US9273283B2
(en)
*
|
2009-10-29 |
2016-03-01 |
The Trustees Of Dartmouth College |
Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
US9950282B2
(en)
|
2012-03-15 |
2018-04-24 |
Flodesign Sonics, Inc. |
Electronic configuration and control for acoustic standing wave generation
|
US10967298B2
(en)
|
2012-03-15 |
2021-04-06 |
Flodesign Sonics, Inc. |
Driver and control for variable impedence load
|
US10704021B2
(en)
|
2012-03-15 |
2020-07-07 |
Flodesign Sonics, Inc. |
Acoustic perfusion devices
|
US9458450B2
(en)
|
2012-03-15 |
2016-10-04 |
Flodesign Sonics, Inc. |
Acoustophoretic separation technology using multi-dimensional standing waves
|
US20150017136A1
(en)
*
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
ES2962571T3
(es)
*
|
2012-05-25 |
2024-03-19 |
Cellectis |
Métodos para modificar células T alogénicas y resistentes a la inmunosupresión para inmunoterapia
|
HUE050797T2
(hu)
*
|
2012-10-10 |
2021-01-28 |
Sangamo Therapeutics Inc |
T-sejt módosító vegyületek és alkalmazásaik
|
DK3300745T3
(da)
|
2013-02-15 |
2019-11-04 |
Univ California |
Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
|
JP6541639B2
(ja)
*
|
2013-03-14 |
2019-07-10 |
ベリカム ファーマシューティカルズ, インコーポレイテッド |
T細胞増殖をコントロールするための方法
|
US9587237B2
(en)
|
2013-03-14 |
2017-03-07 |
Elwha Llc |
Compositions, methods, and computer systems related to making and administering modified T cells
|
US9499855B2
(en)
|
2013-03-14 |
2016-11-22 |
Elwha Llc |
Compositions, methods, and computer systems related to making and administering modified T cells
|
JP6005572B2
(ja)
*
|
2013-03-28 |
2016-10-12 |
Kddi株式会社 |
動画像符号化装置、動画像復号装置、動画像符号化方法、動画像復号方法、およびプログラム
|
CA3185368A1
(en)
*
|
2013-04-03 |
2014-10-09 |
Memorial Sloan-Kettering Cancer Center |
Effective generation of tumor-targeted t cells derived from pluripotent stem cells
|
US11311575B2
(en)
*
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
US20230056268A1
(en)
*
|
2013-05-13 |
2023-02-23 |
Cellectis |
Methods for engineering highly active t cell for immunotheraphy
|
US20230050345A1
(en)
*
|
2013-05-13 |
2023-02-16 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotheraphy
|
US11077144B2
(en)
|
2013-05-13 |
2021-08-03 |
Cellectis |
CD19 specific chimeric antigen receptor and uses thereof
|
EP3974520A1
(en)
|
2013-05-14 |
2022-03-30 |
Board of Regents, The University of Texas System |
Human application of engineered chimeric antigen receptor (car) t-cells
|
CA2913830C
(en)
|
2013-05-29 |
2021-06-29 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
US10208125B2
(en)
|
2013-07-15 |
2019-02-19 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Anti-mucin 1 binding agents and uses thereof
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
US9737604B2
(en)
|
2013-09-06 |
2017-08-22 |
President And Fellows Of Harvard College |
Use of cationic lipids to deliver CAS9
|
EP3363903B1
(en)
|
2013-11-07 |
2024-01-03 |
Editas Medicine, Inc. |
Crispr-related methods and compositions with governing grnas
|
MX2016006177A
(es)
*
|
2013-11-22 |
2016-08-19 |
Cellectis |
Método para diseñar células t resistentes a fármacos de quimioterapia para inmunoterapia.
|
JP2016539117A
(ja)
*
|
2013-11-22 |
2016-12-15 |
セレクティスCellectis |
平均化された効力を持つ同種異系t細胞のバッチを生成するための方法
|
RU2689558C1
(ru)
*
|
2013-11-22 |
2019-05-28 |
Селлектис |
Способ конструирования аллогенных и устойчивых к лекарственным препаратам т-клеток для иммунотерапии
|
US10801070B2
(en)
|
2013-11-25 |
2020-10-13 |
The Broad Institute, Inc. |
Compositions and methods for diagnosing, evaluating and treating cancer
|
US11725237B2
(en)
|
2013-12-05 |
2023-08-15 |
The Broad Institute Inc. |
Polymorphic gene typing and somatic change detection using sequencing data
|
US9068179B1
(en)
|
2013-12-12 |
2015-06-30 |
President And Fellows Of Harvard College |
Methods for correcting presenilin point mutations
|
AU2014368383B2
(en)
*
|
2013-12-20 |
2020-01-16 |
Cellectis |
Method of engineering multi-input signal sensitive T cell for immunotherapy
|
WO2015095811A2
(en)
|
2013-12-20 |
2015-06-25 |
The Board Institute Inc. |
Combination therapy with neoantigen vaccine
|
EP3092049A1
(en)
|
2014-01-08 |
2016-11-16 |
Flodesign Sonics Inc. |
Acoustophoresis device with dual acoustophoretic chamber
|
CA2936693C
(en)
*
|
2014-01-14 |
2020-07-21 |
Cellectis |
Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish
|
MX2016010285A
(es)
|
2014-02-11 |
2017-01-11 |
Univ Colorado Regents |
Ingenieria genetica multiplexada habilitada por crispr.
|
US10836998B2
(en)
|
2014-02-14 |
2020-11-17 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
JP6772063B2
(ja)
|
2014-02-14 |
2020-10-21 |
ベリカム ファーマシューティカルズ, インコーポレイテッド |
誘導可能なキメラポリペプチドを使用して細胞を活性化するための方法
|
CA2938887C
(en)
*
|
2014-02-14 |
2023-04-11 |
Laurence J. N. Cooper |
Chimeric antigen receptors and methods of making
|
US10196608B2
(en)
*
|
2014-02-21 |
2019-02-05 |
Cellectis |
Method for in situ inhibition of regulatory T cells
|
US11385233B2
(en)
|
2015-03-05 |
2022-07-12 |
Autolus Limited |
Methods of depleting malignant T-cells
|
IL278878B
(en)
*
|
2014-03-05 |
2022-07-01 |
Autolus Ltd |
A chimeric antigen receptor having antigen-binding regions for a beta t-cell receptor constant region
|
US11982673B2
(en)
|
2014-03-05 |
2024-05-14 |
Autolus Limited |
Methods
|
EP3116902B1
(en)
|
2014-03-11 |
2020-01-01 |
Cellectis |
Method for generating t-cells compatible for allogenic transplantation
|
TR201910814T4
(tr)
*
|
2014-03-19 |
2019-08-21 |
Cellectis |
Kanser immünoterapisi için cd123 spesifik kimerik antijen reseptörleri.
