CY1123071T1 - Μορια προσδεσης il-18 - Google Patents

Μορια προσδεσης il-18

Info

Publication number
CY1123071T1
CY1123071T1 CY20201100582T CY201100582T CY1123071T1 CY 1123071 T1 CY1123071 T1 CY 1123071T1 CY 20201100582 T CY20201100582 T CY 20201100582T CY 201100582 T CY201100582 T CY 201100582T CY 1123071 T1 CY1123071 T1 CY 1123071T1
Authority
CY
Cyprus
Prior art keywords
bind
binding molecules
complex
inflammatory diseases
autoimmune
Prior art date
Application number
CY20201100582T
Other languages
English (en)
Inventor
Michael Otto BARDROFF
Barbara Brannetti
Emma Michelle Campbell
Beate Diefenbach-Streiber
Adina Eberth
Christian Carsten Silvester Kunz
Sylwia MARSHALL
Jean-Michel Rene RONDEAU
Jean-Marc Alfred SCHLAEPPI
Gino Anselmus VAN HEEKE
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1123071(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1123071T1 publication Critical patent/CY1123071T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η IL-18 συμμετέχει τόσο στην εγγενή όσο και στην επίκτητη ανοσία. Η βιοδραστικότητα της IL-18 ρυθμίζεται αρνητικά από την πρωτεΐνη πρόσδεσης IL-18 (IL18BP), έναν φυσικώς απαντώμενο και υψηλά ειδικό αναστολέα. Η διαλυτή πρωτεΐνη σχηματίζει ένα σύμπλοκο με ελεύθερη IL-18 αποτρέποντας την αλληλεπίδραση της με τον υποδοχέα IL-18, εξουδετερώνοντας και αναστέλλοντας έτσι τη βιολογική της δραστικότητα. Η παρούσα εφεύρεση αποκαλύπτει μόρια πρόσδεσης, ειδικότερα αντισώματα ή θραύσματα αυτών, τα οποία προσδένουν την IL-18 και δεν προσδένουν την IL-18 προσδεδεμένη σε IL-I8BP (σύμπλοκο IL-18/IL-18BP). Εκτός από τον φυσιολογικό της ρόλο, η IL-I8 έχει δειχθεί ότι μεσολαβεί σε μια ποικιλία από αυτοάνοσες και φλεγμονώδεις ασθένειες. Τα μόρια πρόσδεσης της εφεύρεσης μπορεί να χρησιμοποιούνται ως θεραπευτικά μόρια για τη θεραπευτική αγωγή σχετιζόμενων με την 1L-18 αυτοάνοσων και φλεγμονωδών ασθενειών ή ως διαγνωστικά εργαλεία για τον χαρακτηρισμό, την ανίχνευση ή/και μέτρηση της IL-18 που δεν προσδένεται σε IL-18BP ως συστατικό της συνολικής ομάδας IL-18.
CY20201100582T 2012-09-07 2020-06-24 Μορια προσδεσης il-18 CY1123071T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261697981P 2012-09-07 2012-09-07
PCT/IB2013/058317 WO2014037899A2 (en) 2012-09-07 2013-09-05 Il-18 binding molecules

Publications (1)

Publication Number Publication Date
CY1123071T1 true CY1123071T1 (el) 2021-10-29

Family

ID=49596347

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201100582T CY1123071T1 (el) 2012-09-07 2020-06-24 Μορια προσδεσης il-18

Country Status (41)

