MX346500B - Metodos y composiciones para inmunoterapia para enfermedad neural. - Google Patents

Metodos y composiciones para inmunoterapia para enfermedad neural.

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Publication number
MX346500B
MX346500B MX2013004629A MX2013004629A MX346500B MX 346500 B MX346500 B MX 346500B MX 2013004629 A MX2013004629 A MX 2013004629A MX 2013004629 A MX2013004629 A MX 2013004629A MX 346500 B MX346500 B MX 346500B
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MX
Mexico
Prior art keywords
methods
compositions
neural disease
disease immunotherapy
immunotherapy
Prior art date
Application number
MX2013004629A
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English (en)
Other versions
MX2013004629A (es
Inventor
Yan Wu
Robert A Lazarus
Ryan J Watts
Yingnan Zhang
Jasvinder Atwal
Yongmei Chen
Cecilia Pui Chi Chiu
Weiru Wang
Original Assignee
Genentech Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Genentech Inc * filed Critical Genentech Inc *
Publication of MX2013004629A publication Critical patent/MX2013004629A/es
Publication of MX346500B publication Critical patent/MX346500B/es

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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
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Abstract

La presente invención se refiere a un anticuerpo aislado, o fragmento del mismo, que se une al enzima 1 de disociación de proteína precursora del amiloide sitio B (BACE1). Un inmunoconjugado que comprende el anticuerpo y un agente citotóxico. Uso de un anticuerpo o fragmento para preparar un medicamento para tratar una enfermedad o desorden neurológico.
MX2013004629A 2010-11-10 2011-11-09 Metodos y composiciones para inmunoterapia para enfermedad neural. MX346500B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US45664210P 2010-11-10 2010-11-10
US41831010P 2010-11-30 2010-11-30
US41885010P 2010-12-01 2010-12-01
US201061426425P 2010-12-22 2010-12-22
PCT/US2011/059964 WO2012064836A1 (en) 2010-11-10 2011-11-09 Methods and compositions for neural disease immunotherapy

Publications (2)

Publication Number Publication Date
MX2013004629A MX2013004629A (es) 2013-06-28
MX346500B true MX346500B (es) 2017-03-22

Family

ID=45002151

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004629A MX346500B (es) 2010-11-10 2011-11-09 Metodos y composiciones para inmunoterapia para enfermedad neural.

Country Status (22)

Country Link
US (3) US8772457B2 (es)
EP (2) EP2638070B1 (es)
JP (2) JP6163429B2 (es)
KR (1) KR20130133205A (es)
CN (1) CN103228674B (es)
AR (1) AR083819A1 (es)
AU (1) AU2011326564A1 (es)
CA (1) CA2815840A1 (es)
CL (1) CL2013001290A1 (es)
CO (1) CO6690815A2 (es)
EA (1) EA201390669A1 (es)
EC (1) ECSP13012673A (es)
ES (1) ES2607086T3 (es)
IL (1) IL226106A0 (es)
MA (1) MA34722B1 (es)
MX (1) MX346500B (es)
PE (1) PE20140238A1 (es)
PH (1) PH12013500933A1 (es)
SG (1) SG190682A1 (es)
TW (1) TW201300417A (es)
WO (1) WO2012064836A1 (es)
ZA (1) ZA201302980B (es)

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JP6993228B2 (ja) 2014-11-19 2022-03-03 ジェネンテック， インコーポレイテッド 抗トランスフェリン受容体／抗ｂａｃｅ１多重特異性抗体および使用方法
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TW201742625A (zh) * 2016-03-15 2017-12-16 阿斯特捷利康公司 組合療法
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CN107523579A (zh) * 2017-09-08 2017-12-29 东北师范大学 促进大脑中Aβ累积的BACE1亚型的功能研发及应用
CN107475260B (zh) * 2017-09-08 2020-12-04 东北师范大学 抑制大脑中Aβ累积的BACE1亚型的功能研发及应用
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