación con una sal o complejo de cobre aceptable farmacéuticamente y/o una sal o complejo de zinc aceptable farmacéuticamente y con un agente reductor aceptable farmacéuticamente. La invención también proporciona una composición farmacéutica que comprende: un fármaco peptídico o proteínico que tiene un peso molecular menor o igual que aproximadamente 50 kDa; una sal o complejo de cobre aceptable farmacéuticamente y/o una sal o complejo de zinc aceptable farmacéuticamente y un agente reductor aceptable farmacéuticamente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14187885.0A EP3006045B3 (en) | 2014-10-07 | 2014-10-07 | Pharmaceutical formulations for the oral delivery of peptide or protein drugs |
PCT/EP2015/073196 WO2016055550A1 (en) | 2014-10-07 | 2015-10-07 | Pharmaceutical formulations for the oral delivery of peptide or protein drugs |
Publications (1)
Publication Number | Publication Date |
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MX2017004592A true MX2017004592A (es) | 2017-07-10 |
Family
ID=51751911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017004592A MX2017004592A (es) | 2014-10-07 | 2015-10-07 | Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20170304195A1 (es) |
EP (2) | EP3006045B3 (es) |
JP (1) | JP2017531665A (es) |
KR (1) | KR20170061140A (es) |
CN (1) | CN106794252A (es) |
AU (1) | AU2015330016A1 (es) |
BR (1) | BR112017006957A2 (es) |
CA (1) | CA2960334A1 (es) |
DK (1) | DK3006045T3 (es) |
ES (1) | ES2630106T3 (es) |
IL (1) | IL251462A0 (es) |
MX (1) | MX2017004592A (es) |
RU (1) | RU2017115651A (es) |
SG (1) | SG11201702813VA (es) |
WO (1) | WO2016055550A1 (es) |
ZA (1) | ZA201701719B (es) |
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ES2630106T3 (es) | 2014-10-07 | 2017-08-18 | Cyprumed Gmbh | Formulaciones farmacéuticas para la administración oral de fármacos peptídicos o proteicos |
CN108135962A (zh) | 2015-10-07 | 2018-06-08 | 塞浦路迈德有限责任公司 | 用于口服递送肽类药物的药物制剂 |
EP3998061A1 (en) * | 2016-04-18 | 2022-05-18 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
WO2018060736A1 (en) * | 2016-09-29 | 2018-04-05 | Arecor Limited | Novel formulations |
WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
SG10201609131YA (en) | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Zinc-pga compositions and methods for treating cancer |
SG10201609137PA (en) * | 2016-11-01 | 2018-06-28 | Xylonix Ip Holdings Pte Ltd | Gamma-polyglutamic acid and zinc compositions |
CN109381695A (zh) * | 2017-08-09 | 2019-02-26 | 武汉武药科技有限公司 | 一种门冬氨酸帕瑞肽注射液及其制备方法和用途 |
TWI751379B (zh) | 2017-09-21 | 2022-01-01 | 奧孟亞股份有限公司 | 用於遞送胜肽之藥物組合物 |
KR102176069B1 (ko) * | 2017-10-20 | 2020-11-09 | 주식회사 노브메타파마 | 아연염, 시클로-히스프로 및 항당뇨 약물을 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물 |
CN108079280B (zh) * | 2017-12-30 | 2021-06-04 | 陕西慧康生物科技有限责任公司 | 治疗ⅱ型糖尿病的艾塞那肽滴鼻剂 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
CN108721598B (zh) * | 2018-07-03 | 2020-06-05 | 北京市新里程医药科技有限公司 | 一种缩宫素原料的制备方法及其药物组合物和制剂 |
