AR106752A1 - Proteínas de unión a pd1 / ctla4 - Google Patents
Proteínas de unión a pd1 / ctla4Info
- Publication number
- AR106752A1 AR106752A1 ARP160103541A ARP160103541A AR106752A1 AR 106752 A1 AR106752 A1 AR 106752A1 AR P160103541 A ARP160103541 A AR P160103541A AR P160103541 A ARP160103541 A AR P160103541A AR 106752 A1 AR106752 A1 AR 106752A1
- Authority
- AR
- Argentina
- Prior art keywords
- immunoglobulin
- variable domain
- individual
- ctla4
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Developing Agents For Electrophotography (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
Reivindicación 1: Un dominio variable individual de inmunoglobulina (ISVD) multiespecífico que se une a PD1 humana y CTLA4 humana poniendo en contacto CTLA4 humana en uno o más de los siguientes residuos: VRVTVL (aminoácidos 33 - 38 de SEQ ID Nº 195), ADSQVTEVC (aminoácidos 41 - 49 de SEQ ID Nº 195) y CKVELMYPPPYYLG (aminoácidos 93 - 106 de SEQ ID Nº 195); o una proteína de unión de bloqueo cruzado que bloquea de forma cruzada la unión de dicho ISVD a PD1 y/o CTLA4. Reivindicación 17: Un polinucleótido que codifica el dominio variable individual de inmunoglobulina multiespecífico de una cualquiera de las reivindicaciones 1 - 15. Reivindicación 21: Un procedimiento para preparar un dominio variable individual de inmunoglobulina multiespecífico de una cualquiera de las reivindicaciones 1 - 15, que comprende introducir un polinucleótido que codifica el dominio variable individual de inmunoglobulina multiespecífico en una célula huésped y cultivar la célula huésped en un medio en condiciones favorables para la expresión de dicho dominio variable individual de inmunoglobulina multiespecífico a partir de dicho polinucleótido y, opcionalmente, purificar el dominio variable individual de inmunoglobulina multiespecífico a partir de dicha célula huésped y/o dicho medio. Reivindicación 26: Un procedimiento para tratar o evitar el cáncer o una enfermedad infecciosa en un sujeto que comprende administrar una cantidad eficaz de un dominio variable individual de inmunoglobulina multiespecífico de una cualquiera de las reivindicaciones 1 - 15 y 21 opcionalmente en asociación con un agente terapéutico adicional al sujeto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562256985P | 2015-11-18 | 2015-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR106752A1 true AR106752A1 (es) | 2018-02-14 |
Family
ID=57472065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160103541A AR106752A1 (es) | 2015-11-18 | 2016-11-18 | Proteínas de unión a pd1 / ctla4 |
Country Status (15)
Country | Link |
---|---|
US (1) | US10544222B2 (es) |
EP (1) | EP3377526A1 (es) |
JP (1) | JP6779997B2 (es) |
KR (1) | KR20180083418A (es) |
CN (1) | CN109071639B (es) |
AR (1) | AR106752A1 (es) |
AU (1) | AU2016355568A1 (es) |
BR (1) | BR112018010085A2 (es) |
CA (1) | CA3003777A1 (es) |
JO (1) | JO3740B1 (es) |
MA (1) | MA43258A (es) |
MX (1) | MX2018006243A (es) |
RU (1) | RU2755724C2 (es) |
TW (1) | TWI782898B (es) |
WO (1) | WO2017087587A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
CN108653728B (zh) | 2011-06-23 | 2022-11-18 | 埃博灵克斯股份有限公司 | 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术 |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
RS60717B1 (sr) | 2014-05-16 | 2020-09-30 | Ablynx Nv | Varijabilni domeni imunoglobulina |
