SG11201500188YA - Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering - Google Patents

Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Info

Publication number
SG11201500188YA
SG11201500188YA SG11201500188YA SG11201500188YA SG11201500188YA SG 11201500188Y A SG11201500188Y A SG 11201500188YA SG 11201500188Y A SG11201500188Y A SG 11201500188YA SG 11201500188Y A SG11201500188Y A SG 11201500188YA SG 11201500188Y A SG11201500188Y A SG 11201500188YA
Authority
SG
Singapore
Prior art keywords
manufacturing
scaffold
compositions
methods
living cells
Prior art date
Application number
SG11201500188YA
Inventor
Dongan Wang
Ting Ting Lau
Wenyan Leong
Original Assignee
Univ Nanyang Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nanyang Tech filed Critical Univ Nanyang Tech
Publication of SG11201500188YA publication Critical patent/SG11201500188YA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/08—Methods for forming porous structures using a negative form which is filled and then removed by pyrolysis or dissolution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
SG11201500188YA 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering SG11201500188YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261680854P 2012-08-08 2012-08-08
PCT/SG2013/000312 WO2014025312A1 (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Publications (1)

Publication Number Publication Date
SG11201500188YA true SG11201500188YA (en) 2015-02-27

Family

ID=50068421

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201500188YA SG11201500188YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering
SG10201700973YA SG10201700973YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201700973YA SG10201700973YA (en) 2012-08-08 2013-07-26 Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering

Country Status (5)