|
CN106795221B
(zh)
|
2014-04-03 |
2022-06-07 |
塞勒克提斯公司 |
用于癌症免疫治疗的cd33特异性嵌合抗原受体
|
EP3129473B8
(en)
*
|
2014-04-11 |
2020-12-23 |
Cellectis |
Method for generating immune cells resistant to arginine and/or tryptophan depleted microenvironment
|
AU2015248956B2
(en)
|
2014-04-14 |
2020-06-25 |
Cellectis |
BCMA (CD269) specific chimeric antigen receptors for cancer immunotherapy
|
KR20230152175A
(ko)
*
|
2014-04-18 |
2023-11-02 |
에디타스 메디신, 인코포레이티드 |
암 면역요법을 위한 crispr-cas-관련 방법, 조성물 및 구성성분
|
AU2015254595B2
(en)
|
2014-05-02 |
2019-06-27 |
Cellectis |
CS1 specific multi-chain chimeric antigen receptor
|
CA2954414A1
(en)
*
|
2014-07-15 |
2016-01-21 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
JP6721568B2
(ja)
|
2014-07-29 |
2020-07-15 |
セレクティスCellectis |
がん免疫療法のためのror1(ntrkr1)特異的キメラ抗原レセプター
|
EP4079847A1
(en)
|
2014-07-30 |
2022-10-26 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
WO2016016343A1
(en)
|
2014-07-31 |
2016-02-04 |
Cellectis |
Ror1 specific multi-chain chimeric antigen receptor
|
PT3177640T
(pt)
|
2014-08-08 |
2020-08-31 |
Univ Leland Stanford Junior |
Agentes pd-1 de alta afinidade e métodos de utilização
|
JP6868554B2
(ja)
|
2014-09-02 |
2021-05-12 |
ベリカム ファーマシューティカルズ, インコーポレイテッド |
MyD88およびCD40ポリペプチドによるキメラ抗原受容体の共刺激
|
DK3189073T3
(da)
|
2014-09-04 |
2020-03-30 |
Cellectis |
Trophoblast-glycoprotein (5t4, tpbg)-specifikke kimære antigenreceptorer til cancerimmunterapi
|
AU2015334847A1
(en)
*
|
2014-10-24 |
2017-06-08 |
Bcrt Holding Bv |
T cell-based immunotherapeutics
|
CN107249606A
(zh)
|
2014-10-31 |
2017-10-13 |
宾夕法尼亚大学董事会 |
改变修饰的t细胞中的基因表达及其用途
|
DK3757206T3
(da)
*
|
2014-11-05 |
2024-07-15 |
Juno Therapeutics Inc |
Transduktionsfremgangsmåde og cellebehandling
|
GB201421096D0
(en)
*
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
EP3757211A1
(en)
|
2014-12-19 |
2020-12-30 |
The Broad Institute, Inc. |
Methods for profiling the t-cell-receptor repertoire
|
US10975442B2
(en)
|
2014-12-19 |
2021-04-13 |
Massachusetts Institute Of Technology |
Molecular biomarkers for cancer immunotherapy
|
RU2017129455A
(ru)
|
2015-01-26 |
2019-03-04 |
Селлектис |
Сконструированные иммунные клетки с нокаутом рецептора т-клеток, снабженные химерными антигенными рецепторами, связывающимися с cd123, для лечения рецедивирующего/устойчивого острого миелоидного лейкоза или новообразования из бластных плазмоцитоидных дендритных клеток
|
WO2016123100A1
(en)
|
2015-01-26 |
2016-08-04 |
Fate Therapeutics, Inc. |
Methods and compositions for inducing hematopoietic cell differentiation
|
US10557140B2
(en)
*
|
2015-02-02 |
2020-02-11 |
Industry-Academic Cooperation Foundation, Dankook University |
CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof
|
WO2016124765A1
(en)
*
|
2015-02-06 |
2016-08-11 |
Cellectis |
Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles
|
US20170151281A1
(en)
|
2015-02-19 |
2017-06-01 |
Batu Biologics, Inc. |
Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer
|
AU2016222887B2
(en)
|
2015-02-24 |
2022-07-14 |
The Regents Of The University Of California |
Binding-triggered transcriptional switches and methods of use thereof
|
BR112017018770A2
(pt)
*
|
2015-03-02 |
2018-04-17 |
Innovative Cellular Therapeutics CO., LTD. |
redução da tolerância imunológica induzida por pd-l1
|
KR20170137079A
(ko)
*
|
2015-03-11 |
2017-12-12 |
셀렉티스 |
그것들의 지속을 증가시키기 위한 동종이계 t 세포의 조작 및/또는 환자들 내로 이식 방법들
|
BR112017020058A2
(pt)
*
|
2015-03-20 |
2018-06-05 |
Childrens Nat Medical Ct |
processo para produzir uma célula-t específica, composição, banco de células-t específicas, método de tratamento, e, banco ou instalação de armazenamento de células.
