MX342716B - Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza. - Google Patents

Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza.

Info

Publication number
MX342716B
MX342716B MX2012009581A MX2012009581A MX342716B MX 342716 B MX342716 B MX 342716B MX 2012009581 A MX2012009581 A MX 2012009581A MX 2012009581 A MX2012009581 A MX 2012009581A MX 342716 B MX342716 B MX 342716B
Authority
MX
Mexico
Prior art keywords
vaccines
influenza virus
prophylaxis
treatment
virus disease
Prior art date
Application number
MX2012009581A
Other languages
English (en)
Other versions
MX2012009581A (es
Inventor
Palese Peter
Garcia-Sastre Adolfo
T Wang Taia
S Tan Gene
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/788,103 external-priority patent/US8673314B2/en
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Publication of MX2012009581A publication Critical patent/MX2012009581A/es
Publication of MX342716B publication Critical patent/MX342716B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/11—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6012—Haptens, e.g. di- or trinitrophenyl (DNP, TNP)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una composición inmunogénica capaz de inducir anticuerpos que tienen reactividad cruzada entre subtipos de hemaglutinina (HA), en donde la composición inmunogénica comprende (a) un polipépitdo central inmunogénico, (b) un polipéptido de gripe (c) un virus que expresa un polipéptido central inmunogénico, (d) un virus que expresa un polipéptido de gripe, (e) un virus que comprende un polipéptido central inmunogénico, (f) un virus que comprende un polipéptido de gripe, (g) una partícula similar a virus que comprende un polipéptido central inmunogénico, o (h) una partícula similar a virus que comprende una partícula similar de gripe, y un portador farmacéuticamente aceptable, y en donde (A) el polipéptido central inmunogénico comprende la SEQ ID NO: 6.
MX2012009581A 2010-02-18 2011-02-18 Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza. MX342716B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30589810P 2010-02-18 2010-02-18
US12/788,103 US8673314B2 (en) 2009-05-26 2010-05-26 Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof
US35416010P 2010-06-11 2010-06-11
US38508310P 2010-09-21 2010-09-21
PCT/US2011/025467 WO2011103453A2 (en) 2010-02-18 2011-02-18 Vaccines for use in the prophylaxis and treatment of influenza virus disease

Publications (2)

Publication Number Publication Date
MX2012009581A MX2012009581A (es) 2013-01-29
MX342716B true MX342716B (es) 2016-10-11

Family

ID=44483593

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012009581A MX342716B (es) 2010-02-18 2011-02-18 Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza.

Country Status (10)

Country Link
US (1) US9701723B2 (es)
EP (1) EP2536425B1 (es)
JP (3) JP2013520172A (es)
KR (1) KR20120132506A (es)
CN (1) CN102939096B (es)
AU (1) AU2011217903B2 (es)
BR (1) BR112012020839A2 (es)
CA (1) CA2790380A1 (es)
MX (1) MX342716B (es)
WO (1) WO2011103453A2 (es)

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US9701723B2 (en) 2010-02-18 2017-07-11 Icahn School Of Medicine At Mount Sinai Vaccines for use in the prophylaxis and treatment of influenza virus disease
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CN108840911B (zh) * 2018-06-09 2021-03-30 西北农林科技大学 新城疫病毒基质蛋白的抗原表位、抗体、鉴定方法和应用
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CN109097341B (zh) * 2018-08-28 2021-09-24 青岛农业大学 一种同时表达ha和hef的复制缺陷型重组流感病毒
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US9701723B2 (en) 2017-07-11
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CN102939096A (zh) 2013-02-20
EP2536425A4 (en) 2014-11-05
EP2536425A2 (en) 2012-12-26
JP2013520172A (ja) 2013-06-06
CA2790380A1 (en) 2011-08-25
EP2536425B1 (en) 2019-06-19
KR20120132506A (ko) 2012-12-05
WO2011103453A2 (en) 2011-08-25
WO2011103453A3 (en) 2011-12-29
AU2011217903A1 (en) 2012-09-13
BR112012020839A2 (pt) 2017-11-21
JP2018166515A (ja) 2018-11-01
AU2011217903B2 (en) 2017-03-02
US20130209499A1 (en) 2013-08-15
CN102939096B (zh) 2016-03-02
US20170114103A9 (en) 2017-04-27

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