Country Link
US (1) US9974886B2 (en)
EP (1) EP2882465B1 (en)
CN (1) CN104582747B (en)
SG (2) SG11201500188YA (en)
WO (1) WO2014025312A1 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2821992A1 (en) 2010-10-01 2012-04-05 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
DE12722942T1 (en) 2011-03-31 2021-09-30 Modernatx, Inc. RELEASE AND FORMULATION OF MANIPULATED NUCLEIC ACIDS
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP3492109B1 (en) 2011-10-03 2020-03-04 ModernaTX, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
JP2015501844A (en) 2011-12-16 2015-01-19 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Modified nucleosides, nucleotides and nucleic acid compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2833923A4 (en) 2012-04-02 2016-02-24 Moderna Therapeutics Inc Modified polynucleotides for the production of proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
LT2922554T (en) 2012-11-26 2022-06-27 Modernatx, Inc. Terminally modified rna
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
JP6338468B2 (en) * 2014-06-19 2018-06-06 テルモ株式会社 Method for producing gel in which cells are dispersed and cell-dispersed gel produced by the method
WO2016011387A1 (en) * 2014-07-17 2016-01-21 The Regents Of The University Of California Controllable self-annealing microgel particles for biomedical applications
CN104491846B (en) * 2014-12-04 2018-05-11 常州药物研究所有限公司 A kind of composite crosslinking medical chitose preparation and preparation method thereof
CN107614264B (en) 2014-12-05 2020-02-04 佛罗里达大学研究基金会有限公司 3D printing using phase change material as support
CN105734017B (en) * 2014-12-09 2019-11-12 中国科学院大连化学物理研究所 A method of promoting mesenchymal stem cells into nerve precursor directed differentiation, proliferation
CN104399118B (en) * 2014-12-10 2017-11-17 武汉理工大学 A kind of nerve growth factor Injectable in-situ hydrogel, preparation and its application
WO2016130953A1 (en) 2015-02-13 2016-08-18 University Of Florida Research Foundation, Inc. High speed 3d printing system for wound and tissue replacement
US11390835B2 (en) * 2015-05-08 2022-07-19 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
CN104922734B (en) * 2015-05-21 2017-11-24 东南大学 Promote injectable chitosan composite aquogel of myocardial repair and preparation method thereof
CN105078607A (en) * 2015-06-26 2015-11-25 王向阳 Experimental method for reconstructing vascular 3D structure inside rabbit vertebral end-plate
CN106367467B (en) * 2015-07-24 2019-11-26 中国科学院大连化学物理研究所 A kind of transplanting in-vitro screening method of hydrogel microsphere
US11027483B2 (en) 2015-09-03 2021-06-08 University Of Florida Research Foundation, Inc. Valve incorporating temporary phase change material
WO2017049066A1 (en) * 2015-09-18 2017-03-23 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
CN106606804B (en) * 2015-10-22 2020-05-12 四川蓝光英诺生物科技股份有限公司 Method for preparing composite structure
WO2017096263A1 (en) 2015-12-04 2017-06-08 University Of Florida Research Foundation, Incorporated Crosslinkable or functionalizable polymers for 3d printing of soft materials
CN105435311B (en) * 2015-12-11 2018-04-24 西南交通大学 A kind of tissue engineered bone cartilage compound rest and preparation method thereof
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
US11549097B2 (en) 2016-03-01 2023-01-10 Oxford University Innovation Limited Phase transfer of a cargo laden scaffold
GB201609764D0 (en) 2016-06-03 2016-07-20 Isis Innovation 3D printing of gel networks
CN105944143B (en) * 2016-06-06 2019-08-16 东华大学 Based on bionical tissue of acellular matrix-cell-three-dimensional fiber network and preparation method thereof
CN106075597B (en) * 2016-06-06 2019-08-20 东华大学 Bionical tissue and its preparation based on bladder acellular matrix-cell-three-dimensional fiber network
WO2017223315A1 (en) * 2016-06-22 2017-12-28 Tufts University Macroporous chitosan-polyacrylamide hydrogel microspheres and preparation thereof
US11124644B2 (en) 2016-09-01 2021-09-21 University Of Florida Research Foundation, Inc. Organic microgel system for 3D printing of silicone structures
IT201600099380A1 (en) * 2016-10-04 2018-04-04 Univ Bologna Alma Mater Studiorum COMPOSITIONS, DEVICES AND METHODS FOR IN VITRO CONTROL OF THE CHEMICAL CELL CROPS MICRO-ENVIRONMENT
EP3492578B1 (en) * 2016-12-27 2021-05-12 Fullstem Co., Ltd. Method for harvesting cultured cells from three-dimensional porous scaffold
CN117582559A (en) 2016-12-29 2024-02-23 泰普治疗公司 Methods and systems for treating a medical implant site
WO2018132720A1 (en) * 2017-01-13 2018-07-19 The Penn State Research Foundation Organ models
CA3059120C (en) * 2017-04-10 2024-02-06 TheWell Bioscience Hydrogel for cell culture and biomedical applications
TWI659939B (en) * 2017-06-23 2019-05-21 高雄醫學大學 Ceramic material having a positive slowly release effect, method for manufacturing the same, and system comprising the same
US11166920B2 (en) * 2017-10-05 2021-11-09 Auburn University Microfluidics device for fabrication of large, uniform, injectable hydrogel microparticles for cell encapsulation
EP3708605A4 (en) * 2017-11-06 2020-12-16 Konica Minolta, Inc. Hydrogel particle and method for producing same, cell or cell structure each enclosing hydrogel particle therein, method for evaluating activity of cell using hydrogel particle, and use of hydrogel particle as sustained release preparation
CN108410803B (en) * 2018-03-28 2019-02-05 湖南源品细胞生物科技有限公司 A kind of induced lipolysis stem cell at cartilage differentiation cultural method and culture solution