|
GB201504840D0
(en)
*
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
WO2016166268A1
(en)
|
2015-04-17 |
2016-10-20 |
Cellectis |
Engineering animal or plant genome using dna-guided argonaute interference systems (dais) from mesophilic prokaryotes
|
US11708572B2
(en)
|
2015-04-29 |
2023-07-25 |
Flodesign Sonics, Inc. |
Acoustic cell separation techniques and processes
|
US11377651B2
(en)
|
2016-10-19 |
2022-07-05 |
Flodesign Sonics, Inc. |
Cell therapy processes utilizing acoustophoresis
|
US11021699B2
(en)
|
2015-04-29 |
2021-06-01 |
FioDesign Sonics, Inc. |
Separation using angled acoustic waves
|
WO2016179319A1
(en)
*
|
2015-05-04 |
2016-11-10 |
Cellerant Therapeutics, Inc. |
Chimeric antigen receptors with ctla4 signal transduction domains
|
AU2016261600B2
(en)
|
2015-05-08 |
2021-09-23 |
President And Fellows Of Harvard College |
Universal donor stem cells and related methods
|
JP2018515123A
(ja)
|
2015-05-18 |
2018-06-14 |
ティーシーアール2 セラピューティクス インク. |
融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法
|
CN116196401A
(zh)
|
2015-05-20 |
2023-06-02 |
博德研究所 |
共有的新抗原
|
AR104718A1
(es)
|
2015-05-20 |
2017-08-09 |
Cellectis |
Receptores de antígenos quiméricos específicos de anti-gd3 para inmunoterapias contra el cáncer
|
MA43344A
(fr)
|
2015-05-29 |
2018-04-11 |
Juno Therapeutics Inc |
Composition et procédés de régulation des interactions inhibitrices dans les cellules génétiquement modifiées
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
CA2986314C
(en)
|
2015-06-30 |
2024-04-23 |
Cellectis |
Methods for improving functionality in nk cell by gene inactivation using specific endonuclease
|
EP3322297A4
(en)
*
|
2015-07-13 |
2019-04-17 |
Sangamo Therapeutics, Inc. |
RELEASE METHOD AND COMPOSITIONS FOR NUCLEASE-DERIVED GENOMINE ENGINEERING
|
US20170014449A1
(en)
*
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
MA42895A
(fr)
*
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
US11474085B2
(en)
|
2015-07-28 |
2022-10-18 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
US11459540B2
(en)
|
2015-07-28 |
2022-10-04 |
Flodesign Sonics, Inc. |
Expanded bed affinity selection
|
IL295616A
(en)
|
2015-07-31 |
2022-10-01 |
Us Health |
Adapted cells and treatment methods
|
US10709775B2
(en)
|
2015-08-11 |
2020-07-14 |
Cellectis |
Cells for immunotherapy engineered for targeting CD38 antigen and for CD38 gene inactivation
|
US11649435B2
(en)
*
|
2015-08-28 |
2023-05-16 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
WO2017040324A1
(en)
|
2015-08-28 |
2017-03-09 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for cells expressing a chimeric intracellular signaling molecule
|
CN108601821B
(zh)
|
2015-10-05 |
2023-09-19 |
精密生物科学公司 |
包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞
|
CA3001008A1
(en)
|
2015-10-05 |
2017-04-13 |
Precision Biosciences, Inc. |
Engineered meganucleases with recognition sequences found in the human t cell receptor alpha constant region gene
|
US20190255107A1
(en)
|
2015-10-09 |
2019-08-22 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
WO2017070429A1
(en)
*
|
2015-10-22 |
2017-04-27 |
Regents Of The University Of Minnesota |
Methods involving editing polynucleotides that encode t cell receptor
|
IL258821B
(en)
|
2015-10-23 |
2022-07-01 |
Harvard College |
Nucleobase editors and their uses
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
EP3368051A4
(en)
*
|
2015-10-30 |
2019-06-26 |
Children's National Medical Center |
GENERATION OF HPV ANTIGEN-SPECIFIC T CELLS FROM A NAIVEN T CELL POPULATION
|
KR20180066262A
(ko)
|
2015-11-04 |
2018-06-18 |
페이트 세러퓨틱스, 인코포레이티드 |
만능 세포의 유전자 조작
|
KR20180066263A
(ko)
|
2015-11-04 |
2018-06-18 |
페이트 세러퓨틱스, 인코포레이티드 |
조혈 세포 분화를 유도하기 위한 방법 및 조성물
|
EP3370514A4
(en)
*
|
2015-11-05 |
2019-03-27 |
Baylor College of Medicine |
EFFICIENT SCALABLE XENOTRANAPLANT SYSTEM FROM ONE PATIENT BASED ON A CHICKEN CHORIOAL ANTI-TEMEMBRBRANE (CAM) IN VIVO MODEL
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
UA126373C2
(uk)
|
2015-12-04 |
2022-09-28 |
Новартіс Аг |
Композиція і спосіб для імуноонкології
|
AU2016369490C1
(en)
*
|
2015-12-18 |
2021-12-23 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
CN105505869A
(zh)
*
|
2015-12-21 |
2016-04-20 |
河南大学淮河医院 |
一种针对肿瘤干细胞的嵌合抗原受体t细胞
|
EP3184548A1
(en)
*
|
2015-12-23 |
2017-06-28 |
Miltenyi Biotec GmbH |
Chimeric antigen receptor with cytokine receptor activating or blocking domain
|
MX2018008416A
(es)
|
2016-01-08 |
2019-11-11 |
Univ California |
Polipéptidos heterodímericos condicionalmente activos y métodos para su uso.
|
EP3426690A4
(en)
*
|
2016-03-11 |
2019-10-09 |
Bluebird Bio, Inc. |
GENOMEDITIZED IMMUNEFFECTOR CELLS
|
GB201604213D0
(en)
*
|
2016-03-11 |
2016-04-27 |
Proximagen Ltd |
Drug combination and its use in therapy
|
CN109415687A
(zh)
*
|
2016-04-07 |
2019-03-01 |
蓝鸟生物公司 |
嵌合抗原受体t细胞组合物
|
EP3443001A4
(en)
|
2016-04-11 |
2020-04-29 |
Obsidian Therapeutics, Inc. |
REGULATED BIOCIRCUIT SYSTEMS
|
KR102614675B1
(ko)
|
2016-04-15 |
2023-12-19 |
메모리얼 슬로안 케터링 캔서 센터 |
유전자이식 t 세포 및 키메라 항원 수용체 t 세포 조성물 및 관련 방법
|
WO2017177337A1
(en)
*
|
2016-04-15 |
2017-10-19 |
Zymeworks Inc. |
Multi-specific antigen-binding constructs targeting immunotherapeutics
|
EP3429634A1
(en)
|
2016-04-15 |
2019-01-23 |
Cellectis |
A method of engineering prodrug-specific hypersensitive t-cells for immunotherapy by gene expression
|
EP3429633B1
(en)
|
2016-04-15 |
2021-02-24 |
Cellectis |
A method of engineering drug-specific hypersensitive t-cells for immunotherapy by gene inactivation
|
EP3446119A1
(en)
|
2016-04-18 |
2019-02-27 |
The Broad Institute Inc. |
Improved hla epitope prediction
|
WO2017192536A1
(en)
|
2016-05-02 |
2017-11-09 |
University Of Kansas |
Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy
|
US11214789B2
(en)
|
2016-05-03 |
2022-01-04 |
Flodesign Sonics, Inc. |
Concentration and washing of particles with acoustics
|
US11085035B2
(en)
|
2016-05-03 |
2021-08-10 |
Flodesign Sonics, Inc. |
Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
|
US10017760B2
(en)
|
2016-06-24 |
2018-07-10 |
Inscripta, Inc. |
Methods for generating barcoded combinatorial libraries
|
JP7195154B2
(ja)
*
|
2016-07-06 |
2022-12-23 |
セレクティス |
初代免疫細胞における逐次遺伝子編集
|
US11384156B2
(en)
|
2016-07-25 |
2022-07-12 |
The Nemours Foundation |
Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases
|
EP3494138A1
(en)
|
2016-08-02 |
2019-06-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
KR102547316B1
(ko)
|
2016-08-03 |
2023-06-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
아데노신 핵염기 편집제 및 그의 용도
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
US11630103B2
(en)
|
2016-08-17 |
2023-04-18 |
The Broad Institute, Inc. |
Product and methods useful for modulating and evaluating immune responses
|
IL264792B2
(en)
*
|
2016-08-24 |
2023-10-01 |
Sangamo Therapeutics Inc |
Engineered target-specific zinc-finger nucleases
|
TN2019000048A1
(en)
|
2016-08-24 |
2020-07-15 |
Sangamo Therapeutics Inc |
Regulation of gene expression using engineered nucleases.
