EA201891641A1 - Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста - Google Patents

Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста

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EA201891641A1
EA201891641A1 EA201891641A EA201891641A EA201891641A1 EA 201891641 A1 EA201891641 A1 EA 201891641A1 EA 201891641 A EA201891641 A EA 201891641A EA 201891641 A EA201891641 A EA 201891641A EA 201891641 A1 EA201891641 A1 EA 201891641A1
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Prior art keywords
growth factor
epidermal growth
receptors
antigenous
aimed
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EA201891641A
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English (en)
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Ой Квань Вон
Джойс Чин Чоу
Матильда Брюннхильда Дюссо
Джулианна Смит
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Пфайзер Инк.
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Publication of EA201891641A1 publication Critical patent/EA201891641A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Abstract

Изобретение обеспечивает химерные антигенные рецепторы (CAR), которые специфически связываются с EGFRvIII (вариантом III рецептора эпидермального фактора роста). Изобретение дополнительно относится к сконструированным иммунным клеткам, содержащим такие CAR, нуклеиновым кислотам, кодирующим CAR, и способам их получения, сконструированным иммунным клеткам, и нуклеиновым кислотам. Изобретение дополнительно относится к терапевтическим способам применения этих CAR и сконструированным иммунным клеткам для лечения EGFRvIII-опосредованных патологий, включая злокачественные новообразования, такие как глиобластома.
EA201891641A 2016-01-21 2017-01-10 Химерные антигенные рецепторы, нацеленные на вариант iii рецептора эпидермального фактора роста EA201891641A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662281533P 2016-01-21 2016-01-21
US201662431758P 2016-12-08 2016-12-08
PCT/IB2017/050108 WO2017125830A1 (en) 2016-01-21 2017-01-10 Chimeric antigen receptors targeting epidermal growth factor receptor variant iii

Publications (1)

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EA201891641A1 true EA201891641A1 (ru) 2019-01-31

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US (3) US10259876B2 (ru)
EP (1) EP3405481B1 (ru)
JP (2) JP6823659B2 (ru)
KR (1) KR102479606B1 (ru)
CN (1) CN108699124A (ru)
AU (1) AU2017208834B2 (ru)
BR (1) BR112018014585A2 (ru)
CA (1) CA2954014A1 (ru)
DK (1) DK3405481T3 (ru)
EA (1) EA201891641A1 (ru)
ES (1) ES2942362T3 (ru)
IL (1) IL260666B2 (ru)
MX (1) MX2018008978A (ru)
MY (1) MY192474A (ru)
NZ (1) NZ744821A (ru)
PH (1) PH12018501473A1 (ru)
RU (1) RU2751662C2 (ru)
SA (1) SA518392058B1 (ru)
SG (2) SG11201805872SA (ru)
TW (2) TWI755547B (ru)
UA (1) UA125252C2 (ru)
WO (1) WO2017125830A1 (ru)

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AU2017208834A1 (en) 2018-08-09
SA518392058B1 (ar) 2023-02-12
MX2018008978A (es) 2019-01-10
KR102479606B1 (ko) 2022-12-21
US10259876B2 (en) 2019-04-16
US20220227874A1 (en) 2022-07-21
US11267892B2 (en) 2022-03-08
WO2017125830A1 (en) 2017-07-27
BR112018014585A2 (pt) 2018-12-11
AU2017208834B2 (en) 2021-09-02
JP2019506394A (ja) 2019-03-07
NZ744821A (en) 2023-06-30
MY192474A (en) 2022-08-23
EP3405481A1 (en) 2018-11-28
US20190144550A1 (en) 2019-05-16
TW201920237A (zh) 2019-06-01
IL260666A (en) 2018-09-20
US20170210811A1 (en) 2017-07-27
SG10202111458RA (en) 2021-11-29
RU2751662C2 (ru) 2021-07-15
TW201734038A (zh) 2017-10-01
CN108699124A (zh) 2018-10-23
ES2942362T3 (es) 2023-05-31
JP2021036873A (ja) 2021-03-11
JP7198797B2 (ja) 2023-01-04
PH12018501473A1 (en) 2019-03-11
EP3405481B1 (en) 2023-01-18
RU2018130088A3 (ru) 2020-07-29
IL260666B2 (en) 2023-02-01
JP6823659B2 (ja) 2021-02-03
TWI755547B (zh) 2022-02-21
UA125252C2 (uk) 2022-02-09
IL260666B (en) 2022-10-01
SG11201805872SA (en) 2018-08-30
CA2954014A1 (en) 2017-07-21
TWI634125B (zh) 2018-09-01
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DK3405481T3 (da) 2023-04-17
RU2018130088A (ru) 2020-02-25

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