US7262055B2
(en)
|
1998-08-25 |
2007-08-28 |
Gendaq Limited |
Regulated gene expression in plants
|
US7285416B2
(en)
|
2000-01-24 |
2007-10-23 |
Gendaq Limited |
Regulated gene expression in plants
|
USRE45721E1
(en)
|
1994-08-20 |
2015-10-06 |
Gendaq, Ltd. |
Relating to binding proteins for recognition of DNA
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
ES2341926T3
(es)
*
|
1998-03-02 |
2010-06-29 |
Massachusetts Institute Of Technology |
Poliproteinas con dedos de cinc que tienen enlazadores mejorados.
|
EP1064369B1
(de)
|
1998-03-17 |
2006-08-16 |
Gendaq Limited |
Nukleinsäurebindungsproteine
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
US7943731B1
(en)
*
|
1999-08-11 |
2011-05-17 |
Massachusetts Institute Of Technology |
Dimerizing peptides
|
US7329728B1
(en)
|
1999-10-25 |
2008-02-12 |
The Scripps Research Institute |
Ligand activated transcriptional regulator proteins
|
ATE309536T1
(de)
|
1999-12-06 |
2005-11-15 |
Sangamo Biosciences Inc |
Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
|
US7462354B2
(en)
*
|
1999-12-28 |
2008-12-09 |
Pharmexa Inc. |
Method and system for optimizing minigenes and peptides encoded thereby
|
AU2693501A
(en)
|
2000-01-24 |
2001-07-31 |
Gendaq Ltd |
Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
|
ATE483970T1
(de)
|
2000-02-08 |
2010-10-15 |
Sangamo Biosciences Inc |
Zellen zur entdeckung von medikamenten
|
US20030049649A1
(en)
*
|
2000-04-28 |
2003-03-13 |
Wolffe Alan P. |
Targeted modification of chromatin structure
|
AU2001257421A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
|
AU2001257331A1
(en)
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
US7923542B2
(en)
|
2000-04-28 |
2011-04-12 |
Sangamo Biosciences, Inc. |
Libraries of regulatory sequences, methods of making and using same
|
AU5391401A
(en)
*
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences Inc |
Targeted modification of chromatin structure
|
AU2001255748B2
(en)
*
|
2000-04-28 |
2006-08-10 |
Sangamo Therapeutics, Inc. |
Methods for binding an exogenous molecule to cellular chromatin
|
AU2001255870B2
(en)
|
2000-04-28 |
2006-07-13 |
Sangamo Biosciences, Inc. |
Databases of regulatory sequences; methods of making and using same
|
CN1328040A
(zh)
*
|
2000-06-12 |
2001-12-26 |
上海博德基因开发有限公司 |
一种新的多肽——人锌指蛋白18.04和编码这种多肽的多核苷酸
|
CN1331219A
(zh)
*
|
2000-06-30 |
2002-01-16 |
上海博德基因开发有限公司 |
一种新的多肽——人锌指蛋白18.92和编码这种多肽的多核苷酸
|
US7011972B2
(en)
|
2000-07-18 |
2006-03-14 |
The Scripps Research Institute |
Fusion polypeptide comprising two ligand binding domains
|
AU2884102A
(en)
|
2000-12-07 |
2002-06-18 |
Sangamo Biosciences Inc |
Regulation of angiogenesis with zinc finger proteins
|
US7067317B2
(en)
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
US7273923B2
(en)
|
2001-01-22 |
2007-09-25 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
AU2002225187A1
(en)
|
2001-01-22 |
2002-07-30 |
Sangamo Biosciences, Inc. |
Zinc finger polypeptides and their use
|
JP4128955B2
(ja)
*
|
2001-08-17 |
2008-07-30 |
トゥールゲン・インコーポレイテッド |
ジンクフィンガードメインライブラリー
|
WO2003048345A1
(en)
*
|
2001-12-07 |
2003-06-12 |
Toolgen, Inc. |
Phenotypic screen of chimeric proteins
|
US7262054B2
(en)
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
CA2474486C
(en)
|
2002-01-23 |
2013-05-14 |
The University Of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
EP2368982A3
(de)
*
|
2002-03-21 |
2011-10-12 |
Sangamo BioSciences, Inc. |
Verfahren und Zusammensetzungen zur Verwendung von Zinkfinger-Endonukleasen zur Verbesserung der homologen Rekombination
|
AU2003262788A1
(en)
*
|
2002-08-23 |
2004-03-11 |
Sangamo Biosciences, Inc. |
High-throughput screen for modulators of chromatin modifying activity
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
CA2497913C
(en)
*
|
2002-09-05 |
2014-06-03 |
California Institute Of Technology |
Use of chimeric nucleases to stimulate gene targeting
|
AU2003302752A1
(en)
*
|
2002-12-09 |
2004-06-30 |
Toolgen, Inc. |
Regulatory zinc finger proteins
|
US11311574B2
(en)
|
2003-08-08 |
2022-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
AU2004263865B2
(en)
|
2003-08-08 |
2007-05-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US8409861B2
(en)
*
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
CA2579677A1
(en)
|
2004-09-16 |
2006-03-30 |
Sangamo Biosciences, Inc. |
Compositions and methods for protein production
|
EP2166097B1
(de)
|
2004-10-05 |
2014-08-06 |
SunGene GmbH |
Konstitutive Expressionskassetten zur Regulation der Pflanzenexpression
|
EP1655364A3
(de)
|
2004-11-05 |
2006-08-02 |
BASF Plant Science GmbH |
Expressionskassetten zur bevorzugten Expression in Pflanzensamen
|
EP1662000B1
(de)
|
2004-11-25 |
2011-03-30 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in pflanzlichen Schliesszellen
|
EP1666599A3
