PT3723858T - Anticorpo biespecífico fixaxfx com cadeia leve comum - Google Patents
Anticorpo biespecífico fixaxfx com cadeia leve comumInfo
- Publication number
- PT3723858T PT3723858T PT198368060T PT19836806T PT3723858T PT 3723858 T PT3723858 T PT 3723858T PT 198368060 T PT198368060 T PT 198368060T PT 19836806 T PT19836806 T PT 19836806T PT 3723858 T PT3723858 T PT 3723858T
- Authority
- PT
- Portugal
- Prior art keywords
- fixaxfx
- light chain
- bispecific antibody
- common light
- common
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1820977.5A GB201820977D0 (en) | 2018-12-21 | 2018-12-21 | Fixaxfx bispecific antibody with commomn light chain |
| GBGB1906816.2A GB201906816D0 (en) | 2019-05-15 | 2019-05-15 | FIXaxFX bispecific antibody with common light chain |
| GBGB1908190.0A GB201908190D0 (en) | 2019-06-07 | 2019-06-07 | Fixaxfx bispecific antibody with common light chain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3723858T true PT3723858T (pt) | 2022-02-02 |
Family
ID=69167786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT198368060T PT3723858T (pt) | 2018-12-21 | 2019-12-20 | Anticorpo biespecífico fixaxfx com cadeia leve comum |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20220064327A1 (pt) |
| EP (2) | EP3723858B1 (pt) |
| JP (1) | JP2022515770A (pt) |
| KR (1) | KR20210118085A (pt) |
| CN (1) | CN113453757A (pt) |
| BR (1) | BR112021012065A2 (pt) |
| CA (1) | CA3123177A1 (pt) |
| DK (1) | DK3723858T3 (pt) |
| ES (1) | ES2901683T3 (pt) |
| HR (1) | HRP20220088T1 (pt) |
| HU (1) | HUE057634T2 (pt) |
| LT (1) | LT3723858T (pt) |
| PL (1) | PL3723858T3 (pt) |
| PT (1) | PT3723858T (pt) |
| RS (1) | RS62848B1 (pt) |
| SI (1) | SI3723858T1 (pt) |
| TW (1) | TWI772724B (pt) |
| WO (1) | WO2020128049A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201709970D0 (en) * | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| WO2023111018A1 (en) * | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Antibodies against coagulation factor x and uses thereof |
| US20240067944A1 (en) | 2022-07-08 | 2024-02-29 | Novo Nordisk A/S | Highly potent isvd compounds capable of substituting for fviii(a) |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| JP4213224B2 (ja) | 1997-05-02 | 2009-01-21 | ジェネンテック，インコーポレーテッド | ヘテロマルチマー及び共通成分を有する多重特異性抗体の製造方法 |
| AT411997B (de) | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US7297336B2 (en) | 2003-09-12 | 2007-11-20 | Baxter International Inc. | Factor IXa specific antibodies displaying factor VIIIa like activity |
| AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| EP1693448A4 (en) | 2003-10-14 | 2008-03-05 | Chugai Pharmaceutical Co Ltd | DOUBLE SPECIFICITY ANTIBODY FOR FUNCTIONAL PROTEIN SUBSTITUTION |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| CA2957144C (en) | 2005-04-08 | 2020-06-02 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
| CA2646965C (en) | 2006-03-24 | 2016-06-21 | Jonathan H. Davis | Engineered heterodimeric protein domains |
| WO2010151792A1 (en) | 2009-06-26 | 2010-12-29 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
| CN105859889B (zh) * | 2010-11-17 | 2020-01-07 | 中外制药株式会社 | 具有代替凝血因子viii的功能的功能的多特异性抗原结合分子 |
| KR20230091201A (ko) | 2012-04-20 | 2023-06-22 | 메뤼스 엔.페. | Ig-유사 분자의 제조방법 및 제조수단 |
| EP3065768B1 (en) | 2013-11-04 | 2020-09-23 | The Regents of the University of California | Composition for use in treatment or prevention of conditions associated with bleeding or hypocoagulationcompostion |
| NZ720353A (en) | 2013-12-30 | 2019-12-20 | Epimab Biotherapeutics Inc | Fabs-in-tandem immunoglobulin and uses thereof |
| TW201625299A (zh) | 2014-06-20 | 2016-07-16 | Chugai Pharmaceutical Co Ltd | 用於因第ｖｉｉｉ凝血因子及／或活化的第ｖｉｉｉ凝血因子的活性降低或欠缺而發病及／或進展的疾病之預防及／或治療之醫藥組成物 |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| WO2016166014A1 (en) | 2015-04-17 | 2016-10-20 | F. Hoffmann-La Roche Ag | Combination therapy with coagulation factors and multispecific antibodies |
