GT201500054A - Moléculas de enlace a il-18 - Google Patents

Moléculas de enlace a il-18

Info

Publication number
GT201500054A
GT201500054A GT201500054A GT201500054A GT201500054A GT 201500054 A GT201500054 A GT 201500054A GT 201500054 A GT201500054 A GT 201500054A GT 201500054 A GT201500054 A GT 201500054A GT 201500054 A GT201500054 A GT 201500054A
Authority
GT
Guatemala
Prior art keywords
link
link molecules
interleucine
molecules
cytoquine
Prior art date
Application number
GT201500054A
Other languages
English (en)
Inventor
Bardroff Michael Otto
Brannetti Barbara
Campbell Emma Michelle
Diefenbach-Streiber Beate
Eberth Adina
Kunz Christian Carsten Silvester
Marshall Sylwia
Van Heeke Gino Anselmus
Rondeau Jean-Michel Rene
Schlaeppi Jean-Marc Alfred
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201500054(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT201500054A publication Critical patent/GT201500054A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A MOLÉCULAS DE ENLACE Y MÁS PARTICULARMENTE, A INMUNOGLOBULINAS, TALES COMO LOS ANTICUERPOS O FRAGMENTOS DE LOS MISMOS, QUE SE ENLAZAN CON LA CITOQUINA INTERLEUCINA 18 (IL-18) PERO NO SE ENLAZAN A LA IL-18 EN COMPLEJO CON EL INHIBIDOR ENDÓGENO DE LA PROTEÍNA DE ENLACE A LA INTERLEUCINA 18 (IL-18BP)
GT201500054A 2012-09-07 2015-03-06 Moléculas de enlace a il-18 GT201500054A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261697981P 2012-09-07 2012-09-07

Publications (1)

Publication Number Publication Date
GT201500054A true GT201500054A (es) 2015-10-15

Family

ID=49596347

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201500054A GT201500054A (es) 2012-09-07 2015-03-06 Moléculas de enlace a il-18

Country Status (41)

Country Link
US (4) US9376489B2 (es)
EP (2) EP2892923B1 (es)
JP (3) JP6404817B2 (es)
KR (2) KR102207672B1 (es)
CN (2) CN104640879B (es)
AP (1) AP2015008266A0 (es)
AR (1) AR092465A1 (es)
AU (4) AU2013311234A1 (es)
BR (2) BR122019028128B1 (es)
CA (1) CA2883821C (es)
CL (1) CL2015000532A1 (es)
CO (1) CO7400884A2 (es)
CR (1) CR20150121A (es)
CU (1) CU24249B1 (es)
CY (1) CY1123071T1 (es)
DK (1) DK2892923T3 (es)
EA (2) EA201992614A3 (es)
EC (1) ECSP15013209A (es)
ES (1) ES2804704T3 (es)
GT (1) GT201500054A (es)
HK (1) HK1209136A1 (es)
HR (1) HRP20200906T1 (es)
HU (1) HUE050464T2 (es)
IL (2) IL237161B (es)
JO (2) JOP20200308A1 (es)
LT (1) LT2892923T (es)
MA (1) MA37892A1 (es)
MX (2) MX2015002986A (es)
MY (1) MY174691A (es)
PE (1) PE20150649A1 (es)
PH (1) PH12015500466A1 (es)
PL (1) PL2892923T3 (es)
PT (1) PT2892923T (es)
RS (1) RS60394B1 (es)
SG (2) SG10201706623WA (es)
SI (1) SI2892923T1 (es)
TN (1) TN2015000057A1 (es)
TW (2) TWI655208B (es)
UY (1) UY35016A (es)
WO (1) WO2014037899A2 (es)
ZA (1) ZA201500954B (es)

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JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
PL3041864T3 (pl) * 2013-09-05 2021-12-20 Ab2 Bio Sa Białko wiążące il-18 (il-18bp) w chorobach zapalnych
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
RU2755691C2 (ru) 2015-03-05 2021-09-20 Аб2 Био Са Il-18-связывающие белок (il-18bp) и антитела при воспалительных заболеваниях
WO2017076805A1 (en) * 2015-11-02 2017-05-11 Glaxosmithkline Intellectual Property Development Limited Use of an inhibitor of il18 for treatment of acute kidney injury
BR112018008891A8 (pt) 2015-11-03 2019-02-26 Janssen Biotech Inc anticorpos que se ligam especificamente a pd-1 e tim-3 e seus usos
CN108218978B (zh) * 2016-12-13 2020-05-12 沈阳何氏眼产业集团有限公司 一种重组白细胞介素18及其制备方法与应用
US11352432B2 (en) 2017-03-09 2022-06-07 Mab Discovery Gmbh Antibodies specifically binding to human IL-1R7
UY37758A (es) * 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
IL272635B2 (en) * 2017-09-06 2024-02-01 Univ Yale Variants of interleukin-18 and methods of use
WO2019213686A1 (en) * 2018-05-10 2019-11-14 The Council Of The Queensland Institute Of Medical Research Therapeutic compositions and uses therefor
EP3892300A4 (en) 2018-12-03 2022-12-14 Mabprotein Co.,Ltd. ANTIBODY RECOGNIZING A NEOEPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND ITS USE
CN109870570A (zh) * 2018-12-29 2019-06-11 广东云天抗体生物科技有限公司 一种检测猴il-18的酶联免疫试剂盒
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
WO2022221264A1 (en) * 2021-04-12 2022-10-20 Ethos Biosciences, Inc. Methods and compositions for analysis of acute kidney injury
WO2022269451A1 (en) 2021-06-22 2022-12-29 Novartis Ag Bispecific antibodies for use in treatment of hidradenitis suppurativa
JPWO2023286694A1 (es) 2021-07-13 2023-01-19
CN117177999A (zh) * 2022-01-14 2023-12-05 和径医药科技（上海）有限公司 一种靶向IL-18Rβ的抗体及其应用
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
WO2023209568A1 (en) * 2022-04-26 2023-11-02 Novartis Ag Multispecific antibodies targeting il-13 and il-18

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