(de)
|
2004-12-04 |
2006-07-12 |
SunGene GmbH |
Expressionskassetten zur bevorzugten Expression in Mesophyll- und/oder Epidermiszellen in Pflanzen
|
EP2163634A1
(de)
|
2004-12-08 |
2010-03-17 |
SunGene GmbH |
Expressionskassetten zur vaskularen, gewebebevorzugten Expression bei Pflanzen
|
EP1669456A3
(de)
|
2004-12-11 |
2006-07-12 |
SunGene GmbH |
Expressionskasseten für meristembevorzugte Expression in Pflanzen
|
WO2006084868A2
(en)
|
2005-02-09 |
2006-08-17 |
Basf Plant Science Gmbh |
Expression cassettes for regulation of expression in monocotyledonous plants
|
US20090031440A1
(en)
|
2005-02-26 |
2009-01-29 |
Basf Plant Science Gmbh |
Expression Cassettes for Seed-Preferential Expression in Plants
|
JP4988606B2
(ja)
*
|
2005-02-28 |
2012-08-01 |
サンガモ バイオサイエンシズ インコーポレイテッド |
抗血管新生方法及び組成物
|
WO2006120197A2
(en)
|
2005-05-10 |
2006-11-16 |
Basf Plant Science Gmbh |
Expression cassettes for seed-preferential expression in plants
|
WO2007014275A2
(en)
*
|
2005-07-26 |
2007-02-01 |
Sangamo Biosciences, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
US7919583B2
(en)
*
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
US20070154989A1
(en)
*
|
2006-01-03 |
2007-07-05 |
The Scripps Research Institute |
Zinc finger domains specifically binding agc
|
US8318155B2
(en)
|
2006-03-08 |
2012-11-27 |
Kyoto University |
Nucleic acid cleaving agent
|
PL2049663T3
(pl)
|
2006-08-11 |
2015-08-31 |
Dow Agrosciences Llc |
Homologiczna rekombinacja za pośrednictwem nukleazy z palcami cynkowymi
|
KR100812110B1
(ko)
*
|
2006-10-24 |
2008-03-12 |
한국과학기술원 |
징크 핑거 단백질과 원핵 생물의 전사 인자를 포함하는인공 전사 인자의 제조 및 이의 이용
|
EP2092068B1
(de)
|
2006-12-14 |
2014-10-08 |
Dow AgroSciences LLC |
Optimierte nichtkanonische Zinkfingerproteine
|
AU2008214568B2
(en)
|
2007-02-16 |
2013-04-18 |
Basf Plant Science Gmbh |
Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants
|
US8748146B2
(en)
*
|
2007-04-19 |
2014-06-10 |
Celexion, Llc |
Engineered nucleases and their uses for nucleic acid assembly
|
US8110379B2
(en)
|
2007-04-26 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Targeted integration into the PPP1R12C locus
|
AU2008275649B2
(en)
|
2007-07-12 |
2013-09-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT 8) gene expression
|
WO2009018576A1
(en)
*
|
2007-08-02 |
2009-02-05 |
Biodesic |
Compositions and methods for analyte detection and quantitation
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
WO2009042163A2
(en)
*
|
2007-09-27 |
2009-04-02 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
US8399218B2
(en)
|
2007-09-27 |
2013-03-19 |
Dow Agrosciences, Llc |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
|
MX2010005693A
(es)
|
2007-12-03 |
2010-06-01 |
Syngenta Participations Ag |
Proteinas suceptibles diseñadas enzimaticamente.
|
WO2009131632A1
(en)
|
2008-04-14 |
2009-10-29 |
Sangamo Biosciences, Inc. |
Linear donor constructs for targeted integration
|
ES2551318T3
(es)
|
2008-04-21 |
2015-11-18 |
Danziger Innovations Ltd. |
Vectores de expresión virales de plantas y uso de los mismos para generar variaciones genotípicas en genomas de plantas
|
WO2009134409A2
(en)
|
2008-04-30 |
2009-11-05 |
Sanbio, Inc. |
Neural regenerating cells with alterations in dna methylation
|
US9394531B2
(en)
|
2008-05-28 |
2016-07-19 |
Sangamo Biosciences, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
EP2910568B1
(de)
*
|
2008-06-10 |
2018-08-22 |
Sangamo Therapeutics, Inc. |
Verfahren und Zusammensetzungen zur Erzeugung von BAX- und BAK-Mangel-Zelllinien
|
CN102123778B
(zh)
*
|
2008-08-14 |
2014-10-29 |
李伟德 |
利用离心力的动态过滤装置
|
EP2313515B1
(de)
|
2008-08-22 |
2015-03-04 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen für gezielte einzelstrangspaltung und gezielte integration
|
AU2009311697B2
(en)
|
2008-10-29 |
2014-12-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for inactivating glutamine synthetase gene expression
|
US20110023150A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of genes associated with schizophrenia in animals
|
ES2627552T3
(es)
|
2008-12-04 |
2017-07-28 |
Sigma Aldrich Company |
Edición de genoma en ratas usando nucleasas con dedos de cinc
|
US20110023141A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved with parkinson's disease
|
US20110023145A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in autism spectrum disorders
|
US20110023146A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in secretase-associated disorders
|
US20110023154A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Silkworm genome editing with zinc finger nucleases
|
US20110016541A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of sensory-related genes in animals
|
US20110023153A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
