BR112017022255A2 - anticorpo humanizado ou humano isolado, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, e composição farmacêutica - Google Patents

anticorpo humanizado ou humano isolado, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, e composição farmacêutica

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Publication number
BR112017022255A2
BR112017022255A2 BR112017022255A BR112017022255A BR112017022255A2 BR 112017022255 A2 BR112017022255 A2 BR 112017022255A2 BR 112017022255 A BR112017022255 A BR 112017022255A BR 112017022255 A BR112017022255 A BR 112017022255A BR 112017022255 A2 BR112017022255 A2 BR 112017022255A2
Authority
BR
Brazil
Prior art keywords
antibody
isolated
vector
producing
nucleic acid
Prior art date
Application number
BR112017022255A
Other languages
English (en)
Inventor
Dufour Florent
Radvanyi François
Haegel Hélène
Bernard-Pierrot Isabelle
Menguy Thierry
Duong Vanessa
Original Assignee
Centre Nat Rech Scient
Elsalys Biotech
Inst Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Elsalys Biotech, Inst Curie filed Critical Centre Nat Rech Scient
Publication of BR112017022255A2 publication Critical patent/BR112017022255A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Abstract

a presente invenção refere-se a anticorpos, em particular, anticorpos humanos ou humanizados, que se ligam ao domínio extracelular de receptor tyro3 humano, em particular, ao domínio do tipo imunoglobulina ig-1, e reduzem ou inibem a ligação de gas6 humano ao dito receptor. a invenção também se refere aos usos desses anticorpos no diagnóstico, na prevenção ou no tratamento de doenças hiperproliferativas ou infecciosas.
BR112017022255A 2015-04-17 2016-04-15 anticorpo humanizado ou humano isolado, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, e composição farmacêutica BR112017022255A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15305581 2015-04-17
PCT/EP2016/058457 WO2016166348A1 (en) 2015-04-17 2016-04-15 Anti-tyro3 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
BR112017022255A2 true BR112017022255A2 (pt) 2018-08-28

Family

ID=52998002

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017022255A BR112017022255A2 (pt) 2015-04-17 2016-04-15 anticorpo humanizado ou humano isolado, molécula de ácido nucleico isolada, vetor, célula hospedeira, método para produzir um anticorpo, e composição farmacêutica

Country Status (8)

Country Link
US (1) US20180105596A1 (pt)
EP (1) EP3283523A1 (pt)
JP (1) JP2018512892A (pt)
KR (1) KR20170138494A (pt)
CN (1) CN108064245A (pt)
BR (1) BR112017022255A2 (pt)
CA (1) CA2982657A1 (pt)
WO (1) WO2016166348A1 (pt)

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Publication number Priority date Publication date Assignee Title
AU2019328290A1 (en) 2018-08-30 2021-02-25 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
EP3844182A1 (en) 2018-08-30 2021-07-07 HCW Biologics, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
KR20210069639A (ko) 2018-08-30 2021-06-11 에이치씨더블유 바이올로직스, 인크. 단일-사슬 키메라 폴리펩타이드 및 이의 용도
CA3143035A1 (en) 2019-06-21 2020-12-24 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
US20210338724A1 (en) 2020-02-11 2021-11-04 HCW Biologics, Inc. Methods of treating age-related and inflammatory diseases
WO2021163298A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
CN115362169A (zh) 2020-02-11 2022-11-18 Hcw生物科技公司 色谱树脂以及其用途
AU2021262794A1 (en) 2020-04-29 2022-11-24 HCW Biologics, Inc. Anti-CD26 proteins and uses thereof
KR20230031280A (ko) 2020-06-01 2023-03-07 에이치씨더블유 바이올로직스, 인크. 노화 관련 장애의 치료 방법
WO2021247003A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
WO2023168363A1 (en) 2022-03-02 2023-09-07 HCW Biologics, Inc. Method of treating pancreatic cancer

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JP3951062B2 (ja) 1991-09-19 2007-08-01 ジェネンテック・インコーポレーテッド 少なくとも遊離のチオールとして存在するシステインを有する抗体フラグメントの大腸菌での発現、２官能性Ｆ（ａｂ’）２抗体の産生のための使用
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
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EP2165710A1 (en) 2008-09-19 2010-03-24 Institut Curie Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor
HUE037159T2 (hu) * 2009-11-24 2018-08-28 Medimmune Ltd Targetált kötõdõ ágensek B7-H1 ellen
BR112012027995A2 (pt) * 2010-06-18 2017-01-10 Genentech Inc anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl

Also Published As

Publication number Publication date
WO2016166348A1 (en) 2016-10-20
JP2018512892A (ja) 2018-05-24
CN108064245A (zh) 2018-05-22
CA2982657A1 (en) 2016-10-20
KR20170138494A (ko) 2017-12-15
US20180105596A1 (en) 2018-04-19
EP3283523A1 (en) 2018-02-21

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B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]