EA201500204A1 - Антитела к ox40 и способы их применения - Google Patents

Антитела к ox40 и способы их применения

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Publication number
EA201500204A1
EA201500204A1 EA201500204A EA201500204A EA201500204A1 EA 201500204 A1 EA201500204 A1 EA 201500204A1 EA 201500204 A EA201500204 A EA 201500204A EA 201500204 A EA201500204 A EA 201500204A EA 201500204 A1 EA201500204 A1 EA 201500204A1
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EA
Eurasian Patent Office
Prior art keywords
antibodies
human
antibody
receptor
methods
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EA201500204A
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English (en)
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EA031849B1 (ru
Inventor
Юн-Цзюнь Лю
Куи Синь Ву
Лаура Бовер
Наоя Цурусита
Дж. Юнь Тсо
Шанкар Кумар
Original Assignee
Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем
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Publication of EA201500204A1 publication Critical patent/EA201500204A1/ru
Publication of EA031849B1 publication Critical patent/EA031849B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Изобретение описывает антитела человека, предпочтительно рекомбинантные антитела человека, как гуманизированные, так и химерные, которые специфически связываются с OX40 человека. Предпочтительные антитела имеют высокую аффинность к рецептору OX40 и активируют рецептор in vitro и in vivo. Антитело может быть полноразмерным антителом или его антигенсвязывающей детерминантой. Антитела или детерминанты антител полезны в модуляции активности рецептора, например, у людей, страдающих от нарушений, в которых активность OX40 вредна. Описаны нуклеиновые кислоты, векторы и клетки-хозяева для экспрессии рекомбинантных антител человека и также приведены способы синтеза рекомбинантных антител человека.
EA201500204A 2010-08-23 2011-08-23 Антитела к ox40 и способы их применения EA031849B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37599910P 2010-08-23 2010-08-23
US38082710P 2010-09-08 2010-09-08

Publications (2)

Publication Number Publication Date
EA201500204A1 true EA201500204A1 (ru) 2015-11-30
EA031849B1 EA031849B1 (ru) 2019-03-29

Family

ID=45724011

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201500204A EA031849B1 (ru) 2010-08-23 2011-08-23 Антитела к ox40 и способы их применения
EA201390278A EA029793B1 (ru) 2010-08-23 2011-08-23 Антитела к ох40 и способы их применения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201390278A EA029793B1 (ru) 2010-08-23 2011-08-23 Антитела к ох40 и способы их применения

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US (6) US9006399B2 (ru)
EP (2) EP2609118B1 (ru)
JP (2) JP5984810B2 (ru)
KR (2) KR101719118B1 (ru)
CN (2) CN103221427B (ru)
AP (1) AP2013006771A0 (ru)
AU (1) AU2011293558B2 (ru)
BR (2) BR112013004266A8 (ru)
CA (1) CA2809089C (ru)
CL (3) CL2013000545A1 (ru)
CO (1) CO6680693A2 (ru)
CR (1) CR20130126A (ru)
CY (1) CY1118928T1 (ru)
DK (1) DK2609118T3 (ru)
DO (1) DOP2013000045A (ru)
EA (2) EA031849B1 (ru)
ES (2) ES2630328T3 (ru)
HK (1) HK1213272A1 (ru)
HR (1) HRP20170568T1 (ru)
HU (1) HUE031371T2 (ru)
IL (2) IL224886A (ru)
LT (1) LT2609118T (ru)
ME (1) ME02678B (ru)
MX (1) MX339964B (ru)
MY (1) MY171312A (ru)
NZ (3) NZ629913A (ru)
PE (2) PE20180042A1 (ru)
PL (1) PL2609118T3 (ru)
PT (1) PT2609118T (ru)
RS (1) RS55952B1 (ru)
SG (1) SG187945A1 (ru)
SI (1) SI2609118T1 (ru)
WO (1) WO2012027328A2 (ru)
ZA (1) ZA201301442B (ru)

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