MA42447A (fr) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc | Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procédés d'utilisation |
BR112018008867A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e seus usos |
CA3005488A1 (en) * | 2015-11-18 | 2017-05-26 | Ablynx Nv | Improved serum albumin binders |
EA038179B1 (ru) | 2015-11-18 | 2021-07-20 | Мерк Шарп И Доум Корп. | Ctla4-связывающие вещества |
KR102194188B1 (ko) * | 2015-11-18 | 2020-12-24 | 머크 샤프 앤드 돔 코포레이션 | Pd1 및/또는 lag3 결합제 |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
RU2764548C2 (ru) | 2016-08-09 | 2022-01-18 | Кимаб Лимитед | Анти-icos антитела |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
WO2019122882A1 (en) | 2017-12-19 | 2019-06-27 | Kymab Limited | Bispecific antibody for icos and pd-l1 |
AU2019205406A1 (en) * | 2018-01-08 | 2020-08-27 | Nanjing Legend Biotech Co., Ltd. | Multispecific antigen binding proteins and methods of use thereof |
CA3084518A1 (en) | 2018-01-15 | 2019-07-18 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against pd-1 |
WO2020057611A1 (en) * | 2018-09-20 | 2020-03-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Novel bispecific ctla-4/pd-1 polypeptide complexes |
CN113166262A (zh) * | 2018-10-11 | 2021-07-23 | 英伊布里克斯公司 | Pd-1单结构域抗体及其治疗组合物 |
WO2020181402A1 (zh) * | 2019-03-10 | 2020-09-17 | 胡西木 | 一种抗肿瘤多肽及其应用 |
CN111892655B (zh) * | 2019-05-06 | 2022-10-28 | 四川大学 | 抗pd-1纳米抗体的筛选及应用 |
WO2021110106A1 (en) * | 2019-12-04 | 2021-06-10 | Jiangsu Alphamab Biopharmaceuticals Co., Ltd. | Bispecific fusion protein for tumor treatment |
AR120698A1 (es) | 2019-12-09 | 2022-03-09 | Ablynx Nv | Polipéptidos que comprenden dominios variables únicos de inmunoglobulina que se dirigen a il-13 y tslp |
KR20220123237A (ko) | 2019-12-09 | 2022-09-06 | 아블린쓰 엔.브이. | Il-13 및 tslp를 표적으로 하는 면역글로불린 단일 가변 도메인을 포함하는 폴리펩타이드 |
WO2021170750A1 (en) * | 2020-02-28 | 2021-09-02 | Orega Biotech | Combination therapies based on ctla4 and il-17b inhibitors |
CN111944825A (zh) * | 2020-08-24 | 2020-11-17 | 江苏集萃药康生物科技有限公司 | 一种ctla4基因和pd1基因人源化小鼠模型的应用 |
CN114573704B (zh) * | 2021-03-10 | 2022-11-01 | 北京拓界生物医药科技有限公司 | Pd-1/ctla-4结合蛋白及其医药用途 |
WO2023163968A1 (en) * | 2022-02-24 | 2023-08-31 | Merck Sharp & Dohme Llc | Stable formulations of a multivalent vhh based cytotoxic t lymphocyte associated antigen 4 (ctla4) binder binding to human ctla4 and methods of use thereof |
WO2024017281A1 (zh) * | 2022-07-20 | 2024-01-25 | 明慧医药(杭州)有限公司 | 多特异性抗体及其用途 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1319120C (en) | 1985-04-01 | 1993-06-15 | John Henry Kenten | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
CA2145769A1 (en) | 1992-09-29 | 1994-04-14 | Gerald D. Fischbach | Trophic factor having ion channel-inducing activity in neuronal cells |
US6824779B1 (en) | 1993-07-26 | 2004-11-30 | Dana-Farber Cancer Institute, Inc. | Methods for inhibiting the interaction of B7-2 with its natural ligand |
CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Hakko Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
US20020006403A1 (en) | 1999-12-14 | 2002-01-17 | Xue-Zhong Yu | CD28-specific antibody compositions for use in methods of immunosuppression |
US7795002B2 (en) | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