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
JP7160482B2
(ja)
|
2016-09-02 |
2022-10-25 |
レンティジェン・テクノロジー・インコーポレイテッド |
Duocarを用いてがんを処置するための組成物および方法
|
US20190262399A1
(en)
|
2016-09-07 |
2019-08-29 |
The Broad Institute, Inc. |
Compositions and methods for evaluating and modulating immune responses
|
WO2018049226A1
(en)
|
2016-09-08 |
2018-03-15 |
Bluebird Bio, Inc. |
Pd-1 homing endonuclease variants, compositions, and methods of use
|
CA3036972A1
(en)
|
2016-09-14 |
2018-03-22 |
Janssen Biotech, Inc. |
Chimeric antigen receptors comprising bcma-specific fibronectin type iii domains and uses thereof
|
MA46354A
(fr)
|
2016-10-03 |
2019-08-07 |
Juno Therapeutics Inc |
Molécules se liant spécifiquement au vph
|
CA3038690A1
(en)
|
2016-10-05 |
2018-04-12 |
FUJIFILM Cellular Dynamics, Inc. |
Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
|
PL3445787T3
(pl)
|
2016-10-07 |
2021-05-31 |
TCR2 Therapeutics Inc. |
Kompozycje i sposoby reprogramowania receptorów limfocytów t przy użyciu białek fuzyjnych
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
CN110036107A
(zh)
|
2016-10-11 |
2019-07-19 |
蓝鸟生物公司 |
TCRα归巢核酸内切酶变体
|
GB2573062A
(en)
|
2016-10-14 |
2019-10-23 |
Harvard College |
AAV delivery of nucleobase editors
|
CA3041068A1
(en)
|
2016-10-18 |
2018-04-26 |
Regents Of The University Of Minnesota |
Tumor infiltrating lymphocytes and methods of therapy
|
US11873511B2
(en)
*
|
2016-10-19 |
2024-01-16 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
WO2018073394A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Cell death inducing chimeric antigen receptors
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
WO2018075830A1
(en)
|
2016-10-19 |
2018-04-26 |
Flodesign Sonics, Inc. |
Affinity cell extraction by acoustics
|
WO2018073391A1
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Targeted gene insertion for improved immune cells therapy
|
WO2018087285A1
(en)
|
2016-11-10 |
2018-05-17 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Or10h1 antigen binding proteins and uses thereof
|
EP3321280B8
(en)
|
2016-11-10 |
2021-03-10 |
Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts |
Immune modulators for reducing immune-resistance in melanoma and other proliferative diseases
|
US11851491B2
(en)
|
2016-11-22 |
2023-12-26 |
TCR2 Therapeutics Inc. |
Compositions and methods for TCR reprogramming using fusion proteins
|
EP3548622A1
(en)
|
2016-12-02 |
2019-10-09 |
Juno Therapeutics, Inc. |
Engineered b cells and related compositions and methods
|
WO2018115189A1
(en)
|
2016-12-21 |
2018-06-28 |
Cellectis |
Stably enginereed proteasome inhibitor resistant immune cells for immunotherapy
|
US11242402B2
(en)
|
2016-12-23 |
2022-02-08 |
Macrogenics, Inc. |
ADAM9-binding molecules, and methods of use thereof
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
EP3568467A4
(en)
*
|
2017-01-10 |
2020-11-25 |
The General Hospital Corporation |
MODIFIED T LYMPHOCYTES AND THEIR METHODS OF USE
|
EP3574116A1
(en)
|
2017-01-24 |
2019-12-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting a mutant variant of a polynucleotide
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
CA3051481A1
(en)
|
2017-02-07 |
2018-08-16 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Phospholipid ether (ple) car t cell tumor targeting (ctct) agents
|
DK3583203T3
(da)
*
|
2017-02-15 |
2024-01-02 |
2Seventy Bio Inc |
Donorreparationstemplates multiplex-genomeditering
|
EP3589295A4
(en)
|
2017-02-28 |
2020-11-04 |
Endocyte, Inc. |
COMPOSITIONS AND METHODS OF T CAR LYMPHOCYTE THERAPY
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
AU2018235130B2
(en)
|
2017-03-15 |
2023-12-07 |
Oxford Biomedica (Uk) Limited |
Method
|
CA3054621A1
(en)
|
2017-03-22 |
2018-09-27 |
Novartis Ag |
Compositions and methods for immunooncology
|
KR102687373B1
(ko)
|
2017-03-23 |
2024-07-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
EP3592379B1
(en)
|
2017-03-31 |
2024-04-24 |
Cellectis SA |
Universal anti-cd22 chimeric antigen receptor engineered immune cells
|
WO2018183921A1
(en)
|
2017-04-01 |
2018-10-04 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE OF METASTASIS, COMPOSITIONS OF SUBSTANCES AND USES THEREOF
|
WO2018189360A1
(en)
|
2017-04-13 |
2018-10-18 |
Cellectis |
New sequence specific reagents targeting ccr5 in primary hematopoietic cells
|
CA3060443A1
(en)
*
|
2017-04-19 |
2018-10-25 |
Board Of Regents, The University Of Texas System |
Immune cells expressing engineered antigen receptors
|
EP3391907B8
(en)
|
2017-04-20 |
2020-03-04 |
iOmx Therapeutics AG |
Intracellular kinase sik3 associated with resistance against anti-tumour immune responses, and uses thereof
|
US11166985B2
(en)
|
2017-05-12 |
2021-11-09 |
Crispr Therapeutics Ag |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
BR112019023608A2
(pt)
|
2017-05-12 |
2020-05-26 |
Crispr Therapeutics Ag |
Materiais e métodos para células manipuladas e seus usos em imuno-oncologia
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
WO2018231759A1
(en)
*
|
2017-06-12 |
2018-12-20 |
Obsidian Therapeutics, Inc. |
Pde5 compositions and methods for immunotherapy
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
WO2018234239A1
(en)
|
2017-06-19 |
2018-12-27 |
Cellectis |
ANTI-HBV POLYTHERAPIES INVOLVING SPECIFIC ENDONUCLEASES
|
IL271618B2
(en)
|
2017-06-20 |
2024-06-01 |
Inst Curie |
Immune cells are defective in SUV39H1
|
CA3068286A1
(en)
*
|