CN108324991B (en) * 2018-05-16 2020-10-30 王辉 Slow-release GDNF-SCs composite acellular nerve scaffold
CN108841776B (en) * 2018-06-13 2022-05-10 河海大学常州校区 Preparation method and application of 3D gel with adjustable components
CN108815574B (en) * 2018-07-17 2021-04-06 深圳市晶莱新材料科技有限公司 Bone repair hydrogel scaffold and preparation method thereof
CN109289087B (en) * 2018-10-09 2021-02-12 温州医科大学附属第一医院 Composite stent for treating steroid-induced femoral head necrosis and preparation method thereof
CN109260515A (en) * 2018-11-26 2019-01-25 华南理工大学 A kind of adjustable hydrogel of structure size and its preparation method and application
CN109234231A (en) * 2018-11-29 2019-01-18 广州赛莱拉干细胞科技股份有限公司 A kind of method of scale amplification of mesenchymal stem cells
JP2022527949A (en) * 2019-03-29 2022-06-07 ナンヤン テクノロジカル ユニヴァーシティー Therapeutic hydrogel device
CN110279886A (en) * 2019-05-10 2019-09-27 北京化工大学 It is a kind of with it is anti-oxidant and promote osteogenic ability multi-functional poly phosphazene bone renovating material and preparation method thereof
IL295911A (en) * 2019-06-07 2022-10-01 Likarda Llc Tunable degradation in hydrogel microparticles
CN110141679B (en) * 2019-06-17 2021-07-23 嘉兴莱普晟医疗科技有限公司 Slow-release myocardial patch material and application thereof
CN112831459A (en) * 2019-11-25 2021-05-25 杭州协合医疗用品有限公司 Collagen melanocyte compound, preparation method and application
US20230193178A1 (en) * 2020-03-05 2023-06-22 The General Hospital Corporation Methods and systems to print and mature tissues over time in a three-dimensional support matrix
FR3109584B1 (en) * 2020-04-27 2024-05-10 Paulou Massat Sophie De Microcompartment for cnidarian cell culture
CN111888524A (en) * 2020-08-04 2020-11-06 宁波迪创医疗科技有限公司 Tissue filling material, preparation method thereof, tissue engineering scaffold and application
US20230330147A1 (en) 2020-08-31 2023-10-19 The Board Of Trustees Of The University Of Illinois Alginate-coated mesenchymal stromal and progenitor cells and methods for using the same
CN111925977B (en) * 2020-09-24 2021-02-05 北京健为医学检验实验室有限公司 Method for removing dead cells in cell suspension
WO2022082027A1 (en) * 2020-10-15 2022-04-21 University Of Louisville Research Foundation, Inc. Probiotic delivery systems and methods of making and using
WO2022125520A1 (en) * 2020-12-08 2022-06-16 Cornell University Insect cell membrane microparticles for detoxification of insect pollinators
CN113024879A (en) * 2020-12-22 2021-06-25 苏州大学附属第一医院 Gel microsphere and preparation method and application thereof
CN112641996B (en) * 2021-01-11 2023-08-01 常州市第二人民医院 Preparation method of nucleus pulposus mesenchymal stem cell combined chitosan fiber gel scaffold
US20220403309A1 (en) * 2021-06-16 2022-12-22 Upside Foods, Inc. Plant fat-based scaffolds for the growth of cell-based meats and methods of making such products
CN113813448B (en) * 2021-10-08 2022-12-06 大连大学附属中山医院 Hardness-adjustable hydrogel support containing cartilage-like pitted structure
CN114099369A (en) * 2021-11-19 2022-03-01 佐藤生物医药(江苏)有限公司 Nanoparticle composite hydrogel, preparation method thereof and application of nanoparticle composite hydrogel in preventing alopecia and growing hair
EP4444867A1 (en) 2021-12-10 2024-10-16 Mirai International Ag Edible microcarrier for the preparation of cultured meat and method of producing same
CN114917415B (en) * 2022-03-21 2023-01-06 四川大学 Degradable composite membrane for heart occluder and preparation method and application thereof
CN114410574B (en) * 2022-03-24 2024-02-06 烟台鼎昊生物科技有限公司 Preparation method of chondrocyte in-vitro three-dimensional culture system
DE102022120500B3 (en) 2022-08-15 2023-10-12 FILK Freiberg Institute gGmbH Method and device for producing hollow spheres from collagen and collagen derivatives and hollow spheres from collagen and gelatin
CN116077736A (en) * 2022-09-26 2023-05-09 四川大学 Injectable bone repair stent based on porous gelatin composite microspheres and preparation method thereof
CN115553469B (en) * 2022-09-27 2023-10-03 六安益普罗科技有限公司 Stomach mucosa-adhered probiotic slow-release microsphere, preparation method and medicine for preparing helicobacter pylori resisting or stomach mucositis relieving medicine
TWI835690B (en) * 2023-07-26 2024-03-11 臺北醫學大學 Injectable hydrogel for treatment of segmental bone defect
CN116870243B (en) * 2023-08-10 2024-01-19 广州创赛生物医用材料有限公司 Hydrogel with hemostatic and anti-inflammatory effects and preparation method and application thereof
CN117618671A (en) * 2023-12-13 2024-03-01 烟台德胜海洋生物科技有限公司 Collagen filler, preparation method and application thereof
CN117547554B (en) * 2024-01-12 2024-05-14 山东康根源生物集团有限公司 Mesenchymal stem cell repair preparation and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
DE10042484A1 (en) * 2000-08-29 2002-03-28 Merck Patent Gmbh Preparing human cartilage implants, useful for repairing damaged joints, comprises culturing autologous chondrocytes in alginate gel at reduced oxygen partial pressure
US20110104052A1 (en) * 2007-12-03 2011-05-05 The Johns Hopkins University Methods of synthesis and use of chemospheres
EP2429600B1 (en) * 2009-05-15 2017-09-06 Nanyang Technological University Composition for manufacturing a scaffold for tissue engineering, and a method of making it

Also Published As

Publication number Publication date
CN104582747A (en) 2015-04-29
WO2014025312A1 (en) 2014-02-13
CN104582747B (en) 2016-12-21
EP2882465A4 (en) 2016-04-06
EP2882465A1 (en) 2015-06-17
US20150217024A1 (en) 2015-08-06
US9974886B2 (en) 2018-05-22
SG10201700973YA (en) 2017-04-27
EP2882465B1 (en) 2019-05-08

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