MA34004B1 - Protéines de liaison à cd127 - Google Patents
Protéines de liaison à cd127Info
- Publication number
- MA34004B1 MA34004B1 MA35147A MA35147A MA34004B1 MA 34004 B1 MA34004 B1 MA 34004B1 MA 35147 A MA35147 A MA 35147A MA 35147 A MA35147 A MA 35147A MA 34004 B1 MA34004 B1 MA 34004B1
- Authority
- MA
- Morocco
- Prior art keywords
- antigen binding
- binding proteins
- protein link
- diseases
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
L'invention concerne des protéines de liaison à un antigène qui se lient au récepteur humain de l'IL-7 (CD127). Les protéines de liaison à un antigène sont typiquement des anticorps, et sont utiles dans le traitement de maladies ou de troubles chez les êtres humains, particulièrement de maladies auto-immunes telles que la sclérose en plaques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29901010P | 2010-01-28 | 2010-01-28 | |
PCT/US2011/022507 WO2011094259A2 (fr) | 2010-01-28 | 2011-01-26 | Protéines de liaison à cd127 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34004B1 true MA34004B1 (fr) | 2013-02-01 |
Family
ID=44320081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA35147A MA34004B1 (fr) | 2010-01-28 | 2011-01-26 | Protéines de liaison à cd127 |
Country Status (25)
Country | Link |
---|---|
US (2) | US9150653B2 (fr) |
EP (1) | EP2528947A4 (fr) |
JP (1) | JP5850860B2 (fr) |
KR (1) | KR20130028055A (fr) |
CN (1) | CN102812046B (fr) |
AR (1) | AR080027A1 (fr) |
AU (1) | AU2011209713B2 (fr) |
BR (1) | BR112012018914A2 (fr) |
CA (1) | CA2787070A1 (fr) |
CL (1) | CL2012002081A1 (fr) |
CO (1) | CO6592067A2 (fr) |
CR (1) | CR20120404A (fr) |
EA (1) | EA023700B1 (fr) |
IL (1) | IL220899A (fr) |
MA (1) | MA34004B1 (fr) |
MX (1) | MX339083B (fr) |
MY (1) | MY160590A (fr) |
NZ (1) | NZ601271A (fr) |
PE (2) | PE20121702A1 (fr) |
SG (1) | SG182590A1 (fr) |
TW (1) | TWI489996B (fr) |
UA (1) | UA104663C2 (fr) |
UY (1) | UY33202A (fr) |
WO (1) | WO2011094259A2 (fr) |
ZA (1) | ZA201205624B (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2865068T3 (es) | 2011-01-14 | 2021-10-14 | Univ California | Anticuerpos terapéuticos contra la proteína ROR-1 y métodos para usarlos |
EP2583980A1 (fr) * | 2011-10-19 | 2013-04-24 | Effimune | Anticorps dirigés contre la chaîne alpha du récepteur IL7, leur utilisation pour la préparation de candidats médicaments |
EP2955196A1 (fr) * | 2014-06-10 | 2015-12-16 | Effimune | Anticorps dirigés contre CD127 |
WO2016059512A1 (fr) | 2014-10-18 | 2016-04-21 | Pfizer Inc. | Compositions d'anticorps anti-il-7r |
WO2017055966A1 (fr) | 2015-10-01 | 2017-04-06 | Pfizer Inc. | Compositions d'anticorps à faible viscosité |
AU2017205185B2 (en) * | 2016-01-07 | 2022-03-31 | The Schepens Eye Research Institute, Inc. | Therapeutics for ocular immunoinflammatory diseases |
CA3014313A1 (fr) * | 2016-02-29 | 2017-09-08 | Ose Immunotherapeutics | Anticorps non antagonistes diriges contre la chaine alpha du domaine extracellulaire du recepteur de l'il-7 et son utilisation dans le traitement du cancer |
HUE054206T2 (hu) * | 2016-12-09 | 2021-08-30 | Ose Immunotherapeutics | A CD127 ellen irányított antitestek és polipeptidek |
AU2020210635A1 (en) * | 2019-01-22 | 2021-08-19 | Bristol Myers Squibb Company | Antibodies against IL-7R alpha subunit and uses thereof |
JP2022538083A (ja) | 2019-06-21 | 2022-08-31 | ソリッソ ファーマシューティカルズ,インク. | ポリペプチド |