2017-06-22 |
2018-12-27 |
Board Of Regents, The University Of Texas System |
Methods for producing regulatory immune cells and uses thereof
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
US20220233588A1
(en)
|
2017-06-30 |
2022-07-28 |
Cellectis |
Cellular immunotherapy for repetitive administration
|
WO2019006418A2
(en)
|
2017-06-30 |
2019-01-03 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
US11053484B2
(en)
|
2017-06-30 |
2021-07-06 |
Precision Biosciences, Inc. |
Genetically-modified T cells comprising a modified intron in the T cell receptor alpha gene
|
EP3640333A4
(en)
|
2017-07-14 |
2020-12-30 |
Cure Genetics Co., Ltd |
GENE EDITING SYSTEM AND GENE EDITING METHOD
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
WO2019018402A2
(en)
|
2017-07-17 |
2019-01-24 |
Janssen Biotech, Inc. |
ANTIGEN-BINDING REGIONS DIRECTED AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME
|
WO2019016360A1
(en)
|
2017-07-21 |
2019-01-24 |
Cellectis |
MODIFIED IMMUNE CELLS RESISTANT TO TUMOR MICRO-ENVIRONMENT
|
US11903968B2
(en)
|
2017-07-21 |
2024-02-20 |
Cellectis |
Engineered immune cells resistant to tumor microenvironment
|
AU2018306307A1
(en)
*
|
2017-07-25 |
2020-02-20 |
Board Of Regents, The University Of Texas System |
Enhanced chimeric antigen receptors and use thereof
|
WO2019020733A1
(en)
|
2017-07-26 |
2019-01-31 |
Cellectis |
METHODS OF IMMUNE CELL SELECTION OF THE ANTIGEN-DEPENDENT CHIMERIC ANTIGENIC RECEPTOR (CAR)
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
JP2020535128A
(ja)
|
2017-09-19 |
2020-12-03 |
マサチューセッツ インスティテュート オブ テクノロジー |
キメラ抗原受容体t細胞治療のための組成物およびその使用
|
US11618896B2
(en)
|
2017-09-21 |
2023-04-04 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
US12043870B2
(en)
|
2017-10-02 |
2024-07-23 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
JP2020537515A
(ja)
|
2017-10-03 |
2020-12-24 |
ジュノー セラピューティクス インコーポレイテッド |
Hpv特異的結合分子
|
WO2019072824A1
(en)
|
2017-10-09 |
2019-04-18 |
Cellectis |
IMPROVED ANTI-CD123 CAR IN UNIVERSAL MODIFIED IMMUNE T LYMPHOCYTES
|
US11795443B2
(en)
|
2017-10-16 |
2023-10-24 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
KR20200075851A
(ko)
|
2017-10-19 |
2020-06-26 |
셀렉티스 |
개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합
|
EP3703710B1
(en)
|
2017-10-31 |
2024-08-07 |
Allogene Therapeutics, Inc. |
Methods and compositions for dosing of allogeneic chimeric antigen receptor t cells for treating refractory and/or relapsed large b-cell lymphoma or refractory and/or relapsed follicular lymphoma
|
US12018080B2
(en)
|
2017-11-13 |
2024-06-25 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the CLEC2D-KLRB1 pathway
|
TWI833719B
(zh)
|
2017-11-17 |
2024-03-01 |
美商艾歐凡斯生物治療公司 |
來自細針抽吸物及小活體組織切片之腫瘤浸潤淋巴細胞(til)擴增
|
JP2021503885A
(ja)
|
2017-11-22 |
2021-02-15 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
末梢血からの末梢血リンパ球(pbl)の拡大培養
|
WO2019106163A1
(en)
|
2017-12-01 |
2019-06-06 |
Cellectis |
Reprogramming of genetically engineered primary immune cells
|
WO2019118921A1
(en)
|
2017-12-14 |
2019-06-20 |
Flodesign Sonics, Inc. |
Acoustic transducer drive and controller
|
US11793867B2
(en)
|
2017-12-18 |
2023-10-24 |
Biontech Us Inc. |
Neoantigens and uses thereof
|
US20190194617A1
(en)
*
|
2017-12-22 |
2019-06-27 |
Cell Design Labs, Inc. |
Single- and multi-chain chimeric antigen receptors
|
BR112020011017A2
(pt)
|
2017-12-22 |
2020-11-17 |
Fate Therapeutics, Inc. |
células efetoras imunes intensificadas e uso das mesmas
|
WO2019119822A1
(en)
*
|
2017-12-23 |
2019-06-27 |
Uwell Biopharma Inc. |
Pharmaceutical chimeric receptor composition and method thereof
|
WO2019129850A1
(en)
|
2017-12-29 |
2019-07-04 |
Cellectis |
Off-the-shelf engineered cells for therapy
|
WO2019129851A1
(en)
|
2017-12-29 |
2019-07-04 |
Cellectis |
Method for improving production of car t cells
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
KR20200119242A
(ko)
|
2018-01-08 |
2020-10-19 |
이오반스 바이오테라퓨틱스, 인크. |
종양 항원-특이적 t-세포에 대해 풍부화된 til 생성물의 생성 방법
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
EP3508499A1
(en)
|
2018-01-08 |
2019-07-10 |
iOmx Therapeutics AG |
Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof
|
JP7417542B2
(ja)
|
2018-01-22 |
2024-01-18 |
シアトル チルドレンズ ホスピタル (ディービーエイ シアトル チルドレンズ リサーチ インスティテュート) |
Car t細胞の使用方法
|
EP3694546A1
(en)
|
2018-01-30 |
2020-08-19 |
Cellectis |
Combination comprising allogeneic immune cells deficient for an antigen present on both t-cells and pathological cells and therapeutic antibody against said antigen
|
GB201801920D0
(en)
*
|
2018-02-06 |
2018-03-21 |
Autolus Ltd |
Polypeptides and methods
|
SG11202007622SA
(en)
*
|
2018-02-11 |
2020-09-29 |
Memorial Sloan Kettering Cancer Center |
Non-hla restricted t cell receptors and uses thereof
|
BR112020018173A2
(pt)
*
|
2018-03-09 |
2021-04-27 |
TCR2 Therapeutics Inc. |
composições e métodos para reprogramação de tcr usando proteínas de fusão
|
US20210017248A1
(en)
*
|
2018-03-16 |
2021-01-21 |
The Regents Of The University Of California |
Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells
|
CN111954715A
(zh)
|
2018-03-29 |
2020-11-17 |
菲特治疗公司 |
工程改造的免疫效应细胞和其用途
|
AU2019247199A1
(en)
|
2018-04-05 |
2020-10-15 |
Editas Medicine, Inc. |
T cells expressing a recombinant receptor, related polynucleotides and methods
|
MX2020010460A
(es)
|
2018-04-05 |
2021-01-29 |
Juno Therapeutics Inc |
Receptores de células t, y células diseñadas que expresan los mismos.