AU2001296962A1 (en) | 2000-09-29 | 2002-04-08 | Schering Corporation | Pegylated interleukin-10 |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
DK1345969T3 (da) | 2000-12-26 | 2010-11-29 | Inst Nat Sante Rech Med | Anti-CD28-antistof |
EP1456652A4 (en) | 2001-11-13 | 2005-11-02 | Dana Farber Cancer Inst Inc | IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR |
US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
EP2258392A1 (en) | 2002-11-08 | 2010-12-08 | Ablynx N.V. | Method of administering therapeutic polypeptides |
ATE485307T1 (de) | 2003-11-07 | 2010-11-15 | Ablynx Nv | Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung |
WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
HUE045710T2 (hu) | 2005-05-18 | 2020-01-28 | Ablynx Nv | Javított, alfa tumor nekrózis faktor elleni nanobodies |
EP3243839A1 (en) * | 2005-05-20 | 2017-11-15 | Ablynx N.V. | Improved nanobodies tm for the treatment of aggregation-mediated disorders |
TWI323734B (en) * | 2005-08-19 | 2010-04-21 | Abbott Lab | Dual variable domain immunoglobulin and uses thereof |
CA2666599A1 (en) | 2006-08-18 | 2008-02-21 | Ablynx N.V. | Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
WO2008071447A2 (en) * | 2006-12-15 | 2008-06-19 | Ablynx N.V. | Amino acid sequences that modulate the interaction between cells of the immune system |
KR101264473B1 (ko) | 2007-05-24 | 2013-05-29 | 아블린쓰 엔.브이. | Rank-l에 대한 아미노산 서열, 및 이를 포함하는 골 질환 및 장애 치료용 폴리펩티드 |
MX2010005783A (es) | 2007-11-27 | 2010-08-10 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. |
US9212226B2 (en) | 2008-05-16 | 2015-12-15 | Ablynx N.V. | Amino acid sequences directed against CXCR4 and other GPCRs and compounds comprising the same |
EP2454285A2 (en) | 2009-07-16 | 2012-05-23 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
JP6023706B2 (ja) | 2010-07-09 | 2016-11-09 | アデュロ・バイオテック・ホールディングス・ヨーロッパ・ベスローテン・フエンノートシャップAduro Biotech Holdings, Europe B.V. | Cd27に対するアゴニスト抗体 |
CN108653728B (zh) | 2011-06-23 | 2022-11-18 | 埃博灵克斯股份有限公司 | 用于预测、检测和减少涉及免疫球蛋白单可变结构域的测定法中的非特异性蛋白干扰的技术 |
ES2759936T3 (es) | 2011-06-23 | 2020-05-12 | Ablynx Nv | Proteínas de unión a albúmina sérica |
KR102162413B1 (ko) * | 2011-08-17 | 2020-10-07 | 글락소 그룹 리미티드 | 변형된 단백질 및 펩티드 |
WO2013066765A1 (en) | 2011-11-01 | 2013-05-10 | Merck Sharp & Dohme Corp. | Mutation of tup1 in glycoengineered yeast |
JP2015531350A (ja) * | 2012-09-13 | 2015-11-02 | ノバルティス アーゲー | 末端修飾を有する抗原結合分子 |
WO2014111550A1 (en) | 2013-01-17 | 2014-07-24 | Glaxosmithkline Intellectual Property Development Limited | Modified anti-serum albumin binding proteins |
ES2779123T3 (es) | 2013-09-26 | 2020-08-13 | Ablynx Nv | Nanobodies biespecíficos |
GB201322725D0 (en) * | 2013-12-20 | 2014-02-05 | Immodulon Therapeutics Ltd | Cancer therapy |
RS60717B1 (sr) | 2014-05-16 | 2020-09-30 | Ablynx Nv | Varijabilni domeni imunoglobulina |
CN104987421A (zh) * | 2015-05-13 | 2015-10-21 | 北京比洋生物技术有限公司 | 抗ctla-4和pd-1的双重可变结构域免疫球蛋白 |
-
2016
- 2016-11-17 MA MA043258A patent/MA43258A/fr unknown
- 2016-11-17 TW TW105137703A patent/TWI782898B/zh not_active IP Right Cessation
- 2016-11-17 WO PCT/US2016/062391 patent/WO2017087587A1/en active Application Filing
- 2016-11-17 US US15/353,867 patent/US10544222B2/en active Active
- 2016-11-17 EP EP16805653.9A patent/EP3377526A1/en active Pending
- 2016-11-17 CA CA3003777A patent/CA3003777A1/en active Pending
- 2016-11-17 JP JP2018525614A patent/JP6779997B2/ja not_active Expired - Fee Related
