MX2015013288A - Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos. - Google Patents
Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos.Info
- Publication number
- MX2015013288A MX2015013288A MX2015013288A MX2015013288A MX2015013288A MX 2015013288 A MX2015013288 A MX 2015013288A MX 2015013288 A MX2015013288 A MX 2015013288A MX 2015013288 A MX2015013288 A MX 2015013288A MX 2015013288 A MX2015013288 A MX 2015013288A
- Authority
- MX
- Mexico
- Prior art keywords
- human
- antibodies
- lymphocytes
- humanized anti
- specifically bind
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La invención proporciona anticuerpos que se une específicamente al CD134 humano. Los anticuerpos anti-CD134 humanos se unen específicamente al dominio extracelular del CD134 humano, que incluye el ligando no OX40 (OX40L) los dominios de unión en el CD134 humano, que se expresa en por ejemplo linfocitos T CD4 y/o CD8 efectores convencionales humanos activados (Teffs) y en linfocitos T CD4 reguladores supresores humanos activados (Tregs). Los anticuerpos humanizados anti-CD134 humanos son útiles (por ejemplo para facultar la función efectora anti-neoplásica Teffs y/o para inhibir la función supresora Tregs) para el tratamiento de cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13159794 | 2013-03-18 | ||
PCT/NL2014/050162 WO2014148895A1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015013288A true MX2015013288A (es) | 2016-04-07 |
Family
ID=47891522
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015013288A MX2015013288A (es) | 2013-03-18 | 2014-03-18 | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos. |
MX2019004649A MX2019004649A (es) | 2013-03-18 | 2015-09-17 | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019004649A MX2019004649A (es) | 2013-03-18 | 2015-09-17 | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos. |
Country Status (32)
Country | Link |
---|---|
US (3) | US9790281B2 (es) |
EP (2) | EP2976361B1 (es) |
JP (1) | JP2016515544A (es) |
KR (1) | KR20160006168A (es) |
CN (1) | CN105229032A (es) |
AU (2) | AU2014238546C1 (es) |
BR (1) | BR112015023862A2 (es) |
CA (1) | CA2907436A1 (es) |
CL (2) | CL2015002793A1 (es) |
CR (1) | CR20150498A (es) |
CY (1) | CY1120752T1 (es) |
DK (1) | DK2976361T3 (es) |
EA (1) | EA201591495A1 (es) |
ES (1) | ES2687282T3 (es) |
HK (1) | HK1215035A1 (es) |
HR (1) | HRP20181478T1 (es) |
HU (1) | HUE040234T2 (es) |
IL (1) | IL241701A0 (es) |
LT (1) | LT2976361T (es) |
MD (2) | MD20180107A2 (es) |
MX (2) | MX2015013288A (es) |
NZ (1) | NZ712903A (es) |
PE (1) | PE20160690A1 (es) |
PH (1) | PH12015502185A1 (es) |
PL (1) | PL2976361T3 (es) |
PT (1) | PT2976361T (es) |
RS (1) | RS57840B1 (es) |
SG (2) | SG11201507781VA (es) |
SI (1) | SI2976361T1 (es) |
UA (1) | UA119319C2 (es) |
WO (1) | WO2014148895A1 (es) |
ZA (1) | ZA201507021B (es) |
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