US3720760A - Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples - Google Patents

Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples Download PDF

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US3720760A
US3720760A US75813168A US3720760A US 3720760 A US3720760 A US 3720760A US 75813168 A US75813168 A US 75813168A US 3720760 A US3720760 A US 3720760A
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reagin
immunoglobulins
ig
presence
determining
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Leif E Wide
Hans H Bennich
Stig G O Johansson
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Pharmacia AB
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Pharmacia AB
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/804Radioisotope, e.g. radioimmunoassay
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures

Abstract

AN IN VITRO METHOD FOR ANALYZING A BODY FLUID FOR REAGIN-IMMUNOGLOBULINS THEREIN THAT ARE REACTIVE WITH ALLERGENS WHICH COMPRISES CONTACTING A SAMPLE OF BODY FLUID WITH A WATER-INSOLUBLE POLYMER TO WHICH IS ATTACHED AT LEAST ONE TEST ALLERGEN FOR A LONG ENOUGH TIME TO ALLOW REACTION THEREBETWEEN AND THEN CONTACTING WITH EITHER LABELLED ANTIBODIES THAT ARE REACTIVE WITH THE REAGIN IMMUNOGLOBULINS OR WITH ANTIBODIES AGAINST REAGIN-IG AND REAGIN-IG LABELLED WITH A RADIATION EMITTING ATOM OR GROUP, SEPARATING INTO A LIQUID PHASE AND A SOLID PHASE, AND MEASURING THE RADIATION EMITTED FROM AT LEAST ONE OF THE TWO SEPARATED PHASES.
US3720760B1 1968-09-06 1968-09-06 Expired - Lifetime US3720760B1 (en)

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US3720760B1 US3720760B1 (en) 1968-09-06 1968-09-06

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US3720760B1 US3720760B1 (en) 1968-09-06 1968-09-06

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US3720760A true US3720760A (en) 1973-03-13
US3720760B1 US3720760B1 (en) 1984-02-07

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US3720760B1 Expired - Lifetime US3720760B1 (en) 1968-09-06 1968-09-06

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Cited By (134)

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US3896217A (en) * 1973-03-19 1975-07-22 Summa Corp Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent
US3959650A (en) * 1974-08-26 1976-05-25 Intelcom Rad Tech Method for detecting and identifying allergy
US4001583A (en) * 1974-10-04 1977-01-04 Barrett M James Covalently bound biological substances to plastic materials and use in radioassay
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US4039652A (en) * 1973-10-11 1977-08-02 Miles Laboratories, Inc. Column method of immunoassay employing an immobilized binding partner
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US4254096A (en) * 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
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USRE31006E (en) * 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US4343896A (en) * 1975-02-01 1982-08-10 Akzona Incorporated Method and test pack for the demonstration and determination of an antigen or antibody
US4357142A (en) * 1980-07-18 1982-11-02 Akzona Incorporated Glass support coated with synthetic polymer for bioprocess
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Cited By (190)

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