BR112016015140A2 - imunoglobulina com fabs in-tandem e usos das mesmas - Google Patents

imunoglobulina com fabs in-tandem e usos das mesmas

Info

Publication number
BR112016015140A2
BR112016015140A2 BR112016015140-2A BR112016015140A BR112016015140A2 BR 112016015140 A2 BR112016015140 A2 BR 112016015140A2 BR 112016015140 A BR112016015140 A BR 112016015140A BR 112016015140 A2 BR112016015140 A2 BR 112016015140A2
Authority
BR
Brazil
Prior art keywords
tandem
binding proteins
fab immunoglobulin
multivalent
present
Prior art date
Application number
BR112016015140-2A
Other languages
English (en)
Inventor
Wu Chengbin
Original Assignee
Epimab Biotherapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epimab Biotherapeutics Inc. filed Critical Epimab Biotherapeutics Inc.
Publication of BR112016015140A2 publication Critical patent/BR112016015140A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/244—Interleukins [IL]
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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Abstract

a presente invenção fornece proteínas de ligação multivalentes e multiespecíficas que são capazes de se ligar a dois ou mais antígenos ou dois ou mais epítopos. a presente invenção também proporciona métodos de preparação e utilização de tais proteínas de ligação multivalentes e multiespecíficas, incluindo os métodos de utilização de tais proteínas de ligação para a prevenção ou tratamento de várias doenças ou para a detecção de antígenos específicos, in vitro ou in vivo.
BR112016015140-2A 2013-12-30 2014-12-24 imunoglobulina com fabs in-tandem e usos das mesmas BR112016015140A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/090923 2013-12-30
CN2013090923 2013-12-30
PCT/US2014/072336 WO2015103072A1 (en) 2013-12-30 2014-12-24 Fabs-in-tandem immunoglobulin and uses thereof

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BR112016015140A2 true BR112016015140A2 (pt) 2018-01-23

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US (4) US10519251B2 (pt)
EP (2) EP3089994B1 (pt)
JP (2) JP6706578B2 (pt)
KR (1) KR102056963B1 (pt)
CN (1) CN106459182B (pt)
AR (1) AR098979A1 (pt)
AU (1) AU2014374055B2 (pt)
BR (1) BR112016015140A2 (pt)
CA (1) CA2931641C (pt)
CU (1) CU20160101A7 (pt)
DK (1) DK3089994T3 (pt)
ES (1) ES2923641T3 (pt)
IL (1) IL246287B (pt)
MX (1) MX2016008667A (pt)
NZ (1) NZ720353A (pt)
RU (2) RU2016129959A (pt)
TW (1) TWI672316B (pt)
WO (1) WO2015103072A1 (pt)

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US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
WO2014110601A1 (en) 2013-01-14 2014-07-17 Xencor, Inc. Novel heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
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