Country Link
US (4) US9376489B2 (el)
EP (2) EP3725805A1 (el)
JP (3) JP6404817B2 (el)
KR (2) KR102330653B1 (el)
CN (2) CN104640879B (el)
AP (1) AP2015008266A0 (el)
AR (1) AR092465A1 (el)
AU (4) AU2013311234A1 (el)
BR (2) BR112015004783B1 (el)
CA (1) CA2883821C (el)
CL (1) CL2015000532A1 (el)
CO (1) CO7400884A2 (el)
CR (1) CR20150121A (el)
CU (1) CU24249B1 (el)
CY (1) CY1123071T1 (el)
DK (1) DK2892923T3 (el)
EA (2) EA201992614A3 (el)
EC (1) ECSP15013209A (el)
ES (1) ES2804704T3 (el)
GT (1) GT201500054A (el)
HK (1) HK1209136A1 (el)
HR (1) HRP20200906T1 (el)
HU (1) HUE050464T2 (el)
IL (2) IL237161B (el)
JO (2) JOP20200308A1 (el)
LT (1) LT2892923T (el)
MA (1) MA37892A1 (el)
MX (2) MX2015002986A (el)
MY (1) MY174691A (el)
PE (1) PE20150649A1 (el)
PH (1) PH12015500466B1 (el)
PL (1) PL2892923T3 (el)
PT (1) PT2892923T (el)
RS (1) RS60394B1 (el)
SG (2) SG11201501559VA (el)
SI (1) SI2892923T1 (el)
TN (1) TN2015000057A1 (el)
TW (2) TWI613217B (el)
UY (1) UY35016A (el)
WO (1) WO2014037899A2 (el)
ZA (1) ZA201500954B (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
EP3978526A1 (en) * 2013-09-05 2022-04-06 AB2 Bio SA Il-18 binding protein (il-18bp) in inflammatory diseases
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
US10882905B2 (en) 2015-03-05 2021-01-05 Ab2 Bio Sa IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases
WO2017076805A1 (en) * 2015-11-02 2017-05-11 Glaxosmithkline Intellectual Property Development Limited Use of an inhibitor of il18 for treatment of acute kidney injury
SG11201803520PA (en) 2015-11-03 2018-05-30 Janssen Biotech Inc Antibodies specifically binding pd-1 and their uses
CN108218978B (zh) * 2016-12-13 2020-05-12 沈阳何氏眼产业集团有限公司 一种重组白细胞介素18及其制备方法与应用
EP3592384A1 (en) 2017-03-09 2020-01-15 MAB Discovery GmbH Antibodies specifically binding to human il-1r7
UY37758A (es) * 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
IL305370A (en) * 2017-09-06 2023-10-01 Univ Yale Variants of interleukin-18 and methods of use
WO2019213686A1 (en) * 2018-05-10 2019-11-14 The Council Of The Queensland Institute Of Medical Research Therapeutic compositions and uses therefor
BR112021007765A2 (pt) * 2018-10-23 2021-08-03 Scholar Rock, Inc. inibidores seletivos de rgmc e uso dos mesmos
US20210317200A1 (en) 2018-12-03 2021-10-14 mAbProtein Co., Ltd. Antibody that recognizes neoepitope of activated interleukin-18 proteins and application thereof
CN109870570A (zh) * 2018-12-29 2019-06-11 广东云天抗体生物科技有限公司 一种检测猴il-18的酶联免疫试剂盒
US12029778B2 (en) 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
WO2022221264A1 (en) * 2021-04-12 2022-10-20 Ethos Biosciences, Inc. Methods and compositions for analysis of acute kidney injury
US20240294626A1 (en) 2021-06-22 2024-09-05 Novartis Ag Bispecific antibodies for use in treatment of hidradenitis suppurativa
EP4371573A1 (en) 2021-07-13 2024-05-22 National University Corporation Tokai National Higher Education and Research System Medicinal composition for treating inflammatory bowel disease
CN117177999B (zh) * 2022-01-14 2024-07-05 和径医药科技（上海）有限公司 一种靶向IL-18Rβ的抗体及其应用
AU2023236289A1 (en) 2022-03-15 2024-08-15 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
AR129136A1 (es) * 2022-04-26 2024-07-17 Novartis Ag Anticuerpos multiespecíficos que se dirigen a il-13 e il-18
WO2024148243A1 (en) * 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. Anti-il-18bp antibodies
WO2024148241A1 (en) * 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. Anti-il-18bp antibodies