US20110023143A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of neurodevelopmental genes in animals
|
US20110023147A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of prion disorder-related genes in animals
|
US20110016540A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
US20110016539A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
US20110023158A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Bovine genome editing with zinc finger nucleases
|
US20110023152A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of cognition related genes in animals
|
US20110023156A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Feline genome editing with zinc finger nucleases
|
US20110016543A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in inflammation
|
US20110023148A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of addiction-related genes in animals
|
US20110023159A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Ovine genome editing with zinc finger nucleases
|
US20110023140A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Rabbit genome editing with zinc finger nucleases
|
US20110023157A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Equine genome editing with zinc finger nucleases
|
US20110030072A1
(en)
*
|
2008-12-04 |
2011-02-03 |
Sigma-Aldrich Co. |
Genome editing of immunodeficiency genes in animals
|
US20110023149A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in tumor suppression in animals
|
US20110023151A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of abc transporters
|
US20110016546A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Porcine genome editing with zinc finger nucleases
|
US20110023144A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
|
US20110023139A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
US20110016542A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Canine genome editing with zinc finger nucleases
|
CA2747124C
(en)
|
2008-12-17 |
2018-09-04 |
Dow Agrosciences Llc |
Targeted integration into the zp15 locus
|
EP2393506B1
(de)
|
2009-02-04 |
2018-03-28 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von nervenleiden
|
JP6215533B2
(ja)
*
|
2009-04-09 |
2017-10-18 |
サンガモ セラピューティクス, インコーポレイテッド |
幹細胞への標的組込み
|
US8772008B2
(en)
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
WO2011002503A1
(en)
|
2009-06-30 |
2011-01-06 |
Sangamo Biosciences, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
JP5866283B2
(ja)
|
2009-07-28 |
2016-02-17 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
トリヌクレオチド反復疾患を治療するための方法および組成物
|
AU2010279572B2
(en)
*
|
2009-08-03 |
2017-02-02 |
Recombinetics, Inc. |
Methods and compositions for targeted gene modification
|
EP3156504B1
(de)
*
|
2009-08-11 |
2018-10-31 |
Sangamo Therapeutics, Inc. |
Für gezielte modifikation homozygote organismen
|
WO2011048600A1
(en)
|
2009-10-21 |
2011-04-28 |
Danziger Innovations Ltd. |
Generating genotypic variations in plant genomes by gamete infection
|
ES2646138T3
(es)
|
2009-10-22 |
2017-12-12 |
Sangamo Biosciences, Inc. |
Proteínas de dedos de cinc manipuladas genéticamente dirigidas a los genes de planta involucrados en la biosíntesis de ácidos grasos
|
DE112010004582T5
(de)
|
2009-11-27 |
2012-11-29 |
Basf Plant Science Company Gmbh |
Optimierte Endonukleasen und Anwendungen davon
|
US9420770B2
(en)
|
2009-12-01 |
2016-08-23 |
Indiana University Research & Technology Corporation |
Methods of modulating thrombocytopenia and modified transgenic pigs
|
US10260062B2
(en)
*
|
2010-01-22 |
2019-04-16 |
Sangamo Therapeutics, Inc. |
Targeted genomic alteration
|
EP2660318A1
(de)
|
2010-02-09 |
2013-11-06 |
Sangamo BioSciences, Inc. |
Gezielte Genommodifikation mit partiell einzelsträngigen Donatormolekülen
|
WO2011102796A1
(en)
*
|
2010-02-18 |
2011-08-25 |
Elmar Nurmemmedov |
Novel synthetic zinc finger proteins and their spatial design
|
US8771985B2
(en)
|
2010-04-26 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Genome editing of a Rosa locus using zinc-finger nucleases
|
US8772453B2
(en)
|
2010-05-03 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Compositions for linking zinc finger modules
|
CN103025344B
(zh)
|
2010-05-17 |
2016-06-29 |
桑格摩生物科学股份有限公司 |
新型dna-结合蛋白及其用途
|
CA2805442C
(en)
|
2010-07-21 |
2020-05-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of an hla locus
|
JP2013537410A
(ja)
|
2010-07-23 |
2013-10-03 |
シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー |
標的化エンドヌクレアーゼおよび一本鎖核酸を用いたゲノム編集
|
US9566352B2
(en)
|
2010-09-27 |
2017-02-14 |
Sangamo Biosciences, Inc. |
Methods and compositions for inhibiting viral entry into cells
|
BR112013008881B1
(pt)
|
2010-10-12 |
2021-12-07 |
The Children's Hospital Of Philadelphia |
Proteína de ocorrência não natural, nuclease de dedo de zinco, e composição
|
WO2012092379A2
(en)
|
2010-12-29 |
