EA202192413A1 - АНТИТЕЛА ПРОТИВ EGFRvIII И ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ФРАГМЕНТЫ - Google Patents

АНТИТЕЛА ПРОТИВ EGFRvIII И ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ФРАГМЕНТЫ

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Publication number
EA202192413A1
EA202192413A1 EA202192413A EA202192413A EA202192413A1 EA 202192413 A1 EA202192413 A1 EA 202192413A1 EA 202192413 A EA202192413 A EA 202192413A EA 202192413 A EA202192413 A EA 202192413A EA 202192413 A1 EA202192413 A1 EA 202192413A1
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EA
Eurasian Patent Office
Prior art keywords
antigen
binding fragments
egfrviii
antibodies against
against egfrviii
Prior art date
Application number
EA202192413A
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English (en)
Inventor
Энн Марсел
Мария Харамильо
Трайан Сули
Мария Морено
Цуньлэ Ву
Original Assignee
Нэшнл Рисеч Каунсил Оф Канада
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Application filed by Нэшнл Рисеч Каунсил Оф Канада filed Critical Нэшнл Рисеч Каунсил Оф Канада
Publication of EA202192413A1 publication Critical patent/EA202192413A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464403—Receptors for growth factors
    • A61K39/464404—Epidermal growth factor receptors [EGFR]
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

Раскрыты антигенсвязывающие агенты, такие как антитела или их антигенсвязывающие фрагменты, химерные антигенные рецепторы (CAR), привлекающие Т-клетки биспецифические активаторы (BiTE) и т.п., которые специфически связываются с вариантом III рецептора эпидермального фактора роста (EGFRvIII). EGFRvIII-специфические антитела или их антигенсвязывающие фрагменты, CAR и BiTE могут использоваться для лечения рака. В частности, рассматриваются конъюгаты антитело-лекарственное средство, нацеленные на клетки, экспрессирующие EGFRvIII.
EA202192413A 2019-03-27 2020-03-23 АНТИТЕЛА ПРОТИВ EGFRvIII И ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ФРАГМЕНТЫ EA202192413A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962824386P 2019-03-27 2019-03-27
PCT/CA2020/050376 WO2020191485A1 (en) 2019-03-27 2020-03-23 Anti-egfrviii antibodies and antigen-binding fragments thereof

Publications (1)

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EA202192413A1 true EA202192413A1 (ru) 2021-12-30

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EA202192413A EA202192413A1 (ru) 2019-03-27 2020-03-23 АНТИТЕЛА ПРОТИВ EGFRvIII И ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ФРАГМЕНТЫ

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US (1) US20220193132A1 (ru)
EP (1) EP3947461A4 (ru)
KR (1) KR20210148228A (ru)
CN (1) CN113853388A (ru)
AU (1) AU2020249296A1 (ru)
BR (1) BR112021019167A2 (ru)
CA (1) CA3135043A1 (ru)
CL (1) CL2021002500A1 (ru)
CO (1) CO2021012705A2 (ru)
EA (1) EA202192413A1 (ru)
IL (1) IL286690A (ru)
MX (1) MX2021011750A (ru)
PE (1) PE20212212A1 (ru)
SG (1) SG11202110574SA (ru)
WO (1) WO2020191485A1 (ru)

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AU2022267410A1 (en) * 2021-04-26 2023-11-09 Myrio Therapeutics Pty Ltd EGFRvIII BINDING PROTEINS
CA3223079A1 (en) * 2021-09-01 2023-03-09 Patrick Schlegel Novel dysfunctional p2x7 binders
CA3233733A1 (en) * 2021-09-29 2023-04-06 National Research Council Of Canada Egfrviii-targeted compounds and uses thereof
KR20240070579A (ko) * 2021-09-29 2024-05-21 내셔날 리서치 카운실 오브 캐나다 인간화 항-egfrviii 항체 및 이의 항원 결합 단편
CN114044826B (zh) * 2021-10-12 2023-11-17 南京融捷康生物科技有限公司 针对EGFRvIII的单域抗体及其衍生蛋白和应用
WO2024027835A1 (zh) * 2022-08-05 2024-02-08 北京鼎成肽源生物技术有限公司 靶向EGFRvIII的抗体及其在细胞免疫治疗的应用

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EP2335728A1 (en) * 2001-05-11 2011-06-22 Ludwig Institute for Cancer Research Ltd. Specific binding proteins and uses thereof
KR20160003332A (ko) * 2003-06-27 2016-01-08 암젠 프레몬트 인코포레이티드 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그 용도
WO2008014386A2 (en) * 2006-07-27 2008-01-31 Imclone Systems Incorporated Treatment of tumors in pediatric patients with epidermal growth factor receptor antagonists
CN104212800B (zh) * 2013-05-07 2017-01-18 南方医科大学 一种与人表皮生长因子受体iii型突变体特异性结合的核酸适配子及其应用

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BR112021019167A2 (pt) 2021-12-21
JP2022528368A (ja) 2022-06-10
CN113853388A (zh) 2021-12-28
PE20212212A1 (es) 2021-11-19
SG11202110574SA (en) 2021-10-28
US20220193132A1 (en) 2022-06-23
CL2021002500A1 (es) 2022-04-08
WO2020191485A1 (en) 2020-10-01
KR20210148228A (ko) 2021-12-07
MX2021011750A (es) 2021-12-10
EP3947461A1 (en) 2022-02-09
AU2020249296A1 (en) 2021-11-11
CO2021012705A2 (es) 2022-01-28
IL286690A (en) 2021-10-31
CA3135043A1 (en) 2020-10-01

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