|
BR112020020245A2
(pt)
|
2018-04-05 |
2021-04-06 |
Editas Medicine, Inc. |
Métodos de produzir células expressando um receptor recombinante e composições relacionadas
|
WO2019200122A1
(en)
|
2018-04-12 |
2019-10-17 |
Precision Biosciences, Inc. |
Optimized engineered nucleases having specificity for the human t cell receptor alpha constant region gene
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
SG11202010319RA
(en)
|
2018-04-27 |
2020-11-27 |
Iovance Biotherapeutics Inc |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
CA3099364A1
(en)
|
2018-05-11 |
2019-11-14 |
Crispr Therapeutics Ag |
Methods and compositions for treating cancer comprising engineered t cells comprising modified chimeric antigen receptors
|
US20210371932A1
(en)
|
2018-06-01 |
2021-12-02 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
US20210268028A1
(en)
|
2018-07-02 |
2021-09-02 |
Cellectis |
Chimeric antigen receptors (car)-expressing cells and combination treatment for immunotherapy of patients with relapse refractory adverse genetic risk aml
|
MD3823665T2
(ro)
|
2018-07-19 |
2024-05-31 |
Regeneron Pharma |
Receptori antigenci chimerici cu specificitate BCMA și utilizările acestora
|
AU2019312411A1
(en)
*
|
2018-07-26 |
2021-01-07 |
Legend Biotech Ireland Limited |
Nef-containing T cells and methods of producing thereof
|
US20210355522A1
(en)
|
2018-08-20 |
2021-11-18 |
The Broad Institute, Inc. |
Inhibitors of rna-guided nuclease activity and uses thereof
|
US20210177832A1
(en)
|
2018-08-20 |
2021-06-17 |
The Broad Institute, Inc. |
Inhibitors of rna-guided nuclease target binding and uses thereof
|
WO2020041387A1
(en)
|
2018-08-20 |
2020-02-27 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
US20200102370A1
(en)
|
2018-09-28 |
2020-04-02 |
Massachusetts Institute Of Technology |
Collagen-localized immunomodulatory molecules and methods thereof
|
US20210382068A1
(en)
|
2018-10-02 |
2021-12-09 |
Dana-Farber Cancer Institute, Inc. |
Hla single allele lines
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
CR20210295A
(es)
|
2018-11-05 |
2021-07-09 |
Iovance Biotherapeutics Inc |
Procesos para la producción de linfocitos infiltrantes de tumor y usos de estos en inmunoterapia
|
CN113272420A
(zh)
|
2018-11-05 |
2021-08-17 |
艾欧凡斯生物治疗公司 |
经改进的肿瘤反应性t细胞的选择
|
MX2021004775A
(es)
|
2018-11-05 |
2021-06-08 |
Iovance Biotherapeutics Inc |
Expansion de linfocitos infiltrantes de tumores (tils) usando inhibidores de la via de proteina cinasa b (akt).
|
AU2019377422A1
(en)
|
2018-11-05 |
2021-05-27 |
Iovance Biotherapeutics, Inc. |
Treatment of NSCLC patients refractory for anti-PD-1 antibody
|
WO2020097193A1
(en)
|
2018-11-06 |
2020-05-14 |
The Regents Of The University Of California |
Chimeric antigen receptors for phagocytosis
|
AU2019386140A1
(en)
|
2018-11-28 |
2021-06-24 |
Board Of Regents, The University Of Texas System |
Multiplex genome editing of immune cells to enhance functionality and resistance to suppressive environment
|
AU2019386830A1
(en)
|
2018-11-29 |
2021-06-24 |
Board Of Regents, The University Of Texas System |
Methods for ex vivo expansion of natural killer cells and use thereof
|
US20200268797A1
(en)
|
2018-11-30 |
2020-08-27 |
Janssen Biotech, Inc. |
Gamma delta t cells and uses thereof
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
EP3898949A1
(en)
|
2018-12-19 |
2021-10-27 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
WO2020180733A1
(en)
|
2019-03-01 |
2020-09-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
JP2022526908A
(ja)
|
2019-03-19 |
2022-05-27 |
ザ ブロード インスティテュート,インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
MX2021012110A
(es)
|
2019-04-03 |
2022-01-06 |
Prec Biosciences Inc |
Celulas inmunitarias geneticamente modificadas que comprenden un arnhc adaptado a microarn (arnhcmir).