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
DE3856559T2 (de) 1987-05-21 2004-04-29 Micromet Ag Multifunktionelle Proteine mit vorbestimmter Zielsetzung
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
JP3068180B2 (ja) 1990-01-12 2000-07-24 アブジェニックス インコーポレイテッド 異種抗体の生成
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
JPH03230220A (ja) 1990-02-05 1991-10-14 Seiko Epson Corp ソート処理方法
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JPH07503132A (ja) 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
AU4116793A (en) 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
WO1994004690A1 (en) 1992-08-17 1994-03-03 Genentech, Inc. Bispecific immunoadhesins
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
ES2108460T3 (es) 1993-06-03 1997-12-16 Therapeutic Antibodies Inc Fragmentos de anticuerpos en terapeutica.
CA2163345A1 (en) 1993-06-16 1994-12-22 Susan Adrienne Morgan Antibodies
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
TW581771B (en) 1994-11-15 2004-04-01 Hayashibara Biochem Lab Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
JP2007121310A (ja) 1996-07-31 2007-05-17 Hayashibara Biochem Lab Inc 自己免疫疾患診断剤
JP2009047705A (ja) 1996-07-31 2009-03-05 Hayashibara Biochem Lab Inc 生物学的試料の検出方法
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
JP2002512624A (ja) 1997-05-21 2002-04-23 バイオベーション リミテッド 非免疫原性タンパク質の製造方法
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
IL137178A0 (en) 1998-01-23 2001-07-24 Immunex Corp Il-18 receptors
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
DK2180007T4 (da) 1998-04-20 2017-11-27 Roche Glycart Ag Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
KR20060067983A (ko) 1999-01-15 2006-06-20 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
EP2275541B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US6432678B1 (en) 1999-06-21 2002-08-13 Smithkline Beecham Corporation Macaca cynomolgus IL 18
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
WO2001005950A2 (en) 1999-07-20 2001-01-25 Morphosys Ag Methods for displaying (poly)peptides/proteins on bacteriophage particles via disulfide bonds
EP3214175A1 (en) 1999-08-24 2017-09-06 E. R. Squibb & Sons, L.L.C. Human ctla-4 antibodies and their uses
JP3230220B2 (ja) 1999-10-07 2001-11-19 独立行政法人 農業技術研究機構 ブタ由来インターロイキン−１８に対するモノクローナル抗体
EP1101772B1 (en) 1999-11-16 2009-01-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
KR101111103B1 (ko) 2000-02-10 2012-02-13 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
ES2365600T3 (es) * 2000-02-21 2011-10-07 Merck Serono Sa Uso de inhibidores de il-18.
CN1250286C (zh) 2000-05-05 2006-04-12 应用研究系统Ars股份公司 Il－18抑制剂在治疗和/或预防动脉粥样硬化中的应用
WO2002000879A2 (en) 2000-06-28 2002-01-03 Glycofi, Inc. Methods for producing modified glycoproteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
AU2002224417A1 (en) 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
PT1354034E (pt) 2000-11-30 2008-02-28 Medarex Inc Roedores transgénicos transcromossómicos para produção de anticorpos humanos
ME00549B (me) 2001-01-29 2011-10-10 Serono Lab Upotreba inhibitora il-18 za liječenje i/ili prevenciju srčanih oboljenja
US20050048512A1 (en) 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
AU2002337935B2 (en) 2001-10-25 2008-05-01 Genentech, Inc. Glycoprotein compositions
US20040023336A1 (en) 2001-10-26 2004-02-05 Heavner George A. Mut-IL-18 or Mut-IL-18R proteins, antibodies, compositions, methods and uses