- 2016-11-17 RU RU2018121619A patent/RU2755724C2/ru active
- 2016-11-17 BR BR112018010085A patent/BR112018010085A2/pt active Search and Examination
- 2016-11-17 MX MX2018006243A patent/MX2018006243A/es unknown
- 2016-11-17 CN CN201680079404.1A patent/CN109071639B/zh active Active
- 2016-11-17 JO JOP/2016/0242A patent/JO3740B1/ar active
- 2016-11-17 AU AU2016355568A patent/AU2016355568A1/en not_active Abandoned
- 2016-11-17 KR KR1020187017234A patent/KR20180083418A/ko not_active Application Discontinuation
- 2016-11-18 AR ARP160103541A patent/AR106752A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
TWI782898B (zh) | 2022-11-11 |
KR20180083418A (ko) | 2018-07-20 |
EP3377526A1 (en) | 2018-09-26 |
CN109071639B (zh) | 2022-07-08 |
WO2017087587A1 (en) | 2017-05-26 |
JO3740B1 (ar) | 2021-01-31 |
BR112018010085A2 (pt) | 2018-11-13 |
RU2018121619A (ru) | 2019-12-18 |
US20170137520A1 (en) | 2017-05-18 |
JP2019502370A (ja) | 2019-01-31 |
RU2755724C2 (ru) | 2021-09-20 |
MX2018006243A (es) | 2018-11-09 |
TW201726739A (zh) | 2017-08-01 |
CA3003777A1 (en) | 2017-05-26 |
CN109071639A (zh) | 2018-12-21 |
MA43258A (fr) | 2018-09-26 |
JP6779997B2 (ja) | 2020-11-04 |
RU2018121619A3 (es) | 2020-04-24 |
AU2016355568A1 (en) | 2018-06-21 |
US10544222B2 (en) | 2020-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR106752A1 (es) | Proteínas de unión a pd1 / ctla4 | |
AR106753A1 (es) | Proteínas de unión a ctla4p | |
SA518400424B1 (ar) | جزيئات الجسم المضاد لعلاج السرطان | |
EA201990293A1 (ru) | Мультиспецифичные антитела против cd40 и cd137 | |
CL2019001926A1 (es) | Anticuerpos anti-tigit y fragmentos de unión a antígeno; composición farmacéutica que los comprende; polinenucleótido que codifica dicho anticuerpo; vector que los comprende, célula hospedera; método para producir dicho anticuerpo o fragmento de unión a antígeno del mismo; y uso en el tratamiento del cáncer. (divisional de solicitud 310-2017). | |
CO2018012415A2 (es) | Proteínas de unión específica y usos de las mismas | |
EA201891366A1 (ru) | Гуманизированные антитела против cd73 | |
MX2020009366A (es) | Anticuerpos anti-cd73 y usos de los mismos. | |
MY176332A (en) | Multispecific antibody constructs | |
AR103868A1 (es) | Anticuerpos anti-cd47 como agentes terapéuticos | |
AR102239A1 (es) | Anticuerpos anti-ox40 humanizados y sus usos | |
AR104213A1 (es) | Anticuerpos anti-cd38 como agentes terapéuticos | |
BR112017003582A2 (pt) | anticorpos, composições e usos | |
MX2018004503A (es) | Receptores de antigeno quimerico anti-cd30. | |
EA201590085A1 (ru) | Антитела анти-egfr и их применение | |
EA201591131A1 (ru) | Днк-конструкции антитела и способ их применения | |
AR101829A1 (es) | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 | |
PE20181054A1 (es) | Anticuerpos anti-cd19 humano humanizados y metodos de utilizacion | |
AR090047A1 (es) | Dominio variable dual de inmunoglobulinas y sus usos | |
EA201792080A1 (ru) | Гуманизированные анти-c1s антитела и способы их применения | |
MX358447B (es) | Anticuerpos anti-psgl-1 y usos de los mismos. | |
EA201591791A1 (ru) | Антитела pac1 человека | |
EA201991704A3 (ru) | Моноклональные антитела против ингибитора пути тканевого фактора (tfpi) | |
EA201890747A1 (ru) | Способы лечения воспалительных заболеваний | |
EA201690992A1 (ru) | Антитела, специфичные к fcrn |