BR112013009083A2 - anticorpos humanos de oncostatin m e métodos de uso - Google Patents

anticorpos humanos de oncostatin m e métodos de uso

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Publication number
BR112013009083A2
BR112013009083A2 BR112013009083A BR112013009083A BR112013009083A2 BR 112013009083 A2 BR112013009083 A2 BR 112013009083A2 BR 112013009083 A BR112013009083 A BR 112013009083A BR 112013009083 A BR112013009083 A BR 112013009083A BR 112013009083 A2 BR112013009083 A2 BR 112013009083A2
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BR
Brazil
Prior art keywords
antibodies
methods
oncostatin
human oncostatin
human
Prior art date
Application number
BR112013009083A
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English (en)
Other versions
BR112013009083B1 (pt
BR112013009083A8 (pt
Inventor
Johan Fransson
Jose Pardinas
Juan Carlos Almagro
William Bubell
Original Assignee
Janssen Biotech Inc
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of BR112013009083A2 publication Critical patent/BR112013009083A2/pt
Publication of BR112013009083A8 publication Critical patent/BR112013009083A8/pt
Publication of BR112013009083B1 publication Critical patent/BR112013009083B1/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12P21/00—Preparation of peptides or proteins
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

anticorpos humanos de oncostatin m e métodos de uso. a presente invenção refere-se a anticorpose composições capazes de neutralizar funções biológicas de oncostatin m que são úteis no tratamento de doenças e distúrbios associados com oncostatin m, como osteoartrite e fibrose pulmonar idiopática.
BR112013009083-9A 2010-10-13 2011-10-10 Anticorpos humanos para oncostatina m, seu processo de fabricação, fragmento de ligação a antígeno, composição farmacêutica, polinucleotídeo isolado, célula hospedeira recombinante estavelmente transformada ou transfectada BR112013009083B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39268310P 2010-10-13 2010-10-13
US61/392,683 2010-10-13
PCT/US2011/055606 WO2012051111A2 (en) 2010-10-13 2011-10-10 Human oncostatin m antibodies and methods of use

Publications (3)

Publication Number Publication Date
BR112013009083A2 true BR112013009083A2 (pt) 2016-09-13
BR112013009083A8 BR112013009083A8 (pt) 2018-01-02
BR112013009083B1 BR112013009083B1 (pt) 2021-08-10

Family

ID=45934343

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013009083-9A BR112013009083B1 (pt) 2010-10-13 2011-10-10 Anticorpos humanos para oncostatina m, seu processo de fabricação, fragmento de ligação a antígeno, composição farmacêutica, polinucleotídeo isolado, célula hospedeira recombinante estavelmente transformada ou transfectada

Country Status (20)

Country Link
US (5) US20120093833A1 (pt)
EP (1) EP2627356B1 (pt)
JP (3) JP6216917B2 (pt)
KR (1) KR101920250B1 (pt)
CN (1) CN103261223B (pt)
AR (2) AR083418A1 (pt)
AU (1) AU2011313847B2 (pt)
BR (1) BR112013009083B1 (pt)
CA (1) CA2814652C (pt)
EA (1) EA031044B1 (pt)
IL (1) IL225573B (pt)
JO (1) JO3496B1 (pt)
MX (1) MX354095B (pt)
RU (1) RU2600444C2 (pt)
SG (2) SG189322A1 (pt)
TW (1) TWI548749B (pt)
UA (1) UA118646C2 (pt)
UY (1) UY33670A (pt)
WO (1) WO2012051111A2 (pt)
ZA (1) ZA201303429B (pt)

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