2012-07-05 |
Sigma-Aldrich Co. Llc |
Cells having disrupted expression of proteins involved in adme and toxicology processes
|
WO2012094132A1
(en)
|
2011-01-05 |
2012-07-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
CA2828196A1
(en)
|
2011-03-18 |
2012-09-27 |
Basf Plant Science Company Gmbh |
Promoters for regulating expression in plants
|
US20140186340A1
(en)
|
2011-04-08 |
2014-07-03 |
Gilead Biologics, Inc. |
Methods and Compositions for Normalization of Tumor Vasculature by Inhibition of LOXL2
|
WO2012168910A1
(en)
|
2011-06-10 |
2012-12-13 |
Basf Plant Science Company Gmbh |
Nuclease fusion protein and uses thereof
|
EP2726604B1
(de)
|
2011-06-30 |
2018-04-04 |
Sigma Aldrich Co. LLC |
Zellen mit mangel an cmp-n-acetylneuraminsäure-hydroxylase und/oder glycoprotein-alpha-1,3-galactosyltransferase
|
WO2013016446A2
(en)
|
2011-07-25 |
2013-01-31 |
Sangamo Biosciences, Inc. |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
|
IL277027B
(en)
|
2011-09-21 |
2022-07-01 |
Sangamo Therapeutics Inc |
Methods and preparations for regulating transgene expression
|
WO2013059507A1
(en)
|
2011-10-20 |
2013-04-25 |
University Of Iowa Research Foundation |
N-demethyase genes and uses thereof
|
CA3099582A1
(en)
|
2011-10-27 |
2013-05-02 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the hprt locus
|
AU2012340213B2
(en)
|
2011-11-16 |
2017-12-07 |
Sangamo Therapeutics, Inc. |
Modified DNA-binding proteins and uses thereof
|
US8450107B1
(en)
|
2011-11-30 |
2013-05-28 |
The Broad Institute Inc. |
Nucleotide-specific recognition sequences for designer TAL effectors
|
US9376484B2
(en)
|
2012-01-11 |
2016-06-28 |
Sigma-Aldrich Co. Llc |
Production of recombinant proteins with simple glycoforms
|
WO2013112917A1
(en)
|
2012-01-27 |
2013-08-01 |
Sanbio, Inc. |
Methods and compositions for modulating angiogenesis and vasculogenesis
|
JP6309461B2
(ja)
|
2012-02-28 |
2018-04-11 |
シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC |
ヒストンアセチル化の標的化
|
CN104204225A
(zh)
|
2012-02-29 |
2014-12-10 |
桑格摩生物科学股份有限公司 |
治疗亨廷顿氏病的方法和组合物
|
RU2658437C2
(ru)
|
2012-05-02 |
2018-06-21 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Направленная модификация малатдегидрогеназы
|
CA2871524C
(en)
|
2012-05-07 |
2021-07-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for nuclease-mediated targeted integration of transgenes
|
EP2861740A1
(de)
|
2012-06-15 |
2015-04-22 |
University of Iowa Research Foundation |
Koffeinreaktive promotoren und regulatorische gene
|
JP6329537B2
(ja)
|
2012-07-11 |
2018-05-23 |
サンガモ セラピューティクス, インコーポレイテッド |
生物学的薬剤の送達のための方法および組成物
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
DK3196301T3
(en)
|
2012-07-11 |
2019-01-14 |
Sangamo Therapeutics Inc |
METHODS AND COMPOSITIONS FOR TREATING MONOGENIC DISEASES
|
DK2890780T3
(da)
|
2012-08-29 |
2020-09-21 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
RU2665811C2
(ru)
|
2012-09-07 |
2018-09-04 |
ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи |
Локусы fad3 для выполнения операций и соответствующие связывающиеся со специфическими сайтами-мишенями белки, способные к вызову направленных разрывов
|
WO2014059173A2
(en)
|
2012-10-10 |
2014-04-17 |
Sangamo Biosciences, Inc. |
T cell modifying compounds and uses thereof
|
JP2016500254A
(ja)
|
2012-12-05 |
2016-01-12 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
代謝疾患の調節のための方法および組成物
|
RU2015128052A
(ru)
|
2012-12-13 |
2017-01-19 |
Дау Агросайенсиз Ллс |
Точный таргетинг генов в отношении конкретного локуса кукурузы
|
KR20220139433A
(ko)
|
2012-12-17 |
2022-10-14 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Rna-가이드된 인간 게놈 조작
|
AU2014218621B2
(en)
|
2013-02-25 |
2019-11-07 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
WO2014182700A1
(en)
|
2013-05-10 |
2014-11-13 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
DE102013106462B3
(de)
*
|
2013-06-20 |
2014-10-09 |
Airbus Defence and Space GmbH |
Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein
|
AU2014312295C1
(en)
|
2013-08-28 |
2020-08-13 |
Sangamo Therapeutics, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
EP3057432B1
(de)
|
2013-10-17 |
2018-11-21 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen für nukleasevermitteltes genom-engineering in hämotopoietischen stammzellen
|
AU2014337248B2
(en)
|
2013-10-17 |
2020-09-24 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
UA120503C2
(uk)
|
2013-11-04 |
2019-12-26 |
Дау Агросайєнсиз Елелсі |
Спосіб одержання трансгенної клітини рослини кукурудзи
|
EP3065540B1
(de)
|
2013-11-04 |
2021-12-15 |
Corteva Agriscience LLC |
Optimale maispflanzen
|
EP3066202B1
(de)
|
2013-11-04 |
2021-03-03 |
Dow AgroSciences LLC |
Optimale sojabohnen-loci
|
MX362066B
(es)
|
2013-11-04 |
2019-01-07 |
Dow Agrosciences Llc |
Loci óptimos de soya.
