CY1124698T1 - Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους - Google Patents

Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους

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Publication number
CY1124698T1
CY1124698T1 CY20211100816T CY211100816T CY1124698T1 CY 1124698 T1 CY1124698 T1 CY 1124698T1 CY 20211100816 T CY20211100816 T CY 20211100816T CY 211100816 T CY211100816 T CY 211100816T CY 1124698 T1 CY1124698 T1 CY 1124698T1
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CY
Cyprus
Prior art keywords
binding protein
inflammatory diseases
present
diseases
interleukin
Prior art date
Application number
CY20211100816T
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English (en)
Inventor
Andrea Pfeifer
Greg Del Val
Original Assignee
Ab2 Bio Sa
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Publication date
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Publication of CY1124698T1 publication Critical patent/CY1124698T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract

Η παρούσα εφεύρεση παρέχει μέσα και μεθόδους για τη θεραπεία νόσων και διαταραχών που σχετίζονται με Ιντερλευκίνη 18 (IL-18). Συγκεκριμένα, η παρούσα εφεύρεση αποκαλύπτει αντισώματα ειδικά για ελεύθερη 1L-18 και πρωτεΐνη δέσμευσης IL-18 (IL-18BP) για χρήση σε τέτοιες θεραπείες και για τη διάγνωση των ενδείξεων.
CY20211100816T 2013-09-05 2021-09-16 Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους CY1124698T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13183193 2013-09-05
PCT/EP2014/069013 WO2015032932A1 (en) 2013-09-05 2014-09-05 Il-18 binding protein (il-18bp) in inflammatory diseases
EP14759210.9A EP3041864B1 (en) 2013-09-05 2014-09-05 Il-18 binding protein (il-18bp) in inflammatory diseases

Publications (1)

Publication Number Publication Date
CY1124698T1 true CY1124698T1 (el) 2022-07-22

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CY20211100816T CY1124698T1 (el) 2013-09-05 2021-09-16 Πρωτεϊνη δεσμευσης il-18 (il-18bp) σε φλεγμονωδεις νοσους

Country Status (25)

Country Link
US (3) US10858426B2 (el)
EP (2) EP3041864B1 (el)
JP (2) JP6820743B2 (el)
KR (2) KR102321172B1 (el)
CN (2) CN105722858A (el)
AU (1) AU2014317035B2 (el)
CA (1) CA2922498A1 (el)
CL (1) CL2016000506A1 (el)
CY (1) CY1124698T1 (el)
DK (1) DK3041864T3 (el)
ES (1) ES2892923T3 (el)
HK (1) HK1221726A1 (el)
HU (1) HUE055608T2 (el)
IL (1) IL244169B (el)
LT (1) LT3041864T (el)
MX (1) MX2016002719A (el)
NZ (1) NZ717671A (el)
PH (1) PH12016500425A1 (el)
PL (1) PL3041864T3 (el)
PT (1) PT3041864T (el)
RU (1) RU2731713C2 (el)
SG (1) SG11201601717VA (el)
SI (1) SI3041864T1 (el)
UA (1) UA125204C2 (el)
WO (1) WO2015032932A1 (el)

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TWI679279B (zh) * 2018-05-09 2019-12-11 臺中榮民總醫院 檢測成人發作型史笛兒氏症之罹病風險及預後之方法
CA3104362A1 (en) * 2018-06-19 2019-12-26 Shanghaitech University Human antibodies to human interleukin 18 receptor alpha and beta
WO2020116423A1 (ja) 2018-12-03 2020-06-11 株式会社ｍＡｂＰｒｏｔｅｉｎ 活性型インターロイキン－１８タンパク質のネオエピトープを認識する抗体、及びその応用
CN110433289A (zh) * 2019-09-10 2019-11-12 中山大学附属口腔医院 用于治疗牙周致病菌感染引起的牙周膜细胞功能紊乱与牙槽骨丧失的药物
US20230173021A1 (en) 2020-05-06 2023-06-08 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) In Respiratory Diseases
GB202007404D0 (en) * 2020-05-19 2020-07-01 Nasser Syed Muhammad Tahir Treatment for viral respiratory infections
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
KR20220044057A (ko) * 2020-09-29 2022-04-06 주식회사 에이프릴바이오 인터루킨-18 결합 단백질 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질, 및 이의 용도
WO2023286694A1 (ja) 2021-07-13 2023-01-19 国立大学法人東海国立大学機構 炎症性腸疾患を治療するための医薬組成物
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