|
EP3959235B1
(en)
*
|
2019-04-26 |
2023-07-26 |
Allogene Therapeutics, Inc. |
Rituximab-resistant chimeric antigen receptors and uses thereof
|
US11013764B2
(en)
|
2019-04-30 |
2021-05-25 |
Myeloid Therapeutics, Inc. |
Engineered phagocytic receptor compositions and methods of use thereof
|
JP2022531185A
(ja)
|
2019-04-30 |
2022-07-06 |
クリスパー セラピューティクス アクチェンゲゼルシャフト |
遺伝子改変t細胞を標的化するcd19を使用するb細胞悪性病変の同種細胞療法
|
EP3736330A1
(en)
|
2019-05-08 |
2020-11-11 |
European Molecular Biology Laboratory |
Modified adeno-associated virus (aav) particles for gene therapy
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
WO2020236967A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Random crispr-cas deletion mutant
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
CA3142425A1
(en)
*
|
2019-06-01 |
2020-12-10 |
Sivec Biotechnologies, Llc |
A bacterial platform for delivery of gene-editing systems to eukaryotic cells
|
US11642409B2
(en)
|
2019-06-26 |
2023-05-09 |
Massachusetts Insttute of Technology |
Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
|
CN114401992A
(zh)
|
2019-07-05 |
2022-04-26 |
艾欧麦克斯治疗股份公司 |
结合igsf11(vsig3)的igc2的抗体及其用途
|
BR112022001148A2
(pt)
|
2019-07-23 |
2022-03-15 |
Inst Nat Sante Rech Med |
Células imunes modificadas, composição farmacêutica, kit, uso de uma célula imune modificada e invenção de produto
|
BR112022001194A2
(pt)
|
2019-07-24 |
2022-06-07 |
Regeneron Pharma |
Receptores de antígeno quimérico com especificidade de mage a4 e usos dos mesmos
|
US20220282333A1
(en)
|
2019-08-13 |
2022-09-08 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
EP4017526A1
(en)
*
|
2019-08-20 |
2022-06-29 |
Precision BioSciences, Inc. |
Lymphodepletion dosing regimens for cellular immunotherapies
|
AU2020337428A1
(en)
|
2019-08-27 |
2022-03-17 |
Janssen Biotech, Inc. |
Chimeric antigen receptor system and uses thereof
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
JP2022546592A
(ja)
|
2019-09-03 |
2022-11-04 |
マイエロイド・セラピューティクス,インコーポレーテッド |
ゲノム組込みのための方法および組成物
|
JP2022547154A
(ja)
|
2019-09-10 |
2022-11-10 |
オブシディアン セラピューティクス, インコーポレイテッド |
調節可能な制御のためのca2-il15融合タンパク質
|
WO2021061648A1
(en)
|
2019-09-23 |
2021-04-01 |
Massachusetts Institute Of Technology |
Methods and compositions for stimulation of endogenous t cell responses
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
US20240139242A1
(en)
|
2019-10-18 |
2024-05-02 |
Trustees Of Boston University |
Cal-t constructs and uses thereof
|
CA3155727A1
(en)
|
2019-10-25 |
2021-04-29 |
Cecile Chartier-Courtaud |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
TW202134429A
(zh)
*
|
2019-11-25 |
2021-09-16 |
國立大學法人京都大學 |
T細胞主細胞庫
|
WO2021108677A1
(en)
*
|
2019-11-27 |
2021-06-03 |
Board Of Regents, The University Of Texas System |
Natural killer cell immunotherapy for the treatment of glioblastoma and other cancers
|
US10980836B1
(en)
|
2019-12-11 |
2021-04-20 |
Myeloid Therapeutics, Inc. |
Therapeutic cell compositions and methods of manufacturing and use thereof
|
CA3161104A1
(en)
|
2019-12-11 |
2021-06-17 |
Cecile Chartier-Courtaud |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
WO2021130250A1
(en)
|
2019-12-23 |
2021-07-01 |
Cellectis |
New mesothelin specific chimeric antigen receptors (car) for solid tumors cancer immunotherapy
|
US11865168B2
(en)
|
2019-12-30 |
2024-01-09 |
Massachusetts Institute Of Technology |
Compositions and methods for treating bacterial infections
|
JP2023511274A
(ja)
|
2020-01-14 |
2023-03-17 |
シンセカイン インコーポレイテッド |
Il2オルソログおよび使用法
|
MX2022010340A
(es)
|
2020-02-24 |
2022-09-19 |
Allogene Therapeutics Inc |
Celulas t con car de bcma con actividades mejoradas.
|
WO2021170089A1
(en)
*
|
2020-02-28 |
2021-09-02 |
The Chinese University Of Hong Kong |
Engineering immune cells via simultaneous knock-in and gene disruption
|
WO2021176373A1
(en)
|
2020-03-03 |
2021-09-10 |
Janssen Biotech, Inc. |
ꝩδ T CELLS AND USES THEREOF
|
US20230149460A1
(en)
|
2020-03-10 |
2023-05-18 |
Massachusetts Institute Of Technology |
Methods for generating engineered memory-like nk cells and compositions thereof
|
BR112022017924A2
(pt)
|
2020-03-10 |
2022-12-20 |
Massachusetts Inst Technology |
Composições e métodos para imunoterapia de câncer npm1c-positivo
|
CN113402612A
(zh)
|
2020-03-17 |
2021-09-17 |
西比曼生物科技(香港)有限公司 |
靶向cd19和cd20的联合嵌合抗原受体及其应用
|
US20210338833A1
(en)
|
2020-05-01 |
2021-11-04 |
Massachusetts Institute Of Technology |
Chimeric antigen receptor-targeting ligands and uses thereof
|
WO2021221783A1
(en)
|
2020-05-01 |
2021-11-04 |
Massachusetts Institute Of Technology |
Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
EP4146812A1
(en)
|
2020-05-06 |
2023-03-15 |
Cellectis S.A. |
Methods for targeted insertion of exogenous sequences in cellular genomes
|
AU2021267940A1
(en)
|
2020-05-08 |
2022-12-08 |
President And Fellows Of Harvard College |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
EP3910331A1
(en)
|
2020-05-15 |
2021-11-17 |
iOmx Therapeutics AG |
Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
|
EP4176261A1
(en)
|
2020-07-03 |
2023-05-10 |
Cellectis S.A. |
Method for determining potency of chimeric antigen receptor expressing immune cells
|
WO2022008027A1
(en)
|
2020-07-06 |
2022-01-13 |
Iomx Therapeutics Ag |
Antibodies binding igv of igsf11 (vsig3) and uses thereof
|
AU2021308078A1
(en)
|
2020-07-17 |
2023-02-09 |
Children's Hospital Los Angeles |
Chimeric MyD88 receptors for redirecting immunosuppressive signaling and related compositions and methods
|
EP4185616A1
(en)
|
2020-07-24 |
2023-05-31 |
Cellectis S.A. |
T-cells expressing immune cell engagers in allogenic settings
|
KR20230074713A
(ko)
|
2020-07-30 |
2023-05-31 |
엥스띠뛰 퀴리 |
Socs1에 결함이 있는 면역 세포
|
WO2022023529A1
(en)
|
2020-07-31 |