DE60324777D1 (de) 2002-03-22 2009-01-02 Inst Nat Sante Rech Med Verwendung von il-18-inhibitoren zur behandlung und/oder prävention von peripheren gefässkrankheiten
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
AU2004235595C1 (en) * 2003-04-30 2009-09-24 Japan Science And Technology Agency Human antihuman interleukin-18 antibody, fragment thereof and method of using the same
CA2524403C (en) 2003-05-13 2013-07-09 Applied Research Systems Ars Holding N.V. Active variants of the il-18 binding protein and medical uses thereof
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
PT1639011E (pt) 2003-06-30 2009-01-20 Domantis Ltd Anticorpos (dab) de domínio único peguilados
JP2005052021A (ja) 2003-08-07 2005-03-03 Yokohama City インターロイキン−１８変異体タンパク質
US20050075702A1 (en) 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
WO2005075648A1 (en) 2004-01-28 2005-08-18 Gifu University Interleukin-18 mutant proteins
WO2005079766A2 (en) 2004-02-20 2005-09-01 Novo Nordisk A/S Therapeutic combination comprising a tissue factor antagonist and anti-cancer compounds
WO2005097998A2 (en) 2004-03-31 2005-10-20 Regeneron Pharmaceuticals, Inc. Il-18 specific polypeptides and therapeutic uses thereof
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
JP4673068B2 (ja) 2005-01-19 2011-04-20 独立行政法人科学技術振興機構 Ｔｈ１型アレルギー疾患治療用組成物
CA2613204A1 (en) 2005-06-29 2007-01-11 Rules-Based Medicine, Inc. Methods and kits for the diagnosis of acute coronary syndrome
US20090215992A1 (en) 2005-08-19 2009-08-27 Chengbin Wu Dual variable domain immunoglobulin and uses thereof
MY169746A (en) 2005-08-19 2019-05-14 Abbvie Inc Dual variable domain immunoglobulin and uses thereof
LT2578685T (lt) 2005-08-23 2019-06-10 The Trustees Of The University Of Pennsylvania Rnr, apimančios modifikuotus nukleozidus ir jų panaudojimo būdai
JP4728785B2 (ja) 2005-11-30 2011-07-20 独立行政法人科学技術振興機構 Ｉｌ−１８の生物活性を有する新規ポリペプチドの生産方法、および当該ポリペプチドの産生を阻害する物質のスクリーニング方法
BRPI0711908B8 (pt) 2006-05-25 2021-05-25 Glaxo Group Ltd anticorpo anti-interleucina-18 humanizado, composição farmacêutica, uso de um anticorpo anti-interleucina 18, e, método de produção de um anticorpo.
CA2697032C (en) 2007-08-22 2021-09-14 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
EP2247310A4 (en) 2008-01-30 2012-06-27 Abbott Lab COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODY FRAGMENTS
UY31861A (es) 2008-06-03 2010-01-05 Abbott Lab Inmunoglobulina con dominio variable dual y usos de la misma
WO2010006060A2 (en) 2008-07-08 2010-01-14 Abbott Laboratories Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
WO2010020593A1 (en) 2008-08-18 2010-02-25 Glaxo Group Limited Treatment of an autoimmune disease using il-18 antagonists
WO2010040736A2 (en) 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
SG10201702951RA (en) 2008-10-20 2017-06-29 Abbvie Inc Viral inactivation during purification of antibodies
JP2012506239A (ja) 2008-10-20 2012-03-15 アボット・ラボラトリーズ Ｉｌ−１８に結合する抗体およびそれを精製する方法
US20120116978A1 (en) 2008-12-23 2012-05-10 Mtn Mobile Money Sa (Pty) Ltd Method of and system for securely processing a transaction
BRPI1012195A2 (pt) 2009-05-01 2018-04-24 Abbott Lab imunoglobulinas de domínio variável duplo e usos das mesmas
MX2012009167A (es) 2010-02-09 2012-08-23 Glaxo Group Ltd Tratamiento de un trastorno metabolico.
CA2822515C (en) * 2010-12-20 2023-04-25 Medimmune Limited Anti-il-18 antibodies and their uses
JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
UY37758A (es) * 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos

