AR084456A1 - Anticuerpo anti-pcsk9 y metodos de uso - Google Patents
Anticuerpo anti-pcsk9 y metodos de usoInfo
- Publication number
- AR084456A1 AR084456A1 ARP110104843A ARP110104843A AR084456A1 AR 084456 A1 AR084456 A1 AR 084456A1 AR P110104843 A ARP110104843 A AR P110104843A AR P110104843 A ARP110104843 A AR P110104843A AR 084456 A1 AR084456 A1 AR 084456A1
- Authority
- AR
- Argentina
- Prior art keywords
- hvr
- seq
- pcsk9
- antibody
- pcsk9 antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se provee además un ácido nucleico que codifica el anticuerpo anti-PCSK9 divulgado, un vector que lo comprende, una célula huésped conteniendo al vector.Reivindicación 1: Un anticuerpo anti-PCSK9 o un fragmento de anticuerpo que se une a PCSK9 que comprende un dominio variable que comprende al menos uno, dos, tres, cuatro, cinco o seis secuencias de la región hipervariable (HVR) seleccionada del grupo que consiste en: (i) HVR-H1 que comprende GFTFX1X2X3X4IH (SEQ ID Nº 28), donde X1 es S o T; X2 es G, R o S; X3 es H, T o Y; X4 es A o T; (ii) HVR-H2 que comprende RISPANGNTNYADSVKG (SEQ ID Nº 4); (iii) HVR-H3 que comprende WIGSRELYIMDY (SEQ ID Nº 5); (iv) HVR-L1 que comprende RASQDVSX1AVA (SEQ ID Nº 29), donde X1 es S o T; (v) HVR-L2 que comprende SASX1LYS (SEQ ID Nº 30), donde X1 es F o S; y (vi) HVR-L3 que comprende QQSYX1X2X3X4T (SEQ ID Nº31), donde X1 es P, R o T; X2 es A, I, S o T; X3 es L, P o Q; X4 es A, H, P o S. Reivindicación 31: Un método de obtener un anticuerpo anti-PCSK9, dicho método que comprende cultivar la célula huésped de acuerdo con la reivindicación 28 en condiciones adecuadas para la expresión del ácido nucleico que codifica el anticuerpo anti-PCSK9 de acuerdo con cualquiera de las reivindicaciones 1 a 19. Reivindicación 33: Una composición farmacéutica que comprende el anticuerpo anti-PCSK9 de acuerdo con cualquiera de las reivindicaciones 1 a 19 y un portador farmacéuticamente aceptable. Reivindicación 34: Un método de reducir el nivel de colesterol de HDL en un sujeto, dicho método que comprende administrar al sujeto una cantidad efectiva del anticuerpo anti-PCSK9 de acuerdo con cualquiera de las reivindicaciones 1 a 19.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426343P | 2010-12-22 | 2010-12-22 | |
US201161477788P | 2011-04-21 | 2011-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084456A1 true AR084456A1 (es) | 2013-05-15 |
Family
ID=45476670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104843A AR084456A1 (es) | 2010-12-22 | 2011-12-21 | Anticuerpo anti-pcsk9 y metodos de uso |
Country Status (19)
Country | Link |
---|---|
US (1) | US20120195910A1 (es) |
EP (1) | EP2655419A1 (es) |
JP (1) | JP2014511106A (es) |
KR (1) | KR20130118925A (es) |
CN (1) | CN103261230A (es) |
AR (1) | AR084456A1 (es) |
AU (1) | AU2011348232A1 (es) |
BR (1) | BR112013015687A2 (es) |
CA (1) | CA2820953A1 (es) |
CO (1) | CO6721041A2 (es) |
CR (1) | CR20130336A (es) |
EA (1) | EA201390929A1 (es) |
EC (1) | ECSP13012786A (es) |
MA (1) | MA34818B1 (es) |
MX (1) | MX2013007168A (es) |
SG (1) | SG191219A1 (es) |
TW (1) | TW201307391A (es) |
WO (1) | WO2012088313A1 (es) |
ZA (1) | ZA201304153B (es) |
Families Citing this family (140)
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-
2011
- 2011-12-21 CA CA2820953A patent/CA2820953A1/en not_active Abandoned
- 2011-12-21 CN CN2011800598912A patent/CN103261230A/zh active Pending
- 2011-12-21 KR KR1020137019208A patent/KR20130118925A/ko not_active Application Discontinuation
- 2011-12-21 EP EP11808100.9A patent/EP2655419A1/en not_active Withdrawn
- 2011-12-21 MA MA36099A patent/MA34818B1/fr unknown
- 2011-12-21 JP JP2013546383A patent/JP2014511106A/ja active Pending
- 2011-12-21 TW TW100147837A patent/TW201307391A/zh unknown
- 2011-12-21 SG SG2013046792A patent/SG191219A1/en unknown
- 2011-12-21 EA EA201390929A patent/EA201390929A1/ru unknown
- 2011-12-21 AR ARP110104843A patent/AR084456A1/es not_active Application Discontinuation
- 2011-12-21 WO PCT/US2011/066593 patent/WO2012088313A1/en active Application Filing
- 2011-12-21 US US13/333,315 patent/US20120195910A1/en not_active Abandoned
- 2011-12-21 BR BR112013015687A patent/BR112013015687A2/pt not_active IP Right Cessation
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- 2013-07-22 EC ECSP13012786 patent/ECSP13012786A/es unknown
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CN103261230A (zh) | 2013-08-21 |
EP2655419A1 (en) | 2013-10-30 |
WO2012088313A1 (en) | 2012-06-28 |
TW201307391A (zh) | 2013-02-16 |
MA34818B1 (fr) | 2014-01-02 |
ECSP13012786A (es) | 2013-09-30 |
KR20130118925A (ko) | 2013-10-30 |
BR112013015687A2 (pt) | 2016-10-11 |
JP2014511106A (ja) | 2014-05-08 |
EA201390929A1 (ru) | 2013-12-30 |
AU2011348232A1 (en) | 2013-07-18 |
CR20130336A (es) | 2013-10-22 |
SG191219A1 (en) | 2013-07-31 |
CO6721041A2 (es) | 2013-07-31 |
US20120195910A1 (en) | 2012-08-02 |
MX2013007168A (es) | 2013-11-04 |
ZA201304153B (en) | 2014-08-27 |
CA2820953A1 (en) | 2012-06-28 |
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