CO7240362A2 - Molécula de unión il-6 - Google Patents

Molécula de unión il-6

Info

Publication number
CO7240362A2
CO7240362A2 CO14258229A CO14258229A CO7240362A2 CO 7240362 A2 CO7240362 A2 CO 7240362A2 CO 14258229 A CO14258229 A CO 14258229A CO 14258229 A CO14258229 A CO 14258229A CO 7240362 A2 CO7240362 A2 CO 7240362A2
Authority
CO
Colombia
Prior art keywords
antibodies
binding fragments
antigen
binding molecule
inhibit
Prior art date
Application number
CO14258229A
Other languages
English (en)
Inventor
Christophe Blanchetot
Haard Johannes De
Torsten Dreier
Jonge Natalie De
Der Woning Sebastián Paul Van
Nicolas Ongenae
Original Assignee
Argen X N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47559582&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO7240362(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Argen X N V filed Critical Argen X N V
Publication of CO7240362A2 publication Critical patent/CO7240362A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona moléculas de unión (por 5 ejemplo, anticuerpos o fragmentos de unión a antígeno de los mismos) que se unen específicamente a e inhiben laactividad biológica de IL-6 (por ejemplo, IL-6 humana, IL-6 de ratón e IL-6 de primate no humano). En una realización preferida, los anticuerpos o fragmentos de unión antígenode la invención se unen a la IL-6 e inhiben su unión a un receptor de IL-6. Tales anticuerpos o fragmentos de uniónantígeno son particularmente útiles para el tratamiento deenfermedades o trastornos asociados a IL-6 (por ejemplo, enfermedades inflamatorias y cáncer).
CO14258229A 2012-05-23 2014-11-24 Molécula de unión il-6 CO7240362A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261650883P 2012-05-23 2012-05-23
US201261720102P 2012-10-30 2012-10-30

Publications (1)

Publication Number Publication Date
CO7240362A2 true CO7240362A2 (es) 2015-04-17

Family

ID=47559582

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14258229A CO7240362A2 (es) 2012-05-23 2014-11-24 Molécula de unión il-6

Country Status (17)

Country Link
US (4) US10183995B2 (es)
EP (1) EP2852616A1 (es)
JP (1) JP6410712B2 (es)
KR (1) KR20150063311A (es)
CN (1) CN103601806B (es)
AU (1) AU2013264779B2 (es)
BR (1) BR112014029219B1 (es)
CA (1) CA2871148C (es)
CL (1) CL2014003167A1 (es)
CO (1) CO7240362A2 (es)
EC (1) ECSP14029713A (es)
IL (1) IL235134B (es)
MX (1) MX360163B (es)
NZ (1) NZ701370A (es)
PE (1) PE20150335A1 (es)
RU (1) RU2676078C2 (es)
WO (2) WO2013175276A1 (es)

Families Citing this family (9)

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WO2017023699A1 (en) 2015-07-31 2017-02-09 Medimmune Limited Methods for treating hepcidin-mediated disorders
CN105194655A (zh) * 2015-10-21 2015-12-30 胶州市人民中医医院 一种新生儿细菌感染性脑炎的治疗方法
GB201611123D0 (en) * 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
WO2018144773A1 (en) 2017-02-01 2018-08-09 Yale University Treatment of diuretic resistance
AU2019205936B2 (en) 2018-01-05 2022-09-15 Novo Nordisk A/S Methods for treating IL-6 mediated inflammation without immunosuppression
CN111153998B (zh) * 2020-01-16 2022-06-24 佛山汉腾生物科技有限公司 抗ctla-4纳米抗体及其应用
US20230236199A1 (en) * 2020-04-23 2023-07-27 Eli Lilly And Company Subcutaneous absorption and bioavailability of antibodies
CN113150140B (zh) * 2021-01-25 2022-11-04 山西农业大学 一种sox6二价纳米抗体及其应用
WO2023229891A1 (en) * 2022-05-25 2023-11-30 Ayuvis Research, Inc. Novel immunodulating small molecules

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Also Published As

Publication number Publication date
WO2013175427A1 (en) 2013-11-28
CN103601806A (zh) 2014-02-26
BR112014029219A2 (es) 2017-08-15
IL235134B (en) 2019-12-31
KR20150063311A (ko) 2015-06-09
PE20150335A1 (es) 2015-03-20
BR112014029219A8 (pt) 2019-05-14
CA2871148C (en) 2020-07-14
US11827701B2 (en) 2023-11-28
US11117959B2 (en) 2021-09-14
CA2871148A1 (en) 2013-11-28
AU2013264779A1 (en) 2014-10-30
MX2014014218A (es) 2015-11-23
CL2014003167A1 (es) 2015-06-12
US20150140011A1 (en) 2015-05-21
US20190233509A1 (en) 2019-08-01
US20240158492A1 (en) 2024-05-16
CN103601806B (zh) 2019-01-18
EP2852616A1 (en) 2015-04-01
ECSP14029713A (es) 2015-09-30
NZ701370A (en) 2016-11-25
IL235134A0 (en) 2014-12-31
JP6410712B2 (ja) 2018-10-24
RU2676078C2 (ru) 2018-12-26
WO2013175276A1 (en) 2013-11-28
US20220073604A1 (en) 2022-03-10
MX360163B (es) 2018-10-09
JP2015518857A (ja) 2015-07-06
US10183995B2 (en) 2019-01-22
AU2013264779B2 (en) 2018-03-22
BR112014029219B1 (pt) 2022-04-19
RU2014152006A (ru) 2016-07-20

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