Also Published As

Publication number Publication date
EA201992614A2 (ru) 2020-03-31
CL2015000532A1 (es) 2015-06-05
CN104640879B (zh) 2018-12-07
EA034610B1 (ru) 2020-02-27
HK1209136A1 (en) 2016-03-24
WO2014037899A2 (en) 2014-03-13
KR20210011504A (ko) 2021-02-01
PT2892923T (pt) 2020-06-23
AU2020201556B2 (en) 2022-01-13
ES2804704T3 (es) 2021-02-09
PH12015500466A1 (en) 2015-04-20
HUE050464T2 (hu) 2020-12-28
US20190085068A1 (en) 2019-03-21
US9376489B2 (en) 2016-06-28
JOP20200308A1 (ar) 2017-06-16
JO3764B1 (ar) 2021-01-31
AU2017272201A1 (en) 2018-01-04
IL237161B (en) 2019-08-29
HRP20200906T1 (hr) 2020-09-04
SG11201501559VA (en) 2015-03-30
CU24249B1 (es) 2017-02-02
BR112015004783A2 (pt) 2017-11-21
ECSP15013209A (es) 2018-09-30
CU20150022A7 (es) 2015-08-27
UY35016A (es) 2014-04-30
EP2892923B1 (en) 2020-03-25
US20220098296A1 (en) 2022-03-31
IL268336B (en) 2022-03-01
PL2892923T3 (pl) 2020-09-07
MX2015002986A (es) 2015-10-08
JP6404817B2 (ja) 2018-10-17
US20160376361A1 (en) 2016-12-29
CA2883821A1 (en) 2014-03-13
PH12015500466B1 (en) 2015-04-20
CN104640879A (zh) 2015-05-20
BR122019028128B1 (pt) 2023-01-31
TN2015000057A1 (en) 2016-06-29
ZA201500954B (en) 2018-11-28
AU2013311234A1 (en) 2015-03-05
JP2015534546A (ja) 2015-12-03
CA2883821C (en) 2023-03-07
TWI655208B (zh) 2019-04-01
BR112015004783B1 (pt) 2023-01-31
JP2020072704A (ja) 2020-05-14
JP6944509B2 (ja) 2021-10-06
EA201590523A1 (ru) 2015-06-30
EP2892923A2 (en) 2015-07-15
US20140112915A1 (en) 2014-04-24
KR20150047138A (ko) 2015-05-04
PE20150649A1 (es) 2015-05-14
IL237161A0 (en) 2015-04-30
KR102330653B1 (ko) 2021-11-23
CR20150121A (es) 2015-05-04
AU2020201556A1 (en) 2020-03-19
LT2892923T (lt) 2020-06-25
EP3725805A1 (en) 2020-10-21
US11111293B2 (en) 2021-09-07
EA201992614A3 (ru) 2020-05-31
US10081677B2 (en) 2018-09-25
MA37892A1 (fr) 2016-06-30
AR092465A1 (es) 2015-04-22
CO7400884A2 (es) 2015-09-30
AP2015008266A0 (en) 2015-02-28
MY174691A (en) 2020-05-07
GT201500054A (es) 2015-10-15
SI2892923T1 (sl) 2020-07-31
AU2016201741B2 (en) 2017-09-07
TW201414747A (zh) 2014-04-16
KR102207672B1 (ko) 2021-01-26
IL268336A (en) 2019-09-26
CN109517065B (zh) 2022-11-04
TWI613217B (zh) 2018-02-01
MX2020007022A (es) 2020-09-07
SG10201706623WA (en) 2017-09-28
RS60394B1 (sr) 2020-07-31
AU2017272201B2 (en) 2020-01-02
JP2019037230A (ja) 2019-03-14
AU2016201741A1 (en) 2016-04-07
TW201827463A (zh) 2018-08-01
WO2014037899A3 (en) 2014-06-05
CN109517065A (zh) 2019-03-26
DK2892923T3 (da) 2020-06-29

Similar Documents

Publication Publication Date Title
CY1123071T1 (el) Μορια προσδεσης il-18
CY1124698T1 (el) Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους
CY1120626T1 (el) Αντισωματα και αλλα μορια που δεσμευουν β7-η1 και pd-1
CY1118014T1 (el) Aνti-il-23 αντισωματα
CL2014003110A1 (es) Anticuerpo anti-fcrn; secuencias que lo codifican; vector; célula huésped; proceso de producción; composición farmacéutica que lo comprende; uso para el tratamiento de enfermedad autoinmune; y ensayo para probar la capacidad de un anticuerpo para bloquear la actividad de fcrn humano.
EA201492137A1 (ru) Антитела к cd33 и их применение в лечении рака
BR112016016699A2 (pt) Anticorpos humanos para pd-1
EA201492149A1 (ru) St2-антигенсвязывающие белки
AR092662A1 (es) Anticuerpos anti-ddr1
EA202091315A2 (ru) Антитела человека, связывающиеся с g-белком rsv
CY1115349T1 (el) Εξανθρωπισμενα αντι cxcr4 αντισωματα για τη θεραπεια καρκινου
EA201790438A1 (ru) Антигенсвязывающие белки, которые связываются с cxcr5
MX360163B (es) Moleculas de union il-6.
WO2015058861A8 (en) Bispecific constructs and their use in the treatment of various diseases
EA201591514A1 (ru) Антитела к пан-хемокинам подсемейства elrcxc
PH12015500752A1 (en) Her3 antigen binding proteins binding to the beta-hairpin of her3
MX366046B (es) Moléculas de unión que se adhieren al factor de complemento c2 humano y usos de los mismos.
BR112013023513A2 (pt) anticorpos que ligam tgf-alfa e epiregulina
NZ716687A (en) Il-18 binding molecules
TH167242A (th) โมเลกุลการยึดเกาะ il-18
TH167242B (th) โมเลกุลการยึดเกาะ il-18
NZ768582A (en) Antibodies and uses thereof to detect folate receptor 1
TH159056A (th) แอนติบอดีต่อ hla-b*27และการใช้มัน