CL2015000532A1 - Molécula de enlace a interleuquina 18 (il-18); anticuerpo; polinucleótido que lo codifica; vector; célula huésped; composición farmacéutica; uso para tratar sarcoidosis y otras inmunodeficiencias; y kit de diagnóstico. - Google Patents

Molécula de enlace a interleuquina 18 (il-18); anticuerpo; polinucleótido que lo codifica; vector; célula huésped; composición farmacéutica; uso para tratar sarcoidosis y otras inmunodeficiencias; y kit de diagnóstico.

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Publication number
CL2015000532A1
CL2015000532A1 CL2015000532A CL2015000532A CL2015000532A1 CL 2015000532 A1 CL2015000532 A1 CL 2015000532A1 CL 2015000532 A CL2015000532 A CL 2015000532A CL 2015000532 A CL2015000532 A CL 2015000532A CL 2015000532 A1 CL2015000532 A1 CL 2015000532A1
Authority
CL
Chile
Prior art keywords
immunodeficiencies
interleukin
antibody
vector
pharmaceutical composition
Prior art date
Application number
CL2015000532A
Other languages
English (en)
Inventor
Michael Otto Bardroff
Barbara Brannetti
Emma Michelle Campbell
Beate Diefenbachstreiber
Adina Eberth
Christian Carsten Silvester Kunz
Sylwia Marshall
Jean-Michel Rene Rondeau
Jean-Marc Alfred Schlaeppi
Heeke Gino Anselmus Van
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2015000532(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2015000532A1 publication Critical patent/CL2015000532A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52Assays involving cytokines
    • G01N2333/54Interleukins [IL]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Otolaryngology (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
CL2015000532A 2012-09-07 2015-03-04 Molécula de enlace a interleuquina 18 (il-18); anticuerpo; polinucleótido que lo codifica; vector; célula huésped; composición farmacéutica; uso para tratar sarcoidosis y otras inmunodeficiencias; y kit de diagnóstico. CL2015000532A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261697981P 2012-09-07 2012-09-07

Publications (1)

Publication Number Publication Date
CL2015000532A1 true CL2015000532A1 (es) 2015-06-05

Family

ID=49596347

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000532A CL2015000532A1 (es) 2012-09-07 2015-03-04 Molécula de enlace a interleuquina 18 (il-18); anticuerpo; polinucleótido que lo codifica; vector; célula huésped; composición farmacéutica; uso para tratar sarcoidosis y otras inmunodeficiencias; y kit de diagnóstico.

Country Status (41)

Country Link
US (4) US9376489B2 (es)
EP (2) EP3725805A1 (es)
JP (3) JP6404817B2 (es)
KR (2) KR102330653B1 (es)
CN (2) CN104640879B (es)
AP (1) AP2015008266A0 (es)
AR (1) AR092465A1 (es)
AU (4) AU2013311234A1 (es)
BR (2) BR112015004783B1 (es)
CA (1) CA2883821C (es)
CL (1) CL2015000532A1 (es)
CO (1) CO7400884A2 (es)
CR (1) CR20150121A (es)
CU (1) CU24249B1 (es)
CY (1) CY1123071T1 (es)
DK (1) DK2892923T3 (es)
EA (2) EA201992614A3 (es)
EC (1) ECSP15013209A (es)
ES (1) ES2804704T3 (es)
GT (1) GT201500054A (es)
HK (1) HK1209136A1 (es)
HR (1) HRP20200906T1 (es)
HU (1) HUE050464T2 (es)
IL (2) IL237161B (es)
JO (2) JOP20200308A1 (es)
LT (1) LT2892923T (es)
MA (1) MA37892A1 (es)
MX (2) MX2015002986A (es)
MY (1) MY174691A (es)
PE (1) PE20150649A1 (es)
PH (1) PH12015500466A1 (es)
PL (1) PL2892923T3 (es)
PT (1) PT2892923T (es)
RS (1) RS60394B1 (es)
SG (2) SG10201706623WA (es)
SI (1) SI2892923T1 (es)
TN (1) TN2015000057A1 (es)
TW (2) TWI613217B (es)
UY (1) UY35016A (es)
WO (1) WO2014037899A2 (es)
ZA (1) ZA201500954B (es)

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JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
JP6820743B2 (ja) * 2013-09-05 2021-01-27 エイビー2 バイオ ソシエテアノニム 炎症性疾患におけるil−18結合タンパク質(il−18bp)
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
KR102511343B1 (ko) 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(il-18bp) 및 항체
WO2017076805A1 (en) * 2015-11-02 2017-05-11 Glaxosmithkline Intellectual Property Development Limited Use of an inhibitor of il18 for treatment of acute kidney injury
AU2016348391A1 (en) * 2015-11-03 2018-05-17 Janssen Biotech, Inc. Antibodies specifically binding TIM-3 and their uses
CN108218978B (zh) * 2016-12-13 2020-05-12 沈阳何氏眼产业集团有限公司 一种重组白细胞介素18及其制备方法与应用
AU2018232883A1 (en) 2017-03-09 2019-09-19 Mab Discovery Gmbh Antibodies specifically binding to human IL-1 R7
UY37758A (es) 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
CA3080492A1 (en) * 2017-09-06 2019-03-14 Yale University Interleukin-18 variants and methods of use
WO2019213686A1 (en) * 2018-05-10 2019-11-14 The Council Of The Queensland Institute Of Medical Research Therapeutic compositions and uses therefor
WO2020116423A1 (ja) 2018-12-03 2020-06-11 株式会社mAbProtein 活性型インターロイキン-18タンパク質のネオエピトープを認識する抗体、及びその応用
CN109870570A (zh) * 2018-12-29 2019-06-11 广东云天抗体生物科技有限公司 一种检测猴il-18的酶联免疫试剂盒
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Il-18拮抗劑用於治療和/或預防異位性皮炎或相關病症之用途
WO2022221264A1 (en) * 2021-04-12 2022-10-20 Ethos Biosciences, Inc. Methods and compositions for analysis of acute kidney injury
CA3219360A1 (en) 2021-06-22 2022-12-29 Novartis Ag Bispecific antibodies for use in treatment of hidradenitis suppurativa
JPWO2023286694A1 (es) 2021-07-13 2023-01-19
CN117177999A (zh) * 2022-01-14 2023-12-05 和径医药科技(上海)有限公司 一种靶向IL-18Rβ的抗体及其应用
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
WO2023209568A1 (en) * 2022-04-26 2023-11-02 Novartis Ag Multispecific antibodies targeting il-13 and il-18

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