| JP2018123055A (ja) | 2015-04-24 | 2018-08-09 | 公立大学法人奈良県立医科大学 | 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ｘｉ因子（ｆｘｉ）異常症の予防および／または治療に用いられる医薬組成物 |
| WO2017110980A1 (ja) | 2015-12-25 | 2017-06-29 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| BR112018015485A2 (pt) | 2016-02-06 | 2018-12-18 | Epimab Biotherapeutics Inc | imunoglobulina fabs-in-tandem e usos da mesma |
| RU2022108606A (ru) | 2016-05-16 | 2022-04-11 | Такеда Фармасьютикал Компани Лимитед | Антитела к фактору ix padua |
| RU2019104730A (ru) * | 2016-07-29 | 2020-08-28 | Чугаи Сейяку Кабусики Кайся | Биспецифическое антитело, обладающее повышенной активностью, альтернативной функции кофактора fviii |
| AU2017325240A1 (en) | 2016-09-06 | 2019-05-02 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X |
| US20230192896A1 (en) * | 2016-11-23 | 2023-06-22 | Bioverativ Therapeutics Inc. | Bispecific antibodies binding to coagulation factor ix and coagulation factor x |
| EP3577140A1 (en) | 2017-02-01 | 2019-12-11 | Novo Nordisk A/S | Procoagulant antibodies |
| CN110494163A (zh) | 2017-02-06 | 2019-11-22 | 应用干细胞有限公司 | 凝血因子viii模拟蛋白及其用途 |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| CN111108202A (zh) | 2017-09-29 | 2020-05-05 | 中外制药株式会社 | 具有凝血因子viii(fviii)辅因子功能替代活性的多特异性抗原结合分子及含有所述分子作为活性成分的药物制剂 |
| US11787874B2 (en) | 2017-11-15 | 2023-10-17 | Novo Nordisk A/S | Factor X binders enhancing FX activation |
-
2019
- 2019-12-20 EP EP19836806.0A patent/EP3723858B1/en active Active
- 2019-12-20 KR KR1020217022770A patent/KR20210118085A/ko unknown
- 2019-12-20 LT LTEPPCT/EP2019/086808T patent/LT3723858T/lt unknown
- 2019-12-20 BR BR112021012065A patent/BR112021012065A2/pt not_active Application Discontinuation
- 2019-12-20 WO PCT/EP2019/086808 patent/WO2020128049A1/en unknown
- 2019-12-20 CN CN201980091786.3A patent/CN113453757A/zh active Pending
- 2019-12-20 EP EP21204339.2A patent/EP4015538A1/en active Pending
- 2019-12-20 PT PT198368060T patent/PT3723858T/pt unknown
- 2019-12-20 HU HUE19836806A patent/HUE057634T2/hu unknown
- 2019-12-20 RS RS20220069A patent/RS62848B1/sr unknown
- 2019-12-20 PL PL19836806T patent/PL3723858T3/pl unknown
- 2019-12-20 US US17/311,595 patent/US20220064327A1/en active Pending
- 2019-12-20 DK DK19836806.0T patent/DK3723858T3/da active
- 2019-12-20 US US16/722,452 patent/US10815308B2/en active Active
- 2019-12-20 SI SI201930150T patent/SI3723858T1/sl unknown
- 2019-12-20 TW TW108146911A patent/TWI772724B/zh active
- 2019-12-20 HR HRP20220088TT patent/HRP20220088T1/hr unknown
- 2019-12-20 CA CA3123177A patent/CA3123177A1/en active Pending
- 2019-12-20 ES ES19836806T patent/ES2901683T3/es active Active
- 2019-12-20 JP JP2021535950A patent/JP2022515770A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020128049A1 (en) | 2020-06-25 |
| US20210101997A1 (en) | 2021-04-08 |
| TWI772724B (zh) | 2022-08-01 |
| CA3123177A1 (en) | 2020-06-25 |
| HRP20220088T1 (hr) | 2022-04-15 |
| BR112021012065A2 (pt) | 2021-12-07 |
| EP4015538A1 (en) | 2022-06-22 |
| JP2022515770A (ja) | 2022-02-22 |
| CN113453757A (zh) | 2021-09-28 |
| US20200199250A1 (en) | 2020-06-25 |
| EP3723858B1 (en) | 2021-10-27 |
| KR20210118085A (ko) | 2021-09-29 |
| DK3723858T3 (da) | 2022-01-24 |
| ES2901683T3 (es) | 2022-03-23 |
| US10815308B2 (en) | 2020-10-27 |
| EP3723858A1 (en) | 2020-10-21 |
| PL3723858T3 (pl) | 2022-03-07 |
| SI3723858T1 (sl) | 2022-04-29 |
| US20220064327A1 (en) | 2022-03-03 |
| TW202039584A (zh) | 2020-11-01 |
| LT3723858T (lt) | 2022-02-10 |
| HUE057634T2 (hu) | 2022-05-28 |
| RS62848B1 (sr) | 2022-02-28 |
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