CN110251662B (zh) * | 2018-12-12 | 2023-01-31 | 福州市台江区希吉亚健康科技有限公司 | 一种具有减肥作用的药物 |
CN110251661B (zh) * | 2018-12-12 | 2022-09-16 | 福州市台江区希吉亚健康科技有限公司 | 一种用于治疗糖尿病或者减肥的药物制剂 |
KR102327750B1 (ko) * | 2018-12-19 | 2021-11-18 | 대화제약 주식회사 | Glp-1 유사체를 포함하는 경구투여용 약제학적 조성물 |
GB201906917D0 (en) * | 2019-05-16 | 2019-07-03 | Intract Pharma Ltd | Novel compositions |
CN112057619A (zh) * | 2019-06-10 | 2020-12-11 | 苏州兰鼎生物制药有限公司 | 一种具有降血糖作用的药物组合物 |
CN112138148B (zh) * | 2019-06-10 | 2024-04-09 | 苏州兰鼎生物制药有限公司 | 一种生长激素或其类似物的口服药物组合物 |
WO2020257260A1 (en) | 2019-06-17 | 2020-12-24 | Massachusetts Institute Of Technology | Formulation of peptide loaded liposomes and related applications |
WO2021035060A1 (en) * | 2019-08-21 | 2021-02-25 | Brain Chemistry Labs | Compositions comprising a metal and l-serine, and uses thereof |
KR102216578B1 (ko) * | 2019-09-05 | 2021-02-17 | 주식회사 아이큐어비앤피 | 테리파라타이드를 포함하는 경구용 약학 조성물 및 이의 제조방법 |
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CN113509544B (zh) * | 2019-12-14 | 2024-04-09 | 苏州兰鼎生物制药有限公司 | 一种具有降血糖作用的药物组合物 |
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-
2014
- 2014-10-07 ES ES14187885.0T patent/ES2630106T3/es active Active
- 2014-10-07 DK DK14187885.0T patent/DK3006045T3/en active
- 2014-10-07 EP EP14187885.0A patent/EP3006045B3/en active Active
-
2015
- 2015-10-07 US US15/517,306 patent/US20170304195A1/en not_active Abandoned
- 2015-10-07 MX MX2017004592A patent/MX2017004592A/es unknown
- 2015-10-07 KR KR1020177009950A patent/KR20170061140A/ko unknown
- 2015-10-07 AU AU2015330016A patent/AU2015330016A1/en not_active Withdrawn
- 2015-10-07 EP EP15788340.6A patent/EP3204045B1/en not_active Revoked
- 2015-10-07 SG SG11201702813VA patent/SG11201702813VA/en unknown
- 2015-10-07 JP JP2017519568A patent/JP2017531665A/ja active Pending
- 2015-10-07 BR BR112017006957A patent/BR112017006957A2/pt not_active Application Discontinuation
- 2015-10-07 CA CA2960334A patent/CA2960334A1/en not_active Withdrawn
- 2015-10-07 CN CN201580054091.XA patent/CN106794252A/zh not_active Withdrawn
- 2015-10-07 WO PCT/EP2015/073196 patent/WO2016055550A1/en active Application Filing
- 2015-10-07 RU RU2017115651A patent/RU2017115651A/ru unknown
-
2017
- 2017-03-09 ZA ZA2017/01719A patent/ZA201701719B/en unknown
- 2017-03-30 IL IL251462A patent/IL251462A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2017115651A (ru) | 2018-11-20 |
WO2016055550A1 (en) | 2016-04-14 |
EP3204045A1 (en) | 2017-08-16 |
ES2630106T3 (es) | 2017-08-18 |
US20170304195A1 (en) | 2017-10-26 |
AU2015330016A1 (en) | 2017-04-20 |
JP2017531665A (ja) | 2017-10-26 |
EP3006045A1 (en) | 2016-04-13 |
ZA201701719B (en) | 2018-05-30 |
IL251462A0 (en) | 2017-05-29 |
EP3006045B1 (en) | 2017-04-12 |
SG11201702813VA (en) | 2017-05-30 |
KR20170061140A (ko) | 2017-06-02 |
CA2960334A1 (en) | 2016-04-14 |
DK3006045T3 (en) | 2017-07-17 |
EP3006045B3 (en) | 2021-03-17 |
BR112017006957A2 (pt) | 2017-12-19 |
CN106794252A (zh) | 2017-05-31 |
EP3204045B1 (en) | 2018-12-05 |
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