|
EP3068905A4
(de)
|
2013-11-11 |
2017-07-05 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen zur behandlung der huntington-krankheit
|
DK3492593T3
(da)
|
2013-11-13 |
2021-11-08 |
Childrens Medical Center |
Nukleasemedieret regulering af genekspression
|
EP3080143B1
(de)
|
2013-12-09 |
2019-02-20 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von hämophilie
|
PT3102673T
(pt)
|
2014-02-03 |
2020-05-21 |
Sangamo Biosciences Inc |
Métodos e composições para tratamento de beta-talassemia
|
EP3110454B1
(de)
|
2014-02-24 |
2020-11-18 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur nukleasevermittelten gezielten integration
|
ES2797050T3
(es)
|
2014-03-04 |
2020-12-01 |
Sigma Aldrich Co Llc |
Células virales resistentes y sus usos
|
CA2942762C
(en)
|
2014-03-18 |
2023-10-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
US20150301030A1
(en)
|
2014-04-22 |
2015-10-22 |
Q-State Biosciences, Inc. |
Models for parkinson's disease studies
|
CA2947622A1
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Genome editing methods and compositions for prevention or treatment of a disease
|
FI3169778T3
(fi)
|
2014-07-14 |
2023-12-13 |
Univ Washington State |
Ituradan soluja ablatoiva nanos-geeninpoisto
|
WO2016014837A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Gene editing for hiv gene therapy
|
WO2016014794A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
WO2016019144A2
(en)
|
2014-07-30 |
2016-02-04 |
Sangamo Biosciences, Inc. |
Gene correction of scid-related genes in hematopoietic stem and progenitor cells
|
CN106536721B
(zh)
|
2014-08-06 |
2020-12-04 |
车医科学大学校产学协力团 |
核酸酶介导的编辑编码hla的基因所产生的免疫相容性细胞
|
EP3878948A1
(de)
|
2014-09-16 |
2021-09-15 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen für nukleasevermitteltes genom-engineering und korrektur bei hämotopoietischen stammzellen
|
US11352666B2
(en)
|
2014-11-14 |
2022-06-07 |
Institute For Basic Science |
Method for detecting off-target sites of programmable nucleases in a genome
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
US20180002379A1
(en)
|
2015-01-21 |
2018-01-04 |
Sangamo Therapeutics, Inc. |
Methods and compositions for identification of highly specific nucleases
|
US10048275B2
(en)
|
2015-03-13 |
2018-08-14 |
Q-State Biosciences, Inc. |
Cardiotoxicity screening methods
|
JP2018513681A
(ja)
|
2015-03-31 |
2018-05-31 |
エクセリゲン サイエンティフィック, インコーポレイテッドExeligen Scientific, Inc. |
細胞または生物のゲノムへのDNA配列の標的化組み込みのためのCas9レトロウイルスインテグラーゼおよびCas9レコンビナーゼ系
|
EP3277823B1
(de)
|
2015-04-03 |
2023-09-13 |
Dana-Farber Cancer Institute, Inc. |
Zusammensetzung und verfahren zur genomänderung von b-zellen
|
CN108026566A
(zh)
|
2015-05-04 |
2018-05-11 |
特拉维夫大学拉莫特有限公司 |
用于使dna片段化的方法和试剂盒
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
IL284707B2
(en)
|
2015-05-12 |
2024-01-01 |
Sangamo Therapeutics Inc |
Regulation of nuclease-mediated gene expression
|
EP3298448A4
(de)
|
2015-05-21 |
2019-03-27 |
Q-State Biosciences, Inc. |
Optogenetisches mikroskop
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
WO2017011519A1
(en)
|
2015-07-13 |
2017-01-19 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
EP4361279A2
(de)
|
2015-08-06 |
2024-05-01 |
The Curators of the University of Missouri |
Pathogenresistente tiere mit modifizierten cd163-genen
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
CA3005878A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
US10639383B2
(en)
|
2015-11-23 |
2020-05-05 |
Sangamo Therapeutics, Inc. |
Methods and compositions for engineering immunity
|
AU2016369490C1
(en)
|
2015-12-18 |
2021-12-23 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
WO2017106537A2
(en)
|
2015-12-18 |
2017-06-22 |
Sangamo Biosciences, Inc. |
Targeted disruption of the mhc cell receptor
|
WO2017123556A1
(en)
|
2016-01-11 |
2017-07-20 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric proteins and methods of immunotherapy
|
IL304088A
(en)
|
2016-01-11 |
2023-08-01 |
Univ Leland Stanford Junior |
Systems containing chimeric proteins and their uses for controlling gene expression
|
AU2017207818B2
(en)
|
2016-01-15 |
2024-03-28 |
Regents Of The University Of Minnesota |
Methods and compositions for the treatment of neurologic disease
|
EP3411056A4
(de)
|
2016-02-02 |
2019-10-02 |
Sangamo Therapeutics, Inc. |
Zusammensetzungen zur vernetzung von dna-bindungsdomänen und -spaltungsdomänen
|
WO2018005445A1
(en)
|
2016-06-27 |
2018-01-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
JP7033583B2
(ja)
|
2016-07-13 |
2022-03-10 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ゲノム編集効率を高めるための方法、組成物及びキット
|
AU2017295898B2
(en)
|
2016-07-15 |
2023-08-17 |
Salk Institute For Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
JP2019520844A
(ja)
|
2016-07-21 |
2019-07-25 |
マックスサイト インコーポレーティッド |
ゲノムdnaを改変するための方法および組成物
|
AU2017315406B2
(en)
|
2016-08-24 |
2021-04-01 |
Sangamo Therapeutics, Inc. |
Regulation of gene expression using engineered nucleases
|
SG10201913948PA
(en)
|
2016-08-24 |
2020-03-30 |
Sangamo Therapeutics Inc |
