CO6680693A2 - Anticuerpos humanos recombinantes, tanto humanizados como quiméricos, los cuales en lazan especificamente a ox40 humano - Google Patents
Anticuerpos humanos recombinantes, tanto humanizados como quiméricos, los cuales en lazan especificamente a ox40 humanoInfo
- Publication number
- CO6680693A2 CO6680693A2 CO13044004A CO13044004A CO6680693A2 CO 6680693 A2 CO6680693 A2 CO 6680693A2 CO 13044004 A CO13044004 A CO 13044004A CO 13044004 A CO13044004 A CO 13044004A CO 6680693 A2 CO6680693 A2 CO 6680693A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibodies
- human antibodies
- recombinant human
- humanized
- chimeric
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen anticuerpos humanos, preferiblemente anticuerpos humanos recombinantes, tanto humanizados como quiméricos, los cuales enlazan específicamente a OX40 humano.Los anticuerpos preferidos tienen alta afinidad para el receptor OX40 y activan el receptor in vitro e in vivo. El anticuerpo puede ser un anticuerpo de longitud completa o una porción de enlace de antígeno del mismo. Los anticuerpos, o porciones de anticuerpo, son útiles para modular la actividad de receptor, por ejemplo, en un sujeto humano que sufre de un trastorno en el cual la actividad de OX40 es perjudicial. Se proporcionan ácidos nucleicos, vectores y células huéspedes para expresar los anticuerpos humanos recombinantes, y también se proporcionan métodos para sintetizar los anticuerpos humanos recombinantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37599910P | 2010-08-23 | 2010-08-23 | |
US38082710P | 2010-09-08 | 2010-09-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6680693A2 true CO6680693A2 (es) | 2013-05-31 |
Family
ID=45724011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13044004A CO6680693A2 (es) | 2010-08-23 | 2013-03-05 | Anticuerpos humanos recombinantes, tanto humanizados como quiméricos, los cuales en lazan especificamente a ox40 humano |
Country Status (34)
Country | Link |
---|---|
US (6) | US9006399B2 (es) |
EP (2) | EP2933268B1 (es) |
JP (2) | JP5984810B2 (es) |
KR (2) | KR101704865B1 (es) |
CN (2) | CN103221427B (es) |
AP (1) | AP2013006771A0 (es) |
AU (1) | AU2011293558B2 (es) |
BR (2) | BR112013004266A8 (es) |
CA (1) | CA2809089C (es) |
CL (3) | CL2013000545A1 (es) |
CO (1) | CO6680693A2 (es) |
CR (1) | CR20130126A (es) |
CY (1) | CY1118928T1 (es) |
DK (1) | DK2609118T3 (es) |
DO (1) | DOP2013000045A (es) |
EA (2) | EA031849B1 (es) |
ES (2) | ES2649155T3 (es) |
HK (1) | HK1213272A1 (es) |
HR (1) | HRP20170568T1 (es) |
HU (1) | HUE031371T2 (es) |
IL (2) | IL224886A (es) |
LT (1) | LT2609118T (es) |
ME (1) | ME02678B (es) |
MX (1) | MX339964B (es) |
MY (1) | MY171312A (es) |
NZ (3) | NZ629913A (es) |
PE (2) | PE20180042A1 (es) |
PL (1) | PL2609118T3 (es) |
PT (1) | PT2609118T (es) |
RS (1) | RS55952B1 (es) |
SG (1) | SG187945A1 (es) |
SI (1) | SI2609118T1 (es) |
WO (1) | WO2012027328A2 (es) |
ZA (1) | ZA201301442B (es) |
Families Citing this family (178)
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