2022-02-03 |
Cellectis S.A. |
Dual car-t cells
|
US20220031751A1
(en)
|
2020-08-03 |
2022-02-03 |
Kyverna Therapeutics, Inc. |
Methods of producing t regulatory cells, methods of transducing t cells, and uses of the same
|
WO2022036224A1
(en)
|
2020-08-14 |
2022-02-17 |
H. Lee Moffitt Cancer Center And Research Institute Inc. |
Chimeric antigen receptor t cells for treating autoimmunity
|
EP4225330A1
(en)
|
2020-10-06 |
2023-08-16 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
CA3197423A1
(en)
|
2020-11-04 |
2022-05-12 |
Daniel Getts |
Engineered chimeric fusion protein compositions and methods of use thereof
|
IL302741A
(en)
|
2020-11-11 |
2023-07-01 |
European Molecular Biology Laboratory |
Viral particles adapted for gene therapy
|
WO2022109277A1
(en)
*
|
2020-11-20 |
2022-05-27 |
Pact Pharma, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFβRII ENGINEERED T CELL THERAPY
|
WO2022115611A1
(en)
|
2020-11-25 |
2022-06-02 |
Catamaran Bio, Inc. |
Cellular therapeutics engineered with signal modulators and methods of use thereof
|
US20230416786A1
(en)
|
2020-11-30 |
2023-12-28 |
Cellectis Sa |
Use of aminoquinoline compounds for higher gene integration
|
US11661459B2
(en)
|
2020-12-03 |
2023-05-30 |
Century Therapeutics, Inc. |
Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
|
CA3202473A1
(en)
|
2020-12-17 |
2022-06-23 |
Friedrich Graf Finckenstein |
Treatment of cancers with tumor infiltrating lymphocytes
|
JP2023554395A
(ja)
|
2020-12-17 |
2023-12-27 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Ctla-4及びpd-1阻害剤と併用した腫瘍浸潤リンパ球療法による治療
|
EP4263600A1
(en)
|
2020-12-18 |
2023-10-25 |
Century Therapeutics, Inc. |
Chimeric antigen receptor systems with adaptable receptor specificity
|
CN114656565B
(zh)
*
|
2020-12-23 |
2024-04-23 |
广东菲鹏制药股份有限公司 |
一种抗pd-l1抗体及其应用
|
TW202242117A
(zh)
|
2020-12-30 |
2022-11-01 |
美商亞勞諾斯醫療公司 |
包含多順反子表現卡匣之重組載體及其使用方法
|
EP4284919A1
(en)
|
2021-01-29 |
2023-12-06 |
Iovance Biotherapeutics, Inc. |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
WO2022165419A1
(en)
|
2021-02-01 |
2022-08-04 |
Kyverna Therapeutics, Inc. |
Methods for increasing t-cell function
|
MX2023010916A
(es)
|
2021-03-17 |
2023-12-14 |
Myeloid Therapeutics Inc |
Composiciones de proteinas de fusion quimericas modificadas por ingenieria y metodos de uso de las mismas.
|
EP4308691A1
(en)
|
2021-03-19 |
2024-01-24 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
CN118019546A
(zh)
|
2021-03-23 |
2024-05-10 |
艾欧凡斯生物治疗公司 |
肿瘤浸润淋巴细胞的cish基因编辑及其在免疫疗法中的用途
|
JP2024515189A
(ja)
|
2021-04-19 |
2024-04-05 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
細胞免疫療法におけるキメラ共刺激受容体、ケモカイン受容体、及びそれらの使用
|
EP4330288A1
(en)
|
2021-04-30 |
2024-03-06 |
Cellectis S.A. |
New anti-muc1 cars and gene edited immune cells for solid tumors cancer immunotherapy
|
BR112023023067A2
(pt)
|
2021-05-04 |
2024-01-30 |
Regeneron Pharma |
Receptores de antigénios quiméricos com especificidade mage-a4 e usos dos mesmos
|
CA3219148A1
(en)
|
2021-05-17 |
2022-11-24 |
Frederick G. Vogt |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
EP4341300A1
(en)
|
2021-05-21 |
2024-03-27 |
Cellectis S.A. |
Enhancing efficacy of t-cell-mediated immunotherapy by modulating cancer-associated fibroblasts in solid tumors
|
EP4355358A1
(en)
|
2021-06-15 |
2024-04-24 |
Allogene Therapeutics, Inc. |
Selective targeting of host cd70+ alloreactive cells to prolong allogeneic car t cell persistence
|
EP4373270A2
(en)
|
2021-07-22 |
2024-05-29 |
Iovance Biotherapeutics, Inc. |
Method for cryopreservation of solid tumor fragments
|
WO2023009716A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
TW202321287A
(zh)
|
2021-07-29 |
2023-06-01 |
日商武田藥品工業股份有限公司 |
特異性靶向間皮素之經工程改造之免疫細胞及其用途
|
IL310550A
(en)
|
2021-08-04 |
2024-03-01 |
Univ Colorado Regents |
LAT-activating chimeric antigen receptor T cells and methods of using them
|
TW202328439A
(zh)
|
2021-09-09 |
2023-07-16 |
美商艾歐凡斯生物治療公司 |
使用pd-1 talen基因減弱生成til產物之方法
|
AR127482A1
(es)
|
2021-10-27 |
2024-01-31 |
Iovance Biotherapeutics Inc |
Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente
|
WO2023081715A1
(en)
|
2021-11-03 |
2023-05-11 |
Viracta Therapeutics, Inc. |
Combination of car t-cell therapy with btk inhibitors and methods of use thereof
|
WO2023081900A1
(en)
|
2021-11-08 |
2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
CA3238700A1
(en)
|
2021-11-23 |
2022-11-23 |
Philippe Duchateau |
New tale protein scaffolds with improved on-target/off-target activity ratios
|
WO2023126458A1
(en)
|
2021-12-28 |
2023-07-06 |
Mnemo Therapeutics |
Immune cells with inactivated suv39h1 and modified tcr
|
WO2023133509A2
(en)
*
|
2022-01-08 |
2023-07-13 |
Carogen Corporation |
Multi-antigen therapeutic vaccines to treat or prevent chronic hepatitis b virus infection
|
WO2023147488A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023220608A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
EP4279085A1
(en)
|
2022-05-20 |
2023-11-22 |
Mnemo Therapeutics |
Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
|
WO2023233003A1
(en)
|
2022-06-03 |
2023-12-07 |
Cellectis Sa |
Tale base editors for gene and cell therapy
|
WO2024003334A1
(en)
|
2022-06-30 |
2024-01-04 |
Cellectis S.A. |
Enhancing safety of t-cell-mediated immunotherapy
|
WO2024022509A1
(en)
*
|
2022-07-29 |
2024-02-01 |
Nanjing Legend Biotech Co., Ltd. |
Methods for promoting persistence of cell therapy
|
WO2024055017A1
(en)
|
2022-09-09 |
2024-03-14 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products using pd-1/tigit talen double knockdown
|
WO2024055018A1
(en)
|
2022-09-09 |
2024-03-14 |
Iovance Biotherapeutics, Inc. |
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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