MD4633B1 - Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora - Google Patents
Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestoraInfo
- Publication number
- MD4633B1 MD4633B1 MDA20150102A MD20150102A MD4633B1 MD 4633 B1 MD4633 B1 MD 4633B1 MD A20150102 A MDA20150102 A MD A20150102A MD 20150102 A MD20150102 A MD 20150102A MD 4633 B1 MD4633 B1 MD 4633B1
- Authority
- MD
- Moldova
- Prior art keywords
- human
- antibodies
- lymphocytes
- humanized anti
- specifically bind
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Invenţia se referă la anticorpi, care se leagă specific cu CD134 uman. Anticorpii anti-CD134 umani se leagă specific la domeniul extracelular al CD134 uman, inclusiv la domeniile de legare a ligandului non-OX40 (OX40L) al CD134 uman, care este exprimat, de exemplu, pe limfocitele T efectoare (Teff) CD4 şi/sau CD8 umane activate uzual şi pe limfocitele T reglatoare supresoare (Treg) CD4 umane activate. Anticorpii anti-CD134 umanizaţi sunt utili pentru tratamentul cancerului, de exemplu, pentru stimularea funcţiei efectoare anticanceroase a Teff şi/sau pentru inhibarea funcţiei de supresie a Treg.Secvenţe: 151
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13159794 | 2013-03-18 | ||
PCT/NL2014/050162 WO2014148895A1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
MD20150102A2 MD20150102A2 (ro) | 2016-02-29 |
MD4633B1 true MD4633B1 (ro) | 2019-06-30 |
Family
ID=47891522
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20180107A MD20180107A2 (ro) | 2013-03-18 | 2014-03-18 | Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora |
MDA20150102A MD4633B1 (ro) | 2013-03-18 | 2014-03-18 | Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20180107A MD20180107A2 (ro) | 2013-03-18 | 2014-03-18 | Anticorpi anti-CD134 (OX40) umanizaţi şi utilizarea acestora |
Country Status (32)
Country | Link |
---|---|
US (3) | US9790281B2 (ro) |
EP (2) | EP2976361B1 (ro) |
JP (1) | JP2016515544A (ro) |
KR (1) | KR20160006168A (ro) |
CN (1) | CN105229032A (ro) |
AU (2) | AU2014238546C1 (ro) |
BR (1) | BR112015023862A2 (ro) |
CA (1) | CA2907436A1 (ro) |
CL (2) | CL2015002793A1 (ro) |
CR (1) | CR20150498A (ro) |
CY (1) | CY1120752T1 (ro) |
DK (1) | DK2976361T3 (ro) |
EA (1) | EA201591495A1 (ro) |
ES (1) | ES2687282T3 (ro) |
HK (1) | HK1215035A1 (ro) |
HR (1) | HRP20181478T1 (ro) |
HU (1) | HUE040234T2 (ro) |
IL (1) | IL241701A0 (ro) |
LT (1) | LT2976361T (ro) |
MD (2) | MD20180107A2 (ro) |
MX (2) | MX2015013288A (ro) |
NZ (1) | NZ712903A (ro) |
PE (1) | PE20160690A1 (ro) |
PH (1) | PH12015502185A1 (ro) |
PL (1) | PL2976361T3 (ro) |
PT (1) | PT2976361T (ro) |
RS (1) | RS57840B1 (ro) |
SG (2) | SG10201708048XA (ro) |
SI (1) | SI2976361T1 (ro) |
UA (1) | UA119319C2 (ro) |
WO (1) | WO2014148895A1 (ro) |
ZA (1) | ZA201507021B (ro) |
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