Engineered target specific nucleases
|
CA3035534A1
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
WO2018053597A1
(en)
|
2016-09-23 |
2018-03-29 |
Csl Limited |
Coagulation factor binding proteins and uses thereof
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
EP3528852A4
(de)
|
2016-10-20 |
2020-06-03 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von morbus fabry
|
EP3532106A4
(de)
|
2016-10-31 |
2020-06-24 |
Sangamo Therapeutics, Inc. |
Genkorrektur von scid-assoziierten genen bei hämotopoietischen stammzellen und vorläuferzellen
|
US20190264218A1
(en)
|
2016-11-04 |
2019-08-29 |
Flagship Pioneering Innovations V, Inc. |
Novel Plant Cells, Plants, and Seeds
|
US11504389B2
(en)
|
2016-12-01 |
2022-11-22 |
Sangamo Therapeutics, Inc. |
Tau modulators and methods and compositions for delivery thereof
|
CN110249051A
(zh)
|
2016-12-08 |
2019-09-17 |
凯斯西储大学 |
增强功能性髓鞘产生的方法和组合物
|
US20190390241A1
(en)
|
2017-01-24 |
2019-12-26 |
Sigma-Aldrich Co. Llc |
Viral resistant cells and culture systems
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
BR112019020777A2
(pt)
|
2017-04-03 |
2020-04-28 |
Encoded Therapeutics Inc |
expressão de transgene seletiva para tecido
|
WO2018191520A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
EP3610266A4
(de)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
Tumorsignatur für metastasen, zusammensetzungen von substanzen und verwendung davon
|
US20200384115A1
(en)
|
2017-04-21 |
2020-12-10 |
The Broad Institute , Inc. |
Targeted delivery to beta cells
|
AU2018256877B2
(en)
|
2017-04-28 |
2022-06-02 |
Acuitas Therapeutics, Inc. |
Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
WO2018204469A2
(en)
|
2017-05-03 |
2018-11-08 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (cftr) gene
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
WO2019103857A1
(en)
|
2017-11-22 |
2019-05-31 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
WO2018209378A1
(en)
*
|
2017-05-18 |
2018-11-22 |
Portagrid Systems Pty Ltd |
Portable power station and array module attachment therefor
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
JP7454494B2
(ja)
|
2017-06-26 |
2024-03-22 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
標的化された核酸編集のためのcrispr/cas-アデニンデアミナーゼ系の組成物、系及び方法
|
EP3692152A4
(de)
|
2017-10-04 |
2021-12-01 |
The Broad Institute, Inc. |
Verfahren und zusammensetzungen zur veränderung der funktion und struktur von chromatinschleifen und/oder -domänen
|
KR20200079539A
(ko)
|
2017-11-09 |
2020-07-03 |
상가모 테라퓨틱스, 인코포레이티드 |
시토카인 유도성 sh2-함유 단백질 (cish) 유전자의 유전자 변형
|
WO2019094983A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
|
EP3710576A1
(de)
|
2017-11-17 |
2020-09-23 |
Iovance Biotherapeutics, Inc. |
Til-expansion von feinnadelaspiraten und kleinen biopsien
|
MA51619A
(fr)
|
2018-01-17 |
2021-04-14 |
Vertex Pharma |
Inhibiteurs de la protéine kinase dépendante de l'adn
|
US20200361877A1
(en)
|
2018-01-17 |
2020-11-19 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
IL276082B2
(en)
|
2018-01-17 |
2024-01-01 |
Vertex Pharma |
DNA-PK inhibitor compounds, preparations containing them and their uses
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
KR20200118468A
(ko)
|
2018-02-08 |
2020-10-15 |
상가모 테라퓨틱스, 인코포레이티드 |
조작된 표적 특이적 뉴클레아제
|
EP3772928A4
(de)
|
2018-04-06 |
2021-12-29 |
Children's Medical Center Corporation |
Zusammensetzungen und verfahren zur prägung der umprogrammierung und modulation von somatischen zellen
|
US11421007B2
(en)
|
2018-04-18 |
2022-08-23 |
Sangamo Therapeutics, Inc. |
Zinc finger protein compositions for modulation of huntingtin (Htt)
|
ES2922902T3
(es)
|
2018-04-24 |
2022-09-21 |
Kws Saat Se & Co Kgaa |
Plantas con digestibilidad mejorada y haplotipos marcadores
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
CA3098303A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
US20210386829A1
(en)
|
2018-05-04 |
2021-12-16 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
CN112118859A
(zh)
|
2018-05-16 |
2020-12-22 |
杰特有限公司 |
1型可溶性补体受体变体及其用途
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
EP3802839A1
(de)
|
2018-06-07 |
2021-04-14 |
The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center) |
Nukleinsäurekonstrukte und verfahren zu deren verwendung
|
CN112384063A
(zh)
|
2018-06-07 |
2021-02-19 |
以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 |
再生及转殖大麻的方法
|
CN108802357B
(zh)
*
|
2018-06-27 |
2021-03-30 |
中南民族大学 |
一种用于免疫印迹分析的生物发光探针及其应用
|
WO2020006409A1
(en)
|
2018-06-28 |
2020-01-02 |
Trustees Of Boston University |
Systems and methods for control of gene expression
|
WO2020041380A1
(en)
|
2018-08-20 |
2020-02-27 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
KR20210049124A
(ko)
|
2018-08-23 |
2021-05-04 |
상가모 테라퓨틱스, 인코포레이티드 |
조작된 표적 특이적 염기 편집기
|
EP3849565A4
(de)
|
2018-09-12 |
2022-12-28 |
Fred Hutchinson Cancer Research Center |
Verminderung der cd33-expression zum selektiven schutz von therapeutischen zellen
|
US20210317430A1
(en)
|
2018-09-18 |
2021-10-14 |
Sangamo Therapeutics, Inc. |
