MX360163B - Moleculas de union il-6. - Google Patents

Moleculas de union il-6.

Info

Publication number
MX360163B
MX360163B MX2014014218A MX2014014218A MX360163B MX 360163 B MX360163 B MX 360163B MX 2014014218 A MX2014014218 A MX 2014014218A MX 2014014218 A MX2014014218 A MX 2014014218A MX 360163 B MX360163 B MX 360163B
Authority
MX
Mexico
Prior art keywords
antibodies
antigen binding
binding fragments
binding molecules
inhibit
Prior art date
Application number
MX2014014218A
Other languages
English (en)
Other versions
MX2014014218A (es
Inventor
Blanchetot Christophe
De Haard Johannes
Dreier Torsten
De Jonge Natalie
Paul Van Der Woning Sebastian
Ongenae Nicolas
Original Assignee
Argen X N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47559582&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360163(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Argen X N V filed Critical Argen X N V
Publication of MX2014014218A publication Critical patent/MX2014014218A/es
Publication of MX360163B publication Critical patent/MX360163B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a moléculas de unión (por ejemplo, anticuerpos o fragmentos de unión a antígeno de los mismos) que se unen específicamente a e inhiben la actividad biológica de IL-6 (por ejemplo, IL-6 humana, IL-6 de ratón e IL-6 de primate no humano). En una realización preferida, los anticuerpos o fragmentos de unión a antígeno de la invención se unen a la IL-6 e inhiben su unión a un receptor de IL-6. Tales anticuerpos o fragmentos de unión a antígeno son particularmente útiles para el tratamiento de enfermedades o trastornos asociados a IL-6 (por ejemplo, enfermedades inflamatorias y cáncer).
MX2014014218A 2012-05-23 2013-05-23 Moleculas de union il-6. MX360163B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261650883P 2012-05-23 2012-05-23
US201261720102P 2012-10-30 2012-10-30
PCT/IB2012/056424 WO2013175276A1 (en) 2012-05-23 2012-11-14 Il-6 binding molecules
PCT/IB2013/054271 WO2013175427A1 (en) 2012-05-23 2013-05-23 Il-6 binding molecules

Publications (2)

Publication Number Publication Date
MX2014014218A MX2014014218A (es) 2015-11-23
MX360163B true MX360163B (es) 2018-10-09

Family

ID=47559582

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014014218A MX360163B (es) 2012-05-23 2013-05-23 Moleculas de union il-6.

Country Status (17)

Country Link
US (4) US10183995B2 (es)
EP (1) EP2852616A1 (es)
JP (1) JP6410712B2 (es)
KR (1) KR20150063311A (es)
CN (1) CN103601806B (es)
AU (1) AU2013264779B2 (es)
BR (1) BR112014029219B1 (es)
CA (1) CA2871148C (es)
CL (1) CL2014003167A1 (es)
CO (1) CO7240362A2 (es)
EC (1) ECSP14029713A (es)
IL (1) IL235134B (es)
MX (1) MX360163B (es)
NZ (1) NZ701370A (es)
PE (1) PE20150335A1 (es)
RU (1) RU2676078C2 (es)
WO (2) WO2013175276A1 (es)

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GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
KR20200012823A (ko) 2017-02-01 2020-02-05 예일 유니버시티 이뇨제 내성의 치료
EP3735421A4 (en) 2018-01-05 2021-09-22 Corvidia Therapeutics, Inc. METHOD OF TREATMENT OF IL-6 MEDIATED INFLAMMATION WITHOUT IMMUNSUPPRESSION
CN111153998B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体及其应用
EP4138888A1 (en) * 2020-04-23 2023-03-01 Eli Lilly and Company Subcutaneous absorption and bioavailability of antibodies
CN113150140B (zh) * 2021-01-25 2022-11-04 山西农业大学 一种sox6二价纳米抗体及其应用
WO2023229891A1 (en) * 2022-05-25 2023-11-30 Ayuvis Research, Inc. Novel immunodulating small molecules

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Also Published As

Publication number Publication date
MX2014014218A (es) 2015-11-23
CO7240362A2 (es) 2015-04-17
ECSP14029713A (es) 2015-09-30
CN103601806A (zh) 2014-02-26
US11827701B2 (en) 2023-11-28
CN103601806B (zh) 2019-01-18
JP6410712B2 (ja) 2018-10-24
WO2013175427A1 (en) 2013-11-28
RU2676078C2 (ru) 2018-12-26
US20150140011A1 (en) 2015-05-21
BR112014029219A2 (es) 2017-08-15
US11117959B2 (en) 2021-09-14
RU2014152006A (ru) 2016-07-20
BR112014029219A8 (pt) 2019-05-14
US20240158492A1 (en) 2024-05-16
IL235134B (en) 2019-12-31
CA2871148C (en) 2020-07-14
EP2852616A1 (en) 2015-04-01
US10183995B2 (en) 2019-01-22
KR20150063311A (ko) 2015-06-09
JP2015518857A (ja) 2015-07-06
AU2013264779A1 (en) 2014-10-30
US20220073604A1 (en) 2022-03-10
NZ701370A (en) 2016-11-25
CA2871148A1 (en) 2013-11-28
AU2013264779B2 (en) 2018-03-22
IL235134A0 (en) 2014-12-31
PE20150335A1 (es) 2015-03-20
WO2013175276A1 (en) 2013-11-28
CL2014003167A1 (es) 2015-06-12
BR112014029219B1 (pt) 2022-04-19
US20190233509A1 (en) 2019-08-01

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