BR112015023862A2 - anticorpo isolado, molécula de ácido nucléico isolada, vetor, célula hospedeira, método de realçar uma resposta imune, método de tratar câncer, composição farmacêutica, e, anticorpo agonístico isolado - Google Patents
anticorpo isolado, molécula de ácido nucléico isolada, vetor, célula hospedeira, método de realçar uma resposta imune, método de tratar câncer, composição farmacêutica, e, anticorpo agonístico isoladoInfo
- Publication number
- BR112015023862A2 BR112015023862A2 BR112015023862A BR112015023862A BR112015023862A2 BR 112015023862 A2 BR112015023862 A2 BR 112015023862A2 BR 112015023862 A BR112015023862 A BR 112015023862A BR 112015023862 A BR112015023862 A BR 112015023862A BR 112015023862 A2 BR112015023862 A2 BR 112015023862A2
- Authority
- BR
- Brazil
- Prior art keywords
- isolated
- human
- antibody
- enhancing
- vector
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
1 / 1 resumo âanticorpo isolado, molãcula de ãcido nuclãico isolada, vetor, cãlula hospedeira, mãtodo de realãar uma resposta imune, mãtodo de tratar cãncer, composiãão farmacãutica, e, anticorpo agonãstico isolado â a invenã§ã£o fornece anticorpos que especificamente se ligam ã cd134 humana. anticorpos anti-cd134 humana especificamente se ligam ao domãnio extracelular da cd134 humana, incluindo os domãnios de ligaã§ã£o do ligante nã£o ox40 (ox40l) na cd134 humana, que ã© expresso por exemplo nos linfã³citos t cd4 e/ou cd8 efetores convencionais humanos ativados (teffs) e nos linfã³citos t cd4 reguladores supressivos humanos ativados (tregs). os anticorpos humanizados anti-cd134 humana sã£o ãºteis (por exemplo para habilitar a funã§ã£o efetora anticã¢ncer de teffs e/ou inibir a funã§ã£o supressiva de tregs) para o tratamento de cã¢ncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13159794 | 2013-03-18 | ||
PCT/NL2014/050162 WO2014148895A1 (en) | 2013-03-18 | 2014-03-18 | Humanized anti-cd134 (ox40) antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015023862A2 true BR112015023862A2 (pt) | 2017-10-24 |
Family
ID=47891522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015023862A BR112015023862A2 (pt) | 2013-03-18 | 2014-03-18 | anticorpo isolado, molécula de ácido nucléico isolada, vetor, célula hospedeira, método de realçar uma resposta imune, método de tratar câncer, composição farmacêutica, e, anticorpo agonístico isolado |
Country Status (32)
Country | Link |
---|---|
US (3) | US9790281B2 (pt) |
EP (2) | EP2976361B1 (pt) |
JP (1) | JP2016515544A (pt) |
KR (1) | KR20160006168A (pt) |
CN (1) | CN105229032A (pt) |
AU (2) | AU2014238546C1 (pt) |
BR (1) | BR112015023862A2 (pt) |
CA (1) | CA2907436A1 (pt) |
CL (2) | CL2015002793A1 (pt) |
CR (1) | CR20150498A (pt) |
CY (1) | CY1120752T1 (pt) |
DK (1) | DK2976361T3 (pt) |
EA (1) | EA201591495A1 (pt) |
ES (1) | ES2687282T3 (pt) |
HK (1) | HK1215035A1 (pt) |
HR (1) | HRP20181478T1 (pt) |
HU (1) | HUE040234T2 (pt) |
IL (1) | IL241701A0 (pt) |
LT (1) | LT2976361T (pt) |
MD (2) | MD20180107A2 (pt) |
MX (2) | MX2015013288A (pt) |
NZ (1) | NZ712903A (pt) |
PE (1) | PE20160690A1 (pt) |
PH (1) | PH12015502185A1 (pt) |
PL (1) | PL2976361T3 (pt) |
PT (1) | PT2976361T (pt) |
RS (1) | RS57840B1 (pt) |
SG (2) | SG10201708048XA (pt) |
SI (1) | SI2976361T1 (pt) |
UA (1) | UA119319C2 (pt) |
WO (1) | WO2014148895A1 (pt) |
ZA (1) | ZA201507021B (pt) |
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2019
- 2019-01-10 AU AU2019200164A patent/AU2019200164A1/en not_active Abandoned
- 2019-03-13 US US16/351,852 patent/US20190202928A1/en not_active Abandoned
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