EA202091982A1 - Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии - Google Patents

Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии

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EA202091982A1
EA202091982A1 EA202091982A EA202091982A EA202091982A1 EA 202091982 A1 EA202091982 A1 EA 202091982A1 EA 202091982 A EA202091982 A EA 202091982A EA 202091982 A EA202091982 A EA 202091982A EA 202091982 A1 EA202091982 A1 EA 202091982A1
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Eurasian Patent Office
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receptor
il13r2
alpha
tumor
specific
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EA202091982A
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English (en)
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Джакомо Тампелла
Майкл К. Дженсен
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Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют)
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Publication of EA202091982A1 publication Critical patent/EA202091982A1/ru

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Abstract

Некоторые варианты осуществления способов и композиций, предложенных в настоящем документе, относятся к химерным антигенным рецепторам (CAR), которые специфически связываются с человеческими внеклеточными доменами рецептора IL-13 альфа 2 (IL13R2), клеткам, содержащим такие CAR, и способам клеточной иммунотерапии, нацеленной на раковые клетки, такие как клетки солидных опухолей.
EA202091982A 2018-03-14 2019-03-12 Химерный антигенный рецептор к рецептору il-13 альфа 2 (il13r2) для опухолеспецифической т-клеточной иммунотерапии EA202091982A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862643055P 2018-03-14 2018-03-14
PCT/US2019/021823 WO2019178078A1 (en) 2018-03-14 2019-03-12 Il-13 receptor alpha 2 (il13ra2) chimeric antigen receptor for tumor specific t cell immunotherapy

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EA202091982A1 true EA202091982A1 (ru) 2021-06-10

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US (1) US20210000875A1 (ru)
EP (1) EP3765041A4 (ru)
JP (2) JP7438123B2 (ru)
KR (1) KR20200131279A (ru)
CN (1) CN112236151A (ru)
AU (1) AU2019234573A1 (ru)
BR (1) BR112020018670A2 (ru)
CA (1) CA3093810A1 (ru)
EA (1) EA202091982A1 (ru)
IL (1) IL277267A (ru)
MX (1) MX2020009463A (ru)
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WO (1) WO2019178078A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021270299A1 (en) * 2020-05-12 2022-12-15 Lyell Immunopharma, Inc. Chimeric antigen receptor spacers
EP4314069A1 (en) * 2021-04-01 2024-02-07 The United States of America, as represented by The Secretary, Department of Health and Human Services Il-13ra2 chimeric antigen receptors and methods of use
EP4364746A1 (en) * 2021-07-01 2024-05-08 Ningbo T-MAXIMUM Biopharmaceuticals Co., Ltd. UNIVERSAL CAR-T CELL TARGETING IL13Ra2, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
CN116444671B (zh) * 2021-12-29 2024-02-23 华道(上海)生物医药有限公司 一种抗IL13Ra2的纳米抗体及其应用
CN114014941B (zh) * 2022-01-10 2022-04-12 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的嵌合抗原受体及其用途
WO2023138666A1 (en) * 2022-01-19 2023-07-27 Utc Therapeutics (Shanghai) Co., Ltd. Circular rna and use thereof
CN114990069B (zh) * 2022-05-17 2023-09-22 郑州大学第一附属医院 一种过表达slc43a2的嵌合抗原受体t细胞的制备方法和应用
CN114805581B (zh) * 2022-06-29 2022-10-14 上海优替济生生物医药有限公司 靶向il13ra2的抗体、嵌合抗原受体及其用途
WO2024041650A1 (en) * 2022-08-25 2024-02-29 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors targeting interleukin 13 receptor subunit alpha 2 and methods of use thereof
CN115960257B (zh) * 2022-09-29 2023-10-27 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的经优化的嵌合抗原受体及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014072888A1 (en) 2012-11-07 2014-05-15 Pfizer Inc. Anti-il-13 receptor alpha 2 antibodies and antibody-drug conjugates
EP2929045B1 (en) * 2012-12-05 2020-12-02 SOLA Biosciences LLC Protein expression enhancing polypeptides
KR102238226B1 (ko) 2013-05-14 2021-04-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용
TWI751102B (zh) * 2014-08-28 2022-01-01 美商奇諾治療有限公司 對ｃｄ１９具專一性之抗體及嵌合抗原受體
CA2961654A1 (en) 2014-09-19 2016-03-24 City Of Hope Costimulatory chimeric antigen receptor t cells targeting il13r.alpha.2
EP3250609A4 (en) * 2015-01-26 2018-07-11 The University of Chicago Il13ra alpha 2 binding agents and use thereof in cancer treatment
EP3324984A4 (en) * 2015-07-21 2019-03-27 City of Hope T CELLS FOR THE EXPRESSION OF CHIMERIC ANTIGEN RECEPTORS AND OTHER RECEPTORS
CA3018382A1 (en) * 2016-03-29 2017-10-05 University Of Southern California Chimeric antigen receptors targeting cancer
MX2018014950A (es) * 2016-06-07 2019-04-25 Macrogenics Inc Terapia de combinacion.
WO2018156711A1 (en) * 2017-02-22 2018-08-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Il13ra2-binding chimeric antigen receptors

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US20210000875A1 (en) 2021-01-07
CN112236151A (zh) 2021-01-15
JP2024026165A (ja) 2024-02-28
KR20200131279A (ko) 2020-11-23
WO2019178078A1 (en) 2019-09-19
SG11202008795SA (en) 2020-10-29
EP3765041A1 (en) 2021-01-20
IL277267A (en) 2020-10-29
JP2021518108A (ja) 2021-08-02
CA3093810A1 (en) 2019-09-19
JP7438123B2 (ja) 2024-02-26
BR112020018670A2 (pt) 2021-01-05
MX2020009463A (es) 2021-03-09
AU2019234573A1 (en) 2020-10-08

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