Programmed cell death 1 (pd1) specific nucleases
|
KR20210070305A
(ko)
|
2018-09-18 |
2021-06-14 |
브이엔브이 뉴코 인크. |
Arc 기반 캡시드 및 이의 용도
|
JP2022512579A
(ja)
*
|
2018-10-02 |
2022-02-07 |
サンガモ セラピューティクス, インコーポレイテッド |
タウタンパク質のモジュレーションのための方法および組成物
|
WO2020077236A1
(en)
|
2018-10-12 |
2020-04-16 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
CN113348247A
(zh)
|
2018-10-15 |
2021-09-03 |
泰莱托恩基金会 |
基因组编辑方法与构建体
|
WO2020081730A2
(en)
|
2018-10-16 |
2020-04-23 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating microenvironment
|
CN113272420A
(zh)
|
2018-11-05 |
2021-08-17 |
艾欧凡斯生物治疗公司 |
经改进的肿瘤反应性t细胞的选择
|
WO2020096927A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
JOP20210094A1
(ar)
|
2018-11-05 |
2023-01-30 |
Iovance Biotherapeutics Inc |
عمليات لإنتاج الخلايا الليمفاوية للورم الارتشاحي واستخداماتها في العلاج المناعي
|
BR112021008549A2
(pt)
|
2018-11-05 |
2022-01-04 |
Iovance Biotherapeutics Inc |
Método de tratamento de carcinoma pulmonar de células não pequenas com uma população de linfócitos infiltrantes de tumor
|
WO2020131862A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
WO2020131547A1
(en)
|
2018-12-19 |
2020-06-25 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
CA3125485A1
(en)
|
2019-01-11 |
2020-07-16 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
EP3826664A4
(de)
|
2019-02-06 |
2022-10-26 |
Sangamo Therapeutics, Inc. |
Verfahren zur behandlung von mukopolysaccharidose typ i
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
KR20210136050A
(ko)
|
2019-03-01 |
2021-11-16 |
이오반스 바이오테라퓨틱스, 인크. |
액상 종양으로부터의 종양 침윤 림프구의 확장 및 그의 치료 용도
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
WO2020186237A1
(en)
|
2019-03-13 |
2020-09-17 |
The Broad Institute, Inc. |
Microglial progenitors for regeneration of functional microglia in the central nervous system and therapeutics uses thereof
|
EP3937969A1
(de)
|
2019-03-14 |
2022-01-19 |
The Broad Institute, Inc. |
Zusammensetzungen und verfahren zur modulation der cgrp-signalisierung zur regulierung der angeborenen lymphoiden darmzellen
|
US20220142948A1
(en)
|
2019-03-18 |
2022-05-12 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
US20220152148A1
(en)
|
2019-03-18 |
2022-05-19 |
The Broad Institute, Inc. |
Modulation of type 2 immunity by targeting clec-2 signaling
|
JP7379528B2
(ja)
|
2019-03-26 |
2023-11-14 |
ツールジェン・インコーポレイテッド |
血友病b疾患モデルラット
|
WO2020205838A1
(en)
|
2019-04-02 |
2020-10-08 |
Sangamo Therapeutics, Inc. |
Methods for the treatment of beta-thalassemia
|
SG11202111443SA
(en)
|
2019-04-23 |
2021-11-29 |
Sangamo Therapeutics Inc |
Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
EP3969607A1
(de)
|
2019-05-13 |
2022-03-23 |
KWS SAAT SE & Co. KGaA |
Trockenheitstoleranz bei mais
|
WO2020232271A1
(en)
|
2019-05-14 |
2020-11-19 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
JP2022539338A
(ja)
|
2019-06-25 |
2022-09-08 |
イナリ アグリカルチャー テクノロジー, インコーポレイテッド |
改良された相同性依存性修復ゲノム編集
|
EP3772542A1
(de)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifzierung der genetischen variation bei nutzpflanzen durch modulation des pachytän-checkpointproteins 2
|
US20220282333A1
(en)
|
2019-08-13 |
2022-09-08 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
EP4041271A1
(de)
|
2019-10-02 |
2022-08-17 |
Sangamo Therapeutics, Inc. |
Zinkfingerproteintranskriptionsfaktoren zur behandlung der prionenkrankheit
|
EP4041754A1
(de)
|
2019-10-02 |
2022-08-17 |
Sangamo Therapeutics, Inc. |
Zinkfingerprotein-transkriptionsfaktoren zur hemmung der alpha-synnuclein expression
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
WO2021074367A1
(en)
|
2019-10-17 |
2021-04-22 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
ES2938896T3
(es)
|
2019-10-21 |
2023-04-17 |
Univ Freiburg Albert Ludwigs |
Un ensayo in vitro verdaderamente imparcial para perfilar la actividad fuera de objetivo de una o más nucleasas programables específicas de objetivo en células (ABNOBA-SEQ)
|
EP4048295A1
(de)
|
2019-10-25 |
2022-08-31 |
Iovance Biotherapeutics, Inc. |
Genbearbeitung von tumorinfiltrierenden lymphozyten und deren verwendungen in der immuntherapie
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
WO2021087361A1
(en)
|
2019-11-01 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Zinc finger nuclease variants for treating or preventing lysosomal storage diseases
|
US20230027620A1
(en)
|
2019-11-27 |
2023-01-26 |
The Board Of Trustees Of The University Of Illinois |
Pentapeptide and methods of use thereof
|
WO2021118990A1
(en)
|
2019-12-11 |
2021-06-17 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
US20230000063A1
(en)
|
2019-12-13 |
2023-01-05 |
Chugai Seiyaku Kabushiki Kaisha |
System for detecting extracellular purinergic receptor ligand, and non-human animal having the system introduced thereinto
|
TW202134288A
(zh)
|
2020-01-22 |
2021-09-16 |
美商聖加莫治療股份有限公司 |
用於抑制tau蛋白表現之鋅指蛋白轉錄因子
|
MX2022012303A
(es)
|
2020-04-02 |
2022-11-30 |
Takeda Pharmaceuticals Co |
Variante de adamts13, composiciones y usos de las mismas.
