BR112013004266A2 - anticorpos anti-ox40 e métodos de uso dos mesmos. - Google Patents

anticorpos anti-ox40 e métodos de uso dos mesmos.

Info

Publication number
BR112013004266A2
BR112013004266A2 BR112013004266A BR112013004266A BR112013004266A2 BR 112013004266 A2 BR112013004266 A2 BR 112013004266A2 BR 112013004266 A BR112013004266 A BR 112013004266A BR 112013004266 A BR112013004266 A BR 112013004266A BR 112013004266 A2 BR112013004266 A2 BR 112013004266A2
Authority
BR
Brazil
Prior art keywords
antibodies
methods
receptor
antibody
human antibodies
Prior art date
Application number
BR112013004266A
Other languages
English (en)
Other versions
BR112013004266A8 (pt
Inventor
J Yun Tso
Kui Shin Voo
Laura Bover
Naoya Tsurushita
Shankar Kumar
Yong-Jun Liu
Original Assignee
Regents The Unibersity Of Texas System Board Of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regents The Unibersity Of Texas System Board Of filed Critical Regents The Unibersity Of Texas System Board Of
Publication of BR112013004266A2 publication Critical patent/BR112013004266A2/pt
Publication of BR112013004266A8 publication Critical patent/BR112013004266A8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

anticorpos anti-ox40 e métodos de uso dos mesmos. anticorpos humanos, preferencialmente anticorpos humanos recombinantes, tanto humanizados quanto quiméricos, que especificamente se ligam a ox40 humano são descritos. anticorpos preferenciais têm alta afinidade para o receptor ox40e ativam o receptor in vitro e in vivo. o anticorpo pode ser um anticorpo inteiro ou uma porção de ligação ao antígeno do mesmo. os anticorpos ou porções de anticorpos são úteis para modulação da atividade de receptor, por exemplo, em um ser humano que sofre de um distúrbio no qual a atividade de ox40 é prjudicail. os ácidos nucleicos, os vetores e as células hospedeiras para expressar os anticorpos humanos recombinantes são fornecidos, e métodos de síntese dos anticorpos humanos recombinantes, também são fornecidos.
BR112013004266A 2010-08-23 2011-08-23 anticorpos anti-ox40 e métodos de uso dos mesmos. BR112013004266A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37599910P 2010-08-23 2010-08-23
US38082710P 2010-09-08 2010-09-08
PCT/US2011/048752 WO2012027328A2 (en) 2010-08-23 2011-08-23 Anti-ox40 antibodies and methods of using the same

Publications (2)

Publication Number Publication Date
BR112013004266A2 true BR112013004266A2 (pt) 2016-08-02
BR112013004266A8 BR112013004266A8 (pt) 2018-01-02

Family

ID=45724011

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112013004266A BR112013004266A8 (pt) 2010-08-23 2011-08-23 anticorpos anti-ox40 e métodos de uso dos mesmos.
BR112014003982A BR112014003982A2 (pt) 2010-08-23 2012-02-09 anticorpos anti-ox40 e processos de utilização dos mesmos

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112014003982A BR112014003982A2 (pt) 2010-08-23 2012-02-09 anticorpos anti-ox40 e processos de utilização dos mesmos

Country Status (34)

Country Link
US (6) US9006399B2 (pt)
EP (2) EP2609118B1 (pt)
JP (2) JP5984810B2 (pt)
KR (2) KR101719118B1 (pt)
CN (2) CN103221427B (pt)
AP (1) AP2013006771A0 (pt)
AU (1) AU2011293558B2 (pt)
BR (2) BR112013004266A8 (pt)
CA (1) CA2809089C (pt)
CL (3) CL2013000545A1 (pt)
CO (1) CO6680693A2 (pt)
CR (1) CR20130126A (pt)
CY (1) CY1118928T1 (pt)
DK (1) DK2609118T3 (pt)
DO (1) DOP2013000045A (pt)
EA (2) EA031849B1 (pt)
ES (2) ES2630328T3 (pt)
HK (1) HK1213272A1 (pt)
HR (1) HRP20170568T1 (pt)
HU (1) HUE031371T2 (pt)
IL (2) IL224886A (pt)
LT (1) LT2609118T (pt)
ME (1) ME02678B (pt)
MX (1) MX339964B (pt)
MY (1) MY171312A (pt)
NZ (3) NZ629913A (pt)
PE (2) PE20180042A1 (pt)
PL (1) PL2609118T3 (pt)
PT (1) PT2609118T (pt)
RS (1) RS55952B1 (pt)
SG (1) SG187945A1 (pt)
SI (1) SI2609118T1 (pt)
WO (1) WO2012027328A2 (pt)
ZA (1) ZA201301442B (pt)

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US9163085B2 (en) 2015-10-20
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BR112014003982A2 (pt) 2017-05-09
AP2013006771A0 (en) 2013-03-31
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PL2609118T3 (pl) 2017-07-31
US10196450B2 (en) 2019-02-05
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CA2809089A1 (en) 2012-03-01
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US20140308276A1 (en) 2014-10-16
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US9527917B2 (en) 2016-12-27
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WO2012027328A3 (en) 2012-05-31
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