WO2020254828A1 (fr) | 2019-06-21 | 2020-12-24 | Vhsquared Limited | Compositions |
CA3144567A1 (fr) | 2019-06-21 | 2020-12-24 | Scott Crowe | Polypeptides |
CN110894237B (zh) * | 2019-12-05 | 2021-08-03 | 山东省分析测试中心 | 抗cd127的抗体、分泌该抗体的细胞株及其制备方法和应用 |
US20220389104A1 (en) * | 2021-05-28 | 2022-12-08 | Ose Immunotherapeutics | Method for Treating CD127-Positive Cancers by Administering an Anti-CD127 Agent |
WO2023232826A1 (fr) | 2022-05-30 | 2023-12-07 | Ose Immunotherapeutics | Biomarqueurs de l'activité du modulateur de l'il7r |
WO2024040195A1 (fr) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditionnement pour l'ingénierie de cellules immunitaires in vivo |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2 Inc | Geänderte antikörper. |
EP0368684B2 (fr) | 1988-11-11 | 2004-09-29 | Medical Research Council | Clonage de séquences d'immunoglobulines de domaines variables. |
US20040049014A1 (en) * | 1988-12-28 | 2004-03-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
EP0402226A1 (fr) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Vecteurs de transformation de la levure yarrowia |
CA2033082A1 (fr) * | 1989-06-15 | 1990-12-16 | Linda S. Park | Recepteurs de l'interleukine 7 |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
US6800738B1 (en) * | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
WO1993006213A1 (fr) | 1991-09-23 | 1993-04-01 | Medical Research Council | Production d'anticorps chimeriques - une approche combinatoire |
GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
WO1993008829A1 (fr) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions induisant la destruction de cellules infectees par l'hiv |
GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
WO1994004690A1 (fr) | 1992-08-17 | 1994-03-03 | Genentech, Inc. | Immunoadhesines bispecifiques |
ES2138662T3 (es) | 1993-06-03 | 2000-01-16 | Therapeutic Antibodies Inc | Produccion de fragmentos de anticuerpos. |
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
WO1996021000A2 (fr) * | 1994-12-23 | 1996-07-11 | Smithkline Beecham Corporation | Antagonistes de recombinaison de l'il-5 utiles dans le traitement des troubles induits par l'il-5 |
US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
WO1997042329A1 (fr) * | 1996-05-04 | 1997-11-13 | Zeneca Limited | Anticorps monoclonal anti-cea, conjugues contenant cet anticorps et leur utilisation therapeutique dans un systeme adept |
PL335050A1 (en) | 1997-02-07 | 2000-03-27 | Merck & Co Inc | Synthetic genes gag hiv |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
MXPA01010296A (es) * | 1999-04-13 | 2005-06-30 | Wilex Ag | Diagnostico y uso terapeutico de anticuerpos contra el receptor urocinasa. |
US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
US7417130B2 (en) | 2000-09-08 | 2008-08-26 | University Of Zurich | Collection of repeat proteins comprising repeat modules |
MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
WO2003011878A2 (fr) | 2001-08-03 | 2003-02-13 | Glycart Biotechnology Ag | Variants de glycosylation d'anticorps presentant une cytotoxicite cellulaire accrue dependante des anticorps |
GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
ATE541857T1 (de) | 2002-09-27 | 2012-02-15 | Xencor Inc | Optimierte fc-varianten und herstellungsverfahren dafür |