|
JP2023523855A
(ja)
|
2020-05-04 |
2023-06-07 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の製造方法及び免疫療法におけるその使用
|
EP4146812A1
(de)
|
2020-05-06 |
2023-03-15 |
Cellectis S.A. |
Verfahren zur gezielten einführung exogener sequenzen in zelluläre genome
|
US20230279440A1
(en)
|
2020-05-06 |
2023-09-07 |
Cellectis S.A. |
Methods to genetically modify cells for delivery of therapeutic proteins
|
US20230193212A1
(en)
|
2020-05-06 |
2023-06-22 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
JP2023526515A
(ja)
|
2020-05-20 |
2023-06-21 |
ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ |
リソソーム蓄積症をヒスタチンペプチドで処置するための方法
|
CN116782762A
(zh)
|
2020-05-29 |
2023-09-19 |
科沃施种子欧洲股份两合公司 |
植物单倍体诱导
|
WO2021248052A1
(en)
|
2020-06-05 |
2021-12-09 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
EP4204545A2
(de)
|
2020-08-25 |
2023-07-05 |
Kite Pharma, Inc. |
T-zellen mit verbesserter funktionalität
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
MX2023005665A
(es)
|
2020-11-16 |
2023-08-01 |
Pig Improvement Company Uk Ltd |
Animales resistentes a la influenza a que tienen genes de anp32 editados.
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
EP4262827A1
(de)
|
2020-12-17 |
2023-10-25 |
Iovance Biotherapeutics, Inc. |
Behandlung von krebs mit tumorinfiltrierenden lymphozyten
|
JP2024506557A
(ja)
|
2021-01-29 |
2024-02-14 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
修飾された腫瘍浸潤リンパ球を作製する方法及び養子細胞療法におけるそれらの使用
|
CA3212439A1
(en)
|
2021-03-19 |
2022-09-22 |
Michelle SIMPSON-ABELSON |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
KR20240037185A
(ko)
|
2021-04-19 |
2024-03-21 |
이오반스 바이오테라퓨틱스, 인크. |
키메라 공동자극 수용체, 케모카인 수용체, 및 세포 면역치료에서의 이의 용도
|
WO2022245754A1
(en)
|
2021-05-17 |
2022-11-24 |
Iovance Biotherapeutics, Inc. |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
WO2023282688A1
(ko)
|
2021-07-09 |
2023-01-12 |
주식회사 툴젠 |
산화스트레스 저항성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
|
TW202327631A
(zh)
|
2021-07-28 |
2023-07-16 |
美商艾歐凡斯生物治療公司 |
利用腫瘤浸潤性淋巴球療法與kras抑制劑組合治療癌症患者
|
KR20230019791A
(ko)
|
2021-07-29 |
2023-02-09 |
주식회사 툴젠 |
혈액 적합성을 갖는 중간엽 줄기세포, 이의 제조방법 및 용도
|
AR126622A1
(es)
|
2021-07-30 |
2023-10-25 |
Kws Saat Se & Co Kgaa |
Plantas con digestibilidad mejorada y haplotipos marcadores
|
WO2023042104A1
(en)
|
2021-09-16 |
2023-03-23 |
Novartis Ag |
Novel transcription factors
|
US20230226116A1
(en)
|
2021-10-20 |
2023-07-20 |
University Of Rochester |
Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
|
US20230190961A1
(en)
|
2021-10-20 |
2023-06-22 |
University Of Rochester |
Compositions and methods for treating myelin deficiency by rejuvenating glial progenitor cells
|
AR127482A1
(es)
|
2021-10-27 |
2024-01-31 |
Iovance Biotherapeutics Inc |
Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente
|
WO2023086790A1
(en)
|
2021-11-09 |
2023-05-19 |
Amgen Inc. |
Method for producing an antibody peptide conjugate
|
WO2023093862A1
(en)
|
2021-11-26 |
2023-06-01 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
WO2023102156A1
(en)
|
2021-12-03 |
2023-06-08 |
Wisconsin Alumni Research Foundation |
Mutant ace2 proteins and methods of using same
|
WO2023102550A2
(en)
|
2021-12-03 |
2023-06-08 |
The Broad Institute, Inc. |
Compositions and methods for efficient in vivo delivery
|
WO2023105244A1
(en)
|
2021-12-10 |
2023-06-15 |
Pig Improvement Company Uk Limited |
Editing tmprss2/4 for disease resistance in livestock
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
WO2023150557A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods
|
WO2023150553A1
(en)
|
2022-02-01 |
2023-08-10 |
University Of Rochester |
Gpr17 promoter-based targeting and transduction of glial progenitor cells
|
WO2023168397A1
(en)
|
2022-03-04 |
2023-09-07 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the asparagine biosynthesis pathway
|
WO2023196818A1
(en)
|
2022-04-04 |
2023-10-12 |
The Regents Of The University Of California |
Genetic complementation compositions and methods
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023213831A1
(en)
|
2022-05-02 |
2023-11-09 |
Fondazione Telethon Ets |
Homology independent targeted integration for gene editing
|
WO2023220608A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist
|
EP4278891A1
(de)
|
2022-05-20 |
2023-11-22 |
KWS SAAT SE & Co. KGaA |
Kohlhernienresistenz und marker in brassica
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
WO2024013514A2
(en)
|
2022-07-15 |
2024-01-18 |
Pig Improvement Company Uk Limited |
Gene edited livestock animals having coronavirus resistance
|
WO2024042199A1
(en)
|
2022-08-26 |
2024-02-29 |
KWS SAAT SE & Co. KGaA |
Use of paired genes in hybrid breeding
|
WO2024073692A1
(en)
|
2022-09-30 |
2024-04-04 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the glycine-formate biosynthesis pathway
|
WO2024073686A1
(en)
|
2022-09-30 |
2024-04-04 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the serine biosynthesis pathway
|
WO2024079157A1
(en)
|
2022-10-11 |
2024-04-18 |
KWS SAAT SE & Co. KGaA |
Virus and insect resistance and markers in barley
|