MX2020011134A - Proceso cerrado para expansion y edicion de genes de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia. - Google Patents

Proceso cerrado para expansion y edicion de genes de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia.

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Publication number
MX2020011134A
MX2020011134A MX2020011134A MX2020011134A MX2020011134A MX 2020011134 A MX2020011134 A MX 2020011134A MX 2020011134 A MX2020011134 A MX 2020011134A MX 2020011134 A MX2020011134 A MX 2020011134A MX 2020011134 A MX2020011134 A MX 2020011134A
Authority
MX
Mexico
Prior art keywords
tils
immunotherapy
expansion
same
gene editing
Prior art date
Application number
MX2020011134A
Other languages
English (en)
Inventor
Cecile Chartier-Courtaud
Krit Ritthipichai
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Iovance Biotherapeutics Inc
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Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of MX2020011134A publication Critical patent/MX2020011134A/es

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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2523/00—Culture process characterised by temperature

Abstract

La presente invención da a conocer métodos mejorados y/o abreviados para expandir TIL y producir poblaciones terapéuticas de TIL, incluyendo novedosos métodos para expandir poblaciones de TIL en un sistema cerrado que lleva a una eficacia mejorada, fenotipo mejorado y salud metabólica incrementada de los TIL en un período de tiempo más corto, dando lugar a la vez a una contaminación microbiana reducida y a costos reducidos. Los métodos pueden comprender realizar la edición genética de por lo menos una porción de los TIL para potenciar su eficacia terapéutica. Esos TIL son de utilidad en regímenes de tratamiento terapéuticos.
MX2020011134A 2018-04-27 2019-04-26 Proceso cerrado para expansion y edicion de genes de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia. MX2020011134A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862663885P 2018-04-27 2018-04-27
US201862680821P 2018-06-05 2018-06-05
PCT/US2019/029286 WO2019210131A1 (en) 2018-04-27 2019-04-26 Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy

Publications (1)

Publication Number Publication Date
MX2020011134A true MX2020011134A (es) 2020-11-11

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Application Number Title Priority Date Filing Date
MX2020011134A MX2020011134A (es) 2018-04-27 2019-04-26 Proceso cerrado para expansion y edicion de genes de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia.

Country Status (13)

Country Link
US (6) US20210130779A1 (es)
EP (1) EP3784254A1 (es)
JP (1) JP2021521846A (es)
KR (1) KR20210005138A (es)
CN (1) CN112368003A (es)
AU (1) AU2019257749A1 (es)
BR (1) BR112020021660A2 (es)
CA (1) CA3098303A1 (es)
IL (1) IL278231A (es)
MA (1) MA52533A (es)
MX (1) MX2020011134A (es)
SG (1) SG11202010319RA (es)
WO (1) WO2019210131A1 (es)

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