MX2020003046A - Anticuerpos anti-hla-a2 y metodos para utilizar los mismos. - Google Patents
Anticuerpos anti-hla-a2 y metodos para utilizar los mismos.Info
- Publication number
- MX2020003046A MX2020003046A MX2020003046A MX2020003046A MX2020003046A MX 2020003046 A MX2020003046 A MX 2020003046A MX 2020003046 A MX2020003046 A MX 2020003046A MX 2020003046 A MX2020003046 A MX 2020003046A MX 2020003046 A MX2020003046 A MX 2020003046A
- Authority
- MX
- Mexico
- Prior art keywords
- hla
- antibodies
- methods
- car
- humanized anti
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 abstract 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46434—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
Se proporcionan anticuerpos anti-HLA-A2 humanizados. En ciertos aspectos, los anticuerpos anti-HLA-A2 humanizados son capaces de constituir un dominio de unión a antígeno de un receptor de antígeno quimérico (CAR), en donde el CAR es capaz de expresarse en una célula humana de tal manera que el CAR se une específicamente a HLA-A2. También se proporcionan CARs que incluyen los anticuerpos humanizados anti-HLA-A2. También se proporcionan células modificadas que incluyen los anticuerpos y CARs, así como métodos para utilizar dichas células modificadas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762560574P | 2017-09-19 | 2017-09-19 | |
US201862692386P | 2018-06-29 | 2018-06-29 | |
PCT/CA2018/051167 WO2019056099A1 (en) | 2017-09-19 | 2018-09-19 | ANTI-HLA-A2 ANTIBODIES AND METHODS OF USE |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020003046A true MX2020003046A (es) | 2020-10-12 |
Family
ID=65809516
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020003046A MX2020003046A (es) | 2017-09-19 | 2018-09-19 | Anticuerpos anti-hla-a2 y metodos para utilizar los mismos. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20200283529A1 (es) |
EP (1) | EP3684821A4 (es) |
JP (2) | JP7281774B2 (es) |
KR (1) | KR20200067845A (es) |
CN (1) | CN111448215B (es) |
AU (1) | AU2018338418A1 (es) |
BR (1) | BR112020005361A2 (es) |
CA (1) | CA3076261A1 (es) |
IL (1) | IL273402A (es) |
MX (1) | MX2020003046A (es) |
SG (1) | SG11202002520UA (es) |
WO (1) | WO2019056099A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3058425A1 (en) | 2017-03-28 | 2018-10-04 | The Trustees Of The University Of Pennsylvania | Methods to protect transplanted tissue from rejection |
BR112020005519A2 (pt) * | 2017-09-20 | 2020-10-27 | The University Of British Columbia | novos anticorpos anti-hla-a2 e usos dos mesmos |
SG11202010116PA (en) * | 2018-04-13 | 2020-11-27 | Sangamo Therapeutics France | Chimeric antigen receptor specific for interleukin-23 receptor |
CA3109253A1 (en) | 2018-08-10 | 2020-02-13 | Sangamo Therapeutics France | New car constructs comprising tnfr2 domains |
EP4010377A4 (en) * | 2019-08-09 | 2023-09-06 | A2 Biotherapeutics, Inc. | CELL SURFACE RECEPTORS THAT RESPOND TO LOSS OF HETEROZYGOSIS |
WO2021028359A1 (en) | 2019-08-09 | 2021-02-18 | Sangamo Therapeutics France | Controlled expression of chimeric antigen receptors in t cells |
JP2023506184A (ja) | 2019-12-11 | 2023-02-15 | エイ2・バイオセラピューティクス・インコーポレイテッド | Lilrb1ベースのキメラ抗原受容体 |
CN111393533B (zh) * | 2020-04-16 | 2021-05-11 | 成都仕康美生物科技有限公司 | 靶向HLA-A的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途 |
CA3188862A1 (en) | 2020-08-20 | 2022-02-24 | Carl Alexander Kamb | Compositions and methods for treating mesothelin positive cancers |
AU2021328478A1 (en) | 2020-08-20 | 2023-04-20 | A2 Biotherapeutics, Inc. | Compositions and methods for treating egfr positive cancers |
CN116724052A (zh) | 2020-08-20 | 2023-09-08 | A2生物治疗股份有限公司 | 用于治疗ceacam阳性癌症的组合物和方法 |
WO2023076912A2 (en) * | 2021-10-26 | 2023-05-04 | ImmPACT Bio USA Inc. | Cd4+ and/or cd8+ cell populations comprising icars for use in treatment therapies |
WO2023156587A1 (en) * | 2022-02-18 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of tcr-deficient car-tregs in combination with anti-tcr complex monoclonal antibodies for inducing durable tolerance |
WO2023172991A2 (en) * | 2022-03-09 | 2023-09-14 | Immpact Bio Usa, Inc. | Bicistronic inhibitory chimeric antigen receptor (icar)/activating chimeric antigen receptor (acar) constructs for use in cancer therapies |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
GB0919751D0 (en) * | 2009-11-11 | 2009-12-30 | King S College Hospital Nhs Fo | Conjugate molecule |
BR122021026173B1 (pt) * | 2010-12-09 | 2023-12-05 | The Trustees Of The University Of Pennsylvania | Composição farmacêutica |
JP2015180607A (ja) * | 2012-08-01 | 2015-10-15 | 国立大学法人 東京大学 | 移植片対宿主病などの造血幹細胞移植に伴う疾患を治療することのできる抗体およびその機能断片並びにこれらを含んでなる医薬組成物 |
-
2018
- 2018-09-19 SG SG11202002520UA patent/SG11202002520UA/en unknown
- 2018-09-19 EP EP18858795.0A patent/EP3684821A4/en active Pending
- 2018-09-19 JP JP2020537266A patent/JP7281774B2/ja active Active
- 2018-09-19 AU AU2018338418A patent/AU2018338418A1/en active Pending
- 2018-09-19 WO PCT/CA2018/051167 patent/WO2019056099A1/en unknown
- 2018-09-19 CN CN201880074705.4A patent/CN111448215B/zh active Active
- 2018-09-19 CA CA3076261A patent/CA3076261A1/en active Pending
- 2018-09-19 KR KR1020207011293A patent/KR20200067845A/ko not_active Application Discontinuation
- 2018-09-19 US US16/648,967 patent/US20200283529A1/en active Pending
- 2018-09-19 MX MX2020003046A patent/MX2020003046A/es unknown
- 2018-09-19 BR BR112020005361-9A patent/BR112020005361A2/pt unknown
-
2020
- 2020-03-18 IL IL273402A patent/IL273402A/en unknown
-
2023
- 2023-05-01 JP JP2023075383A patent/JP2023100800A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2020112261A (ru) | 2021-10-20 |
BR112020005361A2 (pt) | 2020-09-24 |
CN111448215B (zh) | 2024-01-16 |
WO2019056099A1 (en) | 2019-03-28 |
EP3684821A1 (en) | 2020-07-29 |
EP3684821A4 (en) | 2021-06-16 |
JP7281774B2 (ja) | 2023-05-26 |
CN111448215A (zh) | 2020-07-24 |
IL273402A (en) | 2020-05-31 |
RU2020112261A3 (es) | 2022-03-02 |
JP2020537537A (ja) | 2020-12-24 |
CA3076261A1 (en) | 2019-03-28 |
US20200283529A1 (en) | 2020-09-10 |
SG11202002520UA (en) | 2020-04-29 |
KR20200067845A (ko) | 2020-06-12 |
JP2023100800A (ja) | 2023-07-19 |
AU2018338418A1 (en) | 2020-04-09 |
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