JP2006524039A (ja) | 2003-01-09 | 2006-10-26 | マクロジェニクス,インコーポレーテッド | 変異型Fc領域を含む抗体の同定および作製ならびにその利用法 |
US20050025763A1 (en) | 2003-05-08 | 2005-02-03 | Protein Design Laboratories, Inc. | Therapeutic use of anti-CS1 antibodies |
WO2005003156A1 (fr) | 2003-07-04 | 2005-01-13 | Affibody Ab | Polypeptides presentant une affinite de liaison pour le recepteur 2 du facteur de croissance epidermique humain (her2) |
AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
EP1711196A4 (fr) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 |
EP1776385A1 (fr) | 2004-07-21 | 2007-04-25 | Glycofi, Inc. | Immunoglobulines contenant principalement un glycoforme de type glcnac2man3glcnac2 |
WO2006052660A2 (fr) * | 2004-11-04 | 2006-05-18 | Childrens Hospital Los Angeles Research Institute | Blocage du recepteur il-7 pour supprimer l'immunite |
US7935791B2 (en) | 2006-12-18 | 2011-05-03 | Genentech, Inc. | Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases |
EP1958957A1 (fr) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprenant un partie caractéristique des protéines appellées "Knottins" |
BRPI0906498A2 (pt) * | 2008-01-22 | 2015-07-14 | Biogen Idec Inc | Anticorpo ron e seus usos |
UY32038A (es) * | 2008-08-08 | 2010-03-26 | Glaxo Wellcome Mfg Pte Ltd | Inmunoblobulinas anti-cd127 y sus usos |
-
2011
- 2011-01-26 NZ NZ601271A patent/NZ601271A/en not_active IP Right Cessation
- 2011-01-26 SG SG2012053138A patent/SG182590A1/en unknown
- 2011-01-26 MA MA35147A patent/MA34004B1/fr unknown
- 2011-01-26 PE PE2012001071A patent/PE20121702A1/es not_active Application Discontinuation
- 2011-01-26 CA CA2787070A patent/CA2787070A1/fr not_active Abandoned
- 2011-01-26 US US13/574,847 patent/US9150653B2/en not_active Expired - Fee Related
- 2011-01-26 PE PE2017000247A patent/PE20170687A1/es not_active Application Discontinuation
- 2011-01-26 EA EA201290589A patent/EA023700B1/ru not_active IP Right Cessation
- 2011-01-26 UY UY0001033202A patent/UY33202A/es not_active Application Discontinuation
- 2011-01-26 UA UAA201209254A patent/UA104663C2/ru unknown
- 2011-01-26 MY MYPI2012003394A patent/MY160590A/en unknown
- 2011-01-26 MX MX2012008765A patent/MX339083B/es active IP Right Grant
- 2011-01-26 JP JP2012551247A patent/JP5850860B2/ja not_active Expired - Fee Related
- 2011-01-26 US US13/013,993 patent/US8940303B2/en not_active Expired - Fee Related
- 2011-01-26 CN CN201180015856.0A patent/CN102812046B/zh not_active Expired - Fee Related
- 2011-01-26 AR ARP110100251A patent/AR080027A1/es unknown
- 2011-01-26 WO PCT/US2011/022507 patent/WO2011094259A2/fr active Application Filing
- 2011-01-26 KR KR1020127022553A patent/KR20130028055A/ko active IP Right Grant
- 2011-01-26 BR BR112012018914A patent/BR112012018914A2/pt not_active IP Right Cessation
- 2011-01-26 EP EP11737543.6A patent/EP2528947A4/fr not_active Withdrawn
- 2011-01-26 AU AU2011209713A patent/AU2011209713B2/en not_active Ceased
- 2011-01-26 TW TW100102962A patent/TWI489996B/zh not_active IP Right Cessation
-
2012
- 2012-07-12 IL IL220899A patent/IL220899A/en not_active IP Right Cessation
- 2012-07-24 CO CO12124175A patent/CO6592067A2/es active IP Right Grant
- 2012-07-25 ZA ZA2012/05624A patent/ZA201205624B/en unknown
- 2012-07-26 CL CL2012002081A patent/CL2012002081A1/es unknown
- 2012-07-31 CR CR20120404A patent/CR20120404A/es unknown
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