MX2016008667A - Inmunoglobulina con fab en tandem y usos de esta. - Google Patents

Inmunoglobulina con fab en tandem y usos de esta.

Info

Publication number
MX2016008667A
MX2016008667A MX2016008667A MX2016008667A MX2016008667A MX 2016008667 A MX2016008667 A MX 2016008667A MX 2016008667 A MX2016008667 A MX 2016008667A MX 2016008667 A MX2016008667 A MX 2016008667A MX 2016008667 A MX2016008667 A MX 2016008667A
Authority
MX
Mexico
Prior art keywords
fabs
binding proteins
tandem immunoglobulin
multivalent
present
Prior art date
Application number
MX2016008667A
Other languages
English (en)
Inventor
Wu Chengbin
Original Assignee
Epimab Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epimab Biotherapeutics Inc filed Critical Epimab Biotherapeutics Inc
Publication of MX2016008667A publication Critical patent/MX2016008667A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/244—Interleukins [IL]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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Abstract

La presente invención proporciona proteínas de unión multivalentes y multiespecíficas que son capaces de unirse a dos o más antígenos, o dos o más epítopos; la presente invención también proporciona métodos de elaboración y uso de esas proteínas de unión multivalentes y multiespecíficas, que incluyen métodos de uso de esas proteínas de unión para la prevención o el tratamiento de diversas enfermedades o para la detección de antígenos específicos in vitro o in vivo.
MX2016008667A 2013-12-30 2014-12-24 Inmunoglobulina con fab en tandem y usos de esta. MX2016008667A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2013090923 2013-12-30
PCT/US2014/072336 WO2015103072A1 (en) 2013-12-30 2014-12-24 Fabs-in-tandem immunoglobulin and uses thereof

Publications (1)

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MX2016008667A true MX2016008667A (es) 2017-02-02

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US (4) US10519251B2 (es)
EP (2) EP3089994B1 (es)
JP (2) JP6706578B2 (es)
KR (1) KR102056963B1 (es)
CN (1) CN106459182B (es)
AR (1) AR098979A1 (es)
AU (1) AU2014374055B2 (es)
BR (1) BR112016015140A2 (es)
CA (1) CA2931641C (es)
CU (1) CU20160101A7 (es)
DK (1) DK3089994T3 (es)
ES (1) ES2923641T3 (es)
IL (1) IL246287B (es)
MX (1) MX2016008667A (es)
NZ (1) NZ720353A (es)
RU (2) RU2016129959A (es)
TW (1) TWI672316B (es)
WO (1) WO2015103072A1 (es)

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US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
US10131710B2 (en) 2013-01-14 2018-11-20 Xencor, Inc. Optimized antibody variable regions
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US9701759B2 (en) 2013-01-14 2017-07-11 Xencor, Inc. Heterodimeric proteins
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