UA118646C2 - Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини - Google Patents

Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини

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Publication number
UA118646C2
UA118646C2 UAA201305880A UAA201305880A UA118646C2 UA 118646 C2 UA118646 C2 UA 118646C2 UA A201305880 A UAA201305880 A UA A201305880A UA A201305880 A UAA201305880 A UA A201305880A UA 118646 C2 UA118646 C2 UA 118646C2
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Ukraine
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human
antibodies
methods
antibody
relates
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UAA201305880A
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English (en)
Inventor
Хуан Карлос Альмагро
Уілльям Дабелл
Йохан Франссон
Хосе Пардінас
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Янссен Байотек, Інк.
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Publication of UA118646C2 publication Critical patent/UA118646C2/uk

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

Винахід стосується виділеного антитіла, яке специфічно зв’язується з онкостатином М (ОМ) людини, його антигензв’язувального фрагмента, виділеного полінуклеотиду, що кодує важкий та легкий ланцюг антитіла, стабільно трансформованої або трансфікованої рекомбінантної клітини-хазяїна, способу одержання антитіла, набору, що містить стерильний препарат виділеного антитіла та фармацевтичної композиції. Винахід також стосується способу лікування хворої людини, що страждає на захворювання або розлад, пов’язаний з моделюючою активністю або взаємодією людського ОМ з людським білком gp130.
UAA201305880A 2010-10-13 2011-10-10 Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини UA118646C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39268310P 2010-10-13 2010-10-13
PCT/US2011/055606 WO2012051111A2 (en) 2010-10-13 2011-10-10 Human oncostatin m antibodies and methods of use

Publications (1)

Publication Number Publication Date
UA118646C2 true UA118646C2 (uk) 2019-02-25

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Application Number Title Priority Date Filing Date
UAA201305880A UA118646C2 (uk) 2010-10-13 2011-10-10 Виділене антитіло, яке специфіічно зв'язується з онкостатином м (оm) людини

Country Status (20)

Country Link
US (5) US20120093833A1 (uk)
EP (1) EP2627356B1 (uk)
JP (3) JP6216917B2 (uk)
KR (1) KR101920250B1 (uk)
CN (1) CN103261223B (uk)
AR (2) AR083418A1 (uk)
AU (1) AU2011313847B2 (uk)
BR (1) BR112013009083B1 (uk)
CA (1) CA2814652C (uk)
EA (1) EA031044B1 (uk)
IL (1) IL225573B (uk)
JO (1) JO3496B1 (uk)
MX (1) MX354095B (uk)
RU (1) RU2600444C2 (uk)
SG (2) SG189322A1 (uk)
TW (1) TWI548749B (uk)
UA (1) UA118646C2 (uk)
UY (1) UY33670A (uk)
WO (1) WO2012051111A2 (uk)
ZA